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Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update
AbstractPurposeTo update the American Society of Clinical Oncology (ASCO)-Society of Surgical Oncology (SSO) guideline for sentinel lymph node (SLN) biopsy in melanoma.MethodsAn ASCO-SSO panel was formed, and a systematic review of the literature was conducted regarding SLN biopsy and completion lymph node dissection (CLND) after a positive sentinel node in patients with melanoma.ResultsNine new observational studies, two systematic reviews and an updated randomized controlled trial (RCT) of SLN biopsy, as well as two randomized controlled trials of CLND after positive SLN biopsy, were included.RecommendationsRoutine SLN b...
Source: Annals of Surgical Oncology - December 13, 2017 Category: Cancer & Oncology Source Type: research

Peritoneal Carcinomatosis of Urachus Origin Treated by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): An International Registry of 36 Patients
AbstractPurposePeritoneal carcinomatosis or pseudomyxoma peritonei from urachus is a rare form of presentation, often diagnosed at an advanced state of tumor burden. Because of its rarity, little is known about its natural history, prognosis, or optimal treatment. We searched a large international multicenter database of peritoneal surface disease to identify cases of peritoneal carcinomatosis of urachus that were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) at expert centers. The aim is to improve knowledge and understanding of the disease and standardize its treatment.Met...
Source: Annals of Surgical Oncology - December 13, 2017 Category: Cancer & Oncology Source Type: research

Snapshot Study on the Value of Omentoplasty in Abdominoperineal Resection with Primary Perineal Closure for Rectal Cancer
ConclusionsIn contrast to previous assumptions, OP after APR with PPC appeared not to improve perineal wound healing and seemed to increase the occurrence of perineal hernia. These findings question the routine use of OP for primary filling of the pelvic space. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 12, 2017 Category: Cancer & Oncology Source Type: research

Oncological Assessment of Stent Placement for Obstructive Colorectal Cancer from Circulating Cell-Free DNA and Circulating Tumor DNA Dynamics
ConclusionsDespite equivalent clinical success rates, SEMS placement increased plasma levels of cfDNA and ctDNA by tumor manipulation, but TDT did not. Colonic stenting showed oncological risk in terms of molecular analysis. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 12, 2017 Category: Cancer & Oncology Source Type: research

Intrinsic Contact Between T and N Classifications in Resected Well –Moderately Differentiated Locoregional Pancreatic Neuroendocrine Neoplasms
AbstractBackgroundThe role of N classification is controversial in several prognostication systems proposed for pancreatic neuroendocrine neoplasms (pNENs). The widely accepted modified European Neuroendocrine Tumor Society (mENETS) system suggests this contradiction may be related to T classification.MethodsData were collected retrospectively from 981 patients in the Surveillance, Epidemiology, and End Results (SEER) database (1973 –2012; cohort 1) and 140 patients from the Pancreatic Cancer Institute of Fudan University (2006–2016; cohort 2). All patients had resected well- to moderately differentiated locore...
Source: Annals of Surgical Oncology - December 12, 2017 Category: Cancer & Oncology Source Type: research

Correction to: Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology
AbstractIn the original article the middle initial of Nicholas D. Klemen was inadvertently omitted. On the first page of the original article, under the heading A Novel Way to Fight Cancer, there was an error in the third sentence. The corrected text is as follows: For example, the presence of T cells within tumors of colorectal origin can be a superior predictor of patient survival compared with the standard histopathologic methods currently used to stage colorectal cancer.6,7 (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 12, 2017 Category: Cancer & Oncology Source Type: research

Global Curriculum in Research Literacy for the Surgical Oncologist
ConclusionsA global curriculum in research literacy is proposed which may promote research literacy or encourage involvement in research activity where circumstances permit. It is hoped that this will enhance cancer-related research activity, promote awareness of optimal evidence-based practices and improve outcomes for cancer patients globally. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 11, 2017 Category: Cancer & Oncology Source Type: research

Global Variations in the Level of Cancer-Related Research Activity and Correlation to Cancer-Specific Mortality: Proposal for a Global Curriculum
ConclusionThis study demonstrates significant global variation in the level of cancer-related research activity and a correlation with cancer-specific mortality. The presence of a minimum set of standards for research literacy, as proposed by the European Society of Surgical Oncology and the Society of Surgical Oncology may contribute to enhanced research activity and improve outcomes for cancer patients worldwide. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 11, 2017 Category: Cancer & Oncology Source Type: research

Protein Expression of PTTG1 as a Diagnostic Biomarker in Adrenocortical Carcinoma
AbstractBackgroundAdrenocortical carcinoma (ACC) has a poor prognosis and there is an unmet clinical need for biomarkers to improve both diagnostic and prognostic assessment. Pituitary-tumor transforming gene (PTTG1) has been shown to modulate cancer invasiveness and response to therapy. The potential role of PTTG1 protein levels in ACC has not been previously addressed. We assessed whether increased nuclear protein expression of PTTG1 distinguished ACCs from adrenocortical adenomas (ACAs).MethodsPatients with ACC or ACA were identified from prospective tissue banks at two independent institutions. Two tissue microarrays (...
Source: Annals of Surgical Oncology - December 7, 2017 Category: Cancer & Oncology Source Type: research

SPECT/CT: Looking Beyond Sentinel Lymph Node Identification for Improving Patient Outcomes
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 7, 2017 Category: Cancer & Oncology Source Type: research

Neoadjuvant Therapy Versus Upfront Resection for Pancreatic Cancer: The Actual Spectrum and Clinical Burden of Postoperative Complications
ConclusionsPatients undergoing PD for PDAC after NAT exhibited reduced incidence of POPF and PPH but increased incidence of DGE compared with patients treated with UFS. Among patients developing postoperative complications after PD, those receiving NAT were associated with increased clinical burden. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 6, 2017 Category: Cancer & Oncology Source Type: research

Effects of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Goblet Cell Carcinoma: A Prospective Cohort Study
ConclusionsLong-term survival can be achieved in patients with peritoneal spread treated with CRS  + HIPEC. CRS+HIPEC was associated with a favorable outcome in GCC patients at high-risk of developing peritoneal spread. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 6, 2017 Category: Cancer & Oncology Source Type: research

Impact of Sarcopenia on Unplanned Readmission and Survival After Esophagectomy in Patients with Esophageal Cancer
ConclusionsSarcopenia is a risk factor for 90-day unplanned readmission and OS following esophagectomy. Assessment of sarcopenia could help to identify patients at higher risk of a poor prognosis after esophagectomy. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 6, 2017 Category: Cancer & Oncology Source Type: research

STMN1 is Overexpressed in Adrenocortical Carcinoma and Promotes a More Aggressive Phenotype In Vitro
ConclusionsSTMN1 is overexpressed in human ACC samples, and knockdown of this target in vitro resulted in a less aggressive phenotype of ACC, particularly under serum-starved conditions. Further study is needed to investigate the feasibility of interfering with STMN1 as a potential therapeutic target. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 6, 2017 Category: Cancer & Oncology Source Type: research

Celebrating the Annals of Surgical Oncology ’s 25-Year Anniversary: One of the Most Cited Surgical Journals in the World
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 6, 2017 Category: Cancer & Oncology Source Type: research

Moving Toward Improved Outcomes in Salvage Laryngectomy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 6, 2017 Category: Cancer & Oncology Source Type: research

Use of a Purse-String Suture to Reduce Skin Graft Requirements
ConclusionsPurse-string sutures are helpful for wound closure in wounds that cannot be closed primarily. They can decrease the size of a skin graft if the wound cannot be closed completely. Wound re-expansion, particularly in extremity defects, may occur following early removal of the tension-bearing purse string. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 4, 2017 Category: Cancer & Oncology Source Type: research

Implications of Hyperthermic Intraperitoneal Chemotherapy Perfusion-Related Hyperglycemia
ConclusionsMost patients experience hyperglycemia during HIPEC. This is not clearly associated with patient factors, and may be due to use of dextrose-containing carrier solution. Since perioperative hyperglycemia has potential negative impact, use of dextrose-containing carrier solution should be questioned and is worth investigating further. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 4, 2017 Category: Cancer & Oncology Source Type: research

Reply to An Investigation Into the Serum Thioredoxin, Superoxide Dismutase, Malondialdehyde, and Advanced Oxidation Protein Products for Patients with Breast Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Erratum to: Predictors of Bowel Function in Long-term Rectal Cancer Survivors with Anastomosis
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Age and Charlson Score
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Trial Results of a Phase 2, Randomized, Clinical Trial
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Importance of Platelet Indices in Hepatocellular Carcinoma Prognosis
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Outcomes of Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Patients Older than 70 Years; Survival Benefit at Considerable Morbidity and Mortality: A Reply
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Reply: “Adjuvant” Hyperthermic Intraperitoneal Chemotherapy: A Call to Action
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Intraoperative Ultrasound-Guided Excision of Axillary Clip in Patients with Node-Positive Breast Cancer Treated with Neoadjuvant Therapy (ILINA Trial)
ConclusionsIOUS-guided excision of the axillary clipped node after NAT was feasible, safe, and successful in 100% of cases. The ILINA trial is accurate in predicting axillary nodal status after NAT. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

In Reply: Vitamin D Status May Explain Some of the Racial Disparities in Rectal Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

Questions About In-Breast Tumor Recurrence in Patients Treated with Breast-Conserving Therapy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 1, 2017 Category: Cancer & Oncology Source Type: research

High STMN1 Expression is Associated with Cancer Progression and Chemo-Resistance in Lung Squamous Cell Carcinoma
ConclusionThe results suggest that STMN1 is a prognostic factor that also is associated with caner progression and chemo-resistance. Therefore, STMN1 could be a predictor for poor prognosis and a potential therapeutic target in LSCC. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Tumor Biology Predicts Pathologic Complete Response to Neoadjuvant Chemotherapy in Patients Presenting with Locally Advanced Breast Cancer
AbstractBackgroundNeoadjuvant chemotherapy (NAC) is used to convert patients with inoperable locally advanced breast cancer (LABC) to operability, but has not traditionally been used to avoid mastectomy or axillary dissection in this subset.ObjectiveThe purpose of this study was to determine the rates of pathologic complete response (pCR) in LABC patients, and identify factors predictive of pCR to determine if responding patients might be suitable for limited surgery.MethodsFrom 2006 to 2016, 1522 patients received NAC followed by surgery; 321 had advanced disease in the breast (cT4) and/or in the nodes (cN2/N3). pCR rates...
Source: Annals of Surgical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival
ConclusionCRC can be classified into distinct subtypes by proteomic features independent of common oncogenic driver mutations. Proteomic analysis has identified key biomarkers with prognostic importance, however these findings require further validation in an independent cohort. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Identification of Patients for Adjuvant Therapy After Resection of Carcinoma of the Extrahepatic Bile Ducts: A Propensity Score-Matched Analysis
ConclusionsAdjuvant multimodality therapy is associated with improved survival for patients with resected extrahepatic cholangiocarcinoma and high-risk features. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Expression of 3 β-Hydroxysteroid Dehydrogenase Type 1 in Breast Cancer is Associated with Poor Prognosis Independent of Estrogen Receptor Status
ConclusionsExpression of HSD3B1 in breast cancer is negatively associated with prognosis. The study found HSD3B1 to be a potential therapeutic target for breast cancer independent of estrogen receptor status. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 4, 2017 Category: Cancer & Oncology Source Type: research

Wait Times for Melanoma Surgery: Is There an Association with Overall Survival?
ConclusionsOverall survival for patients with melanoma was not influenced by wait times to WLE, SNB, and LND. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 3, 2017 Category: Cancer & Oncology Source Type: research

EGFR Mutation in Patients with Lung Adenosquamous Cell Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 3, 2017 Category: Cancer & Oncology Source Type: research

Comment On: Survival and Quality of Life Following Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis of Colonic Origin
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 3, 2017 Category: Cancer & Oncology Source Type: research

Refining Tumor Resection Techniques for Managing Inferior Pole Breast Malignancies
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

Accurate Evaluation of Tumour Necrosis in the Preoperative Period: A New Challenge: In Reply
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

Comment on: Need for Differentiating Diabetes-Specific Mortality from Total Mortality when Comparing Metformin with Insulin Regarding Cancer Survival
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 2, 2017 Category: Cancer & Oncology Source Type: research

Comparison of the Indocyanine Green Fluorescence and Blue Dye Methods for the Detection of Sentinel Lymph Nodes in Early-stage Breast Cancer: A Reply
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 1, 2017 Category: Cancer & Oncology Source Type: research

Impact of an In Situ Component on Outcome After In-Breast Tumor Recurrence in Patients Treated with Breast-Conserving Therapy
ConclusionThe presence of an in situ component is associated with prognosis among patients with IBTR following BCT and may be useful in differentiating TRs and NPs. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 1, 2017 Category: Cancer & Oncology Source Type: research

Comment on: Surgery and HIPEC in Recurrent Epithelial Ovarian Cancer: A Prospective Randomized Phase III Study
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 1, 2017 Category: Cancer & Oncology Source Type: research

Comment on: MicroRNA Expression as a Predictive Marker for Gemcitabine Response After Surgical Resection of Pancreatic Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - November 1, 2017 Category: Cancer & Oncology Source Type: research

Treatment Deintensification for Human Papillomavirus-Associated Oropharyngeal Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research

Risk Factors for Lateral Neck Recurrence of N0/N1a Papillary Thyroid Cancer
AbstractBackgroundCurrent guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b.MethodsThe study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b. Logistic regression analysis was used to identify the relationship of clinico...
Source: Annals of Surgical Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research

Negative Impact of Skeletal Muscle Wasting After Neoadjuvant Chemotherapy Followed by Surgery on Survival for Patients with Thoracic Esophageal Cancer
This study aimed to determine the relation between skeletal muscle change and survival for patients with advanced esophageal cancer who underwent neoadjuvant chemotherapy followed by surgery.MethodsThis study retrospectively analyzed 66 patients with thoracic esophageal cancer who had undergone neoadjuvant chemotherapy followed by esophagectomy. The study investigated the correlation between the change in the total muscle cross-sectional area at the third lumbar vertebra before and 4  months after surgery as well as the postoperative recurrence and overall survival (OS).ResultsOf the 66 patients, 39 (59%) showed a ske...
Source: Annals of Surgical Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research

Transoral Resection of Human Papillomavirus (HPV)-Positive Squamous Cell Carcinoma of the Oropharynx: Outcomes with and Without Adjuvant Therapy
ConclusionsTransoral surgery is an effective approach for the treatment of HPV-related oropharyngeal carcinoma. The addition of adjuvant therapy appears to decrease the risk of recurrence and improve disease-free survival but may not significantly improve overall survival. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research

Global Level of Plasma DNA Methylation is Associated with Overall Survival in Patients with Hepatocellular Carcinoma
AbstractBackgroundThe impact of folate deficiency on global DNA methylation is uncertain. It also is unclear whether global DNA methylation is associated with outcome in HCC. LINE-1 methylation levels, as a surrogate marker of global methylation, may be influenced by folate deficiency. However, the interaction between LINE-1 methylation and folate level on overall survival (OS) in hepatocellular carcinoma (HCC) patients is unknown. We evaluated whether LINE-1 hypomethylation and folate deficiency are associated with HCC prognosis.MethodsWe prospectively recruited 172 HCC patients between 2008 and 2012. LINE-1 methylation l...
Source: Annals of Surgical Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research

Incorporation of Treatment Response, Tumor Grade and Receptor Status Improves Staging Quality in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy
ConclusionsIn a heterogenous national cohort of breast cancer patients treated with NAC and surgery, the incorporation of chemotherapy response, tumor grade, ER status, and ERBB2 status into the staging system substantially improved on the AJCC TNM staging system in discrimination of OS. Neo-Bioscore provided the best staging discrimination. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research

Flat Epithelial Atypia on Core Biopsy and Upgrade to Cancer: a Systematic Review and Meta-Analysis
ConclusionsWith patient management change potential for approximately 25% of patients, this analysis supports a general recommendation for surgical excision of FEA diagnosed by core biopsy. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - October 26, 2017 Category: Cancer & Oncology Source Type: research