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Is Pseudoprogression in Lung Cancer Real?
This video reviews pseudoprogression in non –small-cell lung cancer, including the incidence of this phenomenon and treatment considerations when it arises. (Source: CancerNetwork)
Source: CancerNetwork - July 23, 2017 Category: Cancer & Oncology Authors: Dickran Kazandjian, MD Tags: Videos Lung Cancer Source Type: news

Aldoxorubicin Shows Promise in Advanced Soft-Tissue Sarcoma
In this interview we discuss the phase III trial of aldoxorubicin in patients with advanced soft-tissue sarcoma, which showed improved efficacy and reduced toxicity over doxorubicin. (Source: CancerNetwork)
Source: CancerNetwork - July 22, 2017 Category: Cancer & Oncology Authors: Sant P. Chawla, MD Tags: Sarcoma Source Type: news

Breast Mass Found in 48-Year-Old Patient
A 48-year-old woman presents with a mass in her right breast, and a biopsy is obtained. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - July 21, 2017 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Tags: Image IQ Source Type: news

CML Patients Approach Normal Life Expectancy With Imatinib Treatment
Treatment with imatinib results in good overall survival in patients with chronic myeloid leukemia, approaching a normal life expectancy, according to the CML-IV study. (Source: CancerNetwork)
Source: CancerNetwork - July 21, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Chronic Myeloid Leukemia Hematologic Malignancies & Lymphoma News Source Type: news

Increased Node Dissection Improved Survival in Node-Negative Oral Cavity SCC
Higher nodal yield during definitive surgery for clinically node-negative oral cavity squamous cell carcinoma was associated with improved mortality. (Source: CancerNetwork)
Source: CancerNetwork - July 21, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Head & Neck Cancer News Source Type: news

Chemotherapy Decision-Making in Early Breast Cancer
This video discusses chemotherapy decision-making in early-stage breast cancer, and reviews tools such as PREDICT 2.0 and the MammaPrint 70-gene assay that can help guide treatment. (Source: CancerNetwork)
Source: CancerNetwork - July 21, 2017 Category: Cancer & Oncology Authors: N. Lynn Henry, MD, PhD Tags: Videos Breast Cancer Source Type: news

FDA Grants Priority Review for New Leukemia Option
The FDA has granted priority review status for two new indications of dasatinib (Sprycel), according to the drug ’s developer. (Source: CancerNetwork)
Source: CancerNetwork - July 20, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Chronic Myeloid Leukemia Hematologic Malignancies & Lymphoma News Pediatric Cancers Source Type: news

ACA Facilitates More Cancer Clinical Trial Participation
More privately insured cancer patients seeking to participate in clinical trials received approval since the passage of the Affordable Care Act, according to a new study. (Source: CancerNetwork)
Source: CancerNetwork - July 20, 2017 Category: Cancer & Oncology Authors: Mark L. Fuerst Tags: News Practice & Policy Source Type: news

FDA Expands Indication for Scalp Cooling Device to Reduce Hair Loss
The FDA has expanded the indication for a scalp cooling device that reduces hair loss during chemotherapy. (Source: CancerNetwork)
Source: CancerNetwork - July 20, 2017 Category: Cancer & Oncology Authors: Mark L. Fuerst Tags: News Source Type: news

PD-L1 Testing in Lung Cancer
This video reviews the use of PD-L1 testing in selecting patients for frontline lung cancer treatment with pembrolizumab and examines which patients might not be appropriate for immunotherapy. (Source: CancerNetwork)
Source: CancerNetwork - July 19, 2017 Category: Cancer & Oncology Authors: Aaron S. Mansfield, MD Tags: Conferences/ASCO Lung Cancer Videos Lung Cancer Source Type: news

FDA Approves Neratinib for HER2-Positive Breast Cancer
The FDA has approved neratinib (Nerlynx) for use as extended adjuvant treatment in adult patients with early-stage HER2-positive breast cancer. (Source: CancerNetwork)
Source: CancerNetwork - July 19, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer HER2-Positive Breast Cancer News Source Type: news

Drug for Relapsed, Refractory ALL Increased Hepatotoxicity
Treatment of adult relapsed or refractory acute lymphoblastic leukemia with inotuzumab ozogamicin was associated with increased hepatotoxicity, especially after follow-up hematopoietic stem cell transplantation. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Hematologic Malignancies Leukemia & Lymphoma News Source Type: news

Immunotherapy Resistance in Pancreatic Cancer
This video examines the role of immunotherapy in pancreatic cancer, highlighting the resistance to novel treatments in this setting and trials attempting to confront this problem. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2017 Category: Cancer & Oncology Authors: Gregory L. Beatty, MD, PhD Tags: Pancreatic Cancer Videos Gastrointestinal Cancers Source Type: news

Once-Daily RT Fails to Improve Over Standard in Limited-Stage SCLC
Once-daily RT given concurrently with chemotherapy showed no difference in survival compared with the twice-daily standard in small-cell lung cancer. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Lung Cancer News Source Type: news

Bisphosphonates Not Linked to Reduction in Breast Cancer Risk
The use of bisphosphonates was not associated with a decrease in the incidence of breast cancer in postmenopausal women, contrary to hypothesis. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer News Source Type: news

FDA Halts Pembrolizumab Trials in Multiple Myeloma
The US Food and Drug Administration (FDA) placed a clinical hold on three trials of the PD-1 inhibitor pembrolizumab in combination with pomalidomide or lenalidomide for patients with multiple myeloma: KEYNOTE-183, KEYNOTE-185, and KEYNOTE-023. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Hematologic Malignancies Multiple Myeloma News Source Type: news

Planned Radiation in Axillary Management of Breast Cancer
This video examines how planned radiation will impact management of the axilla in breast cancer patients undergoing mastectomy. (Source: CancerNetwork)
Source: CancerNetwork - July 17, 2017 Category: Cancer & Oncology Authors: Henry Kuerer, MD, PhD Tags: Videos Breast Cancer Source Type: news

Height, Adiposity Associated With High-Grade Prostate Cancer, Death
Taller men are at increased risk for high-grade prostate cancer and prostate cancer death, according to a large registry study. Greater adiposity is also associated with higher-grade tumors and mortality. (Source: CancerNetwork)
Source: CancerNetwork - July 17, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Genitourinary Cancers News Prostate Cancer Source Type: news

CheckMate 037: Nivolumab Improved Responses, Not Survival in Advanced Melanoma
Patients with advanced melanoma treated with nivolumab had higher and more durable responses compared with investigator ’s choice of chemotherapy, but these increases did not result in improved survival outcomes. (Source: CancerNetwork)
Source: CancerNetwork - July 17, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Melanoma News Source Type: news

Myeloproliferative Neoplasms: Translating New Discoveries Into Better Outcomes, Better Quality of Life
In this review, we demonstrate the evolving landscape of clinical investigation as researchers and clinicians attempt to address the important therapeutic needs of patients with myeloproliferative neoplasms. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Leslie Padrnos, MD Ruben A. Mesa, MD Tags: Hematologic Malignancies Oncology Journal Review Article Source Type: news

Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets —PART 1: Biologic Therapies Targeting the Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor
Here we review drugs that target the EGFR and VEGF pathways, focusing on patient selection, drug toxicities, and how to choose agents for first-line therapy. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Benjamin A. Weinberg, MD Marion L. Hartley, PhD Mohamed E. Salem, MD Tags: Colorectal Cancer Gastrointestinal Cancer Oncology Journal Review Article Source Type: news

Precision Medicine in Metastatic Colorectal Cancer: Relevant Carcinogenic Pathways and Targets —PART 2: Approaches Beyond First-Line Therapy, and Novel Biologic Agents Under Investigation
Here we review the evidence for use of biologic agents in the second-line setting and beyond. We also discuss off-label indications for biologics in selected patient populations, as well as biologics currently under development. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Benjamin A. Weinberg, MD Marion L. Hartley, PhD Mohamed E. Salem, MD Tags: Colorectal Cancer Gastrointestinal Cancer Oncology Journal Review Article Source Type: news

Don ’t Be Fooled by DCIS
A 46-year-old woman had a routine screening mammogram that showed new calcifications in the posterior left breast. A diagnostic mammogram showed several small punctate calcifications, and a 6-month interval follow-up was recommended. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Colleen D. Murphy, MD Dulcy E. Wolverton, MD Rachel A. Rabinovitch, MD Regina J. Brown, MD Sharon Sams, MD, MPH Tae Chong, MD Virginia F. Borges, MD, MMSc Tags: Breast Cancer Case Studies Oncology Journal Source Type: news

The Role of Genomic Techniques in Predicting Response to Radiation Therapy
The understanding of the relationship between genetic variation and an individual patient ’s response to radiation therapy has gained significant ground over the past several years. Genetic markers have been identified that could ultimately serve as the foundation for predictive models in clinical practice, and that hold the potential to revolutionize the delivery of precision medicine in oncology. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Nicholas G. Zaorsky, MD Noelle L. Williams, MD Robert B. Den, MD Shivank Garg, MD Tu Dan, MD Tags: Oncology Journal Radiation Oncology Review Article Source Type: news

Fertility Preservation in Young Adult Patients With Cancer
This article will outline key information needed and practical ways that clinicians can integrate fertility preservation discussions and guidelines into their day-to-day practice. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Joanne Frankel Kelvin, MSN, RN, CNS, AOCN Tags: Oncology Journal Source Type: news

Jeffrey Vacirca on How the COA Advocates for Community Oncology Practices and Patients
In this interview we discuss the goals of the Community Oncology Alliance, highlights from their annual meeting, and the challenge of transitioning cancer care to the hospital setting. (Source: CancerNetwork)
Source: CancerNetwork - July 15, 2017 Category: Cancer & Oncology Authors: Jeffrey Vacirca, MD Tags: Oncology Journal Practice & Policy Q Source Type: news

Local Control of Brain Mets Improved With Stereotactic Radiosurgery
Patients with resected brain metastases who underwent stereotactic radiosurgery had lower rates of local recurrence compared with observation alone, according to the results of a phase III trial. (Source: CancerNetwork)
Source: CancerNetwork - July 14, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Brain Tumors News Source Type: news

Blinatumomab Gets Full FDA Approval for B-Cell Precursor ALL
The FDA has expanded the approval of blinatumomab (Blincyto) for the treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia in adults and children. (Source: CancerNetwork)
Source: CancerNetwork - July 14, 2017 Category: Cancer & Oncology Authors: Ian Ingram Tags: Hematologic Malignancies Leukemia & Lymphoma News Pediatric Cancers Source Type: news

T-DM1 in Early HER2+/HR+ Breast Cancer Offers Good Response Rates
T-DM1 administered for 12 weeks with or without endocrine therapy yields good rates of pathologic complete response in women with HER2-positive/hormone receptor –positive breast cancer, according to a new randomized trial. (Source: CancerNetwork)
Source: CancerNetwork - July 14, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer HER2-Positive Breast Cancer News Source Type: news

Nivolumab Shows Benefit After Progression in Advanced Melanoma
Treatment of advanced melanoma with the checkpoint inhibitor nivolumab beyond RECIST-defined progression resulted in clinical benefit for selected patients, according to pooled, retrospective data from two phase III trials. (Source: CancerNetwork)
Source: CancerNetwork - July 14, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Melanoma News Source Type: news

Surgery in Early Prostate Cancer Did Not Significantly Reduce Mortality
Long-term follow-up found no significant differences in all-cause or disease-related mortality in men with early prostate cancer randomized to either radical prostatectomy or to observation. Surgery led to more adverse events, but less treatment for disease progression. (Source: CancerNetwork)
Source: CancerNetwork - July 13, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Genitourinary Cancers News Prostate Cancer Source Type: news

Adding Cetuximab in Esophageal Cancer Fails to Improve Survival
Use of the EGFR inhibitor cetuximab with chemoradiation did not improve survival in patients with esophageal carcinoma compared with chemoradiation alone, according to the results of the phase III RTOG 0436 trial. (Source: CancerNetwork)
Source: CancerNetwork - July 13, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Esophageal Cancer Gastrointestinal Cancer News Source Type: news

High-Dose Chemotherapy Plus Transplant Not Recommended for DLBCL
Patients with high-risk diffuse large B-cell lymphoma had a reduced risk of treatment failure, but no survival improvement, with an abbreviated course of rituximab-dose-dense chemotherapy plus high-dose chemotherapy and transplant compared with a full course of chemotherapy. (Source: CancerNetwork)
Source: CancerNetwork - July 13, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Hematologic Malignancies Leukemia & Lymphoma News Source Type: news

Management of Resectable Pancreatic Cancer
This video examines the management of resectable pancreatic cancer, including how this type of disease is best defined, the latest standard of care in the adjuvant setting, and emerging trends in surveillance. (Source: CancerNetwork)
Source: CancerNetwork - July 13, 2017 Category: Cancer & Oncology Authors: Davendra Sohal, MD, MPH Tags: Pancreatic Cancer Videos Gastrointestinal Cancers Source Type: news

Brain Mass Found in 38-Year-Old Patient
A 38-year-old man presents with a fever and headaches. A brain mass is detected, and a biopsy is obtained. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2017 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Tags: Image IQ Source Type: news

TERT Urine Test Can Help Predict Bladder Cancer Recurrence
A urine test of telomerase reverse transcriptase (TERT) was found to be a reliable predictor of recurrence in non –muscle-invasive bladder cancer, according to a new study. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Bladder Cancer Genitourinary Cancers News Source Type: news

Cancer Risk Elevated Among Holocaust Survivors
Holocaust survivors have a small but consistent increase in the risk of developing cancer, in particular colorectal and lung cancers. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2017 Category: Cancer & Oncology Authors: Mark L. Fuerst Tags: Colorectal Cancer Lung Cancer News Source Type: news

Rapid, Durable Responses in Advanced Myeloma With Daratumumab Combo
Treatment with the combination of daratumumab plus pomalidomide/dexamethasone resulted in rapid, deep, and sustained responses with no new safety signals in patients with heavily treated multiple myeloma. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Hematologic Malignancies Multiple Myeloma News Source Type: news

Calcium/Vitamin D May Be Protective Against Blood Cancers
Calcium and vitamin D supplementation had a protective effect against hematologic malignancies, according to a post-hoc analysis of data from the Women ’s Health Initiative Calcium/Vitamin D study. (Source: CancerNetwork)
Source: CancerNetwork - July 11, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Hematologic Malignancies News Source Type: news

Activity of PD-1 Inhibitor Limited in Soft-Tissue Sarcomas
Treatment with the PD-1 inhibitor pembrolizumab plus metronomic cyclophosphamide had limited activity in patients with soft-tissue sarcomas and gastrointestinal stromal tumors. (Source: CancerNetwork)
Source: CancerNetwork - July 11, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: News Sarcoma Source Type: news

Parts of Mediterranean Diet Linked With Reduced Colon Polyp Risk
Adherence to a Mediterranean diet is negatively associated with advanced colorectal polyps, and the specific portions of the diet that appear to have the most influence include high intake of fish and fruit and low intake of soft drinks. (Source: CancerNetwork)
Source: CancerNetwork - July 11, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

Proton-Beam Therapy in Limited-Stage SCLC Shows Promising Efficacy
Proton-beam therapy was found to be safe for patients with limited-stage small-cell lung cancer in the first prospective registry study of the therapy, with only a small number of high-grade toxicities. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Lung Cancer News Radiation Oncology Source Type: news

Gene Signature ID ’s Breast Cancer Patients Who Could Skip Chemotherapy
A 70-gene expression score can identify women with indolent breast cancer at “ultralow” risk, according to a new study. Women with such a score have extremely low risk of disease-specific mortality over 20 years without systemic therapy. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer News Source Type: news

Can Gene Signature ID Breast Cancer Patients Who Can Skip Chemotherapy?
A 70-gene expression score can identify women with indolent breast cancer at “ultralow” risk, according to a new study. Women with such a score have extremely low risk of disease-specific mortality over 20 years without systemic therapy. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer News Source Type: news

Right-Sided Metastatic CRC Benefits From Adding SIRT to Chemotherapy
Patients with colorectal cancer that has metastasized to the liver derive a significant benefit from selective internal radiation therapy (SIRT) combined with chemotherapy if their primary tumor is a right-sided tumor, but not if it is a left-sided primary tumor. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news

A 44-Year-Old Patient Presents With Upper Back Lesion
A 44-year-old man presents with a lesion on his right upper back, and a biopsy is performed. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - July 9, 2017 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Tags: Image IQ Source Type: news

Salivary Gland Lesion in 34-Year-Old Patient
A 34-year-old woman presents with a lesion in the salivary gland, and a biopsy is obtained. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - July 8, 2017 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Tags: Image IQ Source Type: news

No Difference in Survival for Idarubicin, High-Dose Daunorubicin in AML
There was no significant survival difference in newly diagnosed acute myeloid leukemia patients given induction therapy with idarubicin vs high-dose daunorubicin. (Source: CancerNetwork)
Source: CancerNetwork - July 7, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Hematologic Malignancies Leukemia & Lymphoma News Source Type: news

Salvage Surgery Prolonged Survival for Select Patients after TME for Rectal Cancer
Salvage surgery is associated with prolonged survival in patients with rectal cancer who have lung and liver recurrence after TME. (Source: CancerNetwork)
Source: CancerNetwork - July 7, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Gastrointestinal Cancer News Source Type: news

Maintenance Therapy in Mantle Cell Lymphoma
This video reviews different strategies for maintenance therapy in mantle cell lymphoma, as well as highlighting upcoming research in this setting. (Source: CancerNetwork)
Source: CancerNetwork - July 7, 2017 Category: Cancer & Oncology Authors: Brad S. Kahl, MD Tags: Videos Hematologic Malignancies Source Type: news