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FDA Approves First Treatment for Nonmetastatic CRPC
The US Food and Drug Administration (FDA) has approved the oral agent apalutamide (Erleada) for the treatment of nonmetastatic castration-resistant prostate cancer. The oral androgen-receptor inhibitor is the first FDA-approved treatment for patients with nonmetastatic castration-resistant disease and the first to be approved based on the endpoint of metastasis-free survival. (Source: CancerNetwork)
Source: CancerNetwork - February 16, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Editorial Men ' s Health Prostate Cancer Source Type: news

Pazopanib Improves PFS in Extensive-Disease SCLC, But Adds Toxicity
Maintenance therapy with pazopanib significantly prolonged progression-free survival in patients with extensive-disease small-cell lung cancer, but with toxicity. (Source: CancerNetwork)
Source: CancerNetwork - February 16, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Lung Cancer News Source Type: news

Bone Markers Can Predict Bone-Specific Recurrence in Early Breast Cancer
Several markers of bone formation and resorption were found to be predictive of bone-specific recurrence in patients with early breast cancer. (Source: CancerNetwork)
Source: CancerNetwork - February 15, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer News Source Type: news

Polyp Burden Drops With Sulindac/Erlotinib Combo in FAP
Patients with familial adenomatous polyposis have an increased risk for colorectal polyps and cancer; however, treatment with a combination of sulindac and erlotinib reduced their colorectal polyp burden by more than two thirds. (Source: CancerNetwork)
Source: CancerNetwork - February 15, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Colorectal Cancer Genetic Disorders News Source Type: news

Quiz: Molecular Risk Stratification in Acute Myeloid Leukemia
Test your knowledge in our latest quiz. (Source: CancerNetwork)
Source: CancerNetwork - February 1, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Hematologic Malignancies Quiz Source Type: news

Guidelines for Imaging the Full Spectrum of SpA
(Source: CancerNetwork)
Source: CancerNetwork - February 1, 2018 Category: Cancer & Oncology Authors: Rita Baron Faust Source Type: news

Therapeutic Vaccine Combination May Help Patients with Myelodysplastic Syndrome
A new study demonstrates that it is possible to vaccinate patients with MDS against a decitabine-induced antigen and that the level of induced expression is sufficient to trigger cytotoxicity in patient-derived vaccine induced T-cells. (Source: CancerNetwork)
Source: CancerNetwork - January 30, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Hematologic Malignancies Myelodysplastic Syndromes News Source Type: news

New Genetic Sequence Data Map May Lead to New Immunotherapies
ImmunoMap, which can examine T-cell receptor repertoire relatedness, may help predict clinical outcome for patients with cancer and could be a new tool for designing vaccines and immunotherapies. (Source: CancerNetwork)
Source: CancerNetwork - January 26, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Cancer and Genetics News Source Type: news

No Benefit With Bevacizumab Maintenance Therapy for Metastatic CRC During Chemo-Free Intervals
Adding bevacizumab maintenance therapy failed to improve outcomes compared with no treatment when administered during chemotherapy-free intervals to patients with metastatic colorectal cancer after induction chemotherapy. (Source: CancerNetwork)
Source: CancerNetwork - January 25, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

ASCO Guideline Offers Recommendations for Management of Mesothelioma
ASCO recently released a clinical practice guideline on the treatment of malignant pleural mesothelioma, including recommendations on diagnosis, staging, and treatment with chemotherapy, surgical cytoreduction, and radiation therapy. (Source: CancerNetwork)
Source: CancerNetwork - January 24, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Lung Cancer Mesothelioma News Source Type: news

Engineered Tumor-Specific T Cells May Help Relapsed Hodgkin Lymphoma Patients
A recent study found that Hodgkin lymphoma patients with active disease achieved clinical responses with tumor-specific T cells that were genetically modified to be rendered resistant to transforming growth factor beta, a cytokine expressed by most human cancers. (Source: CancerNetwork)
Source: CancerNetwork - January 24, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Hematologic Malignancies Hodgkin Lymphoma News Source Type: news

Engineered Tumor-Specific T-Cells May Help Relapsed Hodgkin Lymphoma Patients
A recent study found that Hodgkin lymphoma patients with active disease achieved clinical responses with tumor-specific T-cells that were genetically modified to be rendered resistant to transforming growth factor beta, a cytokine expressed by most human cancers. (Source: CancerNetwork)
Source: CancerNetwork - January 24, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Hematologic Malignancies Hodgkin Lymphoma News Source Type: news

Nivolumab Plus Ipilimumab Offers Improved Survival Outcomes in Certain Metastatic CRC Patients
Patients with DNA mismatch repair-deficient/microsatellite instability-high metastatic colorectal cancer who received nivolumab along with ipilimumab had high response rates and improved survival outcomes compared with those who received nivolumab alone. (Source: CancerNetwork)
Source: CancerNetwork - January 23, 2018 Category: Cancer & Oncology Authors: Dave Levitan Tags: Colorectal Cancer News Source Type: news

Metastatic Melanoma Patients May Benefit from Beta Blockers
Researchers discovered that melanoma patients who received immunotherapy while taking a pan beta blocker lived longer than patients who received immunotherapy alone. (Source: CancerNetwork)
Source: CancerNetwork - January 22, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Melanoma News Source Type: news

New Analytical Tool May Determine How DCIS Invasion Occurs
A new analytical tool called topographic single-cell sequencing can reveal a direct genomic lineage between in situ and invasive tumor subpopulations, which may help decipher how and why some DCIS become invasive. (Source: CancerNetwork)
Source: CancerNetwork - January 16, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Breast Cancer News Source Type: news

CDC Confirms Persisting Racial Disparities in Cancer Survival
Survival disparities for black patients with ovarian, colon, and breast cancer and childhood ALL suggest a need for efforts toward improved screening and treatment adherence in this population. (Source: CancerNetwork)
Source: CancerNetwork - January 2, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Tags: News Practice & Policy Source Type: news

Community Oncology Practices Poorly Implement Breast MRI Screening Guidelines
A recent analysis from the Breast Cancer Surveillance Consortium revealed that community oncology practices are neglecting to use MRI screening for at-risk women, and lower-risk women are being unnecessarily screened. (Source: CancerNetwork)
Source: CancerNetwork - December 21, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Breast Cancer News Practice & Policy Source Type: news

DNA-Demethylating Agents Combined with Histone Deacetylase Inhibitors May Help Combat NSCLC
The combination therapy increased the attraction of immune cells to fight non-small cell lung cancer and also boosted the response to immune checkpoint inhibitors. (Source: CancerNetwork)
Source: CancerNetwork - December 21, 2017 Category: Cancer & Oncology Authors: John Schieszer Tags: Immuno Oncology Lung Cancer Targets News Source Type: news

Top Lung Cancer News of 2017
In this slide show we highlight some of the top news on lung cancer in 2017, including FDA approvals, a new standard of care for ALK-positive lung cancer, increased risk with vitamin B supplements, and more. (Source: CancerNetwork)
Source: CancerNetwork - December 20, 2017 Category: Cancer & Oncology Authors: Cancer Network Editors Tags: Lung Cancer Lung Cancer Year in Review 2017 Source Type: news

Endings & amp; Beginnings —Grief, Loss, and Letting Go
As an oncology health care provider, it is crucially important to process grief and loss in order to best care for yourself and your patients. (Source: CancerNetwork)
Source: CancerNetwork - December 19, 2017 Category: Cancer & Oncology Authors: Tambre Leighn, MA, CPC, ELI-MP Tags: News Oncology Nursing Source Type: news

Unmet Needs During Extended Survivorship
The needs and challenges of cancer survivors and their family members do not vanish once treatment has been completed, although their follow-up care is often not addressed sufficiently. (Source: CancerNetwork)
Source: CancerNetwork - December 19, 2017 Category: Cancer & Oncology Authors: Deborah A. Boyle, RN, MSN, AOCNS, FAAN Tags: News Oncology Nursing Survivorship Source Type: news

Top Breast Cancer News of 2017
(Source: CancerNetwork)
Source: CancerNetwork - December 19, 2017 Category: Cancer & Oncology Authors: Cancer Network Editors Tags: Breast Cancer Breast Cancer Year in Review 2017 Source Type: news

Poverty, Travel Time Drive Disparities in Access to National Cancer Institute-Designated Centers
Patient access to NCI Cancer Centers is influenced by a complex mix of cancer center distribution and density, ethnicity, urbanicity, and travel time to care, according to a recently published statistical model. (Source: CancerNetwork)
Source: CancerNetwork - December 15, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: News Practice & Policy Source Type: news

Cancer Stem Cells Underlie Testicular Cancer ’s Vulnerability to Genotoxic Chemotherapy
Researchers have discovered that testicular cancer ’s responsiveness to conventional chemotherapy is likely determined during prenatal development. (Source: CancerNetwork)
Source: CancerNetwork - December 14, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Genitourinary Cancers News Testicular Cancer Source Type: news

Rolapitant-Based Antiemetic Combination Improves CINV Symptoms
Rolapitant plus 5-HT3 receptor antagonist and dexamethasone is well tolerated and more effectively controls chemotherapy-induced nausea and vomiting compared with 5-HT3 and dexamethasone alone. (Source: CancerNetwork)
Source: CancerNetwork - December 14, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Nausea and Vomiting News Source Type: news

MMG49 Identified as a New Target in Multiple Myeloma
MMG49 has been identified as a monoclonal antibody that can be targeted using CAR T-cell therapy for patients with multiple myeloma. (Source: CancerNetwork)
Source: CancerNetwork - December 13, 2017 Category: Cancer & Oncology Authors: John Schieszer Tags: Hematologic Cancer Targets Immuno Oncology Multiple Myeloma News Source Type: news

Combo Antiemetic Therapy Safe, Effective for Testicular Cancer Patients on Cisplatin Chemotherapy
Researchers found that combining palonosetron, aprepitant, and dexamethasone represents an effective and well-tolerated treatment to prevent CINV in testicular cancer patients receiving cisplatin. (Source: CancerNetwork)
Source: CancerNetwork - December 13, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Genitourinary Cancers Nausea and Vomiting News Testicular Cancer Source Type: news

Top Hematologic Cancer News of 2017
In this slide show we highlight some of the top news on hematologic cancers in 2017, including effective therapies for pediatric hematologic malignancies, a variety of FDA approvals, new discoveries in myeloma, and more. (Source: CancerNetwork)
Source: CancerNetwork - December 12, 2017 Category: Cancer & Oncology Authors: Cancer Network Editors Tags: Hematologic Malignancies Hematologic Malignancies Year in Review 2017 Source Type: news

Ixekizumab Gets FDA Nod for Active Psoriatic Arthritis
Psoriatic arthritis is the second approved indication for Taltz in the United States. (Source: CancerNetwork)
Source: CancerNetwork - December 12, 2017 Category: Cancer & Oncology Authors: Rheumatology Network Staff Tags: Psoriatic Arthritis Source Type: news

Top Gynecologic Cancer News of 2017
(Source: CancerNetwork)
Source: CancerNetwork - December 8, 2017 Category: Cancer & Oncology Authors: Cancer Network Editors Tags: Gynecologic Cancers Conferences/Gynecologic Cancers Year in Review 2017 News Source Type: news

Could BEP Reduce the Risk of Brain Metastasis in Testicular Cancer?
A post-hoc analysis found that brain metastases are more frequent in patients with advanced germ cell tumors who have received dose-dense chemotherapy compared with those administered the BEP regimen. (Source: CancerNetwork)
Source: CancerNetwork - December 6, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Genitourinary Cancers News Testicular Cancer Source Type: news

Pretreatment Cognitive Impairment Is Common in Patients With Head and Neck Cancer
Results from a study of patients with newly diagnosed head and neck cancer indicate that cognitive screening should be incorporated into pretreatment assessment for patients in order to improve outcomes. (Source: CancerNetwork)
Source: CancerNetwork - December 1, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Head & Neck Cancer News Source Type: news

Tobacco Smoking Associated with Poor Survival Following Head and Neck Cancer Diagnosis
Researchers found a statistically significant difference in median survival time between smokers and nonsmokers at diagnosis of head and neck squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - November 30, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Head & Neck Cancer News Source Type: news

Pembrolizumab Not Active Against Cisplatin-Refractory Testicular Cancer
In a small phase II study of 12 men with nonseminoma germ cell tumors refractory to cisplatin, pembrolizumab did not demonstrate clinical activity. (Source: CancerNetwork)
Source: CancerNetwork - November 27, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Genitourinary Cancers News Testicular Cancer Source Type: news

Is Heavy Cannabis Use Associated with Testicular Cancer?
Researchers analyzed a large population-based sample of men from Sweden and discovered an association between heavy cannabis use and testicular cancer incidence. (Source: CancerNetwork)
Source: CancerNetwork - November 24, 2017 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Genitourinary Cancers News Testicular Cancer Source Type: news

Creating a Win/Win Through Teaching Patient Responsibility
When we do too much for patients, we can unintentionally reinforce their sense of not being able to address their own needs. Reinforcing patients'responsibility for their own healthcare care can result in an improved sense of empowerment and control. (Source: CancerNetwork)
Source: CancerNetwork - November 24, 2017 Category: Cancer & Oncology Authors: Tambre Leighn, MA, CPC, ELI-MP Tags: News Oncology Nursing Source Type: news

What You Need to Know Before Your First RSNA
Tips on preparing for RSNA. (Source: CancerNetwork)
Source: CancerNetwork - November 24, 2017 Category: Cancer & Oncology Authors: Jonathan Flug, MD, MBA Tags: Blog Residents Conferences/RSNA 2015 Conferences/RSNA 2016 Conferences/RSNA 2017 Source Type: news

Shock-Waves Reduce Finger Ulcers in Scleroderma
Compared with conventional treatment, extracorporeal shock-wave therapy resulted in a significant decrease in finger ulcers. (Source: CancerNetwork)
Source: CancerNetwork - November 22, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Scleroderma Systemic Sclerosis Rheumatic Diseases Source Type: news

Obesity Weighs on Spondyloarthropathy Outcomes
Patients experience higher disease activity, lower quality of life, and worse physical functioning. (Source: CancerNetwork)
Source: CancerNetwork - November 22, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Spondyloarthritis Obesity Source Type: news

The Most Overlooked Symptom in Cancer Care
Mood disorders are common mental health sequelae of cancer, but depression in patients with cancer is frequently missed by healthcare providers, and there are many reasons for this oversight. (Source: CancerNetwork)
Source: CancerNetwork - November 22, 2017 Category: Cancer & Oncology Authors: Deborah A. Boyle, RN, MSN, AOCNS, FAAN Tags: News Oncology Nursing Depression Source Type: news

Bone Marrow Swelling: Spondyloarthritis or Healthy Athlete?
MRI of the sacral spine may help determine which patients are in need of rheumatologic care. (Source: CancerNetwork)
Source: CancerNetwork - November 22, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Spondyloarthritis Source Type: news

Juvenile Onset Arthritis Raises Pregnancy Risks
The risk of pregnancy-related complications is further increased when juvenile arthritis persists into adulthood. (Source: CancerNetwork)
Source: CancerNetwork - November 21, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Arthritis Juvenile Arthritis Rheumatoid Arthritis Source Type: news

Opioid Use for Osteoarthritis Is Prevalent
A large percentage of patients with advanced knee, hip, or spine OA take opioids for their chronic pain. (Source: CancerNetwork)
Source: CancerNetwork - November 21, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Osteoarthritis Pain Pain Management Source Type: news

Rheumatoid Arthritis Linked with COPD Hospitalization
The risk is nearly twice as high as in the general population, and women are at significantly higher risk. (Source: CancerNetwork)
Source: CancerNetwork - November 21, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: COPD Rheumatoid Arthritis Source Type: news

Tofacitinib is Effective in Psoriatic Arthritis
This agent was superior to placebo in patients who had not responded to or could not take a conventional DMARD. (Source: CancerNetwork)
Source: CancerNetwork - November 21, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Psoriatic Arthritis Source Type: news

Digital Coaching Enhances Rheumatoid Arthritis Outcomes
This tool may be used to reduce stressors, improve well-being, and decrease symptoms. (Source: CancerNetwork)
Source: CancerNetwork - November 20, 2017 Category: Cancer & Oncology Authors: Mariah Zebrowski Leach, JD, MS Tags: Rheumatoid Arthritis Source Type: news

Fibromyalgia Tied to Chronic Migraines
The frequency is significantly higher than in patients with chronic tension-type headaches and the symptoms are more severe. (Source: CancerNetwork)
Source: CancerNetwork - November 16, 2017 Category: Cancer & Oncology Authors: Gregory M. Weiss, M.D. Tags: Pain Pain Management Fibromyalgia Source Type: news

New Pain Management Strategies Spelled Out
National initiatives are designed to provide education, advance research, solve the opioid crisis, and help patients. (Source: CancerNetwork)
Source: CancerNetwork - November 15, 2017 Category: Cancer & Oncology Authors: Mariah Zebrowski Leach, JD, MS Tags: Pain Pain Management Rheumatic Diseases Source Type: news

Break From Methotrexate Boosts Flu Shot Efficacy in RA
With a drug holiday, patients with rheumatoid arthritis could improve their response to influenza vaccinations without increasing disease activity. (Source: CancerNetwork)
Source: CancerNetwork - November 14, 2017 Category: Cancer & Oncology Authors: Mariah Zebrowski Leach, JD, MS Tags: Rheumatoid Arthritis Source Type: news

In RA, No Added Second Malignancy Risk With Biologics
Some physicians have shown reluctance to use these agents for patients who have rheumatoid arthritis and a previous cancer diagnosis. (Source: CancerNetwork)
Source: CancerNetwork - November 14, 2017 Category: Cancer & Oncology Authors: Mariah Zebrowski Leach, JD, MS Tags: Rheumatoid Arthritis Source Type: news