Treatment Strategies in Octogenarians with Early-Stage, High-Risk Breast Cancer
ConclusionsTailored locoregional and systemic therapy resulted in low incidence of failure in these octogenarians with high-risk cancers with low morbidity. Modern adjuvant therapies should be considered for elderly women with high-risk cancers in the absence of significant comorbidities. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Esophageal Cancer Surgery: Spontaneous Centralization in the US Contributed to Reduce Mortality Without Causing Health Disparities
This study aimed to determine if centralization of esophageal cancer surgery occurred in the US, and to establish its impact on postoperative mortality. In addition, we aimed to analyze the relationship between regionalization of cancer care and health disparities.MethodsA retrospective population-based analysis was performed using the National Inpatient Sample for the period 2000 –2014. Adult patients (≥ 18 years of age) diagnosed with esophageal cancer and who underwent esophagectomy were included. Yearly hospital volume was categorized as low (  20 procedures). Multivariable analyses on the poten...
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Pathological Margin Clearance and Survival After Pancreaticoduodenectomy in a US and European Pancreatic Center
This study was designed to assess the relationship between pathological margin clearance, margin type, and survival.MethodsPatients who underwent pancreaticoduodenectomy with curative intent at two academic institutions, in Amsterdam, the Netherlands, and Boston, Massachusetts, between 2000 and 2014 were retrospectively evaluated. Overall survival, recurrence rates, and progression-free survival (PFS) were assessed by Kaplan –Meier estimates and multivariate Cox proportional hazards analysis, according to pathological margin clearance and type of margin involved.ResultsOf 531 patients identified, the median PFS was 1...
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Centralization of Esophagectomy in the United States: Might It Benefit Underserved Populations?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Tips and Tricks for a Laparoscopic Approach to Paracaval Liver Segments
ConclusionParacaval segments of the liver can be approached safely through laparoscopy by teams with extensive expertise in the field of laparoscopic liver surgery; however, suspected malignant infiltration of the IVC or unclear preoperative anatomy still contraindicate this approach. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

A National-Level Validation of the New American Joint Committee on Cancer 8th Edition Subclassification of Stage IIA and B Anal Squamous Cell Cancer
AbstractIntroductionThe 8th edition of the American Joint Committee on Cancer (AJCC) updated the staging system of anal squamous cell cancer (ASCC) by subdividing stage II into A (T2N0M0) and B (T3N0M0) based on a secondary analysis of the RTOG 98-11 trial. We aimed to validate this new subclassification utilizing two nationally representative databases.MaterialsThe National Cancer Database (NCDB) [2004 –2014] and the Surveillance, Epidemiology, and End Results (SEER) database [1988–2013] were queried to identify patients with stage II ASCC.ResultsA total of 6651 and 2579 stage IIA (2 –5 cm) and 1777...
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

SPECT/CT Adds Distinct Lymph Node Basins and Influences Radiologic Findings and Surgical Approach for Sentinel Lymph Node Biopsy in Head and Neck Melanoma
ConclusionsSPECT/CT influences the location of incision and contributes most to identification of nodes in the supraclavicular region. It also detects additional SLN basins when compared with PL. Further studies are necessary to determine when these additional basins require sampling. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

What is the Incidence of Malignancy in Resected Intraductal Papillary Mucinous Neoplasms? An Analysis of Over 100 US Institutions in a Single Year
AbstractBackgroundA subset of intraductal papillary mucinous neoplasms (IPMNs) will progress to invasive adenocarcinoma, however identifying invasive from non-invasive disease preoperatively remains challenging. The rate of malignancy in resected IPMNs in the US remains unclear.ObjectiveWe aimed to determine the rate of malignancy and factors associated with high-risk pathology in resected IPMNs.MethodsThe most recent annual cohort of patients undergoing pancreatectomy included in the American College of Surgeons National Surgical Quality Improvement Program were assessed, and contributions of demographics, preoperative la...
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Managing Extremity Soft Tissue Sarcoma Patients: Surgery Alone or in Combination with Radiotherapy? An Editorial on the Paper by Fiore et al.
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

‘Under’ Surveillance: Impact of Race and Socioeconomic Status on Post-Treatment Breast Cancer Imaging
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Concurrent Versus Sequential Chemoradiation Therapy in Completely Resected Pathologic N2 Non-Small Cell Lung Cancer: Propensity-Matched Analysis of the National Cancer Data Base
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 30, 2018 Category: Cancer & Oncology Source Type: research

Racial and Socioeconomic Differences in the Use of High-Volume Commission on Cancer-Accredited Hospitals for Cancer Surgery in the United States
ConclusionsDifferences in the use of CoC-accredited high-volume hospitals for major cancer surgery were seen nationwide and persisted over the duration of the study. Strategies to increase referrals and/or access to high-volume hospitals for African American and socioeconomically disadvantaged patients should be explored. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Single-Axillary-Incision Endoscopic-Assisted Hybrid Technique for Nipple-Sparing Mastectomy: Technique, Preliminary Results, and Patient-Reported Cosmetic Outcome from Preliminary 50 Procedures
ConclusionsThe proposed single-axillary-incision endoscopic hybrid technique for nipple-sparing mastectomy was a safe procedure with low morbidity and associated with high patient satisfaction. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Cervicothoracoscopic Approach for Esophageal Cancer in a Patient with Right-Sided Aortic Arch
ConclusionsThe vascular ring at the cervicothoracic junction in a patient with RAA made it difficult to dissect the RLN lymph nodes during oncologic esophagectomy. The cervicothoracoscopic approach enables the complete dissection of these lymph nodes and is a useful esophagectomy technique for patients with RAA. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Precision Hilar Cholangiocarcinoma Surgery
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

A Population-based Study on Lymph Node Retrieval in Patients with Esophageal Cancer: Results from the Dutch Upper Gastrointestinal Cancer Audit
ConclusionsThe number of LNs retrieved increased between 2011 and 2016. Weight loss, Charlson score, cN category, neoadjuvant therapy, surgical approach, year of resection, and hospital volume were all associated with increased LN yield. Retrieval of ≥ 15 LNs was not associated with increased postoperative morbidity/mortality. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Elucidation of the Anatomical Mechanism of Nodal Skip Metastasis in Superficial Thoracic Esophageal Squamous Cell Carcinoma
ConclusionOur anatomical data suggested that the absence of intra-muscle lymphatic vessels in the middle mediastinal and supraclavicular zones causes skip LNM in patients with thoracic ESCC. Thus, standard esophagectomy with lymph node dissection, including distant zones, may be appropriate for treating patients with superficial thoracic ESCC. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Neural Invasion is a Significant Contributor to Peritoneal Recurrence in Signet Ring Cell Gastric Carcinoma
ConclusionsThis report is the first to present the relationship between NI and peritoneal recurrence as the cause of stage-dependent prognoses for SRC. A better understanding of NI may lend insight into cancer spread and recurrence, especially in gastric SRC. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Predicting Survival and Response to Treatment in Gastroesophageal Neuroendocrine Tumors: An Analysis of the National Cancer Database
AbstractBackgroundNeuroendocrine tumors (NETs) of the esophagus and stomach are rare neoplasms with variable behavior. We aim to describe their epidemiology and response to treatment.MethodsNETs of the stomach and the esophagus were selected from the National Cancer Database (2004 –2013) and classified by location. Survival analyses were performed with respect to tumor characteristics and treatment variables.ResultsNETs of the stomach (n = 2700; 92.8%) and esophagus (n = 210, 7.2%) were identified. Gastric cardia NETs had demographics and behavior similar to esophageal tumors and were associated w...
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases From a Small Bowel Adenocarcinoma: Multi-Institutional Experience
ConclusionThe combined treatment strategy of CRS plus HIPEC achieved prolonged survival for selected patients who had PM from SBA with acceptable morbidity and mortality. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Cytoplasmic Hu-Antigen R (HuR) Expression is Associated with Poor Survival in Patients with Surgically Resected Cholangiocarcinoma Treated with Adjuvant Gemcitabine-Based Chemotherapy
AbstractBackgroundHu-antigen R (HuR) is an RNA-binding protein that regulates the stability, translation, and nucleus-to-cytoplasm translocation of messenger RNAs (mRNAs).ObjectiveThe aim of this study was to investigate the prognostic significance of HuR in cholangiocarcinoma patients who received adjuvant gemcitabine-based chemotherapy (AGC) after surgical resection.MethodsNuclear and cytoplasmic HuR expression was investigated immunohistochemically in 131 patients with resected cholangiocarcinoma, including 91 patients administered AGC and 40 patients who did not receive adjuvant chemotherapy. The correlation between Hu...
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

A Predictive Model for Axillary Node Pathologic Complete Response after Neoadjuvant Chemotherapy for Breast Cancer
AbstractBackgroundRecent trials have suggested the feasibility of performing a sentinel lymph node biopsy (SNB) following neoadjuvant chemotherapy (NAC). The selection of suitable patients for this approach remains controversial. We developed a predictive model to identify patients most likely to benefit from SNB following NAC.MethodsThe National Cancer Data Base was used to identify patients with clinically node positive (cN+) breast cancer undergoing NAC followed by breast surgery and axillary lymph node dissection (ALND). Patients were randomly assigned to a 70% testing or 30% validation cohort for model development. A ...
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

The Negative Impact of Body Mass Index on the Tumor Microenvironment in Colon Cancer: Results of a Prospective Trial
AbstractBackgroundThe association between tumor mismatch repair status and obesity in colon cancer is not well understood. The authors of this study hypothesized that mismatch repair deficiency in colon cancer may be associated with a lower Body Mass Index (BMI) and improved patient outcome due to an enhanced tumor immune microenvironment.MethodsFor this study, 70 patients were randomly selected from a prospective trial evaluating nodal ultrastaging for colon cancer. The mismatch repair status of tumors and immunomarker expression were correlated with clinicopathologic characteristics and evaluated for disease-free surviva...
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Significance of Glucose Transporter Type 1 (GLUT-1) Expression in the Therapeutic Strategy for Pancreatic Ductal Adenocarcinoma
ConclusionsAmong the patients with PDAC, those with low GLUT-1 expression in the primary tumor had a better prognosis those with high GLUT-1 expression. Moreover, the patients with low GLUT-1 expression displayed a better therapeutic response to NACRT. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Denis Parsons Burkitt, an Overlooked Surgical Oncologist
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Minimally Invasive Liver Surgery: Has it Achieved the Standard of Care?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Reasons Associated with Total Thyroidectomy as Initial Surgical Management of an Indeterminate Thyroid Nodule
AbstractBackgroundDiagnostic hemithyroidectomy (HT) is the most widely recommended surgical procedure for a nodule with indeterminate cytology; however, additional details may make initial total thyroidectomy (TT) preferable. We sought to identify patient-specific factors (PSFs) associated with initial TT in patients with indeterminate thyroid nodules.MethodsRetrospective analysis of all patients with a thyroid nodule  ≥ 1 cm and initial cytology of atypia of undetermined significance or suspicious for follicular neoplasm between 2012 and 2015 who underwent thyroidectomy. Medical records were reviewed...
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Clinical Significance of Skeletal Muscle Loss Following Lung Resection for Cancer: Recovery and Sarcopenia are Linked to Cancer Outcomes
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 10, 2018 Category: Cancer & Oncology Source Type: research

Long-Term Outcomes of Gastric Cancer Patients with Preoperative Sarcopenia
AbstractBackgroundThere are few reports of long-term outcomes of gastric cancer patients with sarcopenia. The purpose of this study was to assess the impact of sarcopenia on long-term outcomes in gastric cancer patients who underwent curative resection.MethodsA total of 951 patients aged 65  years or older who underwent R0 resection for gastric cancer were investigated. Sarcopenia was defined as a decreased arm muscle area 
Source: Annals of Surgical Oncology - April 9, 2018 Category: Cancer & Oncology Source Type: research

Efficacy of Endoscopic Management for Early Remnant Gastric Cancer: Is Completion Gastrectomy Truly Necessary in Cases with Marginally Noncurative Histopathologic Features?
ConclusionsEndoscopic management might be an effective treatment option for ERGC with potential long-term survival advantage over the completion gastrectomy even in cases with histopathological features, suggesting noncurative resection. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 9, 2018 Category: Cancer & Oncology Source Type: research

Efficacy of the Gallbladder Cancer Predictive Risk Score Based on Pathological Findings: A Propensity Score-Matched Analysis
AbstractBackgroundThe optimal prognostic predictive system for gallbladder carcinoma (GBC) has not been established. The gallbladder cancer predictive risk score (GBRS) based on pathological findings identifies incidental GBC patients at risk of recurrence.ObjectiveWe aimed to validate the prognostic ability of the GBRS in all GBC patients following curative surgery.MethodsFifty-six patients with GBC who underwent curative surgery between 1996 and 2016 were included in this study. Univariate and multivariate analyses were performed to determine prognostic factors associated with overall and recurrence-free survival, and pr...
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

Application of Serum Annexin A3 in Diagnosis, Outcome Prediction and Therapeutic Response Evaluation for Patients with Hepatocellular Carcinoma
AbstractPurposeAnnexin A3 (ANXA3) could induce progression of hepatocellular carcinoma (HCC) via promoting stem cell traits of CD133-positive cells. Moreover, serum ANXA3 showed preliminary diagnostic potential, however further validation was required. Meanwhile, the prognostic value of ANXA3 remained elusive. The present study aimed to validate diagnostic performance and further systematically investigate the prognostic value of serum ANXA3.MethodsSerum ANXA3 of 368 HCC patients was determined by enzyme-linked immunosorbent assay (ELISA); 295 of these patients underwent resection and 73 underwent transcatheter arterial ch...
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

Preoperative Fluorouracil, Doxorubicin, and Streptozocin for the Treatment of Pancreatic Neuroendocrine Liver Metastases
ConclusionsThe use of FAS before liver resection is associated with improved OS compared with surgery alone among patients with advanced synchronous pancreatic neuroendocrine liver metastases. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

Value of Preoperative PET-CT in the Prediction of Pathological Stage of Gastric Cancer
ConclusionsPET-CT appears to be a useful complementary modality in the assessment of pStage III/IV because of the high sensitivity of FDG uptake in the primary tumor and the high specificity of FDG uptake in the lymph nodes. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

Prevalence and Predictors of Preoperative Venous Thromboembolism in Asymptomatic Patients Undergoing Major Oncologic Surgery
AbstractBackgroundPostoperative venous thromboembolism (VTE) is a leading cause of in-hospital mortality for cancer patients; however, the prevalence of preoperative VTE remains unclear.ObjectiveThe aim of this study was to evaluate the prevalence and risk factors associated with preoperative VTE in asymptomatic patients undergoing major oncologic surgery.MethodsRetrospective analysis of 346 patients identified from our prospectively maintained database of patients undergoing abdominopelvic oncologic surgery from 2009 to 2016.ResultsThe prevalence of preoperative VTE found on screening venous duplex scan was 10.1%. Patient...
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

Axillary Surgery for Early-Stage, Node-Positive Mastectomy Patients and the Use of Postmastectomy Chest Wall Radiation Therapy
ConclusionsSurgeons are omitting completion ALND in a third of early-stage, node-positive mastectomy patients. SNB alone patients are more likely to undergo PMRT than patients undergoing ALND. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

2018 Presidential Address —Society of Surgical Oncology: The Fundamental Difference Between Cancer Treatment and Patient Care
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

Patterns of Treatment Failure in Patients with Sinonasal Mucosal Melanoma
ConclusionThe most common cause of treatment failure in SNMM is distant metastasis. The tumor site and the presence of metastatic disease at presentation were the only independent predictors of survival. These data can be used to inform quality improvement efforts and the counseling of high-risk SNMM patients. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 6, 2018 Category: Cancer & Oncology Source Type: research

AJCC 8th Edition: Colorectal Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 3, 2018 Category: Cancer & Oncology Source Type: research

Analysis of the Vascular Interrelationships Among the First Jejunal Vein, the Superior Mesenteric Artery, and the Middle Colic Artery
This study was designed to investigate the vascular interrelationships between the arteries and veins around the middle colic vessels and to provide practically useful classifications.MethodsThis study included 105 consecutive patients who underwent colorectal surgery for colorectal tumors in our institution in 2016. Patients with a history of colectomy were excluded. Vascular anatomical classifications were analyzed by evaluating thin-slice images of preoperative contrast-enhanced computed tomography.ResultsVascular anatomical patterns were classified according to whether the first jejunal vein ran behind (type A) or in f...
Source: Annals of Surgical Oncology - April 3, 2018 Category: Cancer & Oncology Source Type: research

Poor Prognostic Factors in Patients with Malignant Pleural Mesothelioma Classified as Pathological Stage IB According to the Eighth Edition TNM Classification
AbstractIntroductionThe change in TNM classification of malignant pleural mesothelioma (MPM) between the seventh and eighth edition classifications has resulted in the downstaging of many advanced-stage patients into pathological stage IB. Many mesotheliomas without lymph node metastasis have been classified as stage IB in the eighth edition classification. Stage IB mesotheliomas comprised a heterogeneous group with different prognosis. It is necessary to clarify the prognostic factors in this group.MethodsBetween September 2009 and August 2016, a total of 89 patients with MPM underwent curative intent surgery [pleurectomy...
Source: Annals of Surgical Oncology - April 3, 2018 Category: Cancer & Oncology Source Type: research

Prevalence and Prognostic Significance of Extramural Venous Invasion in Patients with Locally Advanced Esophageal Cancer
AbstractBackgroundExtramural venous invasion (EMVI) is a known adverse prognostic factor in patients with colorectal carcinoma. The prevalence and significance of EMVI in esophageal cancer (EC) patients is still unclear.MethodsFrom a prospectively maintained database, we retrospectively reviewed the resection specimens of patients with pathologic locally advanced (pT3/T4/N0-3) EC who were treated with curative intent between 2000 and 2015. Patients with previous malignancies and gastroesophageal junction (type II/III) tumors were excluded. Included were 81 patients who underwent surgery alone and 37 patients who underwent ...
Source: Annals of Surgical Oncology - April 2, 2018 Category: Cancer & Oncology Source Type: research

Comparison of Immunohistochemistry and Direct Sequencing Methods for Identification of the BRAF V600E Mutation in Papillary Thyroid Carcinoma
AbstractBackgroundBRAFV600E mutation is the most common somatic variant in papillary thyroid carcinoma (PTC) and is associated with aggressive prognostic factors. The conventional detection method forBRAF mutations is polymerase chain reaction followed by Sanger sequencing. Recently, an immunohistochemistry (IHC) method using aBRAFV600E-specific antibody (VE1) has been developed and widely adopted in the clinics; however, there is a lack of evidence regarding the comparability of the IHC and Sanger sequencing methods.MethodsOur institution began using theBRAFV600E IHC test in January 2013. We retrospectively analyzed 697 s...
Source: Annals of Surgical Oncology - April 2, 2018 Category: Cancer & Oncology Source Type: research

8th Edition of the AJCC Cancer Staging Manual: Pancreas and Hepatobiliary Cancers
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Epirubicin and Ifosfamide with Preoperative Radiation for High-Risk Soft Tissue Sarcomas
We report follow-up from a phase II study of dose-intense chemotherapy with preoperative hypofractionated radiation in this population supplemented with subsequent data from an extensive institutional experience using this regimen.MethodsPatients with localized, intermediate- or high-grade STS of the extremity or body wall measuring  >  5 cm were treated with epirubicin 30 mg/m2/day and ifosfamide 2.5  g/m2/day on days 1 –4 every 21 days for 3 preoperative and 3 postoperative cycles. During cycle 2 of preoperative therapy, epirubicin was omitted, and a total of 28 Gy of radiation...
Source: Annals of Surgical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Survival Prediction in Pancreatic Ductal Adenocarcinoma by Quantitative Computed Tomography Image Analysis
ConclusionWe present two continuous survival prediction models for resected PDAC patients. Quantitative analysis of CT texture features is associated with overall survival. Further work includes applying the model to an external dataset to increase the sample size for training and to determine its applicability. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Robot-Assisted Technique for Total Gastrectomy and D2 Lymphadenectomy with Anomalous Vasculature
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Metaplastic Breast Cancer: Practice Patterns, Outcomes, and the Role of Radiotherapy
This study of a large, contemporary US database described national practice patterns and addressed the impact of radiotherapy (RT) on survival.MethodsThe National Cancer Data Base was queried (2004 –2013) for women with non-metastatic MBC. Multivariable logistic regression ascertained factors associated with RT administration. Kaplan–Meier analysis evaluated overall survival (OS) between patients treated with either lumpectomy or mastectomy with or without RT, while substratifying patients into pT1–2N0 and pT3–4/N+ subcohorts. Cox proportional hazards modeling determined variables associated with OS...
Source: Annals of Surgical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Neoadjuvant Chemotherapy for Hypopharyngeal Squamous Cell Carcinoma and Personalized Medicine in Head and Neck Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research

Steps to Getting Your Manuscript Published in a High-Quality Medical Journal
We describe key criteria for acceptance of manuscripts and outline a multi-step process for writing the manuscript. The likelihood that a manuscript will be accepted by a major journal is significantly increased if the manuscript is written in polished and fluent scientific English. Although scientific quality is the most important consideration, clear and concise writing often makes the difference between acceptance and rejection. As with any skill, efficient writing of high-quality manuscripts comes with experience and repetition. It is very uncommon for a manuscript to be accepted as submitted to a journal. Thoughtful a...
Source: Annals of Surgical Oncology - March 7, 2018 Category: Cancer & Oncology Source Type: research