Adolescents and Young Adults with Breast Cancer have More Aggressive Disease and Treatment Than Patients in Their Forties
AbstractBackgroundAdolescents and young adults (AYAs; age  
Source: Annals of Surgical Oncology - August 2, 2019 Category: Cancer & Oncology Source Type: research

The Impact of Dedicated Cancer Centers on Outcomes Among Medicare Beneficiaries Undergoing Liver and Pancreatic Cancer Surgery
AbstractBackgroundThe Alliance of Dedicated Cancer Centers (DCCs) is comprised of 11 institutions that are exempt from the prospective payment system utilized by Medicare for hospital reimbursement.ObjectiveThe aim of this study was to compare short- and long-term outcomes of patients undergoing liver and pancreatic surgery for cancer at DCCs versus non-DCCs.MethodsPatients who underwent a liver or pancreatic operation for a malignant indication between 2013 and 2015 were identified using the Medicare Inpatient Standard Analytic Files. Regression analyses and the Kaplan –Meier method were used to assess short- and lo...
Source: Annals of Surgical Oncology - August 2, 2019 Category: Cancer & Oncology Source Type: research

The Prognostic Value of the AJCC 8th Edition Staging System for Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer
AbstractBackgroundThe American Joint Committee on Cancer (AJCC) 8th edition staging system for breast cancer has been validated in the upfront surgery setting, but has not been examined for its prognostic impact on patients undergoing neoadjuvant chemotherapy.MethodsThe National Cancer Data Base was used to identify patients with invasive unilateral breast cancer from 2010 to 2015 who underwent neoadjuvant chemotherapy. AJCC clinical stage classification was compared between the 7th and 8th editions. Receiver operating characteristic analysis of Kaplan –Meier overall survival (OS) was used to determine the predictive...
Source: Annals of Surgical Oncology - August 2, 2019 Category: Cancer & Oncology Source Type: research

A 3-Year Overall Survival Update From a Phase 2 Study of Chemoselection With DCF and Subsequent Conversion Surgery for Locally Advanced Unresectable Esophageal Cancer
ConclusionsLong-term follow-up evaluation confirmed that DCF chemoselection aimed at CS is feasible and promising in terms of survival for patients with locally advanced esophageal cancer. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - August 2, 2019 Category: Cancer & Oncology Source Type: research

Prognostic Role of the Immunoscore for Patients with Urothelial Carcinoma of the Bladder Who Underwent Radical Cystectomy
This study aimed to determine whether the tumor immune infiltrate, as evaluated by the Immunoscore, could act as a useful prognostic marker for UCB patients who have undergone radical cystectomy (RC).MethodsIn this study, immunohistochemistry was used to examine the Immunoscore of 221 UCB patients who underwent RC. The Immunoscore of the patients was determined by the densities of CD3+ and CD8+ T cells at the tumor center and the invasive margin.ResultsA highly significant association between a low Immunoscore and a shortened patient survival (P 
Source: Annals of Surgical Oncology - August 2, 2019 Category: Cancer & Oncology Source Type: research

Requiem for Robotic Cancer Surgery? Not So Fast
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - August 2, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: The Ability of the AJCC 8th Edition to Predict Risk of Recurrence in Differentiated Thyroid Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - August 2, 2019 Category: Cancer & Oncology Source Type: research

Presidential Address: On Resisting the Narcissism of the Present
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - August 1, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Current State of Surgical Sarcopenia in Esophageal Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - August 1, 2019 Category: Cancer & Oncology Source Type: research

Facility Type is Another Factor in the Volume –Outcome Relationship for Complex Hepatopancreatobiliary Procedures
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - August 1, 2019 Category: Cancer & Oncology Source Type: research

Clinical Importance of Sputum in the Respiratory Tract as a Predictive Marker of Postoperative Morbidity After Esophagectomy for Esophageal Cancer
ConclusionsSputum in the respiratory tract is a novel predictor of postesophagectomy pneumonia. Patients with sputum in the more distal respiratory tract might have high risk of postoperative morbidities. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Papillary Thyroid Cancers with Focal Tall Cell Change are as Aggressive as Tall Cell Variants and Should Not be Considered as Low-Risk Disease
AbstractBackgroundThe tall cell variant of papillary thyroid carcinoma (PTC) is as an aggressive histological variant. The proportion of tall cells needed to influence prognosis is debated.MethodsPatients with PTC and tall cells, defined as having a height-to-width ratio of ≥ 3:1, seen at a high-volume center between 2001 and 2015, were reviewed. Specimens were classified as (1) focal tall cell change, containing
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Predicting the Value of Adjuvant Therapy in Esophageal Squamous Cell Carcinoma by Combining the Total Number of Examined Lymph Nodes with the Positive Lymph Node Ratio
ConclusionsIn contrast to TLNs, LNR, and pN stage as single factors, the combination of TLNs and LNR can predict the value of adjuvant therapy. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Adjuvant Chemotherapy Candidates in Stage I Lung Adenocarcinomas Following Complete Lobectomy
This study aimed to explore adjuvant chemotherapy (ACT) candidates based on a recurrence risk-scoring model in completely lobectomized stage I patients with lung adenocarcinoma (LAD).MethodsA retrospective study was performed on 4606 patients (non-ACT group:n = 3514; ACT group:n = 1092) who underwent complete lobectomy for LAD at Shanghai Chest Hospital from 2008 to 2014. The nomogram predicting recurrence-free survival (RFS) was developed in the non-ACT group using Cox proportional hazards regression. The nomogram-based risk score was calculated in the entire cohort. Differences of RFS between ...
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Resolve the Conflict Rather than Dissolve the Relationship
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Sentinel Lymph Node Biopsy for Ipsilateral Breast Tumor Recurrence, Technically Feasible but Influence on Oncologic Outcomes Yet to be Completely Defined
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Para-aortic Lymphadenectomy for Gynecologic Cancers: Introducing the “Trans-Retro-Peritoneal (TRP) Single-Port Access”
ConclusionsWe describe a promising technique that combines all the advantages of the two previously described accesses without their disadvantages, and with the cosmetic benefit of one almost invisible single trans-umbilical scar. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Tending Towards a Personalized Medicine for Colorectal Carcinomatosis by Adding the RAS Mutation Status in the Workup for CRS and HIPEC
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: International Experience of Isolated Limb Infusion for Melanoma Shows Durable Response
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

The Pelvis-First Approach for Robotic Proctectomy in Patients with Redundant Abdominal Colon
ConclusionsThe ‘pelvis-first’ approach to proctectomy is advantageous for patients with a highly redundant sigmoid colon. Transabdominal division of the levator ani during APR ensures excellent circumferential margin. Although Lynch syndrome-associated rectal cancer can show excellent response to NCRT,3 patients undergoing watchful delay of surgery require close monitoring and prompt triggering of salvage proctectomy when tumor regrowth is observed.4,5 (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Does a Lymph Node-Based Model Predict Clinical Value for Adjuvant Therapy in Squamous Cell Carcinoma of the Esophagus Treated With Upfront Surgery?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Laparoscopic Complete Mesocolic Excision for Double Flexural Colon Cancers
ConclusionsThe approach presented in the video might be useful for standardization of laparoscopic CME for double flexural colon cancers. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Managing Symptoms at the End-of-Life —Some Progress, Many Unanswered Questions
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Sentinel Node Biopsy After Neoadjuvant Systemic Therapy for Breast Cancer: The Method Matters
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

How Old is Too Old to Operate for Mesothelioma?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Understanding Recurrence Patterns and Time Courses of Intrahepatic Cholangiocarcinoma After Surgery Helps in Postoperative Surveillance and Treatment
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

Totally Laparoscopic Transluminal Resection Versus Combined Laparo-Endoscopic Technique for Removal of Iuxta-Cardial Gastric Stromal Tumors
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 6, 2019 Category: Cancer & Oncology Source Type: research

4-miRNA Score Predicts the Individual Metastatic Risk of Renal Cell Carcinoma Patients
ConclusionsWe identified a 4-miRNA model that was found to be superior to clinicopathological parameters in accurately predicting individual metastatic risk and can support patient selection for risk-stratified follow-up and adjuvant therapy studies. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 3, 2019 Category: Cancer & Oncology Source Type: research

Survival Outcomes of Patients with Clinical Stage III Melanoma in the Era of Novel Systemic Therapies
AbstractBackgroundImmune checkpoint and BRAF-targeted inhibitors have demonstrated significant survival benefits for advanced melanoma patients within the context of clinical trials. We sought to determine their impact on overall survival (OS) at a population level in order to better understand the current landscape for patients diagnosed with clinical stage III melanoma.MethodsA retrospective study was performed using the National Cancer Database. Patients diagnosed with clinical stage III melanoma were categorized by diagnosis year into two cohorts preceding the advent of novel therapies (P1: 2004 –2005, P2: 2008&n...
Source: Annals of Surgical Oncology - July 3, 2019 Category: Cancer & Oncology Source Type: research

Utility of Early Postoperative Unstimulated Thyroglobulin in Influencing Decision Making in Patients with Papillary Thyroid Carcinoma
ConclusionsPostoperative uTg may be used to guide the use of RAI. Achieving near-undetectable uTg within 6  weeks postoperatively could aid providers in assessing disease burden and minimize RAI use for patients with a low-risk of disease recurrence. Continued follow-up is necessary to accurately determine long-term outcomes. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - July 2, 2019 Category: Cancer & Oncology Source Type: research

Prognosis After Resection of Barcelona Clinic Liver Cancer (BCLC) Stage 0, A, and B Hepatocellular Carcinoma: A Comprehensive Assessment of the Current BCLC Classification
AbstractBackgroundAlthough the Barcelona Clinic Liver Cancer (BCLC) staging system has been largely adopted in clinical practice, recent studies have questioned the prognostic stratification of this classification schema, as well as the proposed treatment allocation of patients with a single large tumor.MethodsPatients who underwent curative-intent hepatectomy for histologically proven hepatocellular carcinoma (HCC) between 1998 and 2017 were identified using an international multi-institutional database. Overall survival (OS) among patients with BCLC stage 0, A, and B was examined. Patients with a single large tumor were ...
Source: Annals of Surgical Oncology - July 2, 2019 Category: Cancer & Oncology Source Type: research

Prevention Therapy for Breast Cancer: How Can We Do Better?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Defining Rupture in Gastrointestinal Stromal Tumor: Semantics and Prognostic Value
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Robotic Central Pancreatectomy for Well-Differentiated Neuroendocrine Tumor: Parenchymal-Sparing Procedure
ConclusionsCentral pancreatectomy can be carefully selected as a relevant surgical option for well-differentiated pNETs circumscribed in the pancreatic isthmus and body. Our robotic procedure might overcome the complexity of central pancreatectomy, a parenchymal-preserving procedure, with adequate oncological outcomes. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Better Survival After 4L Lymph Node Dissection for Early-Stage, Left-Sided, Non-small Cell Lung Cancer: Are We Debating a False Duality?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Exosomes from Pancreatic Juice: A Step Closer to the Holy Grail?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Three-Dimensional Ventral Approach with the Modified Liver-Hanging Maneuver During Laparoscopic Right Hemihepatectomy
ConclusionThe 3D ventral approach with the modified liver-hanging maneuver in LRH is a feasible and useful technique because it resembles open right hemihepatectomy with respect to the surgical concept. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Borderline and Malignant Phyllodes Tumors: How Often do They Locally Recur and is There Anything we can do About it?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Reply to Letter to the Editor Regarding “The Importance of Diagnosing Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) Based on the Defined Criteria”
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

It Is Time
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Salvage Surgery for Jejunal Necrosis After a Free Jejunal Transfer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Routine Lymphadenectomy Should be Recommended Regardless of Morphologic Subtype of Intrahepatic Cholangiocarcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Pure Laparoscopic Anatomical Segment V Resection Using the Extrafascial and Transfissural Glissonean Approach
ConclusionThe extrafascial and transfissural approach in laparoscopic anatomical segment V resection is feasible and effective, and allows easy and direct access to the segment V portal pedicle. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Intrahepatic Cholangiocarcinoma: Rising Burden and Glaring Disparities
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

The Best Approach to Esophagectomy: Do We Know Yet?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Laparoscopic Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (L-CRS/HIPEC) for Perforated Low-Grade Appendiceal Mucinous Neoplasm (LAMN II)
DiscussionL-CRS/HIPEC can be performed when patients are unexpectedly found to have disease, provided the appendiceal pathology is low grade and the PCI score is low. There are potential benefits to this approach, with a shorter length of hospital stay and faster functional recovery when compared with traditional open surgery. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: An Optimal Biological Model for Successful Drug Discovery
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 2, 2019 Category: Cancer & Oncology Source Type: research

Peripheral Circulating Tumor DNA Detection Predicts Poor Outcomes After Liver Resection for Metastatic Colorectal Cancer
ConclusionsPeripheral blood reflects the perihepatic ctDNA signature. Disagreement between tissue and ctDNA mutations may reflect the true natural history of tumor genes or an assay limitation. Peripheral ctDNA detection before liver resection is associated with worse DSS. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research

Radiomics-Based Pretherapeutic Prediction of Non-response to Neoadjuvant Therapy in Locally Advanced Rectal Cancer
AbstractObjectiveThe aim of this study was to investigate whether pretherapeutic, multiparametric magnetic resonance imaging (MRI) radiomic features can be used for predicting non-response to neoadjuvant therapy in patients with locally advanced rectal cancer (LARC).MethodsWe retrospectively enrolled 425 patients with LARC [allocated in a 3:1 ratio to a primary (n = 318) or validation (n = 107) cohort] who received neoadjuvant therapy before surgery. All patients underwent T1-weighted, T2-weighted, diffusion-weighted, and contrast-enhanced T1-weighted MRI scans before receiving neoadjuvant thera...
Source: Annals of Surgical Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research