Surgical outcomes and quality of life assessment of esophagectomy for cancer with colon conduit via retrosternal route
ConclusionsColon conduit via retrosternal route after esophagectomy is feasible, safe, and could provide acceptable long-term functional outcomes. (Source: Esophagus)
Source: Esophagus - January 6, 2023 Category: Gastroenterology Source Type: research
The impact of combined PD-L1 positive score on clinical response to nivolumab in patients with advanced esophageal squamous cell carcinoma
ConclusionsThis study suggests that a CPS of < 1 is not a strong predictor of efficacy but can predict the absence of response to nivolumab in patients with aESCC. (Source: Esophagus)
Source: Esophagus - January 3, 2023 Category: Gastroenterology Source Type: research
Influence of patient position in thoracoscopic esophagectomy on postoperative pneumonia: a comparative analysis from the National Clinical Database in Japan
ConclusionsAlthough prolonged ventilation and surgery-related mortality occurred more frequently in the LP group than in the PP group, the patient position did not significantly influence the occurrence of postoperative pneumonia. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research
High-resolution manometry with additional maneuvers using the Starlet system: normative thresholds and diagnostic yields for relevant esophagogastric junction outflow disorders
ConclusionsHRM with additional maneuvers may facilitate the diagnosis of clinically relevant EGJOD. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research
Safety and short-term efficacy of preoperative FOLFOX therapy in patients with resectable esophageal squamous cell carcinoma who are ineligible for cisplatin
ConclusionsPreoperative FOLFOX had a manageable safety profile and showed favorable short-term efficacy in patients with resectable LAESCC who were ineligible for CDDP-containing treatment. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research
Comprehensive registry of esophageal cancer in Japan, 2015
ConclusionWe hope this report improves all aspects of diagnosing and treating esophageal cancer in Japan. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research
An anti-alcoholism drug, disulfiram and copper complex improves radio-resistance of tumor-initiating cells in esophageal squamous cell carcinoma
ConclusionALDH1 inhibition by the DSF/Cu complex enhances the radiosensitivity of TICs in ESCC. The drug repositioning approach using disulfiram is a potential treatment option to overcome radioresistance in patients with locally advanced ESCC. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research
Essential risk factors for operative mortality in elderly esophageal cancer patients registered in the National Clinical Database of Japan
ConclusionWe should carefully select the treatment for elderly patients with highly advanced tumors, which result in N2 –N3 and M1, to avoid unfavorable short-term outcomes. In addition, R0 resection is important in preventing operative mortality among elderly patients. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research
Isoperistaltic gastric tube: a versatile, length-gaining option for esophageal replacement in children and adolescents
This report presents our technique for creating an isoperistaltic gastric tube (IGT). We believe that the IGT is a versatile option for esophageal replacement as it is never length-limiting, and additional length can be gained by making minor adjustments. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research
Simultaneous regulation of ferroptosis suppressor protein 1 and glutathione peroxidase 4 as a new therapeutic strategy of ferroptosis for esophageal squamous cell carcinoma
ConclusionsOverexpression of FSP1 and GPX4 is a poor prognostic factor for patients with ESCC. Simultaneous suppression of both FSP1 and GPX4 caused potent cell death, which was markedly abrogated by ferroptosis inhibitors. These findings indicate that simultaneous regulation of FSP1 and GPX4 may be a new therapeutic target in ESCC. (Source: Esophagus)
Source: Esophagus - December 28, 2022 Category: Gastroenterology Source Type: research
Significance of dissection in each regional lymph-node station of esophageal cancer based on efficacy index and recurrence patterns after curative esophagectomy
ConclusionDue to the high incidence of systemic recurrence or low EI for pretracheal and posterior thoracic para-aortic LNs, we suggest that these LN stations be regarded as non-regional LNs and be excluded from routine dissection. Supraclavicular LNs may also be excluded from routinely dissected stations. (Source: Esophagus)
Source: Esophagus - December 27, 2022 Category: Gastroenterology Source Type: research
Significance of lymphovascular invasion in esophageal squamous cell carcinoma undergoing neoadjuvant chemotherapy followed by esophagectomy
ConclusionsThe present study suggested that the independent factor associated with prognosis of patients with LAESCC after NAC and surgery may differ according to the NAC regimen, and the presence of both ypN and LVI was a prognostic factor for patients with recurrence, including those with OMR. These results might be helpful when deciding on an additional treatment strategy for LAESCC patients. (Source: Esophagus)
Source: Esophagus - December 24, 2022 Category: Gastroenterology Source Type: research
Effectiveness of taxanes following nivolumab in patients with advanced esophageal squamous cell carcinoma: a retrospective chart review of patients in ATTRACTION-3
ConclusionsFavorable effectiveness and safety profile of taxanes following second-line nivolumab was observed in Japanese patients with advanced esophageal squamous cell carcinoma. When a patient with advanced esophageal squamous cell carcinoma receiving nivolumab becomes refractory or intolerant, subsequent taxane treatment may be a promising option. (Source: Esophagus)
Source: Esophagus - December 23, 2022 Category: Gastroenterology Source Type: research
The pathological conditions and surgical outcomes depending on the degree of hernia in the intra-thoracic stomach
ConclusionsIn the case of ITS, although the operation time was extended depending on the degree of the hernia, the surgical outcomes were the same, and overall good results were obtained. (Source: Esophagus)
Source: Esophagus - December 23, 2022 Category: Gastroenterology Source Type: research
The relationship between the esophageal endoscopic submucosal dissection technical difficulty and its intraoperative process
ConclusionsThe intraoperative process, particularly early phase, was strongly associated with esophageal ESD technical difficulty. This study demonstrated the potential for automatic evaluation of esophageal ESD technical difficulty when combined with an AI-based automatic phase evaluation system. (Source: Esophagus)
Source: Esophagus - December 12, 2022 Category: Gastroenterology Source Type: research
