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Perioperative Risk Calculator Predicts Long-Term Oncologic Outcome for Patients with Esophageal Carcinoma
This study investigated the reliability of a risk calculator as well as classification and regression trees analysis for predicting long-term prognosis after esophagectomy for esophageal cancer.MethodsThe study enrolled 438 patients who underwent esophagectomy at Keio University Hospital, Tokyo, Japan, between July 2000 and June 2016. Patients who underwent R0 or R1 resection or esophagectomy with combined resection of other organs were included. The authors investigated the usefulness of a risk model for 30-day mortality and operative mortality described in their previous report for predicting long-term prognosis after es...
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Challenges Staging Neuroendocrine Tumors of the Pancreas, Jejunum and Ileum, and Appendix
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Anterolateral Thigh Flap Combined with Reconstruction Plate Versus Double Free Flaps for Composite Mandibular Reconstruction: A Propensity Score-Matched Study
This study was designed to examine the comparative effectiveness of oromandibular defect reconstruction via anterolateral thigh flap and bridging plate (ALT only) versus simultaneous soft tissue and vascularized bone flap (DFF), with regards to long-term plate exposure and complications.MethodsA propensity score-matched analysis of patients with an oncologic head and neck defect who underwent microvascular reconstruction was performed. Two surgical groups, i.e., ALT only and DFF, were created. Incidence and subsequent management strategies for postoperative plate exposure were evaluated along with complications, overall su...
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for the Elderly: Is It Reasonable? A Meta-Analysis
ConclusionsTreatment of the elderly with CRS plus HIPEC was associated with increased severe postoperative morbidity and mortality. However, these conclusions should be weighted given the existence of major biases in the included studies. Age alone probably would not be a formal contraindication, but frailty should be taken into account. Further prospective studies are needed. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Decreased Use of Sphincter-Preserving Procedures Among African Americans with Rectal Cancer
This study sought to determine whether African American (AA) patients with rectal cancer receive sphincter-preserving surgery at the same rate as non-AA patients.MethodsThe study used the Nationwide Inpatient Sample for years 1998 –2012 to compare AA and non-AA patients with rectal cancer undergoing low anterior resection or abdominoperineal resection. The logistic regression model was used to adjust for age, gender, admission type, Elixhauser comorbidity index, and hospital factors such as size, location (urban vs.rural), teaching status, and procedure volume.ResultsThe search identified 22,697 patients, 1600 of who...
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Histologic Predictors of Recurrence in Mucinous Appendiceal Tumors with Peritoneal Dissemination after HIPEC
AbstractBackgroundMucinous appendiceal tumors (MAT) are rare neoplasms that can metastasize to the peritoneum and often are treated with cytoreductive surgery (CRS) and HIPEC. Pathologic classification and outcomes vary, but standardized histologic definitions are emerging. We sought to evaluate outcomes in this disease after CRS/HIPEC using standardized pathologic criteria.MethodOutcomes of MAT with peritoneal metastases (PM) after CRS/HIPEC from 2007 to 2015 were reviewed at our institution. Standardized histologic categories per WHO and consensus definitions were used: low-grade appendiceal mucinous neoplasm (LAMN), low...
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

Core Body Temperature but Not Intraabdominal Pressure Predicts Postoperative Complications Following Closed-System Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Administration
ConclusionsIAP level during closed-abdomen technique HIPEC is not associated with postoperative complications. However, elevated CBT may increase postoperative complications. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

PCI is Not Predictive of Survival After Complete CRS/HIPEC in Peritoneal Dissemination from High-Grade Appendiceal Primaries
ConclusionsThe PCI correlates with the ability to achieve a complete CRS in carcinomatosis from HGA. PCI is not associated with survival as long as a complete CRS can be achieved. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 29, 2018 Category: Cancer & Oncology Source Type: research

T-Helper 1 Immune Response in Metastatic Lymph Nodes of Pancreatic Ductal Adenocarcinoma: A Marker For Prolonged Survival
AbstractBackgroundAlthough lymph node (LN) metastases is considered a grave prognostic sign in pancreatic ductal adenocarcinoma (PDAC), patients with positive lymph nodes (PLN) constitute a heterogeneous group. Our purpose was to identify morphological and immune parameters in the primary tumor and in PLN of resected PDAC patients, which could further stratify these patients to different subgroups.MethodsWe retrospectively evaluated histological and immunohistochemical characteristics of 66 patients with PDAC who were operated at our institution. These were subsequently correlated to clinical outcome.ResultsMean patient ag...
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology
This report offers a brief introduction to ACT for cancer, highlights historical milestones in its development, and provides patient selection and operative considerations for surgeons called upon to perform metastasectomy for the purpose of isolating TILs. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Comparison of Recurrence Between Pancreatic and Duodenal Neuroendocrine Neoplasms  After Curative Resection: A Single-Institution Analysis
ConclusionsMost initial recurrences of PanNEN occurred in the liver, whereas those of DuNEN appeared in lymph nodes, suggesting that proper diagnosis of the primary site and appropriate imaging methods for surveillance after resection are necessary. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Prognostic Value of Tumor Volume in Glioblastoma Patients: Size Also Matters for Patients with Incomplete Resection
AbstractBackgroundIncomplete resection of glioblastoma is discussed controversially in the era of combined radiochemotherapy.ObjectiveThe aim of this study was to analyze the benefit of subtotal tumor resection for glioblastoma patients as this was recently questioned in the era of radiochemotherapy.MethodsOverall, 209 patients undergoing surgery for newly diagnosed WHO grade IV gliomas were retrospectively analyzed, and pre- and postoperative tumor volumes were manually segmented (cm3). Survival analyses were performed, including prognostic factors such as age, Karnofsky performance score (KPS), O6-methylguanine-DNA-methy...
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Proposal of a New Preoperative Prognostic Model for Solitary Hepatocellular Carcinoma Incorporating 18 F-FDG-PET Imaging with the ALBI Grade
This study included 207 consecutive patients with solitary HCC who underwent18F-FDG-PET prior to hepatectomy. The tumor to non-tumor maximum standardized uptake value ratio (TNR) was used as an18F-FDG PET imaging parameter.ResultsThe 5-year overall survival (OS) and disease-free survival (DFS) rates were 58.6% and 28.8%, respectively. Multivariate analysis of OS identified TNR  ≥ 2 (hazard ratio [HR] 1.743, 95% confidence interval [CI] 1.114–2.648,p = 0.016) and ALBI grade 2 (HR 1.966, 95% CI 1.349–2.884,p 
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Treatment and Outcome of Synchronous Colorectal Carcinomas: A Nationwide Study
This study evaluated treatment patterns and patient outcomes in synchronous CRCs compared with solitary CRC patients.MethodsAll patients diagnosed with primary CRC between 2008 and 2013, who underwent elective surgery, were selected from the Netherlands Cancer Registry. Using multivariable regressions, the effects of synchronous CRC were assessed for both short-term outcomes (prolonged postoperative hospital admission, anastomotic leakage, postoperative 30-day mortality, administration of neoadjuvant or adjuvant treatment), and 5-year relative survival (RS).ResultsOf 41,060 CRC patients, 1969 patients (5%) had synchronous ...
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

How Low Can We Go —and Should We? Risk Reduction for Minimal-Volume DCIS
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Ultrasound-Guided Restaging and Localization of Axillary Lymph Nodes After Neoadjuvant Chemotherapy for Guidance of Axillary Surgery in Breast Cancer Patients: Experience with Activated Charcoal
ConclusionUS-guided localization of axillary lymph nodes using activated charcoal at restaging after NAC in clinically node-positive breast cancer patients is a useful technique to guide axillary surgery, with a high identification rate. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Correlation Between Biomarker Candidate Proteins with the Effect of Neoadjuvant Chemoradiation Therapy on Esophageal Squamous Cell Carcinoma
ConclusionOur results suggest that two or three negative expressions of p53, p53R2, and ERCC1 in biopsy specimens of primary tumors were associated with a favorable response to CRT for ESCC. Assessment of tumor suppressor and DNA repair protein expressions in biopsy specimens may be useful for the potential utility of CRT therapy for patients with ESCC prior to treatment. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Amputation for Sarcoma: Revisiting a 19th Century Treatment in the 21st Century
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

The Impact of Primary Tumor Location on Long-Term Survival in Patients Undergoing Hepatic Resection for Metastatic Colon Cancer
ConclusionsAmong patients undergoing resection of CRLM, left-sided primary tumors were associated with improved median OS. However, long-term survival and recurrence-free survival were not significantly different stratified by primary location. Patients with left-sided primary tumors displayed a prolonged clinical course suggestive of more indolent biology. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

A Novel T-Stage Classification System for Adrenocortical Carcinoma: Proposal from the US Adrenocortical Carcinoma Study Group
AbstractBackgroundThe 7th AJCC T-stage system for adrenocortical carcinoma (ACC), based on size and extra-adrenal invasion, does not adequately stratify patients by survival. Lymphovascular invasion (LVI) is a known poor prognostic factor. We propose a novel T-stage system that incorporates LVI to better risk-stratify patients undergoing resection for ACC.MethodPatients undergoing curative-intent resections for ACC from 1993 to 2014 at 13 institutions comprising the US ACC Group were included. Primary outcome was disease-specific survival (DSS).ResultsOf the 265 patients with ACC, 149 were included for analysis. The curren...
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Effectiveness of Hepatic Artery Infusion (HAI) Versus Selective Internal Radiation Therapy (Y90) for Pretreated Isolated Unresectable Colorectal Liver Metastases (IU-CRCLM)
This study sought to compare the overall survival (OS) after HAI versus Y90 for IU-CRCLM patients treated with modern chemotherapy and to perform a cost analysis of both regional methods.MethodsThis study retrospectively reviewed patients receiving HAI or Y90 in combination with modern chemotherapy as second-line therapy for IU-CRCLM. Overall survival was calculated from the time of IU-CRCLM diagnosis. Uni- and multivariate models were constructed to identify independent predictors of survival.ResultsThe inclusion criteria were met by 97 patients (48 HAI patients and 49 Y90 patients). Both groups were similar in terms of a...
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Molecular Genomic Testing for Breast Cancer: Utility for Surgeons
AbstractMolecular genomic testing provides clinicians with both prognostic and (sometimes) predictive information that can help individualize treatment and decrease the risk of over- or under-treatment. We review the genomic tests that are currently available for clinical use in management of breast cancer, discuss ongoing research related to validating and expanding their utility in different patient populations, and explain why it is important for surgeons to know how to incorporate these tools into their clinical practice in order to individualize patient treatment, reduce unnecessary morbidity, and, accordingly, improv...
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Morbidity and Outcomes Following Axillary Lymphadenectomy for Melanoma: Weighing the Risk of Surgery in the Era of MSLT-II
ConclusionsThis analysis supports historical data that axillary dissection for melanoma is a low-risk procedure, with smoking, therapeutic lymphadenectomy, and adjuvant radiation associated with increased morbidity. Although morbidity of lymphadenectomy is often cited as a reason to alter surgical approach or even forgo intervention, this may be less of a concern for axillary dissection. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Precision Medicine Core: Progress in Prognostication —Populations to Patients
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Prospective Assessment of First-Year Quality of Life After Pelvic Exenteration for Gynecologic Malignancy: A French Multicentric Study
ConclusionsTherapeutic decision on performing a pelvic exenteration can have a severe and permanent impact on all aspects of patients ’ QOL. Deterioration of QOL was most significant during the first 3 months after surgery. Elderly patients were the only group of patients with permanent decreased physical and social function. Preoperative evaluation and postoperative follow-up evaluation should include health-related QOL instru ments, counseling by a multidisciplinary team to cover all aspects concerning stoma care, sexual function, and long-term concerns after surgery. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Major Amputations for Extremity Soft-Tissue Sarcoma
ConclusionsAmputation maintains an important role in ESTS and achieves durable local control in those unsuitable for limb-conserving surgery. Survival following amputation in the presence of metastatic disease is poor and should be reserved for patients with significant symptoms. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 8, 2018 Category: Cancer & Oncology Source Type: research

Dissemination of Minimally Invasive Liver Resection for Primary Malignancy: Reevaluating Effectiveness
ConclusionsMILR for primary liver malignancy is used across a variety of practice settings, with similar outcomes to OLR. While volume is associated with short-term outcomes of liver resection as a whole, this relationship is not explained by adoption of MILR at low-volume centers. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 4, 2018 Category: Cancer & Oncology Source Type: research

Microscopic Venous Invasion in Pancreatic Cancer
AbstractBackgroundMicroscopic venous invasion (MVI) and the subsequent peripheral blood circulation of cancer cells are considered to be the primary route for systemic dissemination of pancreatic cancer.MethodsPatients who underwent pancreatectomy for invasive ductal carcinoma of the pancreas between January 2007 and December 2015 were retrospectively reviewed. The prognostic significance of MVI was analyzed.ResultsA total of 352 patients underwent pancreatectomy for invasive ductal carcinoma of the pancreas. A pathologic examination showed MVI in 228 (64.5%) of the patients. The median survival time (MST) was 21  mon...
Source: Annals of Surgical Oncology - January 4, 2018 Category: Cancer & Oncology Source Type: research

Completing the Dissection in Melanoma: Increasing Decision Precision
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 4, 2018 Category: Cancer & Oncology Source Type: research

Follow-Up Recommendations after Diagnosis of Primary Cutaneous Melanoma: A Population-Based Study in New South Wales, Australia
ConclusionsFollow-up recommendations were generally consistent with Australian national guidelines for management of melanoma, however some variations could be targeted to improve patient outcomes. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 3, 2018 Category: Cancer & Oncology Source Type: research

Melanoma Surveillance Strategies: Different Approaches to a Shared Goal
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - January 2, 2018 Category: Cancer & Oncology Source Type: research

Factors Associated with 60-Day Readmission Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy
ConclusionsFew measurable variables are associated with readmission following cytoreduction and HIPEC. Patients with high CCI and those with stomas created at the time of CRS/HIPEC may be at increased risk of readmission within 60  days. Earlier or more frequent follow-up for high-risk patients should be considered as a strategy to reduce readmissions. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Adjuvant Chemoradiotherapy is Associated with Improved Survival for Patients with Resected Gallbladder Carcinoma: A Systematic Review and Meta-analysis
AbstractBackgroundThe impact of adjuvant radiotherapy (ART) on survival from gallbladder carcinoma (GBC) remains underexplored, with conflicting results reported. A systematic review and meta-analysis was performed to clarify the impact of ART in GBC.MethodsA systematic literature search of several databases was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, from inception to August 2016. Studies that reported survival outcomes for patients with or without ART after curative surgery were included.ResultsAll the inclusion criteria was met by 14 retrospective s...
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Radioactive Seed Localization Versus Wire Localization for Nonpalpable Breast Lesions: A Two-Year Initial Experience at a Large Community Hospital
ConclusionsThe use of RSL is a viable option in the community setting, with several benefits over WL. While operative times were slightly longer with RSL, there was no difference in specimen size or re-excision rate for malignant lesions. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Timing of Surgical Resection for Curative Colorectal Cancer with Liver Metastasis
ConclusionCurrent evidence supports the feasibility, safety, and equivalent oncological outcomes of simultaneous curative resection of stage IV colorectal cancer with liver metastasis in appropriately selected patients. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Minimally Invasive and Open Approaches to Mediastinal Nodal Assessment
AbstractThere is no consensus on mediastinal lymph node dissection versus sampling for early-stage lung cancer. There are also mixed data on the ability to remove an adequate number of lymph nodes by a minimally invasive approach. In this review, we discuss the difference between dissection and sampling, what circumstances dictate the use of one or the other during an anatomic pulmonary resection for lung cancer, and when it is appropriate to use minimally invasive versus open approaches in the assessment of mediastinal nodes. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Locally Advanced Colorectal Cancer: True Peritoneal Tumor Penetration is Associated with Peritoneal Metastases
ConclusionHistologically confirmed true peritoneal penetration by CRC, rather than inflammatory peritoneal reaction constitutes a high risk for PM. With evolving treatment strategies that aim to treat PM in an earlier phase, identification of high-risk patients becomes highly important clinically. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Systematic Review of Cytoreductive Surgery and Bevacizumab-Containing Chemotherapy in Advanced Ovarian Cancer: Focus on Safety
ConclusionsThe incorporation of bevacizumab into first-line chemotherapy was not associated with increased morbidities before and after cytoreductive surgery in women with AOC. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Redefining the Ki-67 Index Stratification for Low-Grade Pancreatic Neuroendocrine Tumors: Improving Its Prognostic Value for Recurrence of Disease
AbstractBackgroundThe Ki-67 index is an established prognostic marker for recurrence after resection of pancreatic neuroendocrine tumors (PanNETs) that groups tumors into three categories: low grade (  20%). Given that the majority of resected PanNETs have a Ki-67 less than 3%, this study aimed to stratify this group further to predict disease recurrence more accurately.MethodsThe Ki-67 index was pathologically re-reviewed and scored by a pathologist blinded to all other clinicopathologic variables using tissue microarray blocks made in triplicate. All patients who underwent curative-intent resection of non-metastatic...
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

When Should Negative Endobronchial Ultrasonography Findings be Confirmed by a More Invasive Procedure?
This article addresses the situations in which negative results should be confirmed by a more invasive procedure. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

The Annals of Surgical Oncology : An Oncology Journal for Surgeons
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Cervicothoracoscopic Approach in Esophagectomy
ConclusionsThe cervicothoracoscopic approach enables complete en bloc dissection of the lymphatic chain that lies along RLN in the cervicothoracic junction. Also, with this approach, RLNs can be identified easily because RLNs are already exposed at the upper mediastinum by the cervical procedure. Therefore, this approach may contribute to improving the surgical curability and preventing RLN injury. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Four-Dimensional Computed Tomography: Clinical Impact for Patients with Primary Hyperparathyroidism
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 22, 2017 Category: Cancer & Oncology Source Type: research

Hypothyroidism and Wound Healing After Salvage Laryngectomy
ConclusionPostoperative hypothyroidism independently predicts postoperative wound-healing complications. The association of hypothyroidism with fistula formation may yield opportunities to modulate wound healing with thyroid supplementation or to provide a biomarker of wound progression. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 20, 2017 Category: Cancer & Oncology Source Type: research

Pathological and Radiological Splenic Vein Involvement are Predictors of Poor Prognosis and Early Liver Metastasis After Surgery in Patients with Pancreatic Adenocarcinoma of the Body and Tail
ConclusionsPathological/radiological SV invasion were independent adverse prognostic factors associated with early liver metastasis in patients with PDAC of the body/tail. Assessment of these findings may be useful in determining optimal therapeutic options in these patients. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 20, 2017 Category: Cancer & Oncology Source Type: research

Comparative Effectiveness of Preoperative Paravertebral Block for Post-Mastectomy Reconstruction: A Systematic Review of the Literature
ConclusionsAlthough recent reports and RCTs advocate for PVB use in PMR, our review highlights significant heterogeneity and knowledge gaps that must be addressed in order for PVB to become part of the optimal anesthetic protocol in PMR. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 19, 2017 Category: Cancer & Oncology Source Type: research

Is Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy Justified for Biphasic Variants of Peritoneal Mesothelioma? Outcomes from the Peritoneal Surface Oncology Group International Registry
AbstractBackgroundCytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has dramatically improved the survival of patients with epithelioid peritoneal mesothelioma. It is unknown if CRS/HIPEC is indicated for the more aggressive biphasic mesothelioma variant.MethodsA retrospective analysis of the Peritoneal Surface Oncology Group International (PSOGI) registry including data from 33 centers was performed. Survival was reviewed based on mesothelioma type, completion of cytoreduction, and volume of disease.ResultsOverall, 484 of 1165 (41.5%) CRS/HIPEC procedures with complete CC0 and CC1 cytoreducti...
Source: Annals of Surgical Oncology - December 19, 2017 Category: Cancer & Oncology Source Type: research

The Comprehensive Complication Index: a New Measure of the Burden of Complications After Hyperthermic Intraperitoneal Chemotherapy
ConclusionsThe CCI is an adequate tool to capture all complications and their overall burden in patients having undergone HIPEC. This study shows that the CCI can predict LOS and could be used to quantify and compare the burden of multiple complications. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 19, 2017 Category: Cancer & Oncology Source Type: research

Should Fear of Adverse Events Influence the Decision to Administer Preoperative Therapy to Patients with Pancreatic Cancer?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - December 14, 2017 Category: Cancer & Oncology Source Type: research

Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update
AbstractPurposeTo update the American Society of Clinical Oncology (ASCO)-Society of Surgical Oncology (SSO) guideline for sentinel lymph node (SLN) biopsy in melanoma.MethodsAn ASCO-SSO panel was formed, and a systematic review of the literature was conducted regarding SLN biopsy and completion lymph node dissection (CLND) after a positive sentinel node in patients with melanoma.ResultsNine new observational studies, two systematic reviews and an updated randomized controlled trial (RCT) of SLN biopsy, as well as two randomized controlled trials of CLND after positive SLN biopsy, were included.RecommendationsRoutine SLN b...
Source: Annals of Surgical Oncology - December 13, 2017 Category: Cancer & Oncology Source Type: research