Cancers, Vol. 16, Pages 1799: CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
Cancers, Vol. 16, Pages 1799: CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms
Cancers doi: 10.3390/cancers16101799
Authors:
David Sanchis-Pascual
María Isabel Del Olmo-García
Stefan Prado-Wohlwend
Carlos Zac-Romero
Ángel Segura Huerta
Javier Hernández-Gil
Luis Martí-Bonmatí
Juan Francisco Merino-Torres
There are several well-described molecular mechanisms that influence cell growth and are related to the development of cancer. Chemokines constitute a fundamental element that is not only involved in local growth but also affects angiogenesis, tumor spread, and metastatic disease. Among them, the C-X-C motif chemokine ligand 12 (CXCL12) and its specific receptor the chemokine C-X-C motif receptor 4 (CXCR4) have been widely studied. The overexpression in cell membranes of CXCR4 has been shown to be associated with the development of different kinds of histological malignancies, such as adenocarcinomas, epidermoid carcinomas, mesenchymal tumors, or neuroendocrine neoplasms (NENs). The molecular synapsis between CXCL12 and CXCR4 leads to the interaction of G proteins and the activation of different intracellular signaling pathways in both gastroenteropancreatic (GEP) and bronchopulmonary (BP) NENs, conferring greater capacity for locoregional aggressiveness, the epithelial–mesenchymal transition (EMT), and the appearance of metastases. Therefore, it has been hypothesized as to how to design tools that target this...
Source: Cancers - Category: Cancer & Oncology Authors: David Sanchis-Pascual Mar ía Isabel Del Olmo-García Stefan Prado-Wohlwend Carlos Zac-Romero Ángel Segura Huerta Javier Hern ández-Gil Luis Mart í-Bonmatí Juan Francisco Merino-Torres Tags: Review Source Type: research
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