Age and co-morbidities as independent risk factors of infections leading to hospital admission in the last year of life among the elderly: A retrospective registry-based study
CONCLUSION: Chronological age and co-morbidities are independent risk factors of infections associated with hospital admission in the last year in life while male sex and sociodemographic factors have less impact.PMID:38571881 | PMC:PMC10989213 | DOI:10.48101/ujms.v129.10504 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Linda Bj örkhem-Bergman Torbj örn Schultz Peter Strang Source Type: research
Unboxing the network among long non-coding RNAs and TGF- β signaling in cancer
Ups J Med Sci. 2024 Mar 26;129. doi: 10.48101/ujms.v129.10614. eCollection 2024.ABSTRACTDeeper analysis of molecular mechanisms arising in tumor cells is an unmet need to provide new diagnostic and therapeutic strategies to prevent and treat tumors. The transforming growth factor β (TGF-β) signaling has been steadily featured in tumor biology and linked to poor prognosis of cancer patients. One pro-tumorigenic mechanism induced by TGF-β is the epithelial-to-mesenchymal transition (EMT), which can initiate cancer dissemination, enrich the tumor stem cell population, and increase chemoresistance. TGF-β signals via SMAD p...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Dorival Mendes Rodrigues-Junior Aristidis Moustakas Source Type: research
White horses - non-coding sequences drive premature hair greying and predisposition to melanoma
Ups J Med Sci. 2024 Apr 2;129. doi: 10.48101/ujms.v129.10626. eCollection 2024.ABSTRACTThe Grey allele in horses is causing premature hair greying and susceptibility to melanoma. The causal mutation is a 4.6 kb tandem duplication in intron 6 of the Syntaxin 17 gene. A recent study demonstrated that the most common allele at the Grey locus (G3) involves three tandem copies of this sequence, whilst a more rare allele (G2) has two tandem copies and the wild-type allele (G1) only one copy. The G3 allele is causing fast greying and high incidence of skin melanoma, whereas the G2 allele is causing slow greying and no obvious inc...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Leif Andersson Source Type: research
The relationship between game genre, monetization strategy and symptoms of gaming disorder in a clinical sample of adolescents
CONCLUSIONS: This study reveals that game genre preference is influenced by sex, age, and certain psychiatric diagnoses. The categorizing of games into genres is increasingly complex and our research introduces a novel categorization in a developing research field. The result of this study suggests that the monetization model is important to consider while trying to understand the relationship between game characteristics and GD symptoms.PMID:38571884 | PMC:PMC10989217 | DOI:10.48101/ujms.v129.10386 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Frida Andr é Per Bore Theo Toresson Mitchell Andersson Emma Claesdotter-Knutsson Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Meningioma: current updates on genetics, classification, and mouse modeling
Ups J Med Sci. 2024 Mar 18;129. doi: 10.48101/ujms.v129.10579. eCollection 2024.ABSTRACTMeningiomas, the most common primary brain tumors in adults, are often benign and curable by surgical resection. However, a subset is of higher grade, shows aggressive growth behavior as well as brain invasion, and often recurs even after several rounds of surgery. Increasing evidence suggests that tumor classification and grading primarily based on histopathology do not always accurately predict tumor aggressiveness and recurrence behavior. The underlying biology of aggressive treatment-resistant meningiomas and the impact of specific ...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Frank Szulzewsky H Nayanga Thirimanne Eric C Holland Source Type: research
Cellular plasticity in the breast cancer ecosystem
Ups J Med Sci. 2024 Apr 2;129. doi: 10.48101/ujms.v129.10629. eCollection 2024.ABSTRACTThe complex interplay between genetically diverse tumor cells and their microenvironment significantly influences cancer progression and therapeutic responses. This review highlights recent findings on cellular plasticity and heterogeneity within the breast cancer ecosystem, focusing on the roles of cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). We discuss evidence suggesting that breast cancer cells exhibit phenotypic plasticity driven by both intrinsic genetic factors and external microenvironmental cues,...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Kristian Pietras Jonas Sj ölund Source Type: research
A Japanese translation of the Swedish Universities Scales of Personality
CONCLUSION: The resulting three-factor SSP-J11 shows acceptable reliability and should provide informative insights about personality traits in research and clinical practice in a Japanese context.PMID:38571888 | PMC:PMC10989215 | DOI:10.48101/ujms.v129.10349 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Lykke Silfwerbrand Lisa Ekselius Yasuharu Koike Malin Gingnell Source Type: research
Age and co-morbidities as independent risk factors of infections leading to hospital admission in the last year of life among the elderly: A retrospective registry-based study
CONCLUSION: Chronological age and co-morbidities are independent risk factors of infections associated with hospital admission in the last year in life while male sex and sociodemographic factors have less impact.PMID:38571881 | PMC:PMC10989213 | DOI:10.48101/ujms.v129.10504 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Linda Bj örkhem-Bergman Torbj örn Schultz Peter Strang Source Type: research
Unboxing the network among long non-coding RNAs and TGF- β signaling in cancer
Ups J Med Sci. 2024 Mar 26;129. doi: 10.48101/ujms.v129.10614. eCollection 2024.ABSTRACTDeeper analysis of molecular mechanisms arising in tumor cells is an unmet need to provide new diagnostic and therapeutic strategies to prevent and treat tumors. The transforming growth factor β (TGF-β) signaling has been steadily featured in tumor biology and linked to poor prognosis of cancer patients. One pro-tumorigenic mechanism induced by TGF-β is the epithelial-to-mesenchymal transition (EMT), which can initiate cancer dissemination, enrich the tumor stem cell population, and increase chemoresistance. TGF-β signals via SMAD p...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Dorival Mendes Rodrigues-Junior Aristidis Moustakas Source Type: research
White horses - non-coding sequences drive premature hair greying and predisposition to melanoma
Ups J Med Sci. 2024 Apr 2;129. doi: 10.48101/ujms.v129.10626. eCollection 2024.ABSTRACTThe Grey allele in horses is causing premature hair greying and susceptibility to melanoma. The causal mutation is a 4.6 kb tandem duplication in intron 6 of the Syntaxin 17 gene. A recent study demonstrated that the most common allele at the Grey locus (G3) involves three tandem copies of this sequence, whilst a more rare allele (G2) has two tandem copies and the wild-type allele (G1) only one copy. The G3 allele is causing fast greying and high incidence of skin melanoma, whereas the G2 allele is causing slow greying and no obvious inc...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Leif Andersson Source Type: research
The relationship between game genre, monetization strategy and symptoms of gaming disorder in a clinical sample of adolescents
CONCLUSIONS: This study reveals that game genre preference is influenced by sex, age, and certain psychiatric diagnoses. The categorizing of games into genres is increasingly complex and our research introduces a novel categorization in a developing research field. The result of this study suggests that the monetization model is important to consider while trying to understand the relationship between game characteristics and GD symptoms.PMID:38571884 | PMC:PMC10989217 | DOI:10.48101/ujms.v129.10386 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Frida Andr é Per Bore Theo Toresson Mitchell Andersson Emma Claesdotter-Knutsson Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Meningioma: current updates on genetics, classification, and mouse modeling
Ups J Med Sci. 2024 Mar 18;129. doi: 10.48101/ujms.v129.10579. eCollection 2024.ABSTRACTMeningiomas, the most common primary brain tumors in adults, are often benign and curable by surgical resection. However, a subset is of higher grade, shows aggressive growth behavior as well as brain invasion, and often recurs even after several rounds of surgery. Increasing evidence suggests that tumor classification and grading primarily based on histopathology do not always accurately predict tumor aggressiveness and recurrence behavior. The underlying biology of aggressive treatment-resistant meningiomas and the impact of specific ...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Frank Szulzewsky H Nayanga Thirimanne Eric C Holland Source Type: research
Cellular plasticity in the breast cancer ecosystem
Ups J Med Sci. 2024 Apr 2;129. doi: 10.48101/ujms.v129.10629. eCollection 2024.ABSTRACTThe complex interplay between genetically diverse tumor cells and their microenvironment significantly influences cancer progression and therapeutic responses. This review highlights recent findings on cellular plasticity and heterogeneity within the breast cancer ecosystem, focusing on the roles of cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs). We discuss evidence suggesting that breast cancer cells exhibit phenotypic plasticity driven by both intrinsic genetic factors and external microenvironmental cues,...
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Kristian Pietras Jonas Sj ölund Source Type: research
