Novel minimally invasive approach to lymph node dissection around the left renal vein in patients with esophagogastric junction cancer
AbstractThe left renal vein lymph node (LRVLN) may be the extended locoregional node in esophagogastric junction cancer; however, only open-surgical methods of dissection have been reported. We therefore developed a novel minimally invasive laparoscopic method for LRVLN dissection. Following esophagectomy, the stomach was mobilized and LRVLN dissection was started by taping the pancreatic body using two silicone drains. The transverse mesocolon was then retracted through the superior duodenal fossa to expose the horizontal duodenum and permit LRVLN dissection. We carried out the procedure successfully in 17 patients with a...
Source: Esophagus - September 26, 2020 Category: Gastroenterology Source Type: research
Multimodality approaches to control esophageal cancer: development of chemoradiotherapy, chemotherapy, and immunotherapy
AbstractEsophageal cancer has a poor prognosis despite the fact that surgical techniques have been advanced and optimized, and systemic multimodality approaches have progressed recently. Adding chemotherapy, radiotherapy, and immunotherapy to the basic surgical approach have been shown to have therapeutic benefit for esophageal cancer. This review describes the latest development of chemoradiotherapy, chemotherapy, and immunotherapy, which have contributed to the reduction in esophageal cancer growth and improved the survival of patients. Chemoradiation is a treatment option for resectable esophageal cancer to preserve the...
Source: Esophagus - September 21, 2020 Category: Gastroenterology Source Type: research
Vonoprazan shows efficacy similar to that of proton pump inhibitors with respect to symptomatic, endoscopic, and histological responses in patients with eosinophilic esophagitis
ConclusionsVonoprazan showed similar efficacy to PPIs in EoE. (Source: Esophagus)
Source: Esophagus - September 21, 2020 Category: Gastroenterology Source Type: research
Evaluation and treatment results of trimodality therapy for advanced esophageal squamous cell carcinoma
ConclusionPlanned surgery following CRT was the only solution for achieving better treatment results. CRT + S is a promising treatment with low direct surgical mortality. (Source: Esophagus)
Source: Esophagus - September 14, 2020 Category: Gastroenterology Source Type: research
Key molecules involved in the Th17/Treg balance are associated with the pathogenesis of reflux esophagitis and Barrett ’s esophagus
ConclusionThe balance of Th17/Treg was impaired in patients with RE and BE. Th17/Treg may be involved in the development of both RE and BE through regulating the release of inflammatory cytokines, but the concrete mechanisms maybe different in the two diseases. The imbalance of Th17/Treg ratio and the related key molecules had a certain clinical diagnosis and prediction potential for RE and BE. (Source: Esophagus)
Source: Esophagus - September 12, 2020 Category: Gastroenterology Source Type: research
Immunohistochemical expression of filaggrin is decreased in proton pump inhibitor non-responders compared with proton pump inhibitor responders of eosinophilic esophagitis
ConclusionsThe results suggest a role of reduced filaggrin expression in the difference of effectiveness of PPI treatment between PPI-NR and PPI-R. Moreover, immunohistochemical determination of filaggrin expression in EoE patients could be informative in the clinical decision of how to treat the patients. (Source: Esophagus)
Source: Esophagus - September 8, 2020 Category: Gastroenterology Source Type: research
The impact of skeletal muscle wasting during neoadjuvant chemotherapy on postoperative anastomotic leakage in patients with esophageal cancer
ConclusionIn patients with esophageal cancer, SMI tend to decrease during NAC treatment. It is therefore important to prevent the additional impact that SMW during NAC has on postoperative anastomotic leakage. (Source: Esophagus)
Source: Esophagus - September 4, 2020 Category: Gastroenterology Source Type: research
Lymph node response to chemoradiotherapy in oesophageal cancer patients: relationship with radiotherapy fields
ConclusionPatients have the best survival if all LNmets show tumour regression, even if LNmets are located outside the RT field. Response in LNmets to nCRT is heterogeneous which warrants further studies to better understand underlying mechanisms. (Source: Esophagus)
Source: Esophagus - September 4, 2020 Category: Gastroenterology Source Type: research
Will definitive chemoradiotherapy be a new normal for patients with resectable locally advanced esophageal cancer?
(Source: Esophagus)
Source: Esophagus - September 3, 2020 Category: Gastroenterology Source Type: research
Long-term outcomes of endoscopic versus surgical resection for MM-SM1 esophageal squamous cell carcinoma using propensity score analysis
ConclusionsCompared with surgery, ESD does not compromise long-term outcomes. ESD alone or ESD with chemotherapy and/or radiotherapy may be an option for the treatment of MM and SM1 ESCC. (Source: Esophagus)
Source: Esophagus - September 1, 2020 Category: Gastroenterology Source Type: research
Analysis of prognostic factors in patients with lymph node recurrence after radical esophagectomy: importance of locoregional therapy
ConclusionsRecurrence limited to ≤ 2 LN and loco-regional treatment (chemoradiotheapy or surgery) for LN recurrence were associated with favorable survival of patients with history of radical esophagectomy followed by LN recurrence. Our results emphasize the importance of local control of LN recurrence regardless of location . (Source: Esophagus)
Source: Esophagus - August 31, 2020 Category: Gastroenterology Source Type: research
Prognostic significance of serum inflammatory markers in esophageal cancer
ConclusionNLR is an important SIR prognostic biomarker associated with DFS and OS in EC. (Source: Esophagus)
Source: Esophagus - August 30, 2020 Category: Gastroenterology Source Type: research
Relationship between gastroesophageal reflux disease (GERD) and constipation: laxative use is common in GERD patients
ConclusionsThe use of laxatives was significantly more common in GERD patients than in non-GERD patients. The present results suggest that a relationship exists between GERD and constipation. (Source: Esophagus)
Source: Esophagus - August 28, 2020 Category: Gastroenterology Source Type: research
Continuous ghrelin infusion attenuates the postoperative inflammatory response in patients with esophageal cancer
ConclusionsGhrelin was safely administered after esophagectomy and may reduce excess postoperative inflammatory responses. Continuous infusion is better for this purpose than intermittent infusion. (Source: Esophagus)
Source: Esophagus - August 26, 2020 Category: Gastroenterology Source Type: research
Successful reconstruction of an intrathoracic tracheal defect using a muscle flap and conchal cartilage graft
ConclusionsWe believe this report will contribute to the growing body of clinical expertise on procedures for intrathoracic tracheal reconstruction. (Source: Esophagus)
Source: Esophagus - August 25, 2020 Category: Gastroenterology Source Type: research
