First-line nivolumab plus ipilimumab or chemotherapy versus chemotherapy alone in advanced esophageal squamous cell carcinoma: a Japanese subgroup analysis of open-label, phase 3 trial (CheckMate 648/ONO-4538-50)
ConclusionSurvival benefits with acceptable tolerability observed for NIVO  + IPI and NIVO + Chemo treatments strongly support their use as a new standard first-line treatment in Japanese patients with advanced ESCC.ClinicalTrials.gov IDNCT03143153. (Source: Esophagus)
Source: Esophagus - November 19, 2022 Category: Gastroenterology Source Type: research

Efficacy and safety of laparoscopic Roux-en-Y gastric bypass in symptomatic patients following fundoplication failure: a meta-analysis
This study aimed to determine the outcomes of LRYGB in symptomatic patients following failed LF for GERD. MEDLINE, EMBASE, and PubMed databases were systematically searched for studies reporting LRYGB outcomes in symptomatic adults despite undergoing LF for GERD. Postoperative symptom resolution, recurrence of heartburn and dysphagia, proton pump inhibitor (PPI) use, and body mass index (BMI) reduction were assessed to determine LRYGB efficacy. Postoperative morbidity and mortality were used to evaluate LRYGB safety. Twenty-two studies with 1523 patients were included. Pooled rates of symptom resolution, recurrence of hear...
Source: Esophagus - November 8, 2022 Category: Gastroenterology Source Type: research

Differences in salivary secretion and epidermal growth factor concentrations in mild reflux esophagitis and non-erosive reflux disease
ConclusionAfter matching the sex ratio, the saliva secretion was significantly lower in patients with mild reflux esophagitis and NERD than in healthy controls. However, no significant differences were observed in the amount of saliva secretion or salivary EGF concentrations between both groups. (Source: Esophagus)
Source: Esophagus - November 7, 2022 Category: Gastroenterology Source Type: research

Esophageal mast cells may be associated with the perception of symptoms in patients with eosinophilic esophagitis
ConclusionsEsophageal mast cells and their receptors, PAR-2 and VPAC-1, may contribute to the perception of symptoms in patients with EoE. (Source: Esophagus)
Source: Esophagus - November 7, 2022 Category: Gastroenterology Source Type: research

The prognostic significance of preoperative nutritional/inflammatory markers and clinicopathological features in resectable esophagectomy patients: possibility of nutritional intervention
ConclusionAlthough the modified Glasgow prognostic score is not superior to pathologic stage and tumor location as a biomarker of preoperative nutrition/inflammation and clinicopathological factors, it remains an important prognostic marker in resectable esophageal cancers. Preoperative decreased inflammatory response and improved nutritional status may contribute to prognosis in patients with esophageal cancer. (Source: Esophagus)
Source: Esophagus - November 3, 2022 Category: Gastroenterology Source Type: research

Impact of pre-diabetes, well-controlled diabetes, and poorly controlled diabetes on anastomotic leakage after esophagectomy for esophageal cancer: a two-center retrospective cohort study of 1901 patients
ConclusionsDiabetes was associated with AL after esophagectomy even in well-controlled patients, but pre-diabetes was not associated with AL. Operative morbidity, including AL, in poorly controlled diabetes resulted in prolonged hospital stays compared with normoglycemia. (Source: Esophagus)
Source: Esophagus - November 1, 2022 Category: Gastroenterology Source Type: research

A nationwide validation of the prognostic impact of pathological response and the distribution of recurrence patterns in responders after neoadjuvant chemotherapy for esophageal squamous cell carcinoma
ConclusionThe prognostic impact of pathological response was reproduced in the nationwide data. pCR in ESCC patients with cT1/2 provides a favorable prognosis with less incidence of distant failure. This finding may contribute to selecting appropriate candidates for an organ preservation approach based on the response to induction therapy. (Source: Esophagus)
Source: Esophagus - November 1, 2022 Category: Gastroenterology Source Type: research

Usefulness of endoscopic ultrasound in predicting treatment efficacy of salvage endoscopic therapy for local failure after chemoradiotherapy for esophageal squamous cell carcinoma
ConclusionsEUS can be useful in predicting the efficacy of salvage endoscopic treatment for local failure after CRT for ESCC. (Source: Esophagus)
Source: Esophagus - October 19, 2022 Category: Gastroenterology Source Type: research

Novel endoscopic approaches using the endocytoscopy for the target biopsy in esophageal eosinophilia
ConclusionThis study showed that adding ECS to WLI improved the biopsy sensitivity and eosinophil detection in patients with EE. (Source: Esophagus)
Source: Esophagus - October 18, 2022 Category: Gastroenterology Source Type: research

Causal effect of anxiety and depression status on the symptoms of gastroesophageal reflux disease and functional dyspepsia during proton pump inhibitor therapy
ConclusionPsychiatric bias was a risk factor for refractory GERD and FD. Anxiety and depression status reduced the therapeutic effect of PPIs on GERD and FD symptoms. Therefore, attention is required to detect the anxiety/depression status of patients with GERD/FD symptoms to treat patients appropriately and optimize therapeutic outcomes. (Source: Esophagus)
Source: Esophagus - October 17, 2022 Category: Gastroenterology Source Type: research

Dynorphin participates in interaction between depression and non-erosive reflux disease
ConclusionIncreased serum dynorphin level may be a sign of correlation between depression and NERD. (Source: Esophagus)
Source: Esophagus - October 16, 2022 Category: Gastroenterology Source Type: research

Esophageal dysmotility in patients with eosinophilic esophagitis: pathogenesis, assessment tools, manometric characteristics, and clinical implications
In conclusion, esophageal motor abnormalities may have a role in eliciting symptoms, raising clinical suspicion, and influencing treatment outcome in EoE. The assessment of esophageal motility appears valuable in the EoE setting. (Source: Esophagus)
Source: Esophagus - October 11, 2022 Category: Gastroenterology Source Type: research

Safety and efficacy of double-tract reconstruction with remnant stomach conservation in esophagectomy for patients with a history of distal gastrectomy
ConclusionsDTR in esophagectomy is safe and effective for patients with a history of distal gastrectomy. (Source: Esophagus)
Source: Esophagus - October 8, 2022 Category: Gastroenterology Source Type: research

Efficacy of laparoscopic fundoplication in patients with chronic cough and gastro-oesophageal reflux
ConclusionRefinement in the aetiological diagnosis of chronic cough due to GORD is necessary for improved outcome. Patients diagnosed with GORD-related chronic cough need to be counseled regarding their expectations from anti-reflux surgery. (Source: Esophagus)
Source: Esophagus - October 6, 2022 Category: Gastroenterology Source Type: research

Circular-stapled esophagogastrostomy using the keyhole procedure after radical esophagectomy for esophageal cancer
ConclusionsThe keyhole procedure could be a simple and useful alternative technique that reduces the risk of stricture formation in cervical esophagogastric anastomosis, especially when using the smaller-sized CS. (Source: Esophagus)
Source: Esophagus - August 30, 2022 Category: Gastroenterology Source Type: research