Correlation analysis of coagulation dysfunction and liver damage in patients with novel coronavirus pneumonia: a single-center, retrospective, observational study.
CONCLUSION: Coagulation dysfunction in patients with COVID-19 is closely related to liver damage. A longer course of the disease may cause a vicious circle of coagulopathy and liver damage. Clinicians need to closely monitor coagulation and liver function tests and to give prophylactic or supportive therapy when needed. PMID: 32990149 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - September 28, 2020 Category: General Medicine Authors: Chen S, Liu H, Li T, Huang R, Gui R, Zhang J Tags: Ups J Med Sci Source Type: research

Implementation of a decision aid for recognition and correction of volume alterations (Recova ®) in haemodialysis patients.
CONCLUSIONS: Implementation of Recova in haemodialysis care increased the monthly frequencies of bioimpedance measurements and target weight adjustments, and it contributed to symptom reduction. TRIAL REGISTRATION: The Uppsala County Council Registry of Clinical Trials: FoU 2019-0001-15. PMID: 32852250 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 26, 2020 Category: General Medicine Authors: Stenberg J, Lindberg M, Furuland H Tags: Ups J Med Sci Source Type: research

Electrolyte handling in the isolated perfused rat kidney: demonstration of vasopressin V2-receptor-dependent calcium reabsorption.
CONCLUSIONS: A stable isolated perfused kidney model with computer-controlled pressure regulation was developed, which retained key physiological functions. The preparation responds to pharmacological inhibition of ENaC channels and activation of V2R. Using the model, the dynamic effects of V2R stimulation on calcium handling and urine osmolality could be visualised. The study thereby provides evidence for a stimulatory role of V2R in renal calcium reabsorption. PMID: 32812807 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 18, 2020 Category: General Medicine Authors: Bamberg K, William-Olsson L, Johansson U, Arner A, Hartleib-Geschwindner J, Sällström J Tags: Ups J Med Sci Source Type: research

Prevalence and risk factors for age-related cataract in Sweden.
CONCLUSION: Nearly one-third of the sample were estimated to have lens opacities, or had undergone cataract surgery, making cataract a frequent disorder of older age. The study provided further evidence that increasing age, female gender, and myopia are associated with cataract. PMID: 32757792 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 5, 2020 Category: General Medicine Authors: Hugosson M, Ekström C Tags: Ups J Med Sci Source Type: research

Natural language processing and machine learning to enable automatic extraction and classification of patients' smoking status from electronic medical records.
CONCLUSION: A model using machine-learning algorithms to automatically classify patients' smoking status was successfully developed. Such algorithms may enable automatic assessment of smoking status and other unstructured data directly from EMRs without manual classification of complete case notes. PMID: 32696698 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - July 21, 2020 Category: General Medicine Authors: Caccamisi A, Jørgensen L, Dalianis H, Rosenlund M Tags: Ups J Med Sci Source Type: research

Work at inpatient care units is associated with an increased risk of SARS-CoV-2 infection; a cross-sectional study of 8679 healthcare workers in Sweden.
CONCLUSION: Our findings indicate that SARS-CoV-2 transmission is related to inpatient healthcare work, and illustrate the need for a high standard of basic hygiene routines in all inpatient care settings. PMID: 32684119 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - July 19, 2020 Category: General Medicine Authors: Lidström AK, Sund F, Albinsson B, Lindbäck J, Westman G Tags: Ups J Med Sci Source Type: research

Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy.
CONCLUSION: We conclude that both Aβ42 and Tau R406W may affect autophagy through dysregulation of autophagy genes. Interestingly, it seems that these pathological proteins exert their toxic effects on autophagy through different pathways and independently. PMID: 32657227 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - July 10, 2020 Category: General Medicine Authors: Haghi M, Masoudi R, Najibi SM Tags: Ups J Med Sci Source Type: research

Oxygen sensing; a stunningly elegant molecular machinery highjacked in cancer.
Abstract Oxygen is of fundamental importance for most living organisms, and the maintenance of oxygen homeostasis is a key physiological challenge for all large animals. Oxygen deprivation, hypoxia, is a critical component of many human diseases including cancer, heart disease, stroke, vascular disease, and anaemia. The discovery of oxygen sensing provides fundamental knowledge of a stunningly elegant molecular machinery; it also promises development of new therapeutics for serious diseases such as cancer. As a result of their impressive contributions to our understanding of the mechanisms by which cells sense oxy...
Source: Upsala Journal of Medical Sciences - June 23, 2020 Category: General Medicine Authors: Claesson-Welsh L Tags: Ups J Med Sci Source Type: research

Bioactive glass S53P4 eradicates Staphylococcus aureus in biofilm/planktonic states in  vitro.
Bioactive glass S53P4 eradicates Staphylococcus aureus in biofilm/planktonic states in vitro. Ups J Med Sci. 2020 Jun 18;:1-9 Authors: Grønseth T, Vestby LK, Nesse LL, von Unge M, Silvola JT Abstract Background: Increasing antimicrobial resistance to antibiotics is a substantial health threat. Bioactive glass S53P4 (BAG) has an antimicrobial effect that can reduce the use of antibiotics. The aim of this study was to evaluate the antimicrobial efficacy of BAG in vitro on staphylococci in biofilm and in planktonic form. Secondary aims were to investigate whether supernatant fluid primed...
Source: Upsala Journal of Medical Sciences - June 17, 2020 Category: General Medicine Authors: Grønseth T, Vestby LK, Nesse LL, von Unge M, Silvola JT Tags: Ups J Med Sci Source Type: research

Being born preterm or with low weight implies a risk of infertility and premature loss of ovarian function; a national register study.
Conclusions: Being born with non-optimal birth characteristics may increase the risk of premature ovarian insufficiency. PMID: 32532178 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - June 11, 2020 Category: General Medicine Authors: Sydsjö G, Bladh M, Rindeborn K, Hammar M, Rodriguez-Martinez H, Nedstrand E Tags: Ups J Med Sci Source Type: research

Are we looking under the lamp although we know the lost key is somewhere else? Or is it just about the egg?
PMID: 32423270 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 17, 2020 Category: General Medicine Authors: Holte J, Brodin T Tags: Ups J Med Sci Source Type: research

Association of the NEGR1 rs2815752 with obesity and related traits in Pakistani females.
Conclusion: The NEGR1 rs2815752 may be associated with obese phenotype and some of the related anthropometric traits in Pakistani females. PMID: 32419576 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 17, 2020 Category: General Medicine Authors: Rana S, Mobin M Tags: Ups J Med Sci Source Type: research

Adjuvants in IVF-evidence for what works and what does not work.
Abstract The field of assisted reproductive technology is shaped and changed constantly by advances in science and cutting-edge innovations. In a quest to maximise outcomes, add-on interventions are often adopted and utilised prematurely while the principles of evidence-based medicine seem to be less strictly adhered to. In this review we will attempt to summarise the latest evidence about some of the adjuvants. PMID: 32378442 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 6, 2020 Category: General Medicine Authors: Nardo L, Chouliaras S Tags: Ups J Med Sci Source Type: research

Gonadotropin-releasing hormone agonist for ovulation trigger - OHSS prevention and use of modified luteal phase support for fresh embryo transfer.
dan P Abstract The introduction of gonadotrophin-releasing hormone agonist (GnRHa) trigger greatly impacted modern IVF treatment. Patients at low risk of ovarian hyperstimulation syndrome (OHSS) development, undergoing fresh embryo transfer and GnRHa trigger can be offered a virtually OHSS-free treatment with non-inferior reproductive outcomes by using a modified luteal phase support in terms of small boluses of human chorionic gonadotrophin (hCG), daily recombinant luteinizing hormone LH (rLH) or GnRHa. In the OHSS risk patient, GnRHa trigger can safely be performed, followed by a 'freeze-all' policy with a minim...
Source: Upsala Journal of Medical Sciences - May 3, 2020 Category: General Medicine Authors: Castillo JC, Haahr T, Martínez-Moya M, Humaidan P Tags: Ups J Med Sci Source Type: research

Is progress in clinical reproductive medicine happening fast enough?
PMID: 32364444 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 3, 2020 Category: General Medicine Authors: Griesinger G Tags: Ups J Med Sci Source Type: research

Dietary advice and oral nutritional supplements do not increase survival in older malnourished adults: a multicentre randomised controlled trial.
Conclusions: Oral nutritional supplements with or without dietary advice, or dietary advice alone, do not improve the survival of malnourished older adults. These results do not support the routine use of supplements in older malnourished adults, provided that survival is the aim of the treatment.Trial registration: ClinicalTrials.gov with ID: NCT01057914. PMID: 32362168 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 1, 2020 Category: General Medicine Authors: Söderström L, Rosenblad A, Bergkvist L, Frid H, Thors Adolfsson E Tags: Ups J Med Sci Source Type: research

Fertility preservation for young adults, adolescents, and children with cancer.
m B Abstract Options for fertility preservation (FP) through cryopreservation methods are currently available for young adults, adolescents, and children. Guidelines for FP have been provided by international clinical societies, and emergency procedures aimed at FP have been implemented into clinical practice worldwide. In this article, we review the current data on clinical standards of emergency FP in patients who are facing gonadotoxic effects of cancer treatment, and we also describe the methods that are still under development, usually denoted as experimental. In Sweden, programmes for FP have been establishe...
Source: Upsala Journal of Medical Sciences - April 30, 2020 Category: General Medicine Authors: Rodriguez-Wallberg KA, Anastacio A, Vonheim E, Deen S, Malmros J, Borgström B Tags: Ups J Med Sci Source Type: research

Pulmonary artery coil embolisation prevented tumour progression in a patient with advanced squamous cell lung carcinoma.
Conclusion: The long-term clinical benefit indicates a direct effect of coil embolisation on tumour progression. We suggest that coil embolisation of tumour-feeding arteries could be considered as a potential treatment method for patients with SqCLC. PMID: 32352322 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 29, 2020 Category: General Medicine Authors: Šileikienė V, Gurskytė V, Zeleckienė I, Bernotienė E, Čibiras S Tags: Ups J Med Sci Source Type: research

DuoStim - a reproducible strategy to obtain more oocytes and competent embryos in a short time-frame aimed at fertility preservation and IVF purposes. A systematic review.
Abstract Recent evidence suggests that follicular development occurs in a wave-like model during the ovarian cycle, where up to three cohorts of follicles are recruited to complete folliculogenesis. This understanding overtakes the previous dogma stating that follicles grow only during the follicular phase of the menstrual cycle. Therefore, in in vitro fertilization (IVF), novel protocols regarding ovarian stimulation have been theorized based on the use of gonadotrophins to prompt the growth of antral follicles at any stage of the menstrual cycle. These unconventional protocols for ovarian stimulation aim at...
Source: Upsala Journal of Medical Sciences - April 24, 2020 Category: General Medicine Authors: Vaiarelli A, Cimadomo D, Petriglia C, Conforti A, Alviggi C, Ubaldi N, Ledda S, Ferrero S, Rienzi L, Ubaldi FM Tags: Ups J Med Sci Source Type: research

Freeze-all, for whom, when, and how.
Conclusion: Due to the different cases that a reproductive expert might encounter, it is essential to highlight benefits and drawbacks of this practice. PMID: 32283988 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 13, 2020 Category: General Medicine Authors: Celada P, Bosch E Tags: Ups J Med Sci Source Type: research

Utility of micro-TESE in the most severe cases of non-obstructive azoospermia.
Abstract The use of intracytoplasmic sperm injection (ICSI) has been a major breakthrough in the treatment of male infertility. Even patients with non-obstructive azoospermia (NOA) may benefit from the ICSI technique to father a child as long as spermatogenesis is present. There are several techniques to recover testicular sperm in patients with NOA. However, retrieval of spermatozoa is unfortunately still only successful in a subset of patients with NOA, and the most superior sperm retrieval method is still under debate. A more recent technique, microdissection testicular sperm extraction (MD-TESE) with an operat...
Source: Upsala Journal of Medical Sciences - March 31, 2020 Category: General Medicine Authors: Westlander G Tags: Ups J Med Sci Source Type: research

Using total plasma triacylglycerol to assess hepatic de novo lipogenesis as an alternative to VLDL triacylglycerol.
This study aimed to assess the performance of DNL measured in VLDL-TAG (DNLVLDL-TAG) compared to that measured in total plasma TAG (DNLPlasma-TAG).Methods: Using deuterated water, newly synthesised palmitate was determined in fasting plasma VLDL-TAG and total TAG in 63 subjects taking part in multiple studies resulting in n = 123 assessments of DNL (%new palmitate of total palmitate). Subjects were split into tertiles to investigate if DNLPlasma-TAG could correctly classify subjects having 'high' (top tertile) and 'low' (bottom tertile) DNL. Repeatability was assessed in a subgroup (n = 16) with...
Source: Upsala Journal of Medical Sciences - March 24, 2020 Category: General Medicine Authors: Hodson L, Parry SA, Cornfield T, Charlton C, Low WS, Green CJ, Rosqvist F Tags: Ups J Med Sci Source Type: research

Gonadotropin-releasing hormone agonist ovulation trigger-beyond OHSS prevention.
dan P Abstract In this review the advantages of the gonadotropin-releasing hormone agonist (GnRHa) trigger are discussed beyond those immediately associated with ovarian hyperstimulation syndrome (OHSS) prevention. The GnRHa trigger concept has sparked the development of novel protocols, enriching the assisted reproductive technology (ART) armamentarium for the benefit of present and future patients. Thus, GnRHa trigger already has a pivotal role, not only for the standard in vitro fertilisation (IVF) patient, but also for patient groups like oocyte donors, cancer patients, patients with poor ovarian reserve,...
Source: Upsala Journal of Medical Sciences - March 24, 2020 Category: General Medicine Authors: Castillo JC, Haahr T, Martínez-Moya M, Humaidan P Tags: Ups J Med Sci Source Type: research

Perinatal outcome in children born after assisted reproductive technologies.
Abstract Over the past 40 years access and effectiveness of assisted reproductive technologies (ART) have increased, and to date more than 8 million children have been conceived after ART globally. Most pregnancies resulting from ART are uncomplicated and result in the birth of healthy children. Yet, it is well known that pregnancies following ART are more likely to be affected by obstetric complications such as hypertensive disorders in pregnancy, preterm birth, and low birth weight compared with spontaneously conceived pregnancies. ART children are also at increased risk of birth defects. The majority of ...
Source: Upsala Journal of Medical Sciences - March 2, 2020 Category: General Medicine Authors: Wennerholm UB, Bergh C Tags: Ups J Med Sci Source Type: research

Long-term health of children conceived after assisted reproductive technology.
Abstract The aim of this narrative review is to summarize the present knowledge on long-term outcome of children born after assisted reproductive technologies (ART). The main outcomes covered are neurodevelopment including cerebral palsy, cognitive development, attention deficit hyperactivity disorder and autism spectrum disease, growth, cardiovascular function, diabetes type 1, asthma, malignancies, and reproductive health. Results have mainly been obtained from systematic reviews/meta-analyses and large registry studies. It has been shown that children born after ART, when restricted to singletons, have a simila...
Source: Upsala Journal of Medical Sciences - February 25, 2020 Category: General Medicine Authors: Bergh C, Wennerholm UB Tags: Ups J Med Sci Source Type: research

Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in  vitro fertilization treatment outcome in women.
Persistent environmental endocrine-disrupting chemicals in ovarian follicular fluid and in vitro fertilization treatment outcome in women. Ups J Med Sci. 2020 Feb 25;:1-10 Authors: Björvang RD, Damdimopoulou P Abstract Several international organizations have recently highlighted endocrine-disrupting chemicals (EDCs) as factors of concern in human reproduction. Since successful reproduction is dependent on timely and appropriate action of hormones, disruption of the endocrine system could lead to difficulties in conceiving or carrying a pregnancy to term. EDCs are chemicals that disrupt the ...
Source: Upsala Journal of Medical Sciences - February 24, 2020 Category: General Medicine Authors: Björvang RD, Damdimopoulou P Tags: Ups J Med Sci Source Type: research

Time-lapse technology for embryo culture and selection.
Abstract Culturing of human embryos in optimal conditions is crucial for a successful in vitro fertilisation (IVF) programme. In addition, the capacity to assess and rank embryos correctly for quality will allow for transfer of the potentially 'best' embryo first, thereby shortening the time to pregnancy, although not improving cumulative pregnancy and live birth rates. It will also encourage and facilitate the implementation of single embryo transfers, thereby increasing safety for mother and offspring. Time-lapse technology introduces the concept of stable culture conditions, in connection with the possibil...
Source: Upsala Journal of Medical Sciences - February 24, 2020 Category: General Medicine Authors: Lundin K, Park H Tags: Ups J Med Sci Source Type: research

Reduced 10-year risk of developing cardiovascular disease after participating in a lifestyle programme in primary care.
Conclusions: A structured lifestyle programme in primary care contributes to significant improvements of cardiovascular risk factors and the reduction of 10-year risk for CVD for both men and women at high cardiovascular risk. PMID: 32077778 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 19, 2020 Category: General Medicine Authors: Lönnberg L, Ekblom-Bak E, Damberg M Tags: Ups J Med Sci Source Type: research

Surrogacy relationships: a critical interpretative review.
Abstract Based on a critical interpretative review of existing qualitative research investigating accounts of 'lived experience' of surrogates and intended parents from a relational perspective, this article proposes a typology of surrogacy arrangements. The review is based on the analysis of 39 articles, which belong to a range of different disciplines (mostly sociology, social psychology, anthropology, ethnology, and gender studies). The number of interviews in each study range from as few as seven to over one hundred. Countries covered include Australia, Canada, Greece, India, Iran, Israel, Italy, Mexico, Norwa...
Source: Upsala Journal of Medical Sciences - February 18, 2020 Category: General Medicine Authors: Gunnarsson Payne J, Korolczuk E, Mezinska S Tags: Ups J Med Sci Source Type: research

Analgesic effects of dexmedetomidine and remifentanil on periprocedural pain during percutaneous ablation of renal carcinoma.
Conclusions: This proof-of-concept study has shown that analgosedation during percutaneous ablation of renal carcinoma can be performed with a generally tolerable degree of patient satisfaction. However, pain occurs and should be managed adequately. Patient safety must be a major concern for the anaesthetic care. PMID: 32067572 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 17, 2020 Category: General Medicine Authors: Semenas E, Lönnemark M, Dahlman P, Hultström M, Eriksson M Tags: Ups J Med Sci Source Type: research

What animals can teach us about evolution, the human genome, and human disease.
Abstract During the past 20 years, since I started as a postdoc, the world of genetics and genomics has changed dramatically. My main research goal throughout my career has been to understand human disease genetics, and I have developed comparative genomics and comparative genetics to generate resources and tools for understanding human disease. Through comparative genomics I have worked to sequence enough mammals to understand the functional potential of each base in the human genome as well as chosen vertebrates to study the evolutionary changes that have given many species their key traits. Through compa...
Source: Upsala Journal of Medical Sciences - February 13, 2020 Category: General Medicine Authors: Lindblad-Toh K Tags: Ups J Med Sci Source Type: research

U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients.
Abstract Background. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range of SUA concentrations in a retrospective cohort of HCM patients.Methods. A total of 454 HCM patients were enrolled in the study, and SUA concentrations were measured at baseline. The primary and secondary endpoints were all-cause mortality and HCM-related mortality, respectively. The associations between SUA con...
Source: Upsala Journal of Medical Sciences - February 3, 2020 Category: General Medicine Authors: Wang Z, Xu Y, Liao H, Chen X, He S Tags: Ups J Med Sci Source Type: research

Is medical urgency of elderly patients with traumatic brain injury underestimated by emergency department triage?
e;n J Abstract Background: Mortality is high among elderly patients with traumatic brain injury (TBI). Recent data suggest that early surgical intervention and aggressive rehabilitation may reduce mortality rates even in elderly patients. Our aim was therefore to study the Rapid Emergency Triage and Treatment System-Adult (RETTS-A) triage of patients with isolated TBI and examine the differences in acute management according to age.Methods: We included 306 adult patients with isolated severe TBI and an abbreviated injury scale (AIS) score ≥3. Using a cut-off of 60 years of age, differences in triage prio...
Source: Upsala Journal of Medical Sciences - January 27, 2020 Category: General Medicine Authors: Ruge T, Carlsson AC, Hellstrom M, Wihlborg P, Undén J Tags: Ups J Med Sci Source Type: research

Knowledge about the impact of age on fertility: a brief review.
e;n T Abstract Delayed childbearing is currently a major challenge in reproductive medicine as increased age has an important impact on successful conception, both in natural and in assisted reproduction. There is a lack of knowledge about the impact of age on fertility, even in highly educated populations. A number of initiatives have been taken to increase fertility awareness. Health care providers have been encouraged to talk with patients about their reproductive life plan (RLP) for almost a decade based on recommendations from the Centres for Disease Control and Prevention. This concept has been explored succ...
Source: Upsala Journal of Medical Sciences - January 21, 2020 Category: General Medicine Authors: Delbaere I, Verbiest S, Tydén T Tags: Ups J Med Sci Source Type: research

Placental glucocorticoid receptors are not affected by maternal depression or SSRI treatment.
Conclusion: Maternal depression and SSRI treatment do not affect the glucocorticoid receptors in the placenta. PMID: 31960733 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 20, 2020 Category: General Medicine Authors: Edvinsson Å, Hoyer A, Hansson M, Kallak TK, Sundström-Poromaa I, Skalkidou A, Lager S Tags: Ups J Med Sci Source Type: research

Social freezing of oocytes: a means to take control of your fertility.
Abstract In the last few decades, there have been tremendous developments of assisted reproductive technologies, but the outcome of in vitro fertilization is highly dependent on the age of the oocyte. The introduction of vitrification offers a possibility to freeze eggs proactively in younger years and use them at later ages, also called social egg freezing. Knowledge about age-related fertility decline is insufficient among many women, and there is an overoptimistic trust that in vitro fertilization can overcome this. The awareness of proactive egg freezing is limited, both among doctors and in the gene...
Source: Upsala Journal of Medical Sciences - January 13, 2020 Category: General Medicine Authors: Wennberg AL Tags: Ups J Med Sci Source Type: research

In vitro fertilisation in domestic mammals-a brief overview.
Abstract Many factors influence the final oocyte maturation, fertilisation, and early embryo development, and there are both similarities and differences between species. When comparing the advancement of assisted reproductive technologies (ARTs), the development in the bovine species is not far behind the medical front, with around one million in vitro-produced bovine embryos each year. This rate of progress is not seen in the other domestic species. This review aims to give an overview of the development and specific difficulties of in vitro embryo production in various domestic animal species, with th...
Source: Upsala Journal of Medical Sciences - December 12, 2019 Category: General Medicine Authors: Sjunnesson Y Tags: Ups J Med Sci Source Type: research

The value of desmosomal plaque-related markers to distinguish squamous cell carcinoma and adenocarcinoma of the lung.
Conclusions: PKP1, KRT15, and DSG3 are highly specific for SCC, but they were more useful to differentiate between SCC and AC when used together and in combination with conventional markers. PKP1 and DSG3 expressions may have prognostic value. PMID: 31809668 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - December 5, 2019 Category: General Medicine Authors: Galindo I, Gómez-Morales M, Díaz-Cano I, Andrades Á, Caba-Molina M, Miranda-León MT, Medina PP, Martín-Padron J, Fárez-Vidal ME Tags: Ups J Med Sci Source Type: research

Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach.
Ärnlöv J Abstract Background: Diabetic kidney disease (DKD) is a leading risk factor for end-stage renal disease and is one of the most important risk factors for cardiovascular disease in patients with diabetes. It is possible that novel markers portraying the pathophysiological underpinning processes may be useful.Aim: To investigate the associations between 80 circulating proteins, measured by a proximity extension assay, and prevalent DKD and major adverse cardiovascular events (MACE) in type 2 diabetes.Methods: We randomly divided individuals with type 2 diabetes from three cohorts into a two-third...
Source: Upsala Journal of Medical Sciences - December 4, 2019 Category: General Medicine Authors: Carlsson AC, Nowak C, Lind L, Östgren CJ, Nyström FH, Sundström J, Carrero JJ, Riserus U, Ingelsson E, Fall T, Ärnlöv J Tags: Ups J Med Sci Source Type: research

Psychosocial aspects of identity-release gamete donation - perspectives of donors, recipients, and offspring.
c C Abstract Donor conception creates families with varying genetic linkage between family members. This may have short-term as well as lifelong psychosocial consequences for all involved. Gamete donors have traditionally been anonymous to recipients and offspring, but there is a growing trend towards identity-release donor programmes that give offspring the right to obtain the donor's identity. This review aims to provide an overview of the perspectives of donors and recipients and offspring involved in identity-release donation. The results show that both oocyte and sperm donors have primarily altruistic motives...
Source: Upsala Journal of Medical Sciences - December 4, 2019 Category: General Medicine Authors: Skoog Svanberg A, Sydsjö G, Lampic C Tags: Ups J Med Sci Source Type: research

Membrane-associated gamma-glutamyl transferase and alkaline phosphatase in the context of concanavalin A- and wheat germ agglutinin-reactive glycans mark seminal prostasome populations from normozoospermic and oligozoospermic men.
Conclusions: Membrane-associated gamma-glutamyl transferase and alkaline phosphatase in the context of Con A- and WGA-reactive glycans mark seminal prostasomes populations from normozoospermic and oligozoospermic men. PMID: 31774341 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - November 26, 2019 Category: General Medicine Authors: Janković T, Goč S, Mitić N, Danilović Luković J, Janković M Tags: Ups J Med Sci Source Type: research

Tissue factor in ulcerative colitis, with and without concomitant primary sclerosing cholangitis.
Conclusion: Our study provides additional support for a divergent pathogenesis in PSC-UC, with an inflammatory environment that differs from classical UC. Stromal TF emerges as a new marker of colonic inflammation. PMID: 31774347 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - November 26, 2019 Category: General Medicine Authors: Vessby J, Lampinen M, Åberg M, Rorsman F, Siegbahn A, Wanders A, Carlson M Tags: Ups J Med Sci Source Type: research

Pharmacological limitations of phage therapy.
Abstract Clinical trial results of phage treatment of bacterial infections show a low to moderate efficacy, and the variation in infection clearance between subjects within studies is often large. Phage therapy is complicated and introduces many additional components of variance as compared to antibiotic treatment. A large part of the variation is due to in vivo pharmacokinetics and pharmacodynamics being virtually unknown, but also to a lack of standardisation. This is a consequence of the great variation of phages, bacteria, and infections, which results in different experiments or trials being impossible t...
Source: Upsala Journal of Medical Sciences - November 13, 2019 Category: General Medicine Authors: Nilsson AS Tags: Ups J Med Sci Source Type: research

Does the antisecretory peptide AF-16 reduce lung oedema in experimental ARDS?
Conclusions: This pilot study suggests that AF-16 might improve oedema resolution as indicated by a reduction in EVLW in experimental ARDS. PMID: 31701794 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - November 7, 2019 Category: General Medicine Authors: Barrueta Tenhunen A, Massaro F, Hansson HA, Feinstein R, Larsson A, Larsson A, Perchiazzi G Tags: Ups J Med Sci Source Type: research

SPISE and other fasting indexes of insulin resistance: risks of coronary heart disease or type 2 diabetes. Comparative cross-sectional and longitudinal aspects.
Abstract Background: Fasting insulin resistance indexes are used extensively nowadays. We intended to analyze a new recently presented fasting index, SPISE (sensitivity formula: 600 × HDL-cholesterol0.185/triglycerides0.2/BMI1.338), in comparison with three previously known fasting indexes, regarding correlation with the insulin clamp index, and for the predictive effects of future long-term risks of coronary heart disease (CHD) or manifest type 2 diabetes.Methods: A total of 1049 71-year-old male subjects from the Swedish ULSAM study, median follow-up 8 years, were included. All subject...
Source: Upsala Journal of Medical Sciences - November 6, 2019 Category: General Medicine Authors: Cederholm J, Zethelius B Tags: Ups J Med Sci Source Type: research

Use of in  vitro fertilization-ethical issues.
This report is an ethical analysis based on both facts and values. In in vitro fertilization (IVF), there is an intricate interaction between rapid scientific development and changing societal values. In most countries, the ethical discussion is no longer on whether or not IVF in itself is ethically justifiable. Therefore, in this review, I discuss other ethical aspects that have emerged since IVF was first introduced, such as upper age limits, 'ownership' of gametes and embryos, IVF in single women and same-sex couples, preimplantatory genetic testing, social egg freezing, commercialization, public funding, and prior...
Source: Upsala Journal of Medical Sciences - November 4, 2019 Category: General Medicine Authors: Asplund K Tags: Ups J Med Sci Source Type: research

The impact of standardized care pathway on reporting time for invasive melanoma - results from one pathology department in Sweden.
Conclusion: This study demonstrates prolonged reporting times for invasive melanomas since the implementation of SCP. This is probably caused by the crowd-out effect of the SCP samples, limited personnel resources, and inaccuracy of the clinical diagnosis. SCP might therefore be a suboptimal method to shorten reporting times for invasive melanomas. PMID: 31661366 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - October 28, 2019 Category: General Medicine Authors: Agnarsdóttir M, Päären H, Vassilaki I Tags: Ups J Med Sci Source Type: research

A novel VARS2 gene variant in a patient with epileptic encephalopathy.
Conclusion: Our report extends the phenotypic spectrum of VARS2-related disorders with an initial presentation of epileptic encephalopathy and early death due to malignant arrhythmia. PMID: 31623496 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - October 17, 2019 Category: General Medicine Authors: Ruzman L, Kolic I, Radic Nisevic J, Ruzic Barsic A, Skarpa Prpic I, Prpic I Tags: Ups J Med Sci Source Type: research

Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.
Conclusion: The results support the NCSC identity of the CD271-enriched human bone marrow population. It remains to investigate whether the human bone marrow-derived NCSCs have the ability to improve transplantation efficacy of not only human islets but stem cell-derived ICC as well. PMID: 31623497 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - October 17, 2019 Category: General Medicine Authors: Brboric A, Vasylovska S, Saarimäki-Vire J, Espes D, Caballero-Corbalan J, Larfors G, Otonkoski T, Lau J Tags: Ups J Med Sci Source Type: research

An intervention in contraceptive counseling increased the knowledge about fertility and awareness of preconception health-a randomized controlled trial.
Conclusions: Knowledge about fertility and awareness of preconception health increased after the intervention. The RLPC can be recommended as a tool in contraceptive counseling. PMID: 31495254 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - September 8, 2019 Category: General Medicine Authors: Skogsdal Y, Fadl H, Cao Y, Karlsson J, Tydén T Tags: Ups J Med Sci Source Type: research