Cancers, Vol. 16, Pages 1799: CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

Cancers, Vol. 16, Pages 1799: CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms Cancers doi: 10.3390/cancers16101799 Authors: David Sanchis-Pascual María Isabel Del Olmo-García Stefan Prado-Wohlwend Carlos Zac-Romero Ángel Segura Huerta Javier Hernández-Gil Luis Martí-Bonmatí Juan Francisco Merino-Torres There are several well-described molecular mechanisms that influence cell growth and are related to the development of cancer. Chemokines constitute a fundamental element that is not only involved in local growth but also affects angiogenesis, tumor spread, and metastatic disease. Among them, the C-X-C motif chemokine ligand 12 (CXCL12) and its specific receptor the chemokine C-X-C motif receptor 4 (CXCR4) have been widely studied. The overexpression in cell membranes of CXCR4 has been shown to be associated with the development of different kinds of histological malignancies, such as adenocarcinomas, epidermoid carcinomas, mesenchymal tumors, or neuroendocrine neoplasms (NENs). The molecular synapsis between CXCL12 and CXCR4 leads to the interaction of G proteins and the activation of different intracellular signaling pathways in both gastroenteropancreatic (GEP) and bronchopulmonary (BP) NENs, conferring greater capacity for locoregional aggressiveness, the epithelial–mesenchymal transition (EMT), and the appearance of metastases. Therefore, it has been hypothesized as to how to design tools that target this...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research