The treatment effects of acotiamide in esophagogastric outflow obstruction: a prospective longitudinal observational study
ConclusionsAcotiamide has a treatment effect on patients with EGJOO via a reduction in the IRP level through the lowering of both the basal LES pressure and LES accommodation response. Dysphagia is a key symptom to be evaluated and treated in patients with EGJOO. (Source: Esophagus)
Source: Esophagus - October 9, 2021 Category: Gastroenterology Source Type: research
Efficacy and safety of peroral endoscopic myotomy in 100 older patients
ConclusionsPOEM is effective and safe for elderly patients. However, precautions are needed regarding the risk of adverse events associated with delirium when POEM is performed in elderly patients. (Source: Esophagus)
Source: Esophagus - October 9, 2021 Category: Gastroenterology Source Type: research
Significance of chemotherapy-free interval and tumor regression grade in patients with recurrent esophageal squamous cell carcinoma receiving chemotherapy with fluorouracil and platinum after esophagectomy following preoperative chemotherapy
ConclusionFluorouracil plus platinum was ineffective for recurrent ESCC in patients with a CFI < 6 months and in those with a CFI ≥ 6 months and a TRG ≤ 1a. Alternate regimens including nivolumab or pembrolizumab might be considered for the treatment for recurrence in these patients. (Source: Esophagus)
Source: Esophagus - October 5, 2021 Category: Gastroenterology Source Type: research
Visceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in 40 –69-years subjects
ConclusionsVisceral fat obesity is the key risk factor for the development of reflux erosive esophagitis in subjects aged 40 –69 years. (Source: Esophagus)
Source: Esophagus - August 26, 2021 Category: Gastroenterology Source Type: research
The characteristics and prognostic significance of esophageal squamous cell carcinoma with synchronous multiple lesions: over 10-year experience
ConclusionESCC with multiple lesions had unique clinical features and should not be simply treated as the one-lesion ESCC. Due to its worse prognostic impact, advanced multidisciplinary therapies should be considered for patients with multiple esophageal tumor lesions. (Source: Esophagus)
Source: Esophagus - August 26, 2021 Category: Gastroenterology Source Type: research
Modeling the risk of radiation pneumonitis in esophageal squamous cell carcinoma treated with definitive chemoradiotherapy
ConclusionsNon-smoking status, 3DCRT, lungV20 (> 27.5%), and PTV (≥ 713.0 cc) were significantly associated with a higher risk of RP. A nomogram was built with satisfactory prediction ability. (Source: Esophagus)
Source: Esophagus - August 26, 2021 Category: Gastroenterology Source Type: research
Clinical impacts of magnetic resonance thoracic ductography on preventing postoperative chylothorax after thoracoscopic esophagectomy for esophageal cancer
ConclusionsThis study revealed that MRTD was useful for preventing of chylothorax after thoracoscopic esophagectomy for esophageal cancer. (Source: Esophagus)
Source: Esophagus - August 26, 2021 Category: Gastroenterology Source Type: research
Repeated talaporfin sodium photodynamic therapy for esophageal cancer: safety and efficacy
ConclusionRepeated tPDT could be an effective and safe treatment for local failure even after salvage tPDT for esophageal cancer. (Source: Esophagus)
Source: Esophagus - August 26, 2021 Category: Gastroenterology Source Type: research
Two versus three courses of preoperative cisplatin and fluorouracil plus docetaxel for treating locally advanced esophageal cancer: short-term outcomes of a multicenter randomized phase II trial
ConclusionBoth two- and three-course DCF regimens in the NAC setting seemed to be equally feasible in locally advanced ESCC patients. Additional DCF courses led to a better NAC response without increasing the incidence of adverse events or postoperative morbidity.Clinical Trial RegistrationUniversity Hospital Medical Information Network Clinical Trials Registry of Japan (Identification Number UMIN 000015788). (Source: Esophagus)
Source: Esophagus - August 26, 2021 Category: Gastroenterology Source Type: research
Long-term clinical outcomes of patients diagnosed with pT1a-muscularis mucosae with lymphovascular invasion or pT1b after endoscopic resection for cT1N0M0 esophageal squamous cell carcinoma
ConclusionsAdditional treatments showed better long-term outcomes than observation for patients with NCR. As recurrence may occur at > 4 years after ER, careful long-term follow-up examinations are needed. (Source: Esophagus)
Source: Esophagus - August 22, 2021 Category: Gastroenterology Source Type: research
In vitro anti-cancer effect of marmesin by suppression of PI3K/Akt pathway in esophagus cancer cells
ConclusionsMarmesin exerted anti-cancer activity in EC cells by inhibiting the PI3K/Akt pathway. (Source: Esophagus)
Source: Esophagus - August 16, 2021 Category: Gastroenterology Source Type: research
Nationwide survey of the follow-up practices for patients with esophageal carcinoma after radical treatment: historical changes and future perspectives in Japan
ConclusionsThe results suggest that the consensus of follow-up protocol could not be established. More attention is required for detection of metachronous cancers and assessment of the HR-QOL. Establishment of a consensus-based follow-up system and verification of its effectiveness are required. (Source: Esophagus)
Source: Esophagus - August 12, 2021 Category: Gastroenterology Source Type: research
Impact of preoperative 6-minute walk distance on long-term prognosis after esophagectomy in patients with esophageal cancer
ConclusionThe preoperative 6MWD is useful for evaluating exercise capacity and predicting the long-term outcome in patients undergoing esophagectomy. (Source: Esophagus)
Source: Esophagus - August 12, 2021 Category: Gastroenterology Source Type: research
Ineffective esophageal motility in Chicago Classification version 4.0 better predicts abnormal acid exposure
ConclusionsStringent criteria of IEM in CCv4.0 can better predict abnormal acid exposure as compared to CCv3.0. (Source: Esophagus)
Source: Esophagus - August 10, 2021 Category: Gastroenterology Source Type: research
Preoperative 3D-CT evaluation of the bronchial arteries in transmediastinal radical esophagectomy for esophageal cancer
ConclusionsPreoperative 3D-CT evaluation is useful to understand the mediastinal courses of BAs specific to the transcervical approach, which may allow BAs to be handled more carefully according to the type during surgery, contributing to a safer procedure in the deep mediastinum. (Source: Esophagus)
Source: Esophagus - August 7, 2021 Category: Gastroenterology Source Type: research
