Prognostic impact of perioperative change in serum p53 antibody titers in esophageal squamous cell carcinoma
ConclusionsElevation of s-p53-Abs titers after esophagectomy can predict polyrecurrence in distant organs and poor prognosis. (Source: Esophagus)
Source: Esophagus - May 22, 2023 Category: Gastroenterology Source Type: research
Relationship between gut microbiome Fusobacterium nucleatum and LINE-1 methylation level in esophageal cancer
ConclusionsF. nucleatum alters genome-wide methylation levels in cancer cells, which may be one of the mechanisms by whichF. nucleatum affects the malignant behavior of esophageal cancer. (Source: Esophagus)
Source: Esophagus - May 12, 2023 Category: Gastroenterology Source Type: research
Caution against simultaneous integrated boost radiotherapy for upper thoracic esophageal squamous cell carcinoma: results from a single-arm phase II trial
ConclusionsDespite the acceptably tolerated acute toxicity of SIB in concurrent CRT with ENI to the cervical and upper mediastinal LN regions for upper thoracic ESCC, the incidence of severe late esophageal toxicity was relatively high. Cautions are provided against easy clinical application of SIB (50.4 Gy/28F to the CTV, 63 Gy/28F to the GTV) in upper thoracic ESCC. Further exploration on dose optimization is warranted. (Source: Esophagus)
Source: Esophagus - May 7, 2023 Category: Gastroenterology Source Type: research
Prognostic value of 18F-fluorodeoxyglucose uptake in the bone marrow on pretreatment positron emission tomography/computed tomography in patients with esophageal cancer who underwent esophagectomy
ConclusionIncreased FDG uptake in the BM on pretreatment PET/CT may be a surrogate indicator of various clinically disadvantageous backgrounds and may act as a predictor of poor prognosis after esophageal cancer surgery. (Source: Esophagus)
Source: Esophagus - May 2, 2023 Category: Gastroenterology Source Type: research
Timing of the infusion of nivolumab for patients with recurrent or metastatic squamous cell carcinoma of the esophagus influences its efficacy
ConclusionThe timing of the infusion of nivolumab may affect treatment efficacy in R/M-ESCC. (Source: Esophagus)
Source: Esophagus - April 24, 2023 Category: Gastroenterology Source Type: research
The relationship between manometric subtype and symptom details in achalasia
ConclusionsDetailed symptoms of achalasia, such as its site and timing, varied by subtypes. The status of the esophageal body might induce those differences in symptoms. (Source: Esophagus)
Source: Esophagus - April 24, 2023 Category: Gastroenterology Source Type: research
Gut microbiome can predict chemoradiotherapy efficacy in patients with esophageal squamous cell carcinoma
ConclusionsIn conclusion, we found that the relative abundance of Lactobacillaceae was enriched in patients with a partial or complete response among CRT those with ESCC, thus suggesting that the relative abundance of Lactobacillaceae can predict the effect of CRT. (Source: Esophagus)
Source: Esophagus - April 22, 2023 Category: Gastroenterology Source Type: research
Patient adverse events and technical failures with the bravo capsule pH system: insights from the MAUDE database
ConclusionsFindings from the MAUDE database highlight the risk of aspiration, hemorrhage/bleeding, perforation, injury, and retention as potential complications of BRAVO capsule placement. (Source: Esophagus)
Source: Esophagus - April 21, 2023 Category: Gastroenterology Source Type: research
Microscopic venous invasion is a predictor of prognosis in patients with esophageal squamous cell carcinoma undergoing ineffective neoadjuvant chemotherapy and surgery
ConclusionsMicroscopic venous invasion was associated with poor survival and cancer recurrence in the neoadjuvant chemotherapy ineffective group of patients who underwent esophagectomy for esophageal squamous cell carcinoma. (Source: Esophagus)
Source: Esophagus - April 21, 2023 Category: Gastroenterology Source Type: research
Safety and efficacy of endoscopic submucosal dissection for superficial esophageal cancer with esophageal varices
ConclusionsEsophageal cancer with esophageal varices could be treated endoscopically safely and effectively. (Source: Esophagus)
Source: Esophagus - April 15, 2023 Category: Gastroenterology Source Type: research
Clinical predictors of special type of esophageal cancer
ConclusionType R vessels and submucosal tumor-like elevation might be the clinical predictors of STEC. (Source: Esophagus)
Source: Esophagus - April 10, 2023 Category: Gastroenterology Source Type: research
Risk prediction of esophageal squamous cell carcinoma recurrence in patients who underwent esophagectomy after receiving neoadjuvant treatment: a nationwide retrospective study in Japan
ConclusionsThe model developed in this study adequately predicted ESCC recurrence in patients who underwent NAT and then esophagectomy. Further research with this nomogram is needed to assess the effect of adjuvant therapy in patients at high risk for recurrence. (Source: Esophagus)
Source: Esophagus - April 8, 2023 Category: Gastroenterology Source Type: research
Endoscopic findings suggestive of a high risk of non-radical cure after definitive chemoradiotherapy for cT1bN0M0 esophageal squamous cell carcinoma
ConclusionscT1bN0M0 ESCC large size, with B3 vessels, and type 0 –I has a high risk of non-radical cure after DCRT, especially the reddish type 0–I, which may need to be considered for treatment similar to advanced cancer, including surgery with preoperative DCRT. (Source: Esophagus)
Source: Esophagus - April 7, 2023 Category: Gastroenterology Source Type: research
Outcomes of solitary postoperative recurrence of esophageal squamous cell carcinoma diagnosed with FDG-PET/CT and treated with definitive radiation therapy
ConclusionsWhen diagnosed with18F-fluorodeoxyglucose positron emission tomography/computed tomography, solitary recurrence appears to have a more favorable prognosis than multiple recurrences. (Source: Esophagus)
Source: Esophagus - April 7, 2023 Category: Gastroenterology Source Type: research
Esophageal cancer practice guidelines 2022 edited by the Japan Esophageal Society: part 2
(Source: Esophagus)
Source: Esophagus - March 30, 2023 Category: Gastroenterology Source Type: research
