Narjust Duma on How Gender Affects the Tolerability of Immunotherapy
In this interview, we discuss a study of sex differences in the tolerability of anti –programmed death 1 immunotherapy among patients with metastatic melanoma. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Narjust Duma, MD Source Type: news

Sharing Serious News With Cancer Patients: Strategies That Can Help
The way in which serious news is discussed significantly affects many outcomes and aspects of patient care. It is important to consider many factors, including those related to patient diversity, such as cultural and family background; language barriers; socioeconomic factors; and health literacy. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Patricia A. Parker, PhD, Smita C. Banerjee, PhD Source Type: news

Using PARP Inhibitors in Advanced Ovarian Cancer
The approval of PARP inhibitors has caused a paradigm shift in ovarian cancer management and a challenge for clinicians, who must decide how best to use these agents in individualized treatment. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Roisin E. O ’Cearbhaill, MD Source Type: news

Acute Kidney Injury in Patients With Cancer
Acute kidney injury is a common complication in cancer patients, and clinicians should be familiar with the processes that cause it. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Mark A. Perazella, MD, Mitchell H. Rosner, MD Source Type: news

Post-Prostatectomy Radiation Therapy: Patient Selection, Timing, Imaging, and Therapy Intensification
A 62-year-old man with prostate adenocarcinoma elected to proceed with radical prostatectomy as definitive management. After his pathology report showed stage IIIB disease, he elected for observation. What happened next? (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Tyler P. Robin, MD, PhD, Paul D. Maroni, MD, Bennett B. Chin, MD, Francisco G. La Rosa, MD, Brandon Bernard, MD, MPH, Thomas J. Pugh, MD Source Type: news

Harnessing the Immunomodulatory Effects of Radiation Therapy
In this article, we discuss radiation ’s immunomodulatory effects, with particular attention to the impact of dose and fractionation on the antitumoral response. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Allison M. Campbell, MD, PhD, Roy H. Decker, MD, PhD Source Type: news

Peripheral T-Cell Lymphomas: Incorporating New Developments in Diagnostics, Prognostication, and Treatment Into Clinical Practice —PART 1: PTCL-NOS, FTCL, AITL, ALCL
This two-part series highlights the most important aspects of PTCLs and describes current treatment options and investigative opportunities. Part 1 will cover PTCL not otherwise specified, follicular T-cell lymphoma, angioimmunoblastic T-cell lymphoma, anaplastic large-cell lymphoma (ALCL), and breast implant –associated ALCL. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Natalia Pin Chuen Zing, MD, MSc, Thais Fischer, MD, Jasmine Zain, MD, Massimo Federico, MD, Steven T. Rosen, MD Source Type: news

Chemoimmunotherapy Ups PFS in Early-Stage Follicular Lymphoma
TROG 99.03 constitutes “the only high level evidence currently available to guide decision making for this group of patients,” says investigator Michael MacManus. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Why Do Younger Colorectal Cancer Patients Have Better Outcomes Despite More Aggressive Disease?
Canadian Cancer Trials Group investigators say it's unclear if disease biology is different in younger patients or older ones are more likely to undergo CRC screening. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Poorer Survival, Higher Costs With Trimodal Therapy in Bladder Cancer
Patients with muscle-invasive bladder cancer who underwent trimodal therapy had significantly poorer survival than those who underwent radical cystectomy alone. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Should Clinicians Rethink Rectal Cancer Treatment for Younger Patients?
Early ‐onset rectal cancer may differ biologically and in its response to multimodality therapy, according to a large retrospective study of NCCN data. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Survival Boost With Maintenance Rituxumab in Follicular Lymphoma
In addition to significant improvements in 5-year OS and PFS with maintenance rituximab, there was a trend toward an association between maintenance and reduced transformation risk. (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

How to Close Care Gaps in Vulnerable Populations
Oncology nurse leaders share insights into the care of vulnerable oncology populations —from ED triage to tailored telehealth sessions for homeless populations. (Source: CancerNetwork)
Source: CancerNetwork - July 16, 2018 Category: Cancer & Oncology Authors: Lori Smith, BSN, MSN, CRNP Source Type: news

Sorafenib as Effective, Safe in Elderly RCC Patients as in Younger Ones
PFS, tumor response, and safety outcomes were similar in patient cohorts under age 75 vs those 75 years of age and older. (Source: CancerNetwork)
Source: CancerNetwork - July 16, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

IKCC, German Cancer Society Issue Consensus Statement on RCC With Bone Mets
The statement emphasizes strategies for multidisciplinary care, and proposes an algorithm for clinical management of bone metastasis in RCC. (Source: CancerNetwork)
Source: CancerNetwork - July 16, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Cisplatin/Gemcitabine Shows Improvements in Worst Breast Cancer Subtype
Germline BRCA mutations and other HR genes may offer biomarkers for response to this treatment. (Source: CancerNetwork)
Source: CancerNetwork - July 16, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Pleural Effusion in a 58-Year-Old Male With Chest Pain
A 58-year-old man presents with a cough, dyspnea, and chest pain. Chest imaging shows the presence of pleural effusion, and a biopsy is obtained. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - July 16, 2018 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news

Next-Gen Sequencing May Advance Tx of Patients With Poorly Differentiated Thyroid Cancer
Next-generation sequencing may prove to be a useful tool in the identification of co-mutations associated with resistance, an MD Anderson study suggests. (Source: CancerNetwork)
Source: CancerNetwork - July 13, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

The ‘CALM’ Approach to Relieving and Preventing Depression in Advanced Cancer
Three and 6 months after undergoing the psychotherapeutic intervention Managing Cancer and Living Meaningfully (CALM), participants reported less-severe depressive symptoms. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

What Prompts Male Teens With Cancer to Bank Their Sperm?
A team from Children ’s Healthcare of Atlanta reports unexpected factors determining which adolescents participated in sperm banking. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

‘Highjack’ Autoimmunity to Enhance Efficacy of Immunotherapy?
Overexpression ofIKZF1 facilitates immune attack on skin cancer and other solid tumors. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Nurse-Driven Protocol Increased Vaccination for Flu, Pneumonia
A pilot protocol developed at Memorial Sloan Kettering Cancer Center resulted in exponential increases in both influenza and pneumococcal vaccinations in the outpatient setting. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2018 Category: Cancer & Oncology Authors: Elizabeth Rodriguez, DNP, RN, OCN Source Type: news

Nurse-Led Smoking-Cessation Program for Cancer Patients Doubled the Quit Rate
Quit rates reported by a smoking-cessation program at Duke Cancer Center increased from 17% to 34% in the 2 years since it was implemented. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2018 Category: Cancer & Oncology Authors: Lori Smith, BSN, MSN, CRNP Source Type: news

A Call for Better Screening for Hereditary Renal Cell Carcinoma
More than 20% of patients with non –clear cell RCC had a germline mutation, and half of this group could benefit from direct systemic therapy. (Source: CancerNetwork)
Source: CancerNetwork - July 12, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Quiz: Understand the Role of Adipose Tissue in Multiple Myeloma
Our latest quiz highlights the role of bone marrow adiposity in patients with multiple myeloma. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Gardening Intervention Improves Outcomes Among Breast Cancer Survivors
The gardening intervention led to improvements in physical activity measures and other health outcomes in breast cancer survivors. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Does Frontline R2CHOP Reduce CNS Relapse Risk in DLBCL?
There may be prophylactic benefit from using lenalidomide, an orally bioavailable CNS-penetrating agent, combined with R-CHOP in the upfront setting. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Can Elderly Patients With DLBCL Tolerate Standard Treatment?
The OS benefit associated with standard treatment diminished in patients older than 80 with high comorbidity scores, but other age groups fared better. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

More Cancer Survivors Have Metabolic Syndrome, but Knowledge and Awareness Vary Widely
While over half of survivors had heard of metabolic syndrome, in one-third with the condition, fewer than 10% had been diagnosed; educational strategies may be of benefit. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Men Less Likely to Prefer Palliative Care Treatment at End of Life
A small study has found that men with cancer were less likely than women to prefer palliative care if informed that continued treatment would not be helpful. (Source: CancerNetwork)
Source: CancerNetwork - July 10, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Improved Outcomes for Melanoma Brain Metastases With Added Immunotherapy
Immune checkpoint inhibitors initiated soon before or after radiosurgery offer excellent outcomes in patients with brain metastases originating from melanoma. (Source: CancerNetwork)
Source: CancerNetwork - July 9, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

ASCO Updates Guideline on Management of HER2-Positive Breast Cancer
An update to guidelines from ASCO on the optimal management of patients with HER2+ breast cancer offers recommendations on timing and sequence of therapies. (Source: CancerNetwork)
Source: CancerNetwork - July 9, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Multiple Myeloma Incidence Increasing Worldwide, Especially in the US
From 1990 to 2016, incident cases of multiple myeloma increased by 126% globally, while deaths increased 94%. The US had the most incident cases and deaths. (Source: CancerNetwork)
Source: CancerNetwork - July 9, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Ixazomib-Based Regimen Is Promising in Newly Diagnosed Multiple Myeloma
Investigators concluded ixazomib “may offer a more convenient, active, and well-tolerated alternative to a parenterally administered PI in this setting.” (Source: CancerNetwork)
Source: CancerNetwork - July 9, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Splice Variant of MUC4 Promotes Pancreatic Cancer Progression
When MUC4/X-overexpressing pancreatic cancer cells were transplanted into mice, tumors grew aggressively, with significant metastasis to liver and peritoneum. (Source: CancerNetwork)
Source: CancerNetwork - July 6, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Tumoral Mass on 45-Year-Old Male ’s Back
A 45-year-old man presents with a movable, mildly painful mass on the right side of his back, which he noticed a couple of weeks prior to presentation. A biopsy is obtained. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - July 6, 2018 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news

Western Diet Linked With CLL
Findings from the MCC-Spain study suggest that in some cases, CLL could be prevented by modifying dietary habits. (Source: CancerNetwork)
Source: CancerNetwork - July 5, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Time to Next FCR Treatment May Predict Poor Prognosis in CLL
Most CLL patients treated with FCR will experience long-term remissions, but patients who relapse within 24 months have a dismal prognosis. (Source: CancerNetwork)
Source: CancerNetwork - July 5, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Why Haven ’t Older Adults Been Included in More Oncology Clinical Trials?
In this video,Dr. Arti Hurria discusses resources addressing the disconnect between cancer as a growing problem in the elderly and the fact that clinical trials mostly enroll younger patients. (Source: CancerNetwork)
Source: CancerNetwork - July 5, 2018 Category: Cancer & Oncology Authors: Arti Hurria, MD Source Type: news

Tools and Tweaks to Improve Sleep Quality in Patients With Cancer
In this video,  Dr. Jun Mao  describes practical changes that have boosted sleep quality in cancer patients, and highlights results of a study showing sleep benefits from both CBT and acupuncture.  (Source: CancerNetwork)
Source: CancerNetwork - July 4, 2018 Category: Cancer & Oncology Authors: Jun J. Mao, MD, MSCE Source Type: news

Men With Advanced Prostate Cancer, Be Informed About Your Genetics!
In this video,  Dr. Heather Cheng  briefly outlines the GENTleMEN study of the impact of genetic testing for men with advanced prostate cancer.  (Source: CancerNetwork)
Source: CancerNetwork - July 4, 2018 Category: Cancer & Oncology Authors: Heather Cheng, MD, PhD Source Type: news

FDA-NCI Team Warns Against Single-Arm Pembrolizumab Trials in Multiple Myeloma
An analysis by FDA and NCI investigators recommended further study of the utility of immunotherapy in patients unable to mount adequate immune responses. (Source: CancerNetwork)
Source: CancerNetwork - July 3, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Update on Newer Non –EGFR-Targeted Agents in Non–Small-Cell Lung Cancer
MSKCC ’s Dr. Alexander Drilon highlights other known alterations that are being targeted or being used as biomarkers in non–small-cell lung cancer. (Source: CancerNetwork)
Source: CancerNetwork - July 2, 2018 Category: Cancer & Oncology Authors: Alexander Drilon, MD Source Type: news

High-Dose PPI Plus Aspirin Reduced Esophageal Cancer Risk
Combination therapy with a high-dose proton pump inhibitor and aspirin reduced the risk of progression to esophageal cancer in patients with Barrett esophagus. (Source: CancerNetwork)
Source: CancerNetwork - July 2, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

MGMT Methylation a Survival Biomarker in High-Risk Low-Grade Gliomas?
These are the first data to highlight the prognostic value ofMGMTmethylation beyond theIDH1/2 mutation status test currently used to help predict glioma patient survival outcomes. (Source: CancerNetwork)
Source: CancerNetwork - June 29, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Quick but Powerful Tips and Takeways for Nursing Best Practices and Emotional Support
Oncology nursing leader Deborah Boyle highlights some essential tips to address common issues in bedside care, staff communication, and on-the-job distress. (Source: CancerNetwork)
Source: CancerNetwork - June 29, 2018 Category: Cancer & Oncology Authors: Deborah Boyle, MSN, RN, AOCNS, FAAN Source Type: news

Strategies for Communicating Treatment Risks and Uncertainty of Outcomes
In this video,Professor Dame Lesley Fallowfield explains why oncologists need to be aware of their own tolerance of uncertainty before discussing possible treatment risks and outcomes with patients. (Source: CancerNetwork)
Source: CancerNetwork - June 29, 2018 Category: Cancer & Oncology Authors: Lesley Fallowfield, BSc Source Type: news

Liquid Biopsy to Inform Targeted Tx of Colorectal Cancer
In this video,Dr. Heinz-Josef Lenz outlines the many advantages that development of liquid biopsy is affording cancer patients. (Source: CancerNetwork)
Source: CancerNetwork - June 29, 2018 Category: Cancer & Oncology Authors: Heinz-Josef Lenz, MD, FACP Source Type: news

CDK12 Loss a Biomarker for Prostate Cancer Response to Immunotherapy?
DNA and RNA sequencing results suggest prostate cancer treatment “involving inhibition of CDK12 and immune checkpoint blockade,” a U Michigan team said. (Source: CancerNetwork)
Source: CancerNetwork - June 29, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Will DNA Vaccine TetMYB Be a Game-Changer in Advanced Colorectal Cancer?
An Australian team is studying a DNA-based vaccine that the lead investigator feels could be “transformative” in the care of advanced colorectal cancer. (Source: CancerNetwork)
Source: CancerNetwork - June 29, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news