Celebrating 20 years of “Esophagus”
(Source: Esophagus)
Source: Esophagus - March 7, 2023 Category: Gastroenterology Source Type: research

The long-term efficacy of transoral incisionless fundoplication with Medigus Ultrasonic Surgical Endostapler (MUSE) for gastroesophageal reflux disease
ConclusionTIF by MUSE has significant efficacy in the treatment of PPI-dependent GERD, which can improve symptoms and life quality of patients, and reduce the acid exposure time for long-term. Chictr.org.cn.Trial RegistrationChiCTR2000034350. (Source: Esophagus)
Source: Esophagus - March 6, 2023 Category: Gastroenterology Source Type: research

Histological study of the thin membranous dense connective tissues around the curving portion of the bilateral recurrent laryngeal nerves
ConclusionThe recurrent nerve, which branched off from the vagus nerve descending along the vascular sheath, ascended the medial side of the visceral sheath after inversion. However, no clear visceral sheath could be identified in the inverted area. Therefore, during radical esophagectomy, the visceral sheath along No. 101R or 106recL may be recognized and available. (Source: Esophagus)
Source: Esophagus - March 3, 2023 Category: Gastroenterology Source Type: research

Comprehensive analysis of  CDK5 as a novel biomarker for progression in esophageal cancer
ConclusionsThis study shows that CDK5 is a risk factor to promote tumor progression, and Roscovitine could be one of the effective tools in the therapy of ESCA. (Source: Esophagus)
Source: Esophagus - February 28, 2023 Category: Gastroenterology Source Type: research

Early versus delayed surgery following neoadjuvant chemoradiation for esophageal cancer: a systematic review and meta-analysis
ConclusionNational registry-based studies ’ analysis shows that delay in surgery is riskier and leads to higher mortality and major complication rates. Further, well-designed RCTs are required. (Source: Esophagus)
Source: Esophagus - February 17, 2023 Category: Gastroenterology Source Type: research

Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma
ConclusionsFavorable PFS and OS rates were observed in patients with cCR. Tumor length was a predictive factor for cCR. (Source: Esophagus)
Source: Esophagus - February 8, 2023 Category: Gastroenterology Source Type: research

The fragility of significant results from randomized controlled trials in esophageal surgeries
This study aims to calculate the Fragility Index for trials evaluating perioperative esophagectomy-related interventions to determine the strength of RCTs in this field. MEDLINE and EMBASE were searched for RCTs related to esophagectomy that reported a significant dichotomous outcome. Two reviewers independently screened articles and performed the data extractions with risk of bias assessment. The Fragility Index was calculated using a two-tailed Fisher ’s exact test. Bivariate correlation was conducted to evaluate associations between the Fragility Index and study characteristics. 41 RCTs were included, and the median s...
Source: Esophagus - January 23, 2023 Category: Gastroenterology Source Type: research

Old age and intense chemotherapy exacerbate negative prognostic impact of postoperative complication on survival in patients with esophageal cancer who received neoadjuvant therapy: a nationwide study from 85 Japanese esophageal centers
ConclusionsThe negative impact of postoperative complications on survival was confirmed in this nationwide study. Furthermore, its magnitude was higher in elderly patients who received triplet chemotherapy. (Source: Esophagus)
Source: Esophagus - January 20, 2023 Category: Gastroenterology Source Type: research

Correction: Implication of changes in PD-L1 expression during neoadjuvant chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen in esophageal squamous cell carcinoma
(Source: Esophagus)
Source: Esophagus - January 20, 2023 Category: Gastroenterology Source Type: research

Differential prognostic significance of sarcopenia in metastatic esophageal squamous and adenocarcinoma
ConclusionsIn metastatic esophageal adenocarcinomas, sarcopenia is associated with worse PFS and OS. In metastatic esophageal SCC, there was a non-significant trend for worse PFS but no association with OS. In order to offset the poor prognosis associated with sarcopenia particularly in metastatic esophageal adenocarcinoma patients, future research should focus on possible countermeasures. (Source: Esophagus)
Source: Esophagus - January 12, 2023 Category: Gastroenterology Source Type: research

Predictors of the difficulty of transcervical subcarinal lymph node dissection for esophageal cancer
ConclusionsThe cervical angle, aorta distance, and middle thoracic tumor may predict the difficulty of transcervical SCLN dissection. In difficult cases, a transhiatal approach should be combined for complete SCLN dissection. (Source: Esophagus)
Source: Esophagus - January 9, 2023 Category: Gastroenterology Source Type: research

Surgical outcomes and quality of life assessment of esophagectomy for cancer with colon conduit via retrosternal route
ConclusionsColon conduit via retrosternal route after esophagectomy is feasible, safe, and could provide acceptable long-term functional outcomes. (Source: Esophagus)
Source: Esophagus - January 6, 2023 Category: Gastroenterology Source Type: research

The impact of combined PD-L1 positive score on clinical response to nivolumab in patients with advanced esophageal squamous cell carcinoma
ConclusionsThis study suggests that a CPS of  <  1 is not a strong predictor of efficacy but can predict the absence of response to nivolumab in patients with aESCC. (Source: Esophagus)
Source: Esophagus - January 3, 2023 Category: Gastroenterology Source Type: research

Influence of patient position in thoracoscopic esophagectomy on postoperative pneumonia: a comparative analysis from the National Clinical Database in Japan
ConclusionsAlthough prolonged ventilation and surgery-related mortality occurred more frequently in the LP group than in the PP group, the patient position did not significantly influence the occurrence of postoperative pneumonia. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research

High-resolution manometry with additional maneuvers using the Starlet system: normative thresholds and diagnostic yields for relevant esophagogastric junction outflow disorders
ConclusionsHRM with additional maneuvers may facilitate the diagnosis of clinically relevant EGJOD. (Source: Esophagus)
Source: Esophagus - January 1, 2023 Category: Gastroenterology Source Type: research