Obesity as a predictive factor for chronic kidney disease in adults: systematic review and meta-analysis
The objective of this study was to investigate obesity measured by body mass index as a predictor for end-stage renal disease in the general adult population. A systematic review and meta-analysis was carried out by searching 10 databases for prospective or retrospective cohort studies, with no restrictions on the language of publication, including adults with obesity without previous renal disease and who evolved to CKD (diagnosed by estimated glomerular filtration rate below 60 mL&mac_middot;min-1&mac_middot;(1.73 m2)-1 over the follow-up period. The R software and Meta package were used for data analysis. After ...
Source: Braz J Med Biol Res - March 3, 2021 Category: Research Authors: K R D Pinto C M Feckinghaus V N Hirakata Source Type: research

Knockdown of lncRNA H19 suppresses endometriosis in vivo
This study aimed to investigate the role of lncRNA H19 in a nude mouse model of endometriosis. Ectopic endometrial stromal cells (ecESCs) were isolated from ectopic endometrium of patients with endometriosis and infected with lentiviruses expressing short hairpin RNA (shRNA) negative control (LV-NC-shRNA) or lncRNA-H19 shRNA (LV-H19-shRNA). The ecESCs infected with LV-NC-shRNA and LV-H19-shRNA were subcutaneously implanted into forty 6- to 8-week-old female nude mice. The size and weight of the endometriotic implants were measured at 1, 2, 3, and 4 weeks after implantation and compared, and lncRNA H19 levels in endometriot...
Source: Braz J Med Biol Res - March 3, 2021 Category: Research Authors: Songping Liu Weijuan Xin Qi Lu Xiaoyan Tang Fengqin Wang Wei Shao Yajiao Zhang Junjun Qiu Keqin Hua Source Type: research

The value of preoperative systemic immune-inflammation index in predicting vascular invasion of hepatocellular carcinoma: a meta-analysis
Braz J Med Biol Res. 2021 Feb 26;54(4):e10273. doi: 10.1590/1414-431X202010273. eCollection 2021.ABSTRACTVascular invasion and systemic immune-inflammation index (SII) are risk factors for the prognosis of patients with hepatocellular carcinoma. At present, the correlation between the two is not clear. This meta-analysis explored the relationship between preoperative SII and vascular invasion in patients with hepatocellular carcinoma. According to the search formula, the Pubmed, Embase, Cochrane, Web of Science, and CNKI databases were searched for the relevant research until March 2020. After the quality evaluation of the...
Source: Braz J Med Biol Res - March 3, 2021 Category: Research Authors: YiFeng Wu ChaoYong Tu ChuXiao Shao Source Type: research

Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis
In this study, ZNS exerted neuroprotective effects by inhibition of apoptosis in neuronal cells in cerebral ischemia. Therefore, ZNS might be a promising therapy for cerebral ischemia.PMID:33656055 | DOI:10.1590/1414-431X202010498 (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - March 3, 2021 Category: Research Authors: Junna He Xiangjian Zhang Weiliang He Yanzhao Xie Yanxia Chen Yang Yang Rong Chen Source Type: research

Differential proteomic analysis of children infected with respiratory syncytial virus
Braz J Med Biol Res. 2021 Feb 26;54(4):e9850. doi: 10.1590/1414-431X20209850. eCollection 2021.ABSTRACTRespiratory syncytial virus (RSV) infection is the main cause of lower respiratory tract infection in children. However, there is no effective treatment for RSV infection. Here, we aimed to identify potential biomarkers to aid in the treatment of RSV infection. Children in the acute and convalescence phases of RSV infection were recruited and proteomic analysis was performed to identify differentially expressed proteins (DEPs). Subsequently, promising candidate proteins were determined by functional enrichment and protein...
Source: Braz J Med Biol Res - March 3, 2021 Category: Research Authors: Gen-Quan Yin Hui-Xuan Zeng Zi-Long Li Chen Chen Jia-Yong Zhong Mi-Si Xiao Qiang Zeng Wen-Hui Jiang Pei-Qiong Wu Jie-Min Zeng Xiao-Yin Hu Huan-Hui Chen None Ruo-Hu Hai-Jin Zhao Lin Gao Cong Liu Shao-Xi Cai Source Type: research

Erratum notice for: "Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis" [Braz J Med Biol Res (2020) 53(7): e9646 | doi: 10.1590/1414-431X20209646]
Braz J Med Biol Res. 2021 Feb 26;54(4):e9646erratum. doi: 10.1590/1414-431X20219646erratum.ABSTRACT[This corrects the article doi: 10.1590/1414-431X20209646].PMID:33656057 | DOI:10.1590/1414-431X20219646erratum (Source: Braz J Med Biol Res)
Source: Braz J Med Biol Res - March 3, 2021 Category: Research Source Type: research

Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload
Braz J Med Biol Res. 2021 Feb 12;54(4):e10138. doi: 10.1590/1414-431X202010138. eCollection 2021.ABSTRACTSarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and sarcolemmal Na+/Ca2+ exchanger (NCX1) structures are involved in heart cell Ca2+ homeostasis. Previous studies have shown discrepancies in their function and expression in heart failure. The goal of this study was to evaluate heart function and hypertrophied muscle Ca2+-handling protein behavior under pressure overload. Twenty male Wistar rats were divided into two groups: Aortic stenosis (AoS), induced by a clip placed at the beginning of the aorta, and Control (Sham). A...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: I F S Mazeto K Okoshi C F S M P Silveira P G Sant'Ana V L da Silva G A F Mota S L B de Souza D F Vileigas C R Padovani A C Cicogna Source Type: research

microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA cho...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research

Caffeine ingestion improves specific artistic swimming tasks
Braz J Med Biol Res. 2021 Feb 12;54(4):e10346. doi: 10.1590/1414-431X202010346. eCollection 2021.ABSTRACTThe main movements of artistic swimming demand various physical capacities such as flexibility, strength, power, and muscular endurance. The use of ergogenic resources to potentialize performance in this sport, however, is underexplored and deserves investigation. In the present study, we tested whether caffeine ingestion would improve the execution of movements that are essential in a typical figure competition or routines in artistic swimming (i.e., amplitude in the Ariana, height in the Boost and Barracuda, and time ...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: F Dall'Acqua G Cristina-Souza A C Santos-Mariano R Bertuzzi C Rodacki A E Lima-Silva Source Type: research

WeChat-based education and rehabilitation program in unprotected left main coronary artery disease patients after coronary artery bypass grafting: an effective approach in reducing anxiety, depression, loss to follow-up, and improving quality of life
This study aimed to investigate the effect of WeChat-based education and rehabilitation program (WERP) on anxiety, depression, health-related quality of life (HRQoL), major adverse cardiac/cerebrovascular events (MACCE)-free survival, and loss to follow-up rate in unprotected left main coronary artery disease (ULMCAD) patients after coronary artery bypass grafting (CABG). In this randomized controlled study, 140 ULMCAD patients who underwent CABG were randomly assigned to WERP group (n=70) or control care (CC) group (n=70). During the 12-month intervention period, anxiety and depression (using hospital anxiety and depressi...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Chongyi Ma Bo Wang Xiaomeng Zhao Fan Fu Lei Zheng Guorong Li Qingfeng Guo Source Type: research

Death trends based on autopsy data compared to the beginning of the coronavirus pandemic in Brazil
Braz J Med Biol Res. 2021 Feb 12;54(4):e10766. doi: 10.1590/1414-431X202010766. eCollection 2021.ABSTRACTThe novel Coronavirus disease (COVID-19) is responsible for thousands of deaths worldwide, especially in Brazil, currently one of the leading countries in number of infections and deaths. The beginning of the COVID-19 epidemic in Brazil is uncertain due to the low number of tests done in the country. The excess number of deaths can suggest the beginning of the pandemic in this context. In this article, we used an autoregressive integrated moving average (ARIMA) model to investigate possible excesses in the number of dea...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: G A A Gimenez Junior P K Zilli L F F Silva C A Pasqualucci A B Campo C K Suemoto Source Type: research

Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice
This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS ApoE-/- mouse model was established. The mice were treated with HFD, different doses of NAR and simvastatin (Simv). After drug treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), superoxide dismutase (SOD), and alanine aminotransferase (ALT) were determined. The expression of interleukin-6 (IL-6) and...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Ruifeng Zhao Hanyan Xiao Tao Jin Feng Xu Yan Li Haiyan Li Zhouyi Zhang Yan Zhang Source Type: research

Demographics and clinical features of elderly patients undergoing regular dialysis in Brazil
The objective of this study was to report the clinical and socio-demographic data of end-stage renal disease (ESRD) adult patients undergoing regular dialysis treatment comparing elderly (≥65 years old) and non-elderly subjects using data from the Brazilian Dialysis Registry database. The regional distribution of the sample was Southeast (48.8%), South (33.7), Northeast (13.1%), Midwest (5.1%), and North (0.1%). A total of 18,030 patients were included in the analysis with elderly patients accounting for 29.5% of the sample. The elderly patients were predominantly male, white, retired, and literate. Elderly ESRD patient...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: J G Gon çalves J R Lugon M M do Nascimento R C Sesso Source Type: research

Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload
Braz J Med Biol Res. 2021 Feb 12;54(4):e10138. doi: 10.1590/1414-431X202010138. eCollection 2021.ABSTRACTSarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and sarcolemmal Na+/Ca2+ exchanger (NCX1) structures are involved in heart cell Ca2+ homeostasis. Previous studies have shown discrepancies in their function and expression in heart failure. The goal of this study was to evaluate heart function and hypertrophied muscle Ca2+-handling protein behavior under pressure overload. Twenty male Wistar rats were divided into two groups: Aortic stenosis (AoS), induced by a clip placed at the beginning of the aorta, and Control (Sham). A...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: I F S Mazeto K Okoshi C F S M P Silveira P G Sant'Ana V L da Silva G A F Mota S L B de Souza D F Vileigas C R Padovani A C Cicogna Source Type: research

microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA cho...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research

Caffeine ingestion improves specific artistic swimming tasks
Braz J Med Biol Res. 2021 Feb 12;54(4):e10346. doi: 10.1590/1414-431X202010346. eCollection 2021.ABSTRACTThe main movements of artistic swimming demand various physical capacities such as flexibility, strength, power, and muscular endurance. The use of ergogenic resources to potentialize performance in this sport, however, is underexplored and deserves investigation. In the present study, we tested whether caffeine ingestion would improve the execution of movements that are essential in a typical figure competition or routines in artistic swimming (i.e., amplitude in the Ariana, height in the Boost and Barracuda, and time ...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: F Dall'Acqua G Cristina-Souza A C Santos-Mariano R Bertuzzi C Rodacki A E Lima-Silva Source Type: research

WeChat-based education and rehabilitation program in unprotected left main coronary artery disease patients after coronary artery bypass grafting: an effective approach in reducing anxiety, depression, loss to follow-up, and improving quality of life
This study aimed to investigate the effect of WeChat-based education and rehabilitation program (WERP) on anxiety, depression, health-related quality of life (HRQoL), major adverse cardiac/cerebrovascular events (MACCE)-free survival, and loss to follow-up rate in unprotected left main coronary artery disease (ULMCAD) patients after coronary artery bypass grafting (CABG). In this randomized controlled study, 140 ULMCAD patients who underwent CABG were randomly assigned to WERP group (n=70) or control care (CC) group (n=70). During the 12-month intervention period, anxiety and depression (using hospital anxiety and depressi...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Chongyi Ma Bo Wang Xiaomeng Zhao Fan Fu Lei Zheng Guorong Li Qingfeng Guo Source Type: research

Death trends based on autopsy data compared to the beginning of the coronavirus pandemic in Brazil
Braz J Med Biol Res. 2021 Feb 12;54(4):e10766. doi: 10.1590/1414-431X202010766. eCollection 2021.ABSTRACTThe novel Coronavirus disease (COVID-19) is responsible for thousands of deaths worldwide, especially in Brazil, currently one of the leading countries in number of infections and deaths. The beginning of the COVID-19 epidemic in Brazil is uncertain due to the low number of tests done in the country. The excess number of deaths can suggest the beginning of the pandemic in this context. In this article, we used an autoregressive integrated moving average (ARIMA) model to investigate possible excesses in the number of dea...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: G A A Gimenez Junior P K Zilli L F F Silva C A Pasqualucci A B Campo C K Suemoto Source Type: research

Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice
This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS ApoE-/- mouse model was established. The mice were treated with HFD, different doses of NAR and simvastatin (Simv). After drug treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), superoxide dismutase (SOD), and alanine aminotransferase (ALT) were determined. The expression of interleukin-6 (IL-6) and...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Ruifeng Zhao Hanyan Xiao Tao Jin Feng Xu Yan Li Haiyan Li Zhouyi Zhang Yan Zhang Source Type: research

Demographics and clinical features of elderly patients undergoing regular dialysis in Brazil
The objective of this study was to report the clinical and socio-demographic data of end-stage renal disease (ESRD) adult patients undergoing regular dialysis treatment comparing elderly (≥65 years old) and non-elderly subjects using data from the Brazilian Dialysis Registry database. The regional distribution of the sample was Southeast (48.8%), South (33.7), Northeast (13.1%), Midwest (5.1%), and North (0.1%). A total of 18,030 patients were included in the analysis with elderly patients accounting for 29.5% of the sample. The elderly patients were predominantly male, white, retired, and literate. Elderly ESRD patient...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: J G Gon çalves J R Lugon M M do Nascimento R C Sesso Source Type: research

Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload
Braz J Med Biol Res. 2021 Feb 12;54(4):e10138. doi: 10.1590/1414-431X202010138. eCollection 2021.ABSTRACTSarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and sarcolemmal Na+/Ca2+ exchanger (NCX1) structures are involved in heart cell Ca2+ homeostasis. Previous studies have shown discrepancies in their function and expression in heart failure. The goal of this study was to evaluate heart function and hypertrophied muscle Ca2+-handling protein behavior under pressure overload. Twenty male Wistar rats were divided into two groups: Aortic stenosis (AoS), induced by a clip placed at the beginning of the aorta, and Control (Sham). A...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: I F S Mazeto K Okoshi C F S M P Silveira P G Sant'Ana V L da Silva G A F Mota S L B de Souza D F Vileigas C R Padovani A C Cicogna Source Type: research

microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA cho...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research

Caffeine ingestion improves specific artistic swimming tasks
Braz J Med Biol Res. 2021 Feb 12;54(4):e10346. doi: 10.1590/1414-431X202010346. eCollection 2021.ABSTRACTThe main movements of artistic swimming demand various physical capacities such as flexibility, strength, power, and muscular endurance. The use of ergogenic resources to potentialize performance in this sport, however, is underexplored and deserves investigation. In the present study, we tested whether caffeine ingestion would improve the execution of movements that are essential in a typical figure competition or routines in artistic swimming (i.e., amplitude in the Ariana, height in the Boost and Barracuda, and time ...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: F Dall'Acqua G Cristina-Souza A C Santos-Mariano R Bertuzzi C Rodacki A E Lima-Silva Source Type: research

WeChat-based education and rehabilitation program in unprotected left main coronary artery disease patients after coronary artery bypass grafting: an effective approach in reducing anxiety, depression, loss to follow-up, and improving quality of life
This study aimed to investigate the effect of WeChat-based education and rehabilitation program (WERP) on anxiety, depression, health-related quality of life (HRQoL), major adverse cardiac/cerebrovascular events (MACCE)-free survival, and loss to follow-up rate in unprotected left main coronary artery disease (ULMCAD) patients after coronary artery bypass grafting (CABG). In this randomized controlled study, 140 ULMCAD patients who underwent CABG were randomly assigned to WERP group (n=70) or control care (CC) group (n=70). During the 12-month intervention period, anxiety and depression (using hospital anxiety and depressi...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Chongyi Ma Bo Wang Xiaomeng Zhao Fan Fu Lei Zheng Guorong Li Qingfeng Guo Source Type: research

Death trends based on autopsy data compared to the beginning of the coronavirus pandemic in Brazil
Braz J Med Biol Res. 2021 Feb 12;54(4):e10766. doi: 10.1590/1414-431X202010766. eCollection 2021.ABSTRACTThe novel Coronavirus disease (COVID-19) is responsible for thousands of deaths worldwide, especially in Brazil, currently one of the leading countries in number of infections and deaths. The beginning of the COVID-19 epidemic in Brazil is uncertain due to the low number of tests done in the country. The excess number of deaths can suggest the beginning of the pandemic in this context. In this article, we used an autoregressive integrated moving average (ARIMA) model to investigate possible excesses in the number of dea...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: G A A Gimenez Junior P K Zilli L F F Silva C A Pasqualucci A B Campo C K Suemoto Source Type: research

Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice
This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS ApoE-/- mouse model was established. The mice were treated with HFD, different doses of NAR and simvastatin (Simv). After drug treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), superoxide dismutase (SOD), and alanine aminotransferase (ALT) were determined. The expression of interleukin-6 (IL-6) and...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Ruifeng Zhao Hanyan Xiao Tao Jin Feng Xu Yan Li Haiyan Li Zhouyi Zhang Yan Zhang Source Type: research

Demographics and clinical features of elderly patients undergoing regular dialysis in Brazil
The objective of this study was to report the clinical and socio-demographic data of end-stage renal disease (ESRD) adult patients undergoing regular dialysis treatment comparing elderly (≥65 years old) and non-elderly subjects using data from the Brazilian Dialysis Registry database. The regional distribution of the sample was Southeast (48.8%), South (33.7), Northeast (13.1%), Midwest (5.1%), and North (0.1%). A total of 18,030 patients were included in the analysis with elderly patients accounting for 29.5% of the sample. The elderly patients were predominantly male, white, retired, and literate. Elderly ESRD patient...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: J G Gon çalves J R Lugon M M do Nascimento R C Sesso Source Type: research

Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload
Braz J Med Biol Res. 2021 Feb 12;54(4):e10138. doi: 10.1590/1414-431X202010138. eCollection 2021.ABSTRACTSarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and sarcolemmal Na+/Ca2+ exchanger (NCX1) structures are involved in heart cell Ca2+ homeostasis. Previous studies have shown discrepancies in their function and expression in heart failure. The goal of this study was to evaluate heart function and hypertrophied muscle Ca2+-handling protein behavior under pressure overload. Twenty male Wistar rats were divided into two groups: Aortic stenosis (AoS), induced by a clip placed at the beginning of the aorta, and Control (Sham). A...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: I F S Mazeto K Okoshi C F S M P Silveira P G Sant'Ana V L da Silva G A F Mota S L B de Souza D F Vileigas C R Padovani A C Cicogna Source Type: research

microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA cho...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research

Caffeine ingestion improves specific artistic swimming tasks
Braz J Med Biol Res. 2021 Feb 12;54(4):e10346. doi: 10.1590/1414-431X202010346. eCollection 2021.ABSTRACTThe main movements of artistic swimming demand various physical capacities such as flexibility, strength, power, and muscular endurance. The use of ergogenic resources to potentialize performance in this sport, however, is underexplored and deserves investigation. In the present study, we tested whether caffeine ingestion would improve the execution of movements that are essential in a typical figure competition or routines in artistic swimming (i.e., amplitude in the Ariana, height in the Boost and Barracuda, and time ...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: F Dall'Acqua G Cristina-Souza A C Santos-Mariano R Bertuzzi C Rodacki A E Lima-Silva Source Type: research

WeChat-based education and rehabilitation program in unprotected left main coronary artery disease patients after coronary artery bypass grafting: an effective approach in reducing anxiety, depression, loss to follow-up, and improving quality of life
This study aimed to investigate the effect of WeChat-based education and rehabilitation program (WERP) on anxiety, depression, health-related quality of life (HRQoL), major adverse cardiac/cerebrovascular events (MACCE)-free survival, and loss to follow-up rate in unprotected left main coronary artery disease (ULMCAD) patients after coronary artery bypass grafting (CABG). In this randomized controlled study, 140 ULMCAD patients who underwent CABG were randomly assigned to WERP group (n=70) or control care (CC) group (n=70). During the 12-month intervention period, anxiety and depression (using hospital anxiety and depressi...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Chongyi Ma Bo Wang Xiaomeng Zhao Fan Fu Lei Zheng Guorong Li Qingfeng Guo Source Type: research

Death trends based on autopsy data compared to the beginning of the coronavirus pandemic in Brazil
Braz J Med Biol Res. 2021 Feb 12;54(4):e10766. doi: 10.1590/1414-431X202010766. eCollection 2021.ABSTRACTThe novel Coronavirus disease (COVID-19) is responsible for thousands of deaths worldwide, especially in Brazil, currently one of the leading countries in number of infections and deaths. The beginning of the COVID-19 epidemic in Brazil is uncertain due to the low number of tests done in the country. The excess number of deaths can suggest the beginning of the pandemic in this context. In this article, we used an autoregressive integrated moving average (ARIMA) model to investigate possible excesses in the number of dea...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: G A A Gimenez Junior P K Zilli L F F Silva C A Pasqualucci A B Campo C K Suemoto Source Type: research

Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice
This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS ApoE-/- mouse model was established. The mice were treated with HFD, different doses of NAR and simvastatin (Simv). After drug treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), superoxide dismutase (SOD), and alanine aminotransferase (ALT) were determined. The expression of interleukin-6 (IL-6) and...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Ruifeng Zhao Hanyan Xiao Tao Jin Feng Xu Yan Li Haiyan Li Zhouyi Zhang Yan Zhang Source Type: research

Demographics and clinical features of elderly patients undergoing regular dialysis in Brazil
The objective of this study was to report the clinical and socio-demographic data of end-stage renal disease (ESRD) adult patients undergoing regular dialysis treatment comparing elderly (≥65 years old) and non-elderly subjects using data from the Brazilian Dialysis Registry database. The regional distribution of the sample was Southeast (48.8%), South (33.7), Northeast (13.1%), Midwest (5.1%), and North (0.1%). A total of 18,030 patients were included in the analysis with elderly patients accounting for 29.5% of the sample. The elderly patients were predominantly male, white, retired, and literate. Elderly ESRD patient...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: J G Gon çalves J R Lugon M M do Nascimento R C Sesso Source Type: research

Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload
Braz J Med Biol Res. 2021 Feb 12;54(4):e10138. doi: 10.1590/1414-431X202010138. eCollection 2021.ABSTRACTSarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and sarcolemmal Na+/Ca2+ exchanger (NCX1) structures are involved in heart cell Ca2+ homeostasis. Previous studies have shown discrepancies in their function and expression in heart failure. The goal of this study was to evaluate heart function and hypertrophied muscle Ca2+-handling protein behavior under pressure overload. Twenty male Wistar rats were divided into two groups: Aortic stenosis (AoS), induced by a clip placed at the beginning of the aorta, and Control (Sham). A...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: I F S Mazeto K Okoshi C F S M P Silveira P G Sant'Ana V L da Silva G A F Mota S L B de Souza D F Vileigas C R Padovani A C Cicogna Source Type: research

microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA cho...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research

Caffeine ingestion improves specific artistic swimming tasks
Braz J Med Biol Res. 2021 Feb 12;54(4):e10346. doi: 10.1590/1414-431X202010346. eCollection 2021.ABSTRACTThe main movements of artistic swimming demand various physical capacities such as flexibility, strength, power, and muscular endurance. The use of ergogenic resources to potentialize performance in this sport, however, is underexplored and deserves investigation. In the present study, we tested whether caffeine ingestion would improve the execution of movements that are essential in a typical figure competition or routines in artistic swimming (i.e., amplitude in the Ariana, height in the Boost and Barracuda, and time ...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: F Dall'Acqua G Cristina-Souza A C Santos-Mariano R Bertuzzi C Rodacki A E Lima-Silva Source Type: research

WeChat-based education and rehabilitation program in unprotected left main coronary artery disease patients after coronary artery bypass grafting: an effective approach in reducing anxiety, depression, loss to follow-up, and improving quality of life
This study aimed to investigate the effect of WeChat-based education and rehabilitation program (WERP) on anxiety, depression, health-related quality of life (HRQoL), major adverse cardiac/cerebrovascular events (MACCE)-free survival, and loss to follow-up rate in unprotected left main coronary artery disease (ULMCAD) patients after coronary artery bypass grafting (CABG). In this randomized controlled study, 140 ULMCAD patients who underwent CABG were randomly assigned to WERP group (n=70) or control care (CC) group (n=70). During the 12-month intervention period, anxiety and depression (using hospital anxiety and depressi...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Chongyi Ma Bo Wang Xiaomeng Zhao Fan Fu Lei Zheng Guorong Li Qingfeng Guo Source Type: research

Death trends based on autopsy data compared to the beginning of the coronavirus pandemic in Brazil
Braz J Med Biol Res. 2021 Feb 12;54(4):e10766. doi: 10.1590/1414-431X202010766. eCollection 2021.ABSTRACTThe novel Coronavirus disease (COVID-19) is responsible for thousands of deaths worldwide, especially in Brazil, currently one of the leading countries in number of infections and deaths. The beginning of the COVID-19 epidemic in Brazil is uncertain due to the low number of tests done in the country. The excess number of deaths can suggest the beginning of the pandemic in this context. In this article, we used an autoregressive integrated moving average (ARIMA) model to investigate possible excesses in the number of dea...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: G A A Gimenez Junior P K Zilli L F F Silva C A Pasqualucci A B Campo C K Suemoto Source Type: research

Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice
This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS ApoE-/- mouse model was established. The mice were treated with HFD, different doses of NAR and simvastatin (Simv). After drug treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), superoxide dismutase (SOD), and alanine aminotransferase (ALT) were determined. The expression of interleukin-6 (IL-6) and...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Ruifeng Zhao Hanyan Xiao Tao Jin Feng Xu Yan Li Haiyan Li Zhouyi Zhang Yan Zhang Source Type: research

Demographics and clinical features of elderly patients undergoing regular dialysis in Brazil
The objective of this study was to report the clinical and socio-demographic data of end-stage renal disease (ESRD) adult patients undergoing regular dialysis treatment comparing elderly (≥65 years old) and non-elderly subjects using data from the Brazilian Dialysis Registry database. The regional distribution of the sample was Southeast (48.8%), South (33.7), Northeast (13.1%), Midwest (5.1%), and North (0.1%). A total of 18,030 patients were included in the analysis with elderly patients accounting for 29.5% of the sample. The elderly patients were predominantly male, white, retired, and literate. Elderly ESRD patient...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: J G Gon çalves J R Lugon M M do Nascimento R C Sesso Source Type: research

Calcium homeostasis behavior and cardiac function on left ventricular remodeling by pressure overload
Braz J Med Biol Res. 2021 Feb 12;54(4):e10138. doi: 10.1590/1414-431X202010138. eCollection 2021.ABSTRACTSarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and sarcolemmal Na+/Ca2+ exchanger (NCX1) structures are involved in heart cell Ca2+ homeostasis. Previous studies have shown discrepancies in their function and expression in heart failure. The goal of this study was to evaluate heart function and hypertrophied muscle Ca2+-handling protein behavior under pressure overload. Twenty male Wistar rats were divided into two groups: Aortic stenosis (AoS), induced by a clip placed at the beginning of the aorta, and Control (Sham). A...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: I F S Mazeto K Okoshi C F S M P Silveira P G Sant'Ana V L da Silva G A F Mota S L B de Souza D F Vileigas C R Padovani A C Cicogna Source Type: research

microRNA-130b downregulation potentiates chondrogenic differentiation of bone marrow mesenchymal stem cells by targeting SOX9
Braz J Med Biol Res. 2021 Feb 12;54(4):e10345. doi: 10.1590/1414-431X202010345. eCollection 2021.ABSTRACTOsteoarthritis (OA) is a chronic health condition. MicroRNAs (miRs) are critical in chondrocyte apoptosis in OA. We aimed to investigate the mechanism of miR-130b in OA progression. Bone marrow mesenchymal stem cells (BMSCs) and chondrocytes were first extracted. Chondrogenic differentiation of BMSCs was carried out and verified. Chondrocytes were stimulated with interleukin (IL)-1β to imitate OA condition in vitro. The effect of miR-130b on the viability, inflammation, apoptosis, and extracellular matrix of OA cho...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Penggui Zhang Guangming Gao Ziyu Zhou Xuejun He Source Type: research

Caffeine ingestion improves specific artistic swimming tasks
Braz J Med Biol Res. 2021 Feb 12;54(4):e10346. doi: 10.1590/1414-431X202010346. eCollection 2021.ABSTRACTThe main movements of artistic swimming demand various physical capacities such as flexibility, strength, power, and muscular endurance. The use of ergogenic resources to potentialize performance in this sport, however, is underexplored and deserves investigation. In the present study, we tested whether caffeine ingestion would improve the execution of movements that are essential in a typical figure competition or routines in artistic swimming (i.e., amplitude in the Ariana, height in the Boost and Barracuda, and time ...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: F Dall'Acqua G Cristina-Souza A C Santos-Mariano R Bertuzzi C Rodacki A E Lima-Silva Source Type: research

WeChat-based education and rehabilitation program in unprotected left main coronary artery disease patients after coronary artery bypass grafting: an effective approach in reducing anxiety, depression, loss to follow-up, and improving quality of life
This study aimed to investigate the effect of WeChat-based education and rehabilitation program (WERP) on anxiety, depression, health-related quality of life (HRQoL), major adverse cardiac/cerebrovascular events (MACCE)-free survival, and loss to follow-up rate in unprotected left main coronary artery disease (ULMCAD) patients after coronary artery bypass grafting (CABG). In this randomized controlled study, 140 ULMCAD patients who underwent CABG were randomly assigned to WERP group (n=70) or control care (CC) group (n=70). During the 12-month intervention period, anxiety and depression (using hospital anxiety and depressi...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Chongyi Ma Bo Wang Xiaomeng Zhao Fan Fu Lei Zheng Guorong Li Qingfeng Guo Source Type: research

Death trends based on autopsy data compared to the beginning of the coronavirus pandemic in Brazil
Braz J Med Biol Res. 2021 Feb 12;54(4):e10766. doi: 10.1590/1414-431X202010766. eCollection 2021.ABSTRACTThe novel Coronavirus disease (COVID-19) is responsible for thousands of deaths worldwide, especially in Brazil, currently one of the leading countries in number of infections and deaths. The beginning of the COVID-19 epidemic in Brazil is uncertain due to the low number of tests done in the country. The excess number of deaths can suggest the beginning of the pandemic in this context. In this article, we used an autoregressive integrated moving average (ARIMA) model to investigate possible excesses in the number of dea...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: G A A Gimenez Junior P K Zilli L F F Silva C A Pasqualucci A B Campo C K Suemoto Source Type: research

Naringenin promotes cell autophagy to improve high-fat-diet-induced atherosclerosis in ApoE-/- mice
This study aims to investigate the mechanism of NAR in high-fat-diet (HFD)-induced atherosclerosis (AS) in apolipoprotein E-knockout (ApoE-/-) mice. A HFD-induced AS ApoE-/- mouse model was established. The mice were treated with HFD, different doses of NAR and simvastatin (Simv). After drug treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), superoxide dismutase (SOD), and alanine aminotransferase (ALT) were determined. The expression of interleukin-6 (IL-6) and...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: Ruifeng Zhao Hanyan Xiao Tao Jin Feng Xu Yan Li Haiyan Li Zhouyi Zhang Yan Zhang Source Type: research

Demographics and clinical features of elderly patients undergoing regular dialysis in Brazil
The objective of this study was to report the clinical and socio-demographic data of end-stage renal disease (ESRD) adult patients undergoing regular dialysis treatment comparing elderly (≥65 years old) and non-elderly subjects using data from the Brazilian Dialysis Registry database. The regional distribution of the sample was Southeast (48.8%), South (33.7), Northeast (13.1%), Midwest (5.1%), and North (0.1%). A total of 18,030 patients were included in the analysis with elderly patients accounting for 29.5% of the sample. The elderly patients were predominantly male, white, retired, and literate. Elderly ESRD patient...
Source: Braz J Med Biol Res - February 24, 2021 Category: Research Authors: J G Gon çalves J R Lugon M M do Nascimento R C Sesso Source Type: research

Racial inequality in perinatal outcomes in two Brazilian birth cohorts
This study aimed to estimate and compare racial inequality in low birth weight (LBW), preterm birth (PTB), and intrauterine growth restriction (IUGR) in two Brazilian birth cohorts. This was a cross-sectional study nested within two birth cohorts in Ribeirão Preto (RP) and São Luís (SL), whose mothers were interviewed from January to December 2010. In all, 7430 (RP) and 4995 (SL) mothers were interviewed. The maternal skin color was the exposure variable. Associations were adjusted for socioeconomic and biological covariates: maternal education, per capita family income, family economic classification,...
Source: Braz J Med Biol Res - January 27, 2021 Category: Research Authors: J M Fonseca A A M Silva P R H Rocha R L F Batista E B A F Thomaz F Lamy-Filho M A Barbieri H Bettiol Source Type: research

Is soft drink consumption associated with gestational hypertension? Results from the BRISA cohort
This study investigated the association between soft drink consumption and hypertension during pregnancy, analyzing the relationship from the perspective of counterfactual causal theory. Data from pregnant women of the BRISA cohort were analyzed (1,380 in São Luis and 1,370 in Ribeirão Preto, Brazil). The explanatory variable was the frequency of soft drink consumption during pregnancy obtained in a prenatal interview. The outcome was gestational hypertension based on medical diagnosis, at the time of delivery. A theoretical model of the association between soft drink consumption and gestational hypertension ...
Source: Braz J Med Biol Res - January 27, 2021 Category: Research Authors: J M A Barbosa A A M da Silva G Kac V M F Sim ões H Bettiol R C Cavalli M A Barbieri C C C Ribeiro Source Type: research