Five-year follow-up of nivolumab treatment in Japanese patients with esophageal squamous-cell carcinoma (ATTRACTION-1/ONO-4538-07)
ConclusionOur follow-up analysis of more than 5 years is currently the longest and is the first to demonstrate that nivolumab has long-term efficacy and safety for advanced ESCC. (Source: Esophagus)
Source: Esophagus - May 16, 2021 Category: Gastroenterology Source Type: research
Impact of patient position on esophageal motility disorders using high-resolution esophageal manometry with impedance (HREMI): supine versus upright swallows
ConclusionsUpright swallows had lower LES, IRP, DCI and UES pressures in both normal subjects and patients with decreased bolus clearance in patients. Upright positioning can alter esophageal motility patterns and enhance diagnostic yield. Thus, upright swallows supplement supine swallows to help characterize esophageal dysmotility. (Source: Esophagus)
Source: Esophagus - May 11, 2021 Category: Gastroenterology Source Type: research
Metachronous carcinogenesis of superficial esophagus squamous cell carcinoma after endoscopic submucosal dissection: incidence and risk stratification during long-term observation
ConclusionPatients with a history of esophageal carcinoma remain at risk for metachronous carcinogenesis even > 5 years after endoscopic submucosal dissection. Thus, long-term follow-up is important. (Source: Esophagus)
Source: Esophagus - May 11, 2021 Category: Gastroenterology Source Type: research
Diagnosis of recurrent laryngeal nerve paralysis following esophagectomy by evaluating movement of the vocal cords and arytenoid cartilages using ultrasonography
AbstractAdvancements in thoracoscopic surgery have provided us with a deeper anatomical understanding of recurrent laryngeal nerve paralysis (RLNP), which is likely to occur after lymph node dissection. Taking a novel approach to researching the diagnosis of RLNP, we evaluated movement of the vocal cords and arytenoid cartilages using ultrasonography in patients who underwent thoracoscopic esophagectomy. RLNP occurred in six of the 24 patient cohort. The rate of hoarseness and difficulty in discharging sputum was significantly higher in the paralyzed group than in the non-paralyzed group. The diagnostic accuracy of RLNP by...
Source: Esophagus - May 5, 2021 Category: Gastroenterology Source Type: research
A nationwide survey on esophageal gastrointestinal stromal tumors at accredited institutions by the Japan Esophageal Society
ConclusionsThis nationwide survey revealed the current status of esophageal GISTs in Japan and provided important information for making a consensus on the treatment and follow-up method. (Source: Esophagus)
Source: Esophagus - April 29, 2021 Category: Gastroenterology Source Type: research
Therapeutic effect of laparoscopic fundoplication for patients with GERD from the viewpoint of Lyon Consensus
ConclusionThe classification of GERD pathophysiology based on the Lyon Consensus is satisfactory, with no significant differences in the rate of effect of LF. The Lyon Consensus is effective for ascertaining the severity and pathophysiology of GERD; however, we were unable to forecast the treatment results of LF. (Source: Esophagus)
Source: Esophagus - April 23, 2021 Category: Gastroenterology Source Type: research
Saliva secretion is reduced in proton pump inhibitor-responsive non-erosive reflux disease patients
ConclusionStimulated saliva secretion was reduced in PPI-responsive NERD patients. (Source: Esophagus)
Source: Esophagus - April 22, 2021 Category: Gastroenterology Source Type: research
Primary esophageal non-Hodgkin ’s lymphoma: demographics, clinical characteristics, histopathologic types, and survival in 179 patients from the SEER program and systematic review of the literature
ConclusionsIn this large population-based series, diagnosis after 1997 (year of rituximab approval by the FDA) and MZL subtype were associated with improved survival outcomes in patients with PEL. (Source: Esophagus)
Source: Esophagus - April 20, 2021 Category: Gastroenterology Source Type: research
Diverticular per oral endoscopic myotomy (DPOEM) for esophageal diverticular disease: a systematic review and meta-analysis
AbstractThe traditional way to tackle Zenker ’s diverticulum (ZD) has been flexible endoscopic septum division (FESD). Recently, the concept of per oral endoscopic myotomy has been found useful for managing diverticular diseases of the esophagus and has been termed DPOEM. We performed a systematic review and meta-analysis to evaluate the eff icacy and safety of D-POEM in diverticular disease of the esophagus and to compare it with FESD. We systematically searched PubMed and Embase, for studies reporting clinical success, technical success and adverse events in D-POEM alone or D-POEM comparing with FESD. We computed poole...
Source: Esophagus - April 20, 2021 Category: Gastroenterology Source Type: research
Peroral endoscopic myotomy is equally safe and highly effective treatment option in achalasia patients with both lower and higher ASA classification status
ConclusionPOEM is a very safe and highly effective treatment option for achalasia patients with advanced ASA class similar to lower ASA class patients. POEM may be considered as the preferred choice for myotomy in these high-risk achalasia patients due to its low morbidity and high efficacy. (Source: Esophagus)
Source: Esophagus - April 13, 2021 Category: Gastroenterology Source Type: research
Obesity reduces the requirement for subsequent esophageal stricture dilation in adults with eosinophilic esophagitis
ConclusionsEoE patients with strictures who are obese have a reduced requirement for subsequent esophageal dilation. While the mechanism for this is not clear, increased attention of non-obese patients with fibrostenotic EoE is indicated as they are at higher risk for recurrent strictures. (Source: Esophagus)
Source: Esophagus - April 12, 2021 Category: Gastroenterology Source Type: research
Correction to: Prognostic significance of serum inflammatory markers in esophageal cancer
In the original publication of the article, under the section “Clinicopathological characteristics”, the thresholds (Source: Esophagus)
Source: Esophagus - April 12, 2021 Category: Gastroenterology Source Type: research
Peroral endoscopic myotomy for advanced achalasia with megaesophagus
ConclusionsPeroral endoscopic myotomy improved achalasia-related symptoms, and this was technically feasible in patients with megaesophagus. However, the clinical success rate was somewhat low, and the rate of major adverse events was high. Therefore, peroral endoscopic myotomy should be carefully performed for advanced achalasia with megaesophagus. (Source: Esophagus)
Source: Esophagus - April 10, 2021 Category: Gastroenterology Source Type: research
Correction to: The early therapeutic response at 2 weeks is a crucial predictor of proton pump inhibitor-refractory gastroesophageal reflux disease
A correction to this paper has been published: https://doi.org/10.1007/s10388-021-00837-x (Source: Esophagus)
Source: Esophagus - April 8, 2021 Category: Gastroenterology Source Type: research
Whole exome sequencing and deep sequencing of esophageal squamous cell carcinoma and adenocarcinoma in Japanese patients using the Japanese version of the Genome Atlas, JCGA
ConclusionsThese findings may facilitate future precision medicine approaches based on genomic profiling in ESCC and EAC. (Source: Esophagus)
Source: Esophagus - April 7, 2021 Category: Gastroenterology Source Type: research
