ASO Visual Abstract: From the Ronnett to the PSOGI Classification System for Pseudomyxoma Peritonei: A Validation Study
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - March 1, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Defining Gastrectomy Volume Targets for Regionalization of Gastric Cancer Care in the USA
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - March 1, 2021 Category: Cancer & Oncology Source Type: research

Robotic Double Tract Reconstruction After Proximal Gastrectomy for Gastric Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Which Preoperative Breast Localization Method is More Economical: Radioactive Seed or Wire-Guided Localization?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Robotic Radical Hysterectomy for Patients with Early-Stage Cervical Cancer: Oncologic Outcomes
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Re-Excision for Ductal Carcinoma In Situ: Who Is at Risk?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: The Impact of Preoperative Chemotherapy on Survival After Esophagectomy in Elderly Patients with Esophageal Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Immediate Lymphatic Reconstruction: A Proactive Approach to Breast Cancer-Related Lymphedema
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Optimal Procedure of Surgical Resection for Pancreatic Body Cancer under Consideration of Significance of Peripancreatic Head Lymph Node Dissection
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

Robotic Partial Segment VIII Resection
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Lymph Node Metastasis of Esophageal Cancer After Trimodal Therapy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Ultrasound Assessment of the Lymphatic Drainage Area in Melanoma Patients With In-Transit Metastases
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Undertreatment of Pancreatic Cancer After Resection: Don ’t Get Fooled by Favorable Final Pathology
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Complex Cancer Surgery Mortality After 30 Days: An Opportunity for Improvement
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Spotlight on Malignant Peritoneal Cytology in Uterine Sarcoma: A Potential Avenue for Future Research
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 18, 2021 Category: Cancer & Oncology Source Type: research

Impact of Ipsilateral Supraclavicular Lymph Node Dissection (ISLND) for Breast Cancer Patients and a Nomogram for Predicting Ipsilateral Supraclavicular Pathological Complete Response (ispCR)
AbstractBackgroundThe purpose of this study was to evaluate the impact of ipsilateral supraclavicular lymph node dissection (ISLND) on the outcomes of breast cancer patients with ipsilateral supraclavicular lymph node metastasis (ISLNM), and to evaluate the prognostic value of ipsilateral supraclavicular pathological complete response (ispCR). Meanwhile, a nomogram was constructed to predict ispCR.MethodsWe retrospectively reviewed the medical documents of 353 patients with ISLNM but no distant metastasis at presentation. Based on whether ISLND was performed, patients were divided into radiotherapy (RT) and ISLND  +...
Source: Annals of Surgical Oncology - February 17, 2021 Category: Cancer & Oncology Source Type: research

Correction to: ASO Author Reflections: Cumulative GRAS Score Predicts Outcomes After Resection for Adrenal Cortical Carcinoma
Jordan J. Baechle and Paula Marincola Smith contributed equally to this paper. The original article has been updated. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 17, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: Management of Small Bowel Neuroendocrine Tumors
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 17, 2021 Category: Cancer & Oncology Source Type: research

Repeat Cytoreductive Surgery and Intraperitoneal Chemotherapy for Colorectal Cancer Peritoneal Recurrences is Safe and Efficacious
ConclusionsOur analysis, which represents the largest series to date of repeat CRS/HIPEC for CRPM, indicates that this approach as a part of multimodal therapy is both safe and efficacious in appropriately selected patients. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 16, 2021 Category: Cancer & Oncology Source Type: research

Preoperative Biopsy in Patients with Retroperitoneal Sarcoma: Usage and Outcomes in a National Cohort
AbstractIntroductionPreoperative biopsy (PBx) is often recommended for retroperitoneal sarcoma (RPS), but its utilization rate and impact on perioperative management and outcomes remains undefined.MethodsUsing the National Cancer Database, patients who underwent resection of non-metastatic RPS were identified (2006 –2014). Patients who did and did not undergo PBx of the primary tumor were compared using propensity matching, and factors associated with survival were assessed by multivariable analysis.ResultsOf 2620 patients, 1110 (42.4%) underwent PBx. Factors significantly associated with performance of PBx included ...
Source: Annals of Surgical Oncology - February 16, 2021 Category: Cancer & Oncology Source Type: research

Randomised Controlled Trial Evidence Questions the Assumption that Pulmonary Metastasectomy Benefits Patients with Colorectal Cancer
AbstractPulmonary metastasectomy for sarcoma is surgery without proven benefit, and in the  light of a randomized controlled trial examining pulmonary metastasectomy in colorectal cancer, it should be questioned. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 15, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Revision Surgery or Timely Chemotherapy for Incidental Gallbladder Cancers: What is Actually Helping?
AbstractRevision surgery with or without chemotherapy in the neoadjuvant or adjuvant setting remains the standard treatment for incidental gallbladder cancers (iGBCs). Over the years, researchers have retrospectively analyzed the surgical audits and tried to establish the perceived benefit and optimal timing for revision surgery. Patkar and colleagues have analyzed the outcomes for 517 patients with iGBC, concluding that there is no optimal timing for performing a revision surgery after initial cholecystectomy. Revision surgery is essentially the most accurate staging procedure and should be offered to patients at any time...
Source: Annals of Surgical Oncology - February 15, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 15, 2021 Category: Cancer & Oncology Source Type: research

Women Could Avoid Axillary Lymph Node Dissection by Choosing Breast-Conserving Therapy Instead of Mastectomy
AbstractBackgroundThe ACOSOG Z0011 trial showed that completion axillary lymph node dissection (cALND) can be safely omitted for some patients with T1 –2 clinically node-negative breast cancer with one to two involved sentinel lymph nodes (SLNs) treated with breast-conserving therapy (BCT). There is little evidence for the safety of omitting cALND for mastectomy-treated patients. Consequently, cALND is often recommended for sentinel node-positiv e patients treated with mastectomy. The aim of this study is to determine the proportion of patients who could avoid cALND by choosing BCT instead of mastectomy at a tertiary...
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

The Landmark Series: Locally Advanced Pancreatic Cancer and Ablative Therapy Options
This study had several limitations, and ongoing studies are re-evaluating the role of chemoradiation after more effective chemotherapy regimens as well as more advanced radiation techniques. In parallel, there has been increasing interest in other thermal and non-thermal methods of ablation. In particular, irreversible electroporation has gained traction for treatment of LAPC, with at least one ongoing randomized controlled trial designed to address its role compared with systemic chemotherapy alone. Multiple preclinical and clinical studies are investigating combinations of local ablation and immunotherapy with the goal o...
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

Cumulative GRAS Score as a Predictor of Survival After Resection for Adrenocortical Carcinoma: Analysis From the U.S. Adrenocortical Carcinoma Database
This study aimed to assess the value of a cumulative GRAS score as a prognostic indicator after ACC resection.MethodsA retrospective cohort study of adult patients who underwent surgical resection for ACC between 1993 and 2014 was performed using the United States Adrenocortical Carcinoma Group (US-ACCG) database. A sum GRAS score was calculated for each patient by adding one point each when the criteria were met for tumor grade (Weiss criteria ≥ 3 or Ki67 ≥ 20%), resection status (micro- or macroscopically positive margin), age (≥ 50 years), and preoperative symptoms of hormone hypersecretion (pres...
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

Socioeconomic and Surgical Disparities are Associated with Rapid Relapse in Patients with Triple-Negative Breast Cancer
The objective of this study is to define the association between sociodemographic variables and surgical management among rrTNBC patients in the Surveillance, Epidemiology and End Results (SEER) Program.MethodsTNBC patients diagnosed from January 1, 2010 to December 31, 2014 with local or regional disease were identified in SEER. Patients were stratified as rrTNBC, defined as disease specific mortality ≤ 24 months after diagnosis, and non-rrTNBC. Chi-squared tests,t tests, and multivariable logistic regression were used to assess the association of rapid relapse with sociodemographic variables and surgical man...
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

Racial Differences in Response to Neoadjuvant Chemotherapy: Impact on Breast and Axillary Surgical Management
ConclusionsThe black patients were younger at diagnosis, had more advanced disease, and were more likely to have breast-conservation surgery. De-escalating axillary surgery is being adopted increasingly but used disproportionately for white women. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

Time to Rethink Upfront Surgery for Resectable Intrahepatic Cholangiocarcinoma? Implications from the Neoadjuvant Experience
ConclusionsNT is increasingly used for the management of IHC patients with characteristics indicating aggressive tumor biology and is associated with decreased risk of death. These data suggest need for prospective studies of NT in management of patients with potentially resectable IHC. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

Rectosigmoid Mesorectal-Sparing Resection in Advanced Ovarian Cancer Surgery
This report presents the case of a 54-year-old woman with a diagnosis of FIGO stage 3C AOC who underwent PDS. The video (video 1) provides a step-by-step description of the surgical technique adopted for colorectal resection with mesorectal-sparing technique. Rectosigmoid mesorectal-sparing resection is feasible and could be a viable option for selected cases of AOC, maximizing the blood supply to colorectal anastomosis while minimizing the risk of both anastomotic leak and pelvic autonomic nervous system dysfunction.6 (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Disparities in Oncologic Surgery: The Problem We All Live with
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Pulmonary Metastasectomy in Patients with Lung Metastases from Nasopharyngeal Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Albumin-Bilirubin Grade is an Independent Prognostic Factor Complementary to CA19-9 for Pancreatic Cancer Patients
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: R Status Is a Relevant Prognostic Factor for Recurrence and Survival After Pancreatic Head Resection for Ductal Adenocarcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 14, 2021 Category: Cancer & Oncology Source Type: research

The Effect of Postmastectomy Radiotherapy on Breast Cancer Patients After Neoadjuvant Chemotherapy by Molecular Subtype
AbstractBackgroundThe effect of postmastectomy radiotherapy (PMRT) on patient outcomes after neoadjuvant chemotherapy (NAC) remains controversial. We aimed to establish a model to identify the subsets benefiting from PMRT and to examine the effect of PMRT according to molecular subtype.Patients and MethodsWe retrospectively analyzed 1118 cT1-4cN0-3M0 breast cancer patients treated with NAC and mastectomy. A nomogram predicting locoregional recurrence (LRR) was established based on 418 unirradiated patients, and X-tile analysis was performed to divide the patients into two risk groups. The effect of PMRT on LRR, distant rec...
Source: Annals of Surgical Oncology - February 12, 2021 Category: Cancer & Oncology Source Type: research

Long-term Outcomes After Surgical Resection of Pancreatic Metastases from Renal Clear-Cell Carcinoma
ConclusionIn a selected group of patients followed for a median of 141 months and mostly with isolated metachronous PM, resection was associated with a high possibility of long-term disease control in surgically fit patients with metastases confined to the pancreas. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 11, 2021 Category: Cancer & Oncology Source Type: research

Fighting Fire With Fire: Oncolytic Virotherapy for Thoracic Malignancies
AbstractThoracic malignancies are associated with high mortality rates. Conventional therapy for many of the patients with thoracic malignancies is obviated by a high incidence of locoregional recurrence and distant metastasis. Fortunately, developments in immunotherapy provide effective strategies for both local and systemic treatments that have rapidly advanced during the last decade. One promising approach to cancer immunotherapy is to use oncolytic viruses, which have the advantages of relatively high tumor specificity, selective replication-mediated oncolysis, enhanced antigen presentation, and potential for delivery ...
Source: Annals of Surgical Oncology - February 11, 2021 Category: Cancer & Oncology Source Type: research

Surgical Options in Management of the Breast and Axilla: Independent Choices?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 11, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Rectosigmoid Mesorectal Sparing Resection: A Feasible Technique and a Viable Option in Advanced Ovarian Cancer Surgery
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 11, 2021 Category: Cancer & Oncology Source Type: research

Rates, Predictors, and Outcomes of Portal Lymphadenectomy for Resectable Gallbladder Cancer
AbstractIntroductionLymphadenectomy (LND) is recommended following surgical resection of ≥ T1b gallbladder cancer (GBC). However, frequency and stage-specific survival benefits of LND remain unclear.Patients and MethodsThe National Cancer Database (NCDB; 2006-15) was queried for resected pathologic stage I –III GBC. LND performance, predictors of receiving LND, and LND association with overall survival (OS) were assessed.ResultsOf 2302 total patients, 1343 (58.3%) underwent LND. Patients who underwent LND were younger and more frequently had private health insurance, a negative surgical margin, higher pathologic T...
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Redefining High-Volume Gastric Cancer Centers: The Impact of Operative Volume on Surgical Outcomes
AbstractBackgroundPerformance of technically complex surgery at high-volume (HV) centers is associated with improved outcomes.ObjectiveThe aim of this study was to assess whether hospital gastrectomy volume is associated with surgical outcomes, and what threshold of case volume meaningfully impacts surgical outcomes.MethodsWe conducted a retrospective review of adult NCDB patients with gastric adenocarcinoma undergoing gastrectomy between 2004 and 2015. A multivariable Cox proportional hazards model with restricted cubic splines was used to examine the association of annual hospital gastrectomy volume and overall survival....
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Outcomes of Neoadjuvant Chemotherapy for Clinical Stages 2 and 3 Gastric Cancer Patients: Analysis of Timing and Site of Recurrence
ConclusionsThe majority of the recurrences for patients with clinical stage 2 or 3 gastric cancer who received neoadjuvant chemotherapy and underwent curative resection occurred within 2 years. After neoadjuvant chemotherapy, pathologic T stage was a useful risk predictor for early recurrence. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Amlodipine and Verapamil, Voltage-Gated Ca 2+ Channel Inhibitors, Suppressed the Growth of Gastric Cancer Stem Cells
ConclusionsThe present results indicate that VGCCs play a role in maintaining CSCs, and demonstrated the potential of their specific inhibitors, amlodipine and verapamil, as targeted therapeutic agents against gastric cancer. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Undertreatment of Gallbladder Cancer: A Nationwide Analysis
This study aimed to evaluate re-resection rates and the associated survival impact for patients with gallbladder cancer.MethodsPatients with gallbladder adenocarcinoma who underwent resection were identified from the National Cancer Database (2004 –2015). Re-resection was defined as definitive surgery within 180 days after the first operation. Propensity scores were created for the odds of a patient having a re-resection. Patients were matched 1:2. Survival analyses were performed using the Kaplan–Meier and Cox proportional hazard method s.ResultsThe study identified 6175 patients, and 466 of these patient...
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Total Thyroidectomy Versus Lobectomy for Thyroid Cancer: Single-Center Data and Literature Review
ConclusionsLobectomy can be proposed for low-risk microcarcinomas, although in a minority of cases, additional treatments are needed, and a longer follow-up period usually is required to confirm an event-free outcome compared with that for patients treated with TT. On the other hand, to achieve an excellent response, TT should be favored for intermediate-risk micro- and macro-DTCs despite the higher frequency of postsurgical complications. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Predictive Factors for Residual Disease After Conization in Cervical Cancer
ConclusionWe found that tumor size and positive margin were predictive factors for residual disease. We could not suggest a reliable minimum margin distance threshold that could predict residual disease. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Indolent Growth and Small Bowel Neuroendocrine Tumor Management
AbstractSurgical treatment is central to management of small bowel neuroendocrine tumors (SBNETs). Current controversies include whether to resect asymptomatic primary tumors in the setting of unresectable metastases, the role of minimally invasive surgery, and how best to incorporate/sequence medical treatments. Low SBNET incidence, long event-times, and variability in disease burden, surgical technique, and institutional treatment preferences remain obstacles to conducting randomized surgical trials for SBNETs. With increasing referral of these patients to high-volume centers, cooperation between experienced SBNET clinic...
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Reply to: Metaplastic Breast Carcinoma and Other Triple-Negative Subtype Breast Cancers: Which is the Worst?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Is Residual Disease Predictable After Conization in Cervical Cancer?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 10, 2021 Category: Cancer & Oncology Source Type: research

Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma
ConclusionsThe present results indicate that tumor progression is regulated by CLCN2 through its effects on IFN signaling. Furthermore, weak CLCN2 expression was associated with poorer outcomes in ESCC patients. The present study will contribute to a clearer understanding of the role of CLCN2 as a mediator of ESCC, as well as its use as a biomarker for this cancer. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - February 9, 2021 Category: Cancer & Oncology Source Type: research