Risk factors and outcomes of fatal respiratory events after esophageal cancer surgery from 2011 through 2018: a nationwide cohort study in South Korea
ConclusionIn South Korea, 1.4% of patients experienced fatal respiratory events (ARDS or respiratory failure) after esophageal cancer surgery. Some factors were revealed as risk factors for fatal respiratory events, and fatal respiratory events worsened clinical outcomes after esophageal cancer surgery. (Source: Esophagus)
Source: Esophagus - February 26, 2022 Category: Gastroenterology Source Type: research
Advancing high-resolution manometry: evaluating the use of multiple rapid swallows versus apple viscous swallows in clinical practice
ConclusionsMRS may uniquely identify abnormal motility/pressurization patterns, such as paradoxical LES response, distal pressurization, hypercontractile, and spasm patterns. These findings argue for a tailored approach when selecting provocative testing. MRS may be more useful for patients with abnormal pathophysiology, while AVS may help to supplement MRS in detecting severe hypokinetic disorders in preoperative management. (Source: Esophagus)
Source: Esophagus - February 8, 2022 Category: Gastroenterology Source Type: research
Pivotal trial of a biodegradable stent for patients with refractory benign esophageal stricture
ConclusionThe BDS was effective for refractory BES and the safety was acceptable. However, the indication for this procedure in patients RECEIVING CRT for esophageal cancer should be carefully considered. (Source: Esophagus)
Source: Esophagus - February 1, 2022 Category: Gastroenterology Source Type: research
Comprehensive risk evaluation for metachronous carcinogenesis after endoscopic submucosal dissection of superficial pharyngeal squamous cell carcinoma
ConclusionsPatients with a history of superficial PSCC remain at risk for metachronous carcinogenesis over time, and long-term follow-up is imperative. Comprehensive evaluation of endoscopic features with a novel serum marker, namely, the HALP score, can help predict metachronous carcinogenesis. (Source: Esophagus)
Source: Esophagus - January 31, 2022 Category: Gastroenterology Source Type: research
Outcome of sequential dilatation in achalasia cardia patients: a prospective cohort study
ConclusionA sequential increment of balloon diameter for pneumatic dilatation in achalasia is an effective mode of therapy to achieve and maintain clinical remission in achalasia. The incidents of adverse events are low in this approach. Type 3 achalasia patients are more likely to require surgery despite sequential dilatation. (Source: Esophagus)
Source: Esophagus - January 23, 2022 Category: Gastroenterology Source Type: research
Neutrophil-to-lymphocyte ratio change predicts histological response to and oncological outcome of neoadjuvant chemotherapy for esophageal squamous cell carcinoma
ConclusionThe present study demonstrated that NLR change is associated with both histological response to and oncological outcomes of NAC for patients with esophageal cancer. NLR change can help not only to predict survival, but also to facilitate personalized multidisciplinary treatment. (Source: Esophagus)
Source: Esophagus - January 21, 2022 Category: Gastroenterology Source Type: research
Multicenter phase II study of trifluridine/tipiracil for esophageal squamous carcinoma refractory/intolerant to 5-fluorouracil, platinum compounds, and taxanes: the ECTAS study
ConclusionsTrifluridine/tipiracil monotherapy is feasible and shows modest activity in patients with refractory esophageal squamous cell carcinoma. (Source: Esophagus)
Source: Esophagus - January 20, 2022 Category: Gastroenterology Source Type: research
Esophageal motility disorders missed during endoscopy
ConclusionsBased on retrospective analysis, 15% of esophageal motility disorders were missed during endoscopy. Understanding the clinical characteristics of missed esophageal motility disorders could help improve endoscopic diagnoses. (Source: Esophagus)
Source: Esophagus - January 17, 2022 Category: Gastroenterology Source Type: research
Biased expression of mutant alleles in cancer-related genes in esophageal squamous cell carcinoma
ConclusionsThe results of this study suggest that the allelic imbalance of the abundance of somatic mutations plays important roles in the initiation and progression of ESCC by modulating cancer-related biological pathways. (Source: Esophagus)
Source: Esophagus - January 11, 2022 Category: Gastroenterology Source Type: research
Correlation between TXNRD1/HO-1 expression and response to neoadjuvant chemoradiation therapy in patients with esophageal squamous cell carcinoma
ConclusionsThe study findings indicate that HO-1 status in pre-therapeutic biopsy specimens could predict response to NACRT, and TXNRD1 status could predict overall survival of ESCC patients. (Source: Esophagus)
Source: Esophagus - January 8, 2022 Category: Gastroenterology Source Type: research
Maximum standardized uptake value change rate before and after neoadjuvant chemotherapy can predict early recurrence in patients with locally advanced esophageal cancer: a multi-institutional cohort study of 220 patients in Japan
ConclusionΔSUVmax before and after NAC is clinically useful as it could help predict TRG, survival outcome, and early recurrence within 6 months post esophagectomy and is easily obtainable in general clinical practice. We believe that it may also help determine suitable treatment strategies for LAEC. (Source: Esophagus)
Source: Esophagus - January 7, 2022 Category: Gastroenterology Source Type: research
Genomic analyses reveal SCN7A is associated with the prognosis of esophageal squamous cell carcinoma
ConclusionIn summary, this study provided comprehensive analysis of the somatic mutation profiles of ESCC, and identified SCN7A and Signature_15 for the prognosis of ESCC for the first time. The findings might serve as a conceptual basis for molecular diagnosis and prevention of ESCC. (Source: Esophagus)
Source: Esophagus - January 7, 2022 Category: Gastroenterology Source Type: research
Visceral obesity is associated with an increased risk of developing esophago-gastric junctional adenocarcinoma in Japan: a population-based case –control study in Akita Prefecture
ConclusionsWe found paradoxical associations between EGJACs and obesity-related parameters (BMI vs. VFA) in a Japanese population, suggesting a potentially pivotal role of the VFA rather than the BMI as a risk factor for EGJACs. (Source: Esophagus)
Source: Esophagus - January 6, 2022 Category: Gastroenterology Source Type: research
Safety and feasibility of esophagectomy following combined neoadjuvant immunotherapy and chemotherapy for locally advanced esophageal cancer: a propensity score matching
ConclusionsBased on our preliminary experience, esophagectomy is safe and feasible following combined neoadjuvant immunotherapy with chemotherapy for locally advanced esophageal cancer. (Source: Esophagus)
Source: Esophagus - January 5, 2022 Category: Gastroenterology Source Type: research
Characteristics of patients with esophageal motility disorders on high-resolution manometry and esophagography —a large database analysis in Japan
ConclusionThis first large-scale database analysis indicates that more Japanese patients with achalasia are type I and have a normal range of LES pressure on starlet HRM. Failure of HRM is not rare; therefore, esophagography continuously has a complementary role in achalasia diagnosis. (Source: Esophagus)
Source: Esophagus - January 1, 2022 Category: Gastroenterology Source Type: research
