ASO Author Reflection: Postoperative Chemotherapy for Nonmetastatic, Poorly Differentiated Gastroenteropancreatic Neuroendocrine Carcinomas
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Which Patients with Colon Cancer Refuse Recommended Surgery?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Accuracy of Maxillary and Mandibular Reconstruction Enhanced by Advances in Technology
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Local Periostin Expression and Systemic Immunoinflammatory Measures in Esophageal Cancer: A Single-Center, Retrospective Study
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 1, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Clinical Significance of Peripheral Blood Inflammatory Markers in Thymic Epithelial Tumors
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Exenterative Surgery for Squamous Cell Carcinoma Arising from Pelvic Organs of Cloacal Origin
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Liver Resection for Hepatocellular Carcinoma and the Barcelona Clinic Liver Cancer Criteria: Is It Time to Push the Limits?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Combining Ablation and Resection for the Treatment of Hepatocellular Carcinoma: An Attempt to Expand Treatment Options
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Essential to Reduce Adverse Outcomes in Perihilar Cholangiocarcinoma Surgery —Portal Vein Embolization
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Sowing the Seeds of Surgical Oncology
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Long-Term Oncologic Impact of Esophageal Anastomotic Leak After Esophagectomy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Wives as Key Persons Positively Impact Prognosis for Male Patients Undergoing Esophagectomy for Esophageal Cancer: A Retrospective Study from a Single Japanese Institute
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Leveraging Implementation Science to Improve Delivery of Oncologic Reconstructive Surgery
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Genetic Testing is Not “One and Done”
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Editorial Comment On: Prognostic Implication of Body Mass Index on Survival Outcomes in Surgically-Treated Non-metastatic Renal Cell Carcinoma: A Single Institutional, Retrospective Analysis of a Large Cohort
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: The Influence of Surgeon Characteristics on Patient-Centered Approaches to Treatment Decision-Making
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Recurrence Patterns and Outcomes After Resection of Hepatocellular Carcinoma Within and Beyond the Barcelona Clinic Liver Cancer Criteria
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Residual Breast Tissue After Skin- and Nipple-Sparing Mastectomies: A Matter of Concern or a Point for Improvement/Action?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Left Trisectionectomy for Bismuth –Corlette Type IV Perihilar Cholangiocarcinoma with Left-Sided Predominance
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: The Significance of Limited Surgery Among Patients with Sarcopenia
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: How to Detect Peritoneal Metastases of Urachal Carcinoma? The Value of Diagnostic Laparoscopy and Abdominal Cytology in Staging This Rare Malignancy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Advanced and Recurrent Pelvic Squamous Cell Cancer: Unfinished Business
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Phase II Trial of Adjuvant Chemotherapy with S-1 for Node-Positive Biliary Tract Cancer (N-SOG 09)
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 24, 2020 Category: Cancer & Oncology Source Type: research

Impact of Perioperative Steroid Administration in Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection: A Randomized Controlled Trial
ConclusionPerioperative steroid administration did not reduce the risk of postoperative complications, including liver failure following major hepatectomy with extrahepatic bile duct resection. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

Radioactive Seed Versus Wire-Guided Localization for Ductal Carcinoma in Situ of the Breast: Comparable Resection Margins
AbstractBackgroundThere are currently two widely used methods for preoperative localization of ductal carcinoma in situ (DCIS) of the breast: wire-guided localization (WGL) and radioactive seed localization (RSL). Several studies compared these localization techniques in small cohorts.ObjectiveThe aim of this study was to compare the surgical resection margin status between RSL and WGL in a large national cohort of patients with DCIS.Patients and MethodsWe included patients from the Dutch Pathology Registry who underwent breast-conserving surgery for DCIS by either RSL (n = 1851) or WGL (n = 218...
Source: Annals of Surgical Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

Diaphragmatic Involvement Should Not Preclude Curative-Intent Surgical Resection for Hepatocellular Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Is Hepatectomy Plus Diaphragmatic Resection for Hepatocellular Carcinoma with Diaphragmatic Involvement Justified?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

Extraskeletal Myxoid Chondrosarcoma with Molecularly Confirmed Diagnosis: A Multicenter Retrospective Study Within the Italian Sarcoma Group
ConclusionsProlonged survival can be expected in patients with EMC, in spite of a high rate of recurrence. Size is significantly associated with distant relapse. The type of NR4A3 translocation could influence outcome. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 22, 2020 Category: Cancer & Oncology Source Type: research

Three-Dimensionally Printed Patient-Specific Surgical Plates Increase Accuracy of Oncologic Head and Neck Reconstruction Versus Conventional Surgical Plates: A Comparative Study
ConclusionsThis is the first study to prove that compared with conventional plates, 3D-printed patient-specific surgical plates improve the accuracy of oncologic head and neck reconstruction. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 22, 2020 Category: Cancer & Oncology Source Type: research

Systemic Pharmacokinetics of Oxaliplatin After Intraperitoneal Administration by Electrostatic Pressurized Intraperitoneal Aerosol Chemotherapy (ePIPAC) in Patients with Unresectable Colorectal Peritoneal Metastases in the CRC-PIPAC Trial
DiscussionSystemic exposure to oxaliplatin after ePIPAC seemed comparable to that after systemic chemotherapy, as described in other literature. Since this is an indirect comparison, future research should focus on the direct comparison between the systemic exposure to oxaliplatin after ePIPAC and after systemic chemotherapy.Trial registration: NCT03246321, Pre-results; ISRCTN89947480, Pre-results; NTR6603, Pre-results; EudraCT: 2017-000927-29, Pre-results. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 22, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Assessing the Value of Primary Tumor Resection in Midgut Neuroendocrine Tumors with Liver-Only Metastases
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 22, 2020 Category: Cancer & Oncology Source Type: research

Editorial Comment on: DPP9 Increases Chemoresistance and is an Indicator of Poor Prognosis in Colorectal Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 22, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Is Minimally Invasive Ivor –Lewis the Future of Esophagectomy?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 21, 2020 Category: Cancer & Oncology Source Type: research

Effects of Fibrin Sealant on Seroma Reduction for Patients with Breast Cancer Undergoing Axillary Dissection: Meta-Analysis of Randomized Controlled Trials
ConclusionsFibrin sealants provide limited benefits in reducing the volume of seroma and the volume and duration of drainage. Therefore, after shared decision making, surgeons may apply fibrin sealants to patients with breast cancer undergoing axillary dissection. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 20, 2020 Category: Cancer & Oncology Source Type: research

Significance of Frailty in Prognosis After Hepatectomy for Elderly Patients with Hepatocellular Carcinoma
AbstractBackgroundThe concept of frailty becomes important for patients who undergo surgery in this recent aging society. The aim of this study is to investigate the frailty as a prognostic factor in elderly patients with hepatocellular carcinoma (HCC) who underwent hepatectomy.Patients and MethodsA total of 92 patients over 75  years old who underwent hepatectomy were enrolled in this study. Frailty was defined as clinical frailty scale (CFS) ≥ 4. Patients were divided into two groups, i.e., frailty group (n = 21) and no-frailty group (n = 71), and clinicopathological feat...
Source: Annals of Surgical Oncology - June 19, 2020 Category: Cancer & Oncology Source Type: research

Impact of Postoperative Chemotherapy on the Survival of Patients with High-Grade Gastroenteropancreatic Neuroendocrine Carcinoma
ConclusionsIn this national database analysis, postoperative chemotherapy was not associated with improved survival for patients with poorly differentiated gastroenteropancreatic (GEP) NECs. These findings highlight the need for continued efforts to understand better which patients in this high-risk population will benefit from additional systemic therapy and the need for continued development of more effective therapies for these patients. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 18, 2020 Category: Cancer & Oncology Source Type: research

Simultaneous Ipsilateral Vascularized Lymph Node Transplantation and Contralateral Lymphovenous Anastomosis in Bilateral Extremity Lymphedema with Different Severities
AbstractBackgroundExtremity lymphedema can occur bilaterally with different severities on each side. The aim of this study is to investigate the treatment outcomes of such patients with bilateral extremity lymphedema of different severities.Patients and MethodsBetween 2013 and 2017, patients with bilateral extremity lymphedema of different severities according to the Taiwan Lymphoscintigraphy Staging (TLS) system were retrospectively reviewed. Ipsilateral vascularized lymph node transplantation (VLNT) was indicated in TLS total obstruction and contralateral lymphovenous anastomosis (LVA) in TLS partial obstruction with pat...
Source: Annals of Surgical Oncology - June 18, 2020 Category: Cancer & Oncology Source Type: research

Total Laparoscopic Uncut Roux-en-Y for Radical Distal Gastrectomy: An Interim Analysis of a Randomized, Controlled, Clinical Trial
AbstractBackgroundThe traditional Billroth II and Roux-en-Y anastomosis after laparoscopic distal gastrectomy for gastric cancer are associated with bile reflux gastritis and roux stasis syndrome, respectively. The uncut Roux-en-Y gastrojejunostomy can decrease the incidence of these complications by blocking the entry of bile and pancreatic juice into the residual stomach and retaining the impulses originating from the duodenum. The purpose of the present study was to compare the short-term outcomes of uncut Roux-en-Y (URY) and Billroth II combined Braun (BB) anastomosis.MethodsIn this prospective, multi-center, two-arm r...
Source: Annals of Surgical Oncology - June 18, 2020 Category: Cancer & Oncology Source Type: research

A Phase II Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion with Chemotherapy for Patients with Gastric Cancer and Carcinomatosis or Positive Cytology
ConclusionsSurvival rates for patients with gastric adenocarcinoma and peritoneal disease treated with cytoreduction, gastrectomy, and HIPEC are encouraging; our early results are similar to those of recent prospective registry studies. Multi-institutional and cooperative group trials should be supported to confirm survival and safety outcomes. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 17, 2020 Category: Cancer & Oncology Source Type: research

Prediction Efficacy for Clinical Outcome of Prognostic Nutritional Index in Patients with Resectable Biliary Tract Cancer Depends on Sex and Obstructive Jaundice Status
AbstractBackgroundThe Prognostic Nutritional Index (PNI), a marker of nutritional status and systemic inflammation, is a proven prognostic biomarker in some cancers. The predictive value of PNI in biliary tract cancer (BTC) has not been established.ObjectiveThe aim of this study was to determine the relationship between the PNI and outcomes of resectable BTC.MethodsIn total, 430 patients with stage I –III resectable BTC [gallbladder cancer (GBC),n = 212; cholangiocarcinoma (CHO),n = 218] who had attended Fudan University Zhongshan Hospital were enrolled. The relationship between the PNI an...
Source: Annals of Surgical Oncology - June 16, 2020 Category: Cancer & Oncology Source Type: research

Lymph Node Metastasis and Recurrences from Esophageal Squamous Cell Carcinoma in Patients with Previous Gastrectomy
ConclusionsThe present study showed that the incidence of abdominal LN metastasis from ESCC after gastrectomy was not necessarily low, regardless of the tumor location and the reason for previous gastrectomy. This result suggests that gastrectomy should not be omitted easily in ESCC patients after previous gastrectomy. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 16, 2020 Category: Cancer & Oncology Source Type: research

Reply to: & quot;When Should Hepatectomy be Performed for the Treatment of Bismuth Type I and II Hilar Cholangiocarcinoma? & quot;
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 16, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Developing Personalized Care for Hepatocellular Adenoma Based on Subtype Classification
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 16, 2020 Category: Cancer & Oncology Source Type: research

A Shifting Paradigm in Diagnosis and Management of Hepatic Adenoma
ConclusionsClassification of HCA by subtype has important implications for patient counseling and treatment given variable risks of malignant transformation and hemorrhage. Males and those with β-catenin exon 3 mutated HCAs are two groups who should always be counselled to undergo surgical resection. On the other hand, in the lower risk HF1α subtype observation is appropriate in lesions
Source: Annals of Surgical Oncology - June 15, 2020 Category: Cancer & Oncology Source Type: research

Race and Gender Disparities in Access to Parathyroidectomy: A Need to Change Processes for Diagnosis and Referral to Surgeons
AbstractBackgroundHyperparathyroidism substantially impairs quality of life, and effective treatment depends on timely referral to surgeons. We hypothesized that there would be race and gender disparities in the time from initial diagnosis of hyperparathyroidism to treatment with parathyroidectomy.MethodsWe reviewed administrative data on 2289 patients with hypercalcemia (calcium  >  10.5 mg/dL) and abnormal parathyroid hormone levels who were seen at a tertiary referral center from 2011 to 2016. We used two-phase parametric hazard modeling to identify predictors of time from index abnormal calcium un...
Source: Annals of Surgical Oncology - June 15, 2020 Category: Cancer & Oncology Source Type: research

Quantitative and Spatial Analysis of CD8+/PD-1 Tumor-Infiltrating Lymphocytes as a Predictive Biomarker for Clinical Response of Melanoma In-Transit Metastases to Topical Immunotherapy
AbstractBackgroundMelanoma in-transit metastases (ITMs) are a challenge to treat and associated with systemic disease and poor prognosis. Topical diphencyprone (DPCP), a potent contact sensitizer, is an established treatment for melanoma ITMs. This exploratory study investigated the utility ofBRAF mutation status, CD8, PD-1, PD-L1, and TILs distribution as biomarkers for response of ITMs to topical immunotherapy (DPCP).MethodsThe ITM deposits of 40 patients treated with DPCP were subjected to biomarker analysis forBRAF status, CD8 and PD-1 expression on tumor-infiltrating lymphocytes (TILs), and tumor PD-L1 expression. Res...
Source: Annals of Surgical Oncology - June 15, 2020 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Race and Gender Disparities in Access to Parathyroidectomy: A Need to Change Processes for Diagnosis and Referral to Surgeons
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 15, 2020 Category: Cancer & Oncology Source Type: research

Laparoscopic Right Hemihepatectomy Using the Glissonean Approach: Detachment of the Hilar Plate (with Video)
ConclusionThe detachment of the hilar plate was a feasible and effective technique in laparoscopic right hemihepatectomy using the Glissonean approach. Our standardized technique prevents biliary complications by meticulous dissection of potential injury sites related to the hilar plate. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 14, 2020 Category: Cancer & Oncology Source Type: research

Surgical Oncologists and the COVID-19 Pandemic: Guiding Cancer Patients Effectively through Turbulence and Change
ConclusionsUntil an effective vaccine becomes available for widespread use, it is imperative that surgical oncologists remain focused on providing optimal care for our cancer patients while managing the demands that the COVID-19 pandemic will continue to impose on all of us. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 14, 2020 Category: Cancer & Oncology Source Type: research

Rate of Peritoneal Carcinomatosis in Resected Stage II and III Colon Cancer
ConclusionOverall PC incidence in patients with resected stage II and III colon cancer was 6.4%. Although the high-risk group developed PC at a significantly higher rate, the rate of PC in this group was still below 10%. The results of this study represent real-world rates of PC and should be taken into account when designing future studies. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 14, 2020 Category: Cancer & Oncology Source Type: research