Reduced 10-year risk of developing cardiovascular disease after participating in a lifestyle programme in primary care.
Conclusions: A structured lifestyle programme in primary care contributes to significant improvements of cardiovascular risk factors and the reduction of 10-year risk for CVD for both men and women at high cardiovascular risk. PMID: 32077778 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 20, 2020 Category: General Medicine Authors: Lönnberg L, Ekblom-Bak E, Damberg M Tags: Ups J Med Sci Source Type: research

Surrogacy relationships: a critical interpretative review.
Abstract Based on a critical interpretative review of existing qualitative research investigating accounts of 'lived experience' of surrogates and intended parents from a relational perspective, this article proposes a typology of surrogacy arrangements. The review is based on the analysis of 39 articles, which belong to a range of different disciplines (mostly sociology, social psychology, anthropology, ethnology, and gender studies). The number of interviews in each study range from as few as seven to over one hundred. Countries covered include Australia, Canada, Greece, India, Iran, Israel, Italy, Mexico, Norwa...
Source: Upsala Journal of Medical Sciences - February 19, 2020 Category: General Medicine Authors: Gunnarsson Payne J, Korolczuk E, Mezinska S Tags: Ups J Med Sci Source Type: research

Analgesic effects of dexmedetomidine and remifentanil on periprocedural pain during percutaneous ablation of renal carcinoma.
Conclusions: This proof-of-concept study has shown that analgosedation during percutaneous ablation of renal carcinoma can be performed with a generally tolerable degree of patient satisfaction. However, pain occurs and should be managed adequately. Patient safety must be a major concern for the anaesthetic care. PMID: 32067572 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - February 18, 2020 Category: General Medicine Authors: Semenas E, Lönnemark M, Dahlman P, Hultström M, Eriksson M Tags: Ups J Med Sci Source Type: research

What animals can teach us about evolution, the human genome, and human disease.
Abstract During the past 20 years, since I started as a postdoc, the world of genetics and genomics has changed dramatically. My main research goal throughout my career has been to understand human disease genetics, and I have developed comparative genomics and comparative genetics to generate resources and tools for understanding human disease. Through comparative genomics I have worked to sequence enough mammals to understand the functional potential of each base in the human genome as well as chosen vertebrates to study the evolutionary changes that have given many species their key traits. Through compa...
Source: Upsala Journal of Medical Sciences - February 14, 2020 Category: General Medicine Authors: Lindblad-Toh K Tags: Ups J Med Sci Source Type: research

U-shaped association between serum uric acid concentration and mortality in hypertrophic cardiomyopathy patients.
Abstract Background. No study has examined the effect of low serum uric acid (SUA) concentrations on mortality in hypertrophic cardiomyopathy (HCM) patients. The aim of the present study was to assess the relations between both low and high SUA concentrations and the risk of mortality across the full range of SUA concentrations in a retrospective cohort of HCM patients.Methods. A total of 454 HCM patients were enrolled in the study, and SUA concentrations were measured at baseline. The primary and secondary endpoints were all-cause mortality and HCM-related mortality, respectively. The associations between SUA con...
Source: Upsala Journal of Medical Sciences - February 4, 2020 Category: General Medicine Authors: Wang Z, Xu Y, Liao H, Chen X, He S Tags: Ups J Med Sci Source Type: research

Is medical urgency of elderly patients with traumatic brain injury underestimated by emergency department triage?
e;n J Abstract Background: Mortality is high among elderly patients with traumatic brain injury (TBI). Recent data suggest that early surgical intervention and aggressive rehabilitation may reduce mortality rates even in elderly patients. Our aim was therefore to study the Rapid Emergency Triage and Treatment System-Adult (RETTS-A) triage of patients with isolated TBI and examine the differences in acute management according to age.Methods: We included 306 adult patients with isolated severe TBI and an abbreviated injury scale (AIS) score ≥3. Using a cut-off of 60 years of age, differences in triage prio...
Source: Upsala Journal of Medical Sciences - January 28, 2020 Category: General Medicine Authors: Ruge T, Carlsson AC, Hellstrom M, Wihlborg P, Undén J Tags: Ups J Med Sci Source Type: research

Knowledge about the impact of age on fertility: a brief review.
e;n T Abstract Delayed childbearing is currently a major challenge in reproductive medicine as increased age has an important impact on successful conception, both in natural and in assisted reproduction. There is a lack of knowledge about the impact of age on fertility, even in highly educated populations. A number of initiatives have been taken to increase fertility awareness. Health care providers have been encouraged to talk with patients about their reproductive life plan (RLP) for almost a decade based on recommendations from the Centres for Disease Control and Prevention. This concept has been explored succ...
Source: Upsala Journal of Medical Sciences - January 22, 2020 Category: General Medicine Authors: Delbaere I, Verbiest S, Tydén T Tags: Ups J Med Sci Source Type: research

Placental glucocorticoid receptors are not affected by maternal depression or SSRI treatment.
Conclusion: Maternal depression and SSRI treatment do not affect the glucocorticoid receptors in the placenta. PMID: 31960733 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 21, 2020 Category: General Medicine Authors: Edvinsson Å, Hoyer A, Hansson M, Kallak TK, Sundström-Poromaa I, Skalkidou A, Lager S Tags: Ups J Med Sci Source Type: research

Social freezing of oocytes: a means to take control of your fertility.
Abstract In the last few decades, there have been tremendous developments of assisted reproductive technologies, but the outcome of in vitro fertilization is highly dependent on the age of the oocyte. The introduction of vitrification offers a possibility to freeze eggs proactively in younger years and use them at later ages, also called social egg freezing. Knowledge about age-related fertility decline is insufficient among many women, and there is an overoptimistic trust that in vitro fertilization can overcome this. The awareness of proactive egg freezing is limited, both among doctors and in the gene...
Source: Upsala Journal of Medical Sciences - January 14, 2020 Category: General Medicine Authors: Wennberg AL Tags: Ups J Med Sci Source Type: research

In vitro fertilisation in domestic mammals-a brief overview.
Abstract Many factors influence the final oocyte maturation, fertilisation, and early embryo development, and there are both similarities and differences between species. When comparing the advancement of assisted reproductive technologies (ARTs), the development in the bovine species is not far behind the medical front, with around one million in vitro-produced bovine embryos each year. This rate of progress is not seen in the other domestic species. This review aims to give an overview of the development and specific difficulties of in vitro embryo production in various domestic animal species, with th...
Source: Upsala Journal of Medical Sciences - December 13, 2019 Category: General Medicine Authors: Sjunnesson Y Tags: Ups J Med Sci Source Type: research

The value of desmosomal plaque-related markers to distinguish squamous cell carcinoma and adenocarcinoma of the lung.
Conclusions: PKP1, KRT15, and DSG3 are highly specific for SCC, but they were more useful to differentiate between SCC and AC when used together and in combination with conventional markers. PKP1 and DSG3 expressions may have prognostic value. PMID: 31809668 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - December 6, 2019 Category: General Medicine Authors: Galindo I, Gómez-Morales M, Díaz-Cano I, Andrades Á, Caba-Molina M, Miranda-León MT, Medina PP, Martín-Padron J, Fárez-Vidal ME Tags: Ups J Med Sci Source Type: research

Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes: a proteomics approach.
Ärnlöv J Abstract Background: Diabetic kidney disease (DKD) is a leading risk factor for end-stage renal disease and is one of the most important risk factors for cardiovascular disease in patients with diabetes. It is possible that novel markers portraying the pathophysiological underpinning processes may be useful.Aim: To investigate the associations between 80 circulating proteins, measured by a proximity extension assay, and prevalent DKD and major adverse cardiovascular events (MACE) in type 2 diabetes.Methods: We randomly divided individuals with type 2 diabetes from three cohorts into a two-third...
Source: Upsala Journal of Medical Sciences - December 5, 2019 Category: General Medicine Authors: Carlsson AC, Nowak C, Lind L, Östgren CJ, Nyström FH, Sundström J, Carrero JJ, Riserus U, Ingelsson E, Fall T, Ärnlöv J Tags: Ups J Med Sci Source Type: research

Psychosocial aspects of identity-release gamete donation - perspectives of donors, recipients, and offspring.
c C Abstract Donor conception creates families with varying genetic linkage between family members. This may have short-term as well as lifelong psychosocial consequences for all involved. Gamete donors have traditionally been anonymous to recipients and offspring, but there is a growing trend towards identity-release donor programmes that give offspring the right to obtain the donor's identity. This review aims to provide an overview of the perspectives of donors and recipients and offspring involved in identity-release donation. The results show that both oocyte and sperm donors have primarily altruistic motives...
Source: Upsala Journal of Medical Sciences - December 5, 2019 Category: General Medicine Authors: Skoog Svanberg A, Sydsjö G, Lampic C Tags: Ups J Med Sci Source Type: research

Membrane-associated gamma-glutamyl transferase and alkaline phosphatase in the context of concanavalin A- and wheat germ agglutinin-reactive glycans mark seminal prostasome populations from normozoospermic and oligozoospermic men.
Conclusions: Membrane-associated gamma-glutamyl transferase and alkaline phosphatase in the context of Con A- and WGA-reactive glycans mark seminal prostasomes populations from normozoospermic and oligozoospermic men. PMID: 31774341 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - November 27, 2019 Category: General Medicine Authors: Janković T, Goč S, Mitić N, Danilović Luković J, Janković M Tags: Ups J Med Sci Source Type: research

Tissue factor in ulcerative colitis, with and without concomitant primary sclerosing cholangitis.
Conclusion: Our study provides additional support for a divergent pathogenesis in PSC-UC, with an inflammatory environment that differs from classical UC. Stromal TF emerges as a new marker of colonic inflammation. PMID: 31774347 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - November 27, 2019 Category: General Medicine Authors: Vessby J, Lampinen M, Åberg M, Rorsman F, Siegbahn A, Wanders A, Carlson M Tags: Ups J Med Sci Source Type: research

Pharmacological limitations of phage therapy.
Abstract Clinical trial results of phage treatment of bacterial infections show a low to moderate efficacy, and the variation in infection clearance between subjects within studies is often large. Phage therapy is complicated and introduces many additional components of variance as compared to antibiotic treatment. A large part of the variation is due to in vivo pharmacokinetics and pharmacodynamics being virtually unknown, but also to a lack of standardisation. This is a consequence of the great variation of phages, bacteria, and infections, which results in different experiments or trials being impossible t...
Source: Upsala Journal of Medical Sciences - November 14, 2019 Category: General Medicine Authors: Nilsson AS Tags: Ups J Med Sci Source Type: research

Does the antisecretory peptide AF-16 reduce lung oedema in experimental ARDS?
Conclusions: This pilot study suggests that AF-16 might improve oedema resolution as indicated by a reduction in EVLW in experimental ARDS. PMID: 31701794 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - November 8, 2019 Category: General Medicine Authors: Barrueta Tenhunen A, Massaro F, Hansson HA, Feinstein R, Larsson A, Larsson A, Perchiazzi G Tags: Ups J Med Sci Source Type: research

SPISE and other fasting indexes of insulin resistance: risks of coronary heart disease or type 2 diabetes. Comparative cross-sectional and longitudinal aspects.
Abstract Background: Fasting insulin resistance indexes are used extensively nowadays. We intended to analyze a new recently presented fasting index, SPISE (sensitivity formula: 600 × HDL-cholesterol0.185/triglycerides0.2/BMI1.338), in comparison with three previously known fasting indexes, regarding correlation with the insulin clamp index, and for the predictive effects of future long-term risks of coronary heart disease (CHD) or manifest type 2 diabetes.Methods: A total of 1049 71-year-old male subjects from the Swedish ULSAM study, median follow-up 8 years, were included. All subject...
Source: Upsala Journal of Medical Sciences - November 7, 2019 Category: General Medicine Authors: Cederholm J, Zethelius B Tags: Ups J Med Sci Source Type: research

Use of in  vitro fertilization-ethical issues.
This report is an ethical analysis based on both facts and values. In in vitro fertilization (IVF), there is an intricate interaction between rapid scientific development and changing societal values. In most countries, the ethical discussion is no longer on whether or not IVF in itself is ethically justifiable. Therefore, in this review, I discuss other ethical aspects that have emerged since IVF was first introduced, such as upper age limits, 'ownership' of gametes and embryos, IVF in single women and same-sex couples, preimplantatory genetic testing, social egg freezing, commercialization, public funding, and prior...
Source: Upsala Journal of Medical Sciences - November 5, 2019 Category: General Medicine Authors: Asplund K Tags: Ups J Med Sci Source Type: research

The impact of standardized care pathway on reporting time for invasive melanoma - results from one pathology department in Sweden.
Conclusion: This study demonstrates prolonged reporting times for invasive melanomas since the implementation of SCP. This is probably caused by the crowd-out effect of the SCP samples, limited personnel resources, and inaccuracy of the clinical diagnosis. SCP might therefore be a suboptimal method to shorten reporting times for invasive melanomas. PMID: 31661366 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - October 29, 2019 Category: General Medicine Authors: Agnarsdóttir M, Päären H, Vassilaki I Tags: Ups J Med Sci Source Type: research

A novel VARS2 gene variant in a patient with epileptic encephalopathy.
Conclusion: Our report extends the phenotypic spectrum of VARS2-related disorders with an initial presentation of epileptic encephalopathy and early death due to malignant arrhythmia. PMID: 31623496 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - October 18, 2019 Category: General Medicine Authors: Ruzman L, Kolic I, Radic Nisevic J, Ruzic Barsic A, Skarpa Prpic I, Prpic I Tags: Ups J Med Sci Source Type: research

Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function.
Conclusion: The results support the NCSC identity of the CD271-enriched human bone marrow population. It remains to investigate whether the human bone marrow-derived NCSCs have the ability to improve transplantation efficacy of not only human islets but stem cell-derived ICC as well. PMID: 31623497 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - October 18, 2019 Category: General Medicine Authors: Brboric A, Vasylovska S, Saarimäki-Vire J, Espes D, Caballero-Corbalan J, Larfors G, Otonkoski T, Lau J Tags: Ups J Med Sci Source Type: research

An intervention in contraceptive counseling increased the knowledge about fertility and awareness of preconception health-a randomized controlled trial.
Conclusions: Knowledge about fertility and awareness of preconception health increased after the intervention. The RLPC can be recommended as a tool in contraceptive counseling. PMID: 31495254 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - September 9, 2019 Category: General Medicine Authors: Skogsdal Y, Fadl H, Cao Y, Karlsson J, Tydén T Tags: Ups J Med Sci Source Type: research

Expression of Na/K-ATPase subunits in the human cochlea: a confocal and super-resolution microscopy study with special reference to auditory nerve excitation and cochlear implantation.
Conclusion: The human auditory nerve displays distinct morphologic features represented in its molecular expression. It was found that electric signals generated via hair cells may not go uninterrupted across the spiral ganglion, but are locally processed. This may be related to particular filtering properties in the human acoustic pathway. PMID: 31460814 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 28, 2019 Category: General Medicine Authors: Liu W, Luque M, Glueckert R, Danckwardt-Lillieström N, Nordström CK, Schrott-Fischer A, Rask-Andersen H Tags: Ups J Med Sci Source Type: research

Clusterin as a potential marker of brain ischemia-reperfusion injury in patients undergoing carotid endarterectomy.
The objective of the study was to report the changes in serum CLU concentrations of patients undergoing CEA. Materials and methods: The study involved 25 patients with severe internal carotid artery stenosis. Serum samples were taken from patients at three different times: within 24 hours preoperatively to CEA, 12 hours postoperatively, and 48 hours postoperatively. Serum CLU concentrations were measured using a commercially available enzyme-linked immunosorbent assay. Results: When compared to concentrations preoperatively, the serum CLU concentration initially decreased during the 12 hours fol...
Source: Upsala Journal of Medical Sciences - August 28, 2019 Category: General Medicine Authors: Iłżecka J, Iłżecki M, Grabarska A, Dave S, Feldo M, Zubilewicz T Tags: Ups J Med Sci Source Type: research

Prevalence and natural history of and risk factors for subaneurysmal aorta among 65-year-old men.
nhainen A Abstract Background: The aims of this study were to determine the prevalence of screening-detected subaneurysmal aorta (SAA), i.e. an aortic diameter of 2.5-2.9 cm, its associated risk factors, and natural history among 65-year-old men. Methods: A total of 14,620 men had their abdominal aortas screened with ultrasound and completed a health questionnaire containing information on smoking habits and medical history. They were categorized based on the aortic diameter: normal aorta (
Source: Upsala Journal of Medical Sciences - August 28, 2019 Category: General Medicine Authors: Thorbjørnsen K, Svensjö S, Djavani Gidlund K, Gilgen NP, Wanhainen A Tags: Ups J Med Sci Source Type: research

Cathepsin D improves the prediction of undetected diabetes in patients with myocardial infarction.
Conclusions: Newly detected dysglycaemia, including manifest diabetes, is common in patients with acute MI. Cathepsin D improved the prediction of dysglycaemia, which may be helpful in the a priori risk determination of diabetes as a motivation for confirmatory OGTT. PMID: 31429631 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 20, 2019 Category: General Medicine Authors: Velders MA, Calais F, Dahle N, Fall T, Hagström E, Leppert J, Nowak C, Tenerz Å, Ärnlöv J, Hedberg P Tags: Ups J Med Sci Source Type: research

Adipocytes express tissue factor and FVII and are procoagulant in a TF/FVIIa-dependent manner.
Conclusion: Human primary adipocytes express active TF and FVII, and the TF/FVIIa complex formed on the adipocyte surface can activate substrate FX. Whether the TF/FVIIa complex conveys signaling pathways leading to biological functions and has any biological activity in adipocytes beyond coagulation remains to be elucidated. PMID: 31407948 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - August 13, 2019 Category: General Medicine Authors: Edén D, Panagiotou G, Mokhtari D, Eriksson JW, Åberg M, Siegbahn A Tags: Ups J Med Sci Source Type: research

New insights into the roles of the FOXO3 and P27Kip1 genes in signaling pathways.
Conclusion: Simultaneous silencing of FOXO3 and activation of p27Kip1 in MDA-MB-231 cells caused alterations in the expression level of several genes involved in apoptosis, cell proliferation, cell cycle control, tissue invasion, drug resistance, and metastasis. It seems that the identified genes might serve as useful biomarkers for breast cancer. PMID: 31294654 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - July 11, 2019 Category: General Medicine Authors: Mayahi S, Golalipour M, Yamchi A, Jhingan GD, Shahbazi M Tags: Ups J Med Sci Source Type: research

Encounters with adenovirus.
Abstract In this paper I describe aspects of work on the human adenoviruses in which my laboratory has participated. It consists of two sections-one historic dealing with work performed in the previous century, and one dealing with the application of 'omics' technologies to understand how adenovirus-infected cells become reprogrammed to benefit virus multiplication. PMID: 31142167 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 29, 2019 Category: General Medicine Authors: Pettersson U Tags: Ups J Med Sci Source Type: research

A national survey on routines regarding sedation in Swedish intensive care units.
Conclusions: All ICUs used a sedation scale, an increase compared with previous studies. Concerning the choice of hypno- and analgosedatives, the use of dexmedetomidine, clonidine, and remifentanil has increased, and the use of benzodiazepines has decreased since the Nordic survey in 2004. PMID: 31119971 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 23, 2019 Category: General Medicine Authors: Talsi O, Kiiski Berggren R, Johansson G, Winsö O Tags: Ups J Med Sci Source Type: research

Experiences of sexual violence among women seeking services at a family planning unit in Sweden.
r G Abstract BACKGROUND: Experiences of sexual violence among women can lead to ill health and increase the risk of lifetime co-occurrence of violence. Identifying risk factors and victims facilitates development of effective programmes for treatment and prevention of additional violence. The primary aim of this study was to assess the prevalence and correlates of sexual violence experiences among women seeking care at a family planning unit in Sweden. A secondary aim was to examine associations between sexual violence and other types of violence. METHODS: Women (n = 1226) seeking services at a ...
Source: Upsala Journal of Medical Sciences - May 13, 2019 Category: General Medicine Authors: Öberg M, Skalkidou A, Heimer G Tags: Ups J Med Sci Source Type: research

Improved unhealthy lifestyle habits in patients with high cardiovascular risk: results from a structured lifestyle programme in primary care.
CONCLUSIONS: The results support the utility of a multifactorial, structured approach to change unhealthy lifestyle habits for cardiovascular risk prevention in a primary care setting. PMID: 31063003 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 7, 2019 Category: General Medicine Authors: Lönnberg L, Ekblom-Bak E, Damberg M Tags: Ups J Med Sci Source Type: research

High-fat diet in pregnant rats and adverse fetal outcome.
CONCLUSION: HFD alters the maternal metabolic state, increases fetal resorptions in vivo, and increases the rate of fetal/embryonic malformations both in vivo and in vitro. These findings suggest that metabolic disturbances in HFD pregnant rats have profound adverse developmental effects in the offspring. PMID: 31063006 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - May 7, 2019 Category: General Medicine Authors: Wentzel P, Eriksson UJ, Herrera E Tags: Ups J Med Sci Source Type: research

Equal palliative care for patients with COPD? A nationwide register study.
This study aimed to compare patients with COPD in SPC with those in NH and to compare the care provided. METHODS: A national register study was carried out where the Swedish National Airway Register and the Swedish Register of Palliative Care were merged. COPD patients who died in NHs or short-term facilities were included in the NH group (n = 415) and those who died in SPC were included in the SPC group (n = 355). Demographic and clinical variables were included from the Swedish National Airway Register and variables concerning EOL care from the Swedish Register of Palliative Care. RE...
Source: Upsala Journal of Medical Sciences - April 23, 2019 Category: General Medicine Authors: Henoch I, Strang P, Löfdahl CG, Ekberg-Jansson A Tags: Ups J Med Sci Source Type: research

Surface glycans contribute to differences between seminal prostasomes from normozoospermic and oligozoospermic men.
CONCLUSIONS: Subtle differences in the presentation of surface molecules may be helpful for differentiation among vesicles sharing the same physical properties. In addition, this may point to some unexpected regulatory mechanisms of interaction of distinct populations of vesicles with their binding partners. PMID: 30957617 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 8, 2019 Category: General Medicine Authors: Milutinović B, Goč S, Mitić N, Kosanović M, Janković M Tags: Ups J Med Sci Source Type: research

Intratumoral expression of FoxP3-positive regulatory T-cells in T-cell lymphoma: no correlation with survival.
CONCLUSIONS: Intratumoral Tregs are frequently found in TCL in immunocompetent individuals. In this heterogeneous group of TCL, there was no correlation between the density of intratumoral FoxP3+ cells and overall survival. PMID: 30856039 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - March 11, 2019 Category: General Medicine Authors: Lundberg J, Berglund D, Molin D, Kinch A Tags: Ups J Med Sci Source Type: research

De-identified linkage of data across separate registers: a proposal for improved protection of personal information in registry-based clinical research.
ansen C Abstract Over the last decades the advent of digital documentation has provided research communities with valuable resources of information for clinical research. To utilize the potential of information about patients, their health care, and its outcome that is already available in different registers, the possibility to cross-reference information from different registers is inevitably required. When performing linkage, we are currently forced to disclose information of participating subjects either to the administration of the other register(s) or to the researcher. Considering the increased concern of i...
Source: Upsala Journal of Medical Sciences - February 7, 2019 Category: General Medicine Authors: Snäckerström T, Johansen C Tags: Ups J Med Sci Source Type: research

Swedish guidelines for registry-based randomized clinical trials.
Abstract During the last decade Sweden has invested in a national infrastructure for collection of structured clinical data in the form of healthcare registries (in Sweden known as Kvalitetsregister). These data can be combined with other public data using the national personal identifiers that are issued to Swedish citizens. The healthcare registries have an almost complete coverage of Swedish healthcare, and a large network of clinicians is involved in the quality assurance and continuous improvement of healthcare using these registries. Uppsala Clinical Research Center (UCR) has been a technology provider of la...
Source: Upsala Journal of Medical Sciences - February 6, 2019 Category: General Medicine Authors: Nyberg K, Hedman P Tags: Ups J Med Sci Source Type: research

Uppsala Biobank-the development of a biobank organization in a local, regional, and national setting.
Abstract A biobank is generally in an international setting considered as a sample collection with linked data. In Sweden we have a lot of sample collections, but the definition of a biobank has changed, and it has become an organization that administrates many sample collections as well as an infrastructure to support research. Uppsala Biobank was started in September 2008 as a joint biobank organization between Uppsala County Council and Uppsala University. At the start there were 138 registered biobanks in Uppsala for these two principals. The decision was to have only one biobank, where all previous biobanks w...
Source: Upsala Journal of Medical Sciences - February 1, 2019 Category: General Medicine Authors: Beskow A Tags: Ups J Med Sci Source Type: research

A framework for monitoring of new drugs in Sweden.
m J Abstract In order to monitor the net public health benefit of new drugs, especially in the light of recent stepwise approval approaches, there is a need to optimize real-time post-marketing evaluation of new drugs using data collected in routine care. Sweden, with its unique possibilities for observational research, can provide these data. We herein propose a framework for continuous monitoring of the effectiveness, safety, and cost-effectiveness of new drugs, using prospectively determined protocols designed in collaboration between all relevant stakeholders. We believe that this framework can be a useful too...
Source: Upsala Journal of Medical Sciences - January 28, 2019 Category: General Medicine Authors: Cars T, Lindhagen L, Sundström J Tags: Ups J Med Sci Source Type: research

Effects of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency, and myocardial contractile work in type 2 diabetes patients-a description of the DAPACARD study.
CONCLUSION: The DAPACARD study is an extensive investigation of cardiac function and metabolism, by advanced imaging with PET and MRI, as well as biomarkers, performed in order to further explore how the SGLT2 inhibitor dapagliflozin could influence cardiovascular outcomes in patients with T2DM. PMID: 30618324 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - January 8, 2019 Category: General Medicine Authors: Åkerblom A, Oldgren J, Latva-Rasku A, Johansson L, Lisovskaja V, Karlsson C, Oscarsson J, Nuutila P Tags: Ups J Med Sci Source Type: research

Rationale for a Swedish cohort consortium.
S, Snäckerström T, Stenbeck M, Söderberg S, Weiderpass E, Wanhainen A, Wennberg P, Fortier I, Heller S, Storgärds M, Svennblad B Abstract We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposures and outcomes, leading to better utilization of study participants' data, better return of funders' investments, and higher benefit to patient...
Source: Upsala Journal of Medical Sciences - January 8, 2019 Category: General Medicine Authors: Sundström J, Björkelund C, Giedraitis V, Hansson PO, Högman M, Janson C, Koupil I, Kristenson M, Trolle Lagerros Y, Leppert J, Lind L, Lissner L, Johansson I, Ludvigsson JF, Nilsson PM, Olsson H, Pedersen NL, Rosenblad A, Rosengren A, Sandin S, Snäcke Tags: Ups J Med Sci Source Type: research

Can Reproductive Life Plan-based counselling increase men's fertility awareness?
Larsson M Abstract BACKGROUND: Many men have limited knowledge about reproductive health and fertility. The aim of the study was to evaluate if Reproductive Life Plan (RLP)-based counselling during a sexual health visit could increase men's fertility awareness. MATERIAL AND METHODS: The study was a randomized controlled trial including 201 men aged 18-50 who visited either of two participating sexual health clinics in Sweden for sexually transmitted infection testing during 2014-2016. All men received standard care, and men in the intervention group (IG) also received oral and written RLP-based information ab...
Source: Upsala Journal of Medical Sciences - December 13, 2018 Category: General Medicine Authors: Bodin M, Tydén T, Käll L, Larsson M Tags: Ups J Med Sci Source Type: research

Status one year after fertility assessment and counselling in women of reproductive age-a qualitative study.
CONCLUSIONS: Our study highlights the impact of a fertility assessment and counselling intervention which included a perceived increase in knowledge. The clinic allows for an individualized approach to fertility awareness which is necessary given the unique nature of childbearing decisions. PMID: 30539672 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - December 12, 2018 Category: General Medicine Authors: Sylvest R, Koert E, Vittrup I, Birch Petersen K, Nyboe Andersen A, Pinborg A, Schmidt L Tags: Ups J Med Sci Source Type: research

Personality disorder: a disease in disguise.
Abstract Personality disorders (PDs) can be described as the manifestation of extreme personality traits that interfere with everyday life and contribute to significant suffering, functional limitations, or both. They are common and are frequently encountered in virtually all forms of health care. PDs are associated with an inferior quality of life (QoL), poor health, and premature mortality. The aetiology of PDs is complex and is influenced by genetic and environmental factors. The clinical expression varies between different PD types; the most common and core aspect is related to an inability to build and mainta...
Source: Upsala Journal of Medical Sciences - December 12, 2018 Category: General Medicine Authors: Ekselius L Tags: Ups J Med Sci Source Type: research

Cancer treatment of today in view of the Nobel Prize.
PMID: 30526172 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - December 11, 2018 Category: General Medicine Authors: Ullenhag G Tags: Ups J Med Sci Source Type: research

Gynecologists are afraid of prescribing hormone replacement to endometrial/ovarian cancer survivors despite national guidelines-a survey in Sweden.
CONCLUSION: Swedish gynecologic oncologists have a more favorable attitude towards HRT for endometrial/ovarian cancer patients and feel more comfortable treating their patients than do gynecologists. This study illustrates a need for education in these matters in order not to withhold HRT from women due to doctors' sometimes unjustified anxiety. PMID: 30526173 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - December 10, 2018 Category: General Medicine Authors: Halldorsdottir S, Dahlstrand H, Stålberg K Tags: Ups J Med Sci Source Type: research

A new contribution to research metrics.
n J PMID: 30513247 [PubMed - as supplied by publisher] (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - December 4, 2018 Category: General Medicine Authors: Andersson A, Lau Börjesson J Tags: Ups J Med Sci Source Type: research

Uppsala Clinical Research Center-development of a platform to promote national and international clinical science.
Abstract Uppsala Clinical Research Center (UCR) is a non-profit organization that provides service for clinical research aiming for development and improvement of health care in Sweden and worldwide. UCR was started in 2001 with the ambition to shift the focus of clinical research from new medications or devices launched by the industry to problem-based research on issues identified in clinical reality, for example through the national quality registries. In order to accomplish these goals, UCR has established services in: 1) clinical trials of new and old methods in health care; 2) quality development of the heal...
Source: Upsala Journal of Medical Sciences - December 4, 2018 Category: General Medicine Authors: Wallentin L, Lindahl B Tags: Ups J Med Sci Source Type: research