A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats
This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for the treatment of indomethacin-induced duodenitis in rats. Adult male Wistar rats were given indomethacin (10 mg/kg/day) for four weeks. They were divided into a positive control group (PC, untreated) and two groups treated orally with 3 mg/kg per day of OM or OMZ for the last two weeks of the 4-week indomethacin-treatment. At end of the four weeks, blood and duodenum were collected. Duodenal homogenate was used for measurement of...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: H A Murad T M Alqurashi Source Type: research
In vitro effects of lapachol and β-lapachone against Leishmania amazonensis
This study evaluated the activity of the bioactive naphthoquinones, lapachol and β-lapachone, against Leishmania amazonensis. The cell alterations were evaluated in vitro on promastigote and amastigote forms. The lethal dose (LD50) at 24, 48, and 72 h on the promastigote's forms using lapachol was 75.60, 72.82, and 58.85 μg/mL and for β-lapachone was 0.65, 1.24, and 0.71 μg/mL, respectively. The naphthoquinones significantly inhibited the survival rate of L. amazonensis amastigotes at 83.11, 57.59, and 34.95% for lapachol (82.28, 41.14, and 20.57 µg/mL), and 78.49, 83.25, and 80.22% for β-lapachone (3.26, 1.63, and 0...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: Á C F H Ramos-Milaré B G Sydor A Á Brustolin D S S L Lera-Nonose J Oyama E L Silva W Caetano K S S Campanholi I G Demarchi T G V Silveira M V C Lonardoni Source Type: research
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2
This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used. The rats were randomly divided into four equal groups, and sepsis was induced in 30 rats by intraperitoneal administration of a fecal saline solution prepared from rat feces. Group 1: normal control (n=10) [non-surgical], Group 2: fecal intraperitoneal injection (FIP) (n=10) [untreated septic group], Group 3: FIP+saline (placebo) (n=10) [saline administered intraperitoneally], Group 4 (n=10): FIP+sulfasalazin...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: C Dibeko ğlu Y Uyan ıkgil O Erba ş Source Type: research
Repetitive transcranial magnetic stimulation for treatment of limb spasticity following multiple sclerosis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 May 29;56:e12708. doi: 10.1590/1414-431X2023e12708. eCollection 2023.ABSTRACTPilot trials have suggested that repetitive transcranial magnetic stimulation (rTMS) may reduce limb spasticity in multiple sclerosis (MS). We carried out the current meta-analysis to synthesize currently available evidence regarding such correlation. Up to November 2022, five international electronic databases (Cochrane CENTRAL, PubMed, Embase, Web of Science, and CINAHL) and four Chinese electronic databases (CBM, CNKI, WanFang Data, and VIP) were systematically searched to identify randomized trials comparing active rT...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: Dongyun Su Anzi Wang Meirong Zhu Fei Yang Wei Li Bo Ma Min Liu Zongqi Li Bo Wang Huanyi Tu Bo Ning Source Type: research
High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil
Braz J Med Biol Res. 2023 May 29;56:e12720. doi: 10.1590/1414-431X2023e12720. eCollection 2023.ABSTRACTCervical cancer is a serious public health problem in Brazil, especially in Manaus (Amazonas), the city with the highest incidence rate of cervical cancer in the country. Persistent infection with oncogenic human papillomavirus (HPV) genotypes is the cause of disease development. The aim of this study was to investigate the prevalence of oncogenic genotypes in women at high risk for cervical precancer examined in two policlinics in Manaus. One hundred and two patients who underwent colposcopy took part in the research. Th...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: C Fantin J B Freitas H F M Teles B A S Oliveira D V Brito Source Type: research
A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats
This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for the treatment of indomethacin-induced duodenitis in rats. Adult male Wistar rats were given indomethacin (10 mg/kg/day) for four weeks. They were divided into a positive control group (PC, untreated) and two groups treated orally with 3 mg/kg per day of OM or OMZ for the last two weeks of the 4-week indomethacin-treatment. At end of the four weeks, blood and duodenum were collected. Duodenal homogenate was used for measurement of...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: H A Murad T M Alqurashi Source Type: research
In vitro effects of lapachol and β-lapachone against Leishmania amazonensis
This study evaluated the activity of the bioactive naphthoquinones, lapachol and β-lapachone, against Leishmania amazonensis. The cell alterations were evaluated in vitro on promastigote and amastigote forms. The lethal dose (LD50) at 24, 48, and 72 h on the promastigote's forms using lapachol was 75.60, 72.82, and 58.85 μg/mL and for β-lapachone was 0.65, 1.24, and 0.71 μg/mL, respectively. The naphthoquinones significantly inhibited the survival rate of L. amazonensis amastigotes at 83.11, 57.59, and 34.95% for lapachol (82.28, 41.14, and 20.57 µg/mL), and 78.49, 83.25, and 80.22% for β-lapachone (3.26, 1.63, and 0...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: Á C F H Ramos-Milaré B G Sydor A Á Brustolin D S S L Lera-Nonose J Oyama E L Silva W Caetano K S S Campanholi I G Demarchi T G V Silveira M V C Lonardoni Source Type: research
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2
This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used. The rats were randomly divided into four equal groups, and sepsis was induced in 30 rats by intraperitoneal administration of a fecal saline solution prepared from rat feces. Group 1: normal control (n=10) [non-surgical], Group 2: fecal intraperitoneal injection (FIP) (n=10) [untreated septic group], Group 3: FIP+saline (placebo) (n=10) [saline administered intraperitoneally], Group 4 (n=10): FIP+sulfasalazin...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: C Dibeko ğlu Y Uyan ıkgil O Erba ş Source Type: research
Repetitive transcranial magnetic stimulation for treatment of limb spasticity following multiple sclerosis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 May 29;56:e12708. doi: 10.1590/1414-431X2023e12708. eCollection 2023.ABSTRACTPilot trials have suggested that repetitive transcranial magnetic stimulation (rTMS) may reduce limb spasticity in multiple sclerosis (MS). We carried out the current meta-analysis to synthesize currently available evidence regarding such correlation. Up to November 2022, five international electronic databases (Cochrane CENTRAL, PubMed, Embase, Web of Science, and CINAHL) and four Chinese electronic databases (CBM, CNKI, WanFang Data, and VIP) were systematically searched to identify randomized trials comparing active rT...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: Dongyun Su Anzi Wang Meirong Zhu Fei Yang Wei Li Bo Ma Min Liu Zongqi Li Bo Wang Huanyi Tu Bo Ning Source Type: research
High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil
Braz J Med Biol Res. 2023 May 29;56:e12720. doi: 10.1590/1414-431X2023e12720. eCollection 2023.ABSTRACTCervical cancer is a serious public health problem in Brazil, especially in Manaus (Amazonas), the city with the highest incidence rate of cervical cancer in the country. Persistent infection with oncogenic human papillomavirus (HPV) genotypes is the cause of disease development. The aim of this study was to investigate the prevalence of oncogenic genotypes in women at high risk for cervical precancer examined in two policlinics in Manaus. One hundred and two patients who underwent colposcopy took part in the research. Th...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: C Fantin J B Freitas H F M Teles B A S Oliveira D V Brito Source Type: research
A novel nano-formulation of olmesartan medoxomil with improved delivery and efficacy in the treatment of indomethacin-induced duodenitis in rats
This study was designed to investigate the effects of a recently developed biotechnological product, a nano-formulation of olmesartan medoxomil (OM) - olmesartan medoxomil zeinmersomes (OMZ) - for the treatment of indomethacin-induced duodenitis in rats. Adult male Wistar rats were given indomethacin (10 mg/kg/day) for four weeks. They were divided into a positive control group (PC, untreated) and two groups treated orally with 3 mg/kg per day of OM or OMZ for the last two weeks of the 4-week indomethacin-treatment. At end of the four weeks, blood and duodenum were collected. Duodenal homogenate was used for measurement of...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: H A Murad T M Alqurashi Source Type: research
In vitro effects of lapachol and β-lapachone against Leishmania amazonensis
This study evaluated the activity of the bioactive naphthoquinones, lapachol and β-lapachone, against Leishmania amazonensis. The cell alterations were evaluated in vitro on promastigote and amastigote forms. The lethal dose (LD50) at 24, 48, and 72 h on the promastigote's forms using lapachol was 75.60, 72.82, and 58.85 μg/mL and for β-lapachone was 0.65, 1.24, and 0.71 μg/mL, respectively. The naphthoquinones significantly inhibited the survival rate of L. amazonensis amastigotes at 83.11, 57.59, and 34.95% for lapachol (82.28, 41.14, and 20.57 µg/mL), and 78.49, 83.25, and 80.22% for β-lapachone (3.26, 1.63, and 0...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: Á C F H Ramos-Milaré B G Sydor A Á Brustolin D S S L Lera-Nonose J Oyama E L Silva W Caetano K S S Campanholi I G Demarchi T G V Silveira M V C Lonardoni Source Type: research
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2
This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used. The rats were randomly divided into four equal groups, and sepsis was induced in 30 rats by intraperitoneal administration of a fecal saline solution prepared from rat feces. Group 1: normal control (n=10) [non-surgical], Group 2: fecal intraperitoneal injection (FIP) (n=10) [untreated septic group], Group 3: FIP+saline (placebo) (n=10) [saline administered intraperitoneally], Group 4 (n=10): FIP+sulfasalazin...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: C Dibeko ğlu Y Uyan ıkgil O Erba ş Source Type: research
Repetitive transcranial magnetic stimulation for treatment of limb spasticity following multiple sclerosis: a systematic review and meta-analysis
Braz J Med Biol Res. 2023 May 29;56:e12708. doi: 10.1590/1414-431X2023e12708. eCollection 2023.ABSTRACTPilot trials have suggested that repetitive transcranial magnetic stimulation (rTMS) may reduce limb spasticity in multiple sclerosis (MS). We carried out the current meta-analysis to synthesize currently available evidence regarding such correlation. Up to November 2022, five international electronic databases (Cochrane CENTRAL, PubMed, Embase, Web of Science, and CINAHL) and four Chinese electronic databases (CBM, CNKI, WanFang Data, and VIP) were systematically searched to identify randomized trials comparing active rT...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: Dongyun Su Anzi Wang Meirong Zhu Fei Yang Wei Li Bo Ma Min Liu Zongqi Li Bo Wang Huanyi Tu Bo Ning Source Type: research
High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil
Braz J Med Biol Res. 2023 May 29;56:e12720. doi: 10.1590/1414-431X2023e12720. eCollection 2023.ABSTRACTCervical cancer is a serious public health problem in Brazil, especially in Manaus (Amazonas), the city with the highest incidence rate of cervical cancer in the country. Persistent infection with oncogenic human papillomavirus (HPV) genotypes is the cause of disease development. The aim of this study was to investigate the prevalence of oncogenic genotypes in women at high risk for cervical precancer examined in two policlinics in Manaus. One hundred and two patients who underwent colposcopy took part in the research. Th...
Source: Braz J Med Biol Res - May 31, 2023 Category: Research Authors: C Fantin J B Freitas H F M Teles B A S Oliveira D V Brito Source Type: research
