Keytruda (Pembrolizumab) Issued New Dosage and Indication
The FDA has recently approved new dosage form and two new indications for the drug.   (Source: CancerNetwork)
Source: CancerNetwork - April 22, 2019 Category: Cancer & Oncology Authors: Drew Boxler Source Type: news

Study Highlights Disparities in Genetic Testing in Ovarian and Breast Cancer
A study of genetic testing in ovarian and breast cancer patients found substantial disparities in testing rates for ovarian cancer patients. (Source: CancerNetwork)
Source: CancerNetwork - April 22, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

How Various Breast Cancer Screening Guidelines Compare
In this slideshow, various clinical guidelines on breast cancer screening are summarized, including the ACP's recent recommendations that have come under some scrutiny. (Source: CancerNetwork)
Source: CancerNetwork - April 19, 2019 Category: Cancer & Oncology Authors: Lori Smith, BSN, MSN, CRNP Source Type: news

Quiz: Role of Proteasome Inhibitors in Relapsed/Refractory Multiple Myeloma
How knowledgeable are you about the use of proteasome inhibitors in relapsed/refractory multiple myeloma? Take our latest quiz to find out. (Source: CancerNetwork)
Source: CancerNetwork - April 19, 2019 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Implementing a Toxicity Screening Form to Report Chemo Side Effects
The number of patients reporting side effects related to chemotherapy increased by more than 40 percentage points after the implementation of a chemotherapy toxicity screening form. (Source: CancerNetwork)
Source: CancerNetwork - April 17, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Niraparib Offers New Option in Heavily Pretreated Ovarian Cancer
Researchers conducted the QUADRA trial to examine if niraparib could improve outcomes in heavily pretreated patients with ovarian cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 17, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Certain Factors Associated With Decreased QOL in Thyroid Cancer Survivors
A recent study in Surgery found that thyroid cancer survivors  reported increased complications related to surgery and radioactive iodine ablation. (Source: CancerNetwork)
Source: CancerNetwork - April 16, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Combination Therapy Enhances Stem Cell Mobilization in Patients With Multiple Myeloma
A phase III trial evaluated intermediate-dose cytarabine plus  granulocyte-colony stimulating factor (G-CSF) vs G-CSF alone prior to autoSCT in multiple myeloma. (Source: CancerNetwork)
Source: CancerNetwork - April 16, 2019 Category: Cancer & Oncology Authors: Lauren M. Dembeck, PhD Source Type: news

Thyroidectomy Still Popular Despite Less Aggressive Treatment Recommendations
A recent study evaluated the impact of recommendations encouraging  less aggressive lobectomy for patients with small papillary thyroid cancers. (Source: CancerNetwork)
Source: CancerNetwork - April 16, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Dr. Schmidt on AMAROS Trial Results: Radiotherapy vs Surgery of the Axilla in Breast Cancer
Cancer Network spoke with Hank Schmidt, MD, about the 10-year follow-up results of the EORTC AMAROS trial of radiotherapy vs surgery of the axilla in breast cancer patients with a positive sentinel node. (Source: CancerNetwork)
Source: CancerNetwork - April 15, 2019 Category: Cancer & Oncology Authors: Hank Schmidt, MD Source Type: news

Men Open to Starting Physical Activity Prior to Prostate Cancer Treatment
The researchers explored implementation of physical activity for men recently diagnosed with prostate cancer to see which interventions will be best sustained over time. (Source: CancerNetwork)
Source: CancerNetwork - April 14, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Balversa Fast-Tracked for Bladder Cancer
Erdafitinib is first targeted therapy for FGFR3 or FGFR2 genetic alteration. (Source: CancerNetwork)
Source: CancerNetwork - April 12, 2019 Category: Cancer & Oncology Authors: David Frabotta Source Type: news

Seven-Year Follow-Up Results Can Help HER2+ Breast Cancer Patients Avoid Overtreatment
The combination of trastuzumab and paclitaxel'represents an important step forward in de-escalating therapy'for HER2+ breast cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 12, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Is It Too Soon to Augment Lung Cancer Screening Guidelines for High-Risk Patients?
A study looked at whether a  lung cancer risk prediction model could identify patients at high risk for lung cancer who could receive less frequent low-dose CT screening. (Source: CancerNetwork)
Source: CancerNetwork - April 12, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

Using the THRIVE Program to Teach Self-Care to Oncology Nurses
The THRIVE Program includes an 8-hour retreat designed to teach staff skills for combating compassion fatigue and for promoting resilience. (Source: CancerNetwork)
Source: CancerNetwork - April 11, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Nurse-Led Prostate Cancer Clinic Examines Patient Anxiety
The clinic educates, evaluates, and guides patients with prostate cancer on available treatments and helps to control associated anxiety. (Source: CancerNetwork)
Source: CancerNetwork - April 11, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Role of Oncology Nurses in Primary Palliative Care Growing
Oncology advanced practice registered nurses can play a critical role in providing primary palliative care to patients with cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 11, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Using Telerehabilitation to Improve Function and Pain in Advanced Cancer Patients
Telerehabilitation and pharmacological pain management approaches were tested in patients with advanced cancers, including prostate cancer, to see if pain and function could be improved. (Source: CancerNetwork)
Source: CancerNetwork - April 10, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Regional Delivery of Mesothelin-Targeted CAR T-Cell Therapy Creates a Win for Solid Tumors
Research presented at AACR 2019 evaluated  autologous mesothelin-targeted chimeric antigen receptor T-cell therapy in patients with malignant pleural disease. (Source: CancerNetwork)
Source: CancerNetwork - April 10, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

PRIMA-PI Risk Score for Follicular Lymphoma Promising for Trials, Clinical Practice
Researchers compared the newly developed PRIMA-PI risk score against FLIPI and FLIPI-2 in patients with follicular lymphoma. (Source: CancerNetwork)
Source: CancerNetwork - April 10, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

MyPathway Subanalysis Backs Combination HER2-Targeting Antibodies in Colorectal Cancer
Investigators studied a combination of  pertuzumab and trastuzumab in patients with metastatic, HER2-positive colorectal cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 10, 2019 Category: Cancer & Oncology Authors: Jim Kling Source Type: news

CD38-Targeting Isatuximab Combo Active in Refractory Myeloma
Researchers tested the combination of isatuximab with dexamethasone and pomalidomide in patients with relapsed or refractory multiple myeloma. (Source: CancerNetwork)
Source: CancerNetwork - April 9, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

For Advanced Sarcoma, Adding Lymphodepletion to HER2-Targeted CAR T-Cell Therapy Excites
A phase I trial evaluated the safety and efficacy of adding  lymphodepletion to HER2-targeted T-cell therapy in patients with advanced HER2-positive sarcoma. (Source: CancerNetwork)
Source: CancerNetwork - April 9, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

Should Adjuvant Chemo Be Added to Treatment in Early High-Risk Prostate Cancer?
Researchers tested the addition of adjuvant chemotherapy to androgen suppression and radiotherapy in patients with localized high-risk prostate cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 8, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Phase III SIERRA Trial Finds Iomab-B Promising for Relapsed/Refractory AML
Researchers are evaluating  Iodine (131I) apamistamab plus HCT vs conventional care in older patients with active relapsed/refractory acute myeloid leukemia. (Source: CancerNetwork)
Source: CancerNetwork - April 8, 2019 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Osimertinib Plus Savolitinib Shows Activity in EGFR-Mutant, MET-Amplified NSCLC
Cancer Network spoke with Lecia V. Sequist, MD, MPH, about the TATTON study, which tested the combination of osimertinib and savolitinib in previously treated non –small-cell lung cancer patients. (Source: CancerNetwork)
Source: CancerNetwork - April 8, 2019 Category: Cancer & Oncology Authors: Lecia V. Sequist, MD, MPH Source Type: news

Venetoclax Plus LDAC May Benefit Patients with AML Ineligible for Intensive Chemotherapy
A new study evaluated combination venetoclax and low-dose cytarabine in previously untreated acute myeloid leukemia. (Source: CancerNetwork)
Source: CancerNetwork - April 8, 2019 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

10 Recent Oncology Drug Approvals
This slideshow summarizes recent US Food and Drug Administration approvals of new oncology drugs and oncology drug indications. (Source: CancerNetwork)
Source: CancerNetwork - April 5, 2019 Category: Cancer & Oncology Authors: Lori Smith, BSN, MSN, CRNP Source Type: news

Primary Radiotherapy Plays Important Role in Early Follicular Lymphoma
A retrospective study supported the role of primary radiotherapy in early-stage follicular lymphoma. (Source: CancerNetwork)
Source: CancerNetwork - April 5, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Precursor Immunotherapy to Prevent Squamous Cell Carcinoma
Researchers evaluated whether  treatment with calcipotriol plus 5-fluorouracil aided in reducing the risk of squamous cell carcinoma. (Source: CancerNetwork)
Source: CancerNetwork - April 5, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Does Tumor Biology Play a Role in Colon Cancer Racial Disparities?
Cancer Network spoke with Jennie Williams, PhD, and colleague about how tumor biology impacts chemotherapy response in African American vs Caucasian patients. (Source: CancerNetwork)
Source: CancerNetwork - April 5, 2019 Category: Cancer & Oncology Authors: Jennie Williams, PhD Source Type: news

Potential Role of the HPV Vaccine in Preventing Non-Melanoma Skin Cancers
The association between the presence of several viruses and non-melanoma skin cancer was investigated in a recent study. (Source: CancerNetwork)
Source: CancerNetwork - April 5, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Entinostat Plus Pembrolizumab Shows Promise in Previously Treated Melanoma
Cancer Network spoke with Ryan J. Sullivan, MD, about the efficacy and safety of entinostat plus pembrolizumab in patients previously treated with immunotherapy. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Ryan J. Sullivan, MD Source Type: news

Looking to Agriculture Strategies to Manage Drug Resistance in Cancer
Cancer Network spoke with Carlo Maley, PhD, about how strategies utilized in agriculture can be applied to drug resistance in oncology. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Carlo Maley, PhD Source Type: news

Targeting the Metastatic Tumor Microenvironment to Limit Cancer Progression
Cancer Network spoke with Sheila A. Stewart, PhD, on how age-related changes in the tumor microenvironment may impact progression and metastasis. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Sheila A. Stewart, PhD Source Type: news

Favorable Results Seen With APX005M in Combination Therapy for Metastatic Ductal Pancreatic Adenocarcinoma
Cancer Network spoke with Mark H. O'Hara, MD, about the safety and efficacy of APX005M in combination with standard chemotherapy with or without nivolumab. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Mark H. O & #039;Hara, MD Source Type: news

A Young Child With Fatigue and an Enlarged Liver
A young child presents with symptoms of fatigue and general malaise. A physical examination reveals the presence of an enlarged liver, and a liver biopsy is performed. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news

Stem Cell Transplant Approaches for Patients With Blood Cancers
Dr. Scadden discusses which blood cancer patients are eligible for stem cell transplantation, as well as the latest advances in the field. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: David T. Scadden, MD Source Type: news

A 52-Year-Old Woman With Splenomegaly
A 52-year-old woman presents with abdominal discomfort, which on physical examination revealed the presence of splenomegaly. A splenectomy is performed. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news

A 73-Year-Old Man With a Subcutaneous Lesion in the Calf
A 73-year-old man presents with a subcutaneous lesion in his right calf. Surgical resection is performed. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news

New CAR T-Cell Therapy for Multiple Myeloma Targets GPRC5D
Researchers have identified a potential new target for CAR T-cell therapy in patients with multiple myeloma. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Cabozanitinib Shows Anti-Tumor Activity Beyond Clear-Cell Renal Cell Carcinoma
A recent study inThe Lancet Oncology suggests that the benefits of one tyrosine kinase inhibitor may extend to other subtypes of RCC. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

On the TRAIL of a Solution to Trastuzumab Resistance in HER2+ Breast Cancer
A genomic and proteomic analysis of HER2+ breast cancer cell lines that are resistant to trastuzumab found a deregulation of the cell death pathway known as TRAIL. (Source: CancerNetwork)
Source: CancerNetwork - April 3, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Are Assessment Guidelines for HER2 Status Leading to Many False Positives?
Researchers tested whether the use of recommended alternative control probes to classify HER2 status in breast cancer could lead to substantial false positives. (Source: CancerNetwork)
Source: CancerNetwork - April 2, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Examining Opioid-Related Hospitalizations for Patients With Cancer
Researchers looked at the trends and risk factors for opioid-related hospitalizations among patients with cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 2, 2019 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Umbralisib Offers Promise for Marginal Zone Lymphoma
Researchers tested the PI3K inhibitor umbralisib in patients with relapsed/refractory marginal zone lymphoma in a phase II study that was presented at the AACR Annual Meeting. (Source: CancerNetwork)
Source: CancerNetwork - April 2, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Adding an Oncolytic Virus to Neoadjuvant Chemo for Triple-Negative Breast Cancer
A small early-phase trial tested the addition of the oncolytic virus T-VEC to neoadjuvant chemotherapy in patients with triple-negative breast cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 1, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Pembrolizumab Offers New Option in Extensive-Stage Lung Cancer
A pooled analysis of two trials presented at the AACR Annual Meeting looked at the use of pembrolizumab in patients with heavily pretreated extensive small-cell lung cancer. (Source: CancerNetwork)
Source: CancerNetwork - April 1, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Practice-Changing Results Seen in Phase III Relapsed/Refractory AML Trial
Results of the phase III ADMIRAL trial, which tested the FLT3 inhibitor gilteritinib in patients with relapsed/refractory acute myeloid leukemia, were presented at the AACR Annual Meeting. (Source: CancerNetwork)
Source: CancerNetwork - April 1, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

What Role Does Systemic Inflammation Play in Triple-Negative Breast Cancer?
Researchers looked at the role of biomarkers associated with systemic inflammation among patients with triple-negative breast cancer. (Source: CancerNetwork)
Source: CancerNetwork - March 31, 2019 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news