Use of Vascularized Fibular Epiphyseal Transfer with Massive Bone Allograft for Proximal Humeral Reconstruction in Children with Bone Sarcoma
ConclusionsThe combination of vascularized fibula epiphyseal transfer with massive allograft bone provides a reliable oncologic reconstruction of proximal humerus in children. It not only offers the ability of longitudinal growth, hypertrophy, and osseous union but also diminishes reconstructive complications and improves shoulder function.Level of EvidenceTherapeutic Level IV. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 11, 2021 Category: Cancer & Oncology Source Type: research

Development and Validation of a Short Version of the Metric for the Observation of Decision-Making in Multidisciplinary Tumor Boards: MODe-Lite
This study aimed to develop a robust observational assessment tool for use on cancer multidisciplinary tumor boards (MTBs) by health care professionals in everyday practice.MethodsA retrospective cross-sectional observational study was conducted in the United Kingdom from September 2015 to July 2016. Three tumor boards from three teaching hospitals were recruited, with 44 members overall. Six weekly meetings involving 146 consecutive cases were video-recorded and scored using the validated MODe tool. Data were subjected to reliability and validity analysis in the current study to develop a shorter version of the MODe.Resul...
Source: Annals of Surgical Oncology - May 11, 2021 Category: Cancer & Oncology Source Type: research

Oncologic Outcome of Endoscopic Assisted Breast Surgery Compared with Conventional Approach in Breast Cancer: An Analysis of 3426 Primary Operable Breast Cancer Patients from Single Institute with and Without Propensity Score Matching
ConclusionThe preliminary oncologic safety analysis from current study showed EABS is a safe procedure and results in low margin involved rate, and no increase of locoregional recurrence, distant metastasis or mortality compared with CBS. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 11, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: The Disease-Free Interval is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal Tumor
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 11, 2021 Category: Cancer & Oncology Source Type: research

Management of Soft Tissue Sarcomas in Extremities: Variation in Treatment Recommendations and Surveillance According to Specialty and Continent
This study aimed to provide an insight into clinical decision-making and surveillance strategy of sarcoma specialists for patients with primary soft tissue sarcoma of the extremities (eSTS). The secondary aim was to quantify the role of patient- and tumor-specific factors in the perioperative management.MethodsMembers of sarcoma societies were sent a Web-based 21-item survey about eSTS management. The survey concerned only primary resectable high-grade eSTS in adults.ResultsThe study enrolled 396 respondents. The majority of the surgical specialists thought the evidence for perioperative chemotherapy (CTX) for high-grade e...
Source: Annals of Surgical Oncology - May 10, 2021 Category: Cancer & Oncology Source Type: research

Author ’s Reply: Comparison of Outcomes Between Additional Esophagectomy After Noncurative Endoscopic Resection and Upfront Esophagectomy for T1N0 Esophageal Squamous Cell Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 10, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Why Are Young Ductal Carcinoma In Situ Patients Electing to Undergo Bilateral Mastectomies?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 10, 2021 Category: Cancer & Oncology Source Type: research

Repeat hepatectomy versus radiofrequency ablation in management of recurrent hepatocellular carcinoma: an average treatment effect analysis
ConclusionsRH confers a late survival benefit compared with RFA for patients with recurrent HCC despite a higher morbidity rate. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 9, 2021 Category: Cancer & Oncology Source Type: research

Minimally Invasive Versus Open Pancreatectomy for Right-Sided and Left-Sided G1/G2 Nonfunctioning Pancreatic Neuroendocrine Tumors: A Multicenter Matched Analysis with an Inverse Probability of Treatment-Weighting Method
This study aimed to compare the surgical outcomes of MIS and open surgery (OS) for right- or left-sided NF-PNETs.MethodsThe study collected data on patients who underwent surgical resection (pancreatoduodenectomy, distal/total/central pancreatectomy, duodenum-preserving pancreas head resection, or enucleation) of a localized NF-PNET between January 2000 and July 2017 at 14 institutions. The inverse probability of treatment-weighting method with propensity scores was used for analysis.ResultsThe study enrolled 859 patients: 478 OS and 381 MIS patients. A matched analysis by tumor location showed no differences in resection ...
Source: Annals of Surgical Oncology - May 9, 2021 Category: Cancer & Oncology Source Type: research

The Landmark Series: Surgical Treatment of Colorectal Cancer Peritoneal Metastases
ConclusionsCurrent evidence does not support the use of second look surgery with oxaliplatin HIPEC or prophylactic oxaliplatin HIPEC in patients with high risk colon cancer nor the use of oxaliplatin HIPEC with CRS of colorectal PM. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 9, 2021 Category: Cancer & Oncology Source Type: research

Comparison of Two Major Staging Systems in Predicting Survival and Recommendation of Postoperative Radiotherapy Based on the 11th Japanese Classification for Esophageal Carcinoma After Curative Resection: A Propensity Score-Matched Analysis
AbstractObjectiveThe aim of this study was to compare the prognostic predictive power of the 11th Japan Esophageal Society (JES) staging system with the 8th edition of the American Joint Committee on Cancer (AJCC) staging system in patients with thoracic esophageal squamous cell carcinoma (TESCC), and to estimate the survival benefits of postoperative radiotherapy (PORT) based on a substage of the JES staging system.MethodsArea under the curve (AUC) values of the receiver operating characteristic curve were calculated to evaluate prognostic efficacy. Propensity score matching (PSM) analysis was conducted to balance the two...
Source: Annals of Surgical Oncology - May 9, 2021 Category: Cancer & Oncology Source Type: research

Disease-free Interval Is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal Tumor
AbstractBackgroundGastrointestinal stromal tumors (GIST) commonly recur following curative-intent resection. Patients with recurrent GIST display heterogeneous outcomes with limited prognostic tools. We investigated factors associated with post-recurrence survival (PRS) and progression-free survival (PFS).MethodsWe performed a review of our institutional cancer registry from 2003 to 2018 for patients with GIST. Clinicopathologic and outcome data were collected. The disease-free interval (DFI) was calculated from the end of curative-intent oncologic therapy until recurrence. Outcomes were evaluated using Kaplan –Meier...
Source: Annals of Surgical Oncology - May 9, 2021 Category: Cancer & Oncology Source Type: research

High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer
AbstractBackgroundMutations ofBRCA genes are the most studied in breast cancer, but the clinical relevance ofBRCA2 gene expression has been less well studied. Given thatBRCA2 is a DNA repair gene, we hypothesized that highBRCA2 expression is associated with highly proliferative and aggressive biology in breast cancer.Materials and MethodsA total of 4342 breast cancer patients were analyzed from The Cancer Genome Atlas (TCGA,n = 1069) as the testing cohort and Gene Expression Omnibus (GEO) dataset GSE96058 (n = 3273) as a validation cohort.ResultsThere was no relationship betweenBRCA2 mutation andBRCA2 gene expression.BRCA2...
Source: Annals of Surgical Oncology - May 8, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: High BRCA2 Gene Expression is Associated with Aggressive and Highly Proliferative Breast Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 8, 2021 Category: Cancer & Oncology Source Type: research

Staging and Surveillance of Myxoid Liposarcoma: Follow-up Assessment and the Metastatic Pattern of 169 Patients Suggests Inadequacy of Current Practice Standards
ConclusionDue to metastatic disease identified outside surveillance imaging for 58 % of the patients, the diversity of locations, and the significant failure of CT and bone scan to identify bone metastases, this study questioned the adequacy of CT scan for surveillance of MLS. Consideration should be given to the use of whole-body MRI for detection of metastasis in MLS. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 7, 2021 Category: Cancer & Oncology Source Type: research

Editorial: Stop, Look, and Contextually Value
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 7, 2021 Category: Cancer & Oncology Source Type: research

Reply to: “Ketorolac Following Mastectomy: Is There an Increased Risk of Reoperation?”
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 7, 2021 Category: Cancer & Oncology Source Type: research

Surgery for Bismuth-Corlette Type 4 Perihilar Cholangiocarcinoma: Results from a Western Multicenter Collaborative Group
ConclusionsIn this analysis of a large Western multi-institutional cohort, resection was shown to be an acceptable curative treatment option for selected patients with BC type 4 pCCA although a more technically challenging surgical approach was required. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

Perioperative Inpatient Opioid Consumption Following Autologous Free-Flap Breast Reconstruction Patients: An Examination of Risk and Patient-Reported Outcomes
ConclusionSystem-level components of ERAS pathways may reduce opioid use following autologous breast reconstruction, but surgical and patient factors may increase opioid requirements in certain patients. ERAS programs including liposomal bupivacaine and ketorolac should be established on a system level in conjunction with continued focus on individualized care, particularly for patients at risk for high opioid consumption. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

Comparison of Breast Cancer Staging Systems After Neoadjuvant Chemotherapy
AbstractBackgroundNo consensus exists for optimal staging following neoadjuvant chemotherapy (NAC). We compared the performance of the American Joint Committee on Cancer (AJCC) pathologic prognostic staging system, Residual Cancer Burden (RCB) Index, and the Neo-Bioscore in breast cancer patients after NAC.MethodsPatients with stage I –III breast cancer who received NAC at Dana-Farber Cancer Institute from 2004 to 2014 were identified. Kaplan–Meier curves were used to estimate disease-free survival (DFS) and overall survival (OS), and model fits were compared by receiver operator characteristic (ROC) curve usin...
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

Clinical Outcome of Additional Esophagectomy After Endoscopic Treatment for Superficial Esophageal Cancer
ConclusionEndoscopic treatment combined with esophagectomy or CRT can be a curative treatment option in patients with superficial esophageal cancer. However, esophagectomy rather than CRT should be recommended for patients with massive submucosal tumor invasion due to the risk of recurrence after CRT. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

Differences in Sociodemographic Disparities Between Patients Undergoing Surgery for Advanced Colorectal or Ovarian Cancer
AbstractBackgroundCytoreductive surgery (CRS) for ovarian cancer with peritoneal metastases (OPM) is an established treatment, yet access-related racial and socioeconomic disparities are well documented. CRS for colorectal cancer with peritoneal metastases (CRPM) is garnering more widespread acceptance, and it is unknown what disparities exist with regards to access.MethodsThis retrospective cross-sectional multicenter study analyzed medical records from the National Cancer Database from 2010 to 2015. Patients diagnosed with CRPM or ORP only and either no or confirmed resection were included. Patient- and facility-level ch...
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Nationwide Data on Ostomy Use in Elderly Patients After Colorectal Cancer Surgery
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

Letter to the Editor: Comparison of Outcomes Between Additional Esophagectomy After Noncurative Endoscopic Resection and Upfront Esophagectomy for T1N0 Esophageal Squamous Cell Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: Oncologic Outcome of Endoscopic-Assisted Breast Surgery Compared with Conventional Approach in Breast Cancer: An Analysis of 3426 Primary Operable Breast Cancer Patients from a Single Institute With and Without Propensity Score Matching
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: Contribution of Genomics to the  Surgical Management and Study of Oral Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: Prognostic Impact of Surgical Intervention After Lenvatinib Treatment for Advanced Hepatocellular Carcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 6, 2021 Category: Cancer & Oncology Source Type: research

Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery: ERAS for Patients Undergoing Cytoreductive Surgery with or Without HIPEC
AbstractERAS protocols may reduce length of stay and return to full functional recovery after cytoreductive surgery and HIPEC. Prehabilitation programs and post-operative goal directed pathways, along with other essential components of ERAS are discussed with supporting evidence. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 5, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Selecting Patients for Recurrent Retroperitoneal Sarcoma Surgery: The Challenging Trade-Off Between Oncologic Outcome and Morbidity
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 5, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Psychosocial Outcomes After Breast Cancer Treatment
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 5, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: Sentinel Node Biopsy Should Not Be Routine in Older Patients with ER-Positive HER2-Negative Breast Cancer Who Are Willing and Able to Take Hormone Therapy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 5, 2021 Category: Cancer & Oncology Source Type: research

The American Society of Breast Surgeons Official Proceedings, Volume XXII 2021 Annual Meeting Scientific Session Abstracts
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 4, 2021 Category: Cancer & Oncology Source Type: research

Editorial: Time to Surgery and Thyroid Cancer Survival in the United States
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 4, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Hilar Cholangiocarcinoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 4, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: Cumulative Burden of Postoperative Complications  in Patients Undergoing Surgery for Primary Retroperitoneal Sarcoma
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 4, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Global Forum of Cancer Surgeons: Position Statement to Promote Cancer Surgery Globally
A correction to this paper has been published: https://doi.org/10.1245/s10434-021-09970-4 (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 4, 2021 Category: Cancer & Oncology Source Type: research

Thyroid Lobectomy for Low-Risk Papillary Thyroid Cancer: A National Survey of Low- and High-Volume Surgeons
AbstractBackgroundThe 2015 American Thyroid Association guidelines endorsed lobectomy for patients with low-risk papillary thyroid cancer (PTC) measuring 1 –4 cm. Attitudes about the use of lobectomy for these patients are lacking, particularly from low-volume surgeons who perform the majority of thyroidectomies in the US.MethodsA survey was mailed to 1000 surgeons stratified by specialty (500 general surgeons and 500 otolaryngologists) registered with the American Medical Association, to evaluate beliefs and practices about the extent of surgery for low-risk PTC. Comparisons examined differences by surgeon volu...
Source: Annals of Surgical Oncology - May 3, 2021 Category: Cancer & Oncology Source Type: research

Contralateral Suppression Index Does Not Predict Clinical Cure in Patients Undergoing Surgery for Primary Aldosteronism
We examined the presence of CoS in patients who underwent adrenalectomy while adjusting for clinical and biochemical factors associated with a clinical cure of hypertension (ccHTN).MethodsWe performed a retrospective review of patients with successful AVS who underwent unilateral adrenalectomy for PA at a quaternary referral center. Patients were excluded if they had overt cortisol co-secretion, or inadequate follow-up. We first evaluated the aldosterone resolution score (ARS) in predicting ccHTN in our cohort. Next, the receiver-operator characteristic analysis (ROC) was used to determine the optimal contralateral suppres...
Source: Annals of Surgical Oncology - May 3, 2021 Category: Cancer & Oncology Source Type: research

Cytoreductive Surgery Plus HIPEC With and Without NIPEC for Malignant Peritoneal Mesothelioma: A Propensity-Matched Analysis
ConclusionsThe addition of NIPEC was associated with long-term survival in this cohort of patients. A multi-institutional randomized trial may be the next step. (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 3, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: The Peritoneum is an Active Immunological Compartment
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 3, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: The Impact of Minimally Invasive McKeown on Survival in Patients with Resectable Esophageal Cancer
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 3, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: Conditional Recurrence-Free Survival After Oncologic Extended Resection for Gallbladder Cancer —An International Multicenter Analysis
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 3, 2021 Category: Cancer & Oncology Source Type: research

Reply to: CT and PET/CT Surveillance in Stage IIIA-D Melanoma Results in More False-Positive Than True-Positive Findings and Should Not be Routinely Recommended, by Nicholas Taylor et al.
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - May 2, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Real-world Clinical Staging Failures of Presumed Early Gastric Cancers and their Negative Impact on Patient Outcomes
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Local Excision Following Neoadjuvant Therapy for Rectal Cancer: A Compromise Between TME and Watch-and-Wait in Patients with Major Response
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Visual Abstract: “Going Flat” After Mastectomy: Patient-Reported Outcomes by Online Survey
SummaryThe “Going Flat” movement aims to increase awareness and acceptance of mastectomy alone as a viable option for patients. Little is known about the motivation for and satisfaction with surgical outcomes in this population. Among 931 women surveyed in online “Going Flat” communities, 74% were sati sfied with their surgical outcome after mastectomy without reconstruction (http://doi.org/10.1245/s10434-020-09448-9). However, 22% of women experienced a low level of surgeon support for going flat, and this “flat denial” strongly predicted dissatisfaction. Most patients undergoing mastec...
Source: Annals of Surgical Oncology - April 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Access to Healthcare Does Not Mean Access to Health: Food Deserts in the Land of Plenty
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: D2 Lymphadenectomy Must be Complied No Matter the Arterial Variation
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: What will be Required to Safely Omit Breast Surgery for Early-Stage Breast Cancer?
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 14, 2021 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Understanding the Complexity of Microsurgical Reconstruction in the Vessel-Depleted Neck
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - April 14, 2021 Category: Cancer & Oncology Source Type: research