TRP63 isoforms in mammary gland and cancer
Transformation-related protein 63 (Trp63) is expressed in breast neoplasia. Specific TRP63 isoforms are linked to cell cycle arrest, apoptosis, survival, and epithelial–mesenchymal transition. Although TRP63 over-expression in cultured cells is used to elucidate functions, little is known about Trp63 regulation. Assefnia and colleagues used ChIP-seq to interrogate transcription factor binding and histone modifications of the Trp63 locus in mammary tissue. Increased expression of dominant negative isoforms was correlated with increased progesterone receptor binding to the proximal Trp63 promoter. The results contr...
Source: Society for Endocrinology - July 22, 2014 Category: Endocrinology Source Type: news
Mesothelioma Clinical Trial Should Prove Worth of Photodynamic Therapy
Eli Glatstein, M.D., has touted the benefits of photodynamic therapy for decades, but not everyone was listening.
Maybe now they will.
Glatstein, vice chairman of the radiation oncology department at Penn Medicine, leads the first randomized clinical trial of photodynamic therapy (PDT) for pleural mesothelioma cancer and aims to prove its effectiveness.
"If the results confirm what we expect, this could be a very positive, significant step forward for treatment of this disease," Glatstein told Asbestos.com. "If it doesn't work like we think it will, there's a lot of egg on our face."
Glatstein was instrumental in landing a...
Source: Asbestos and Mesothelioma News - July 18, 2014 Category: Environmental Health Authors: Tim Povtak Tags: Research & Clinical Trials Source Type: news
Upregulated SMAD3 in Pancreatic Ductal AdenocarcinomaUpregulated SMAD3 in Pancreatic Ductal Adenocarcinoma
SMAD3 has been identified as gene related to the epithelial-mesenchymal transition. Might it serve as a biomarker of poor prognosis in pancreatic cancer? Laboratory Investigation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 7, 2014 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news
Tugging on the 'malignant' switch in breast cancer
A possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer, has been discovered by researchers. Dense mammary tissue has long been recognized as a strong indicator of risk for breast cancer. This is why regular breast examinations are considered essential to early detection. Until now, however, the significance of that tissue density has been poorly understood. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 16, 2014 Category: Science Source Type: news
Tugging on the 'malignant' switch
(Harvard University) A team of Harvard researchers have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 16, 2014 Category: Cancer & Oncology Source Type: news
Lipid-Based Nanomedicines for Type-Specific Ovarian CancerLipid-Based Nanomedicines for Type-Specific Ovarian Cancer
Epithelial ovarian cancers are currently all treated with the same chemotherapeutic regimen, but delivery via lipid-based nanoparticles has the potential to allow greater specificity by cancer subtype. Nanomedicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 2, 2014 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
Dartmouth scientists identify genetic blueprint for cancerous tumors of the appendix
(The Geisel School of Medicine at Dartmouth) Using next generation DNA sequencing, Dartmouth scientists have identified potentially actionable mutations in cancers of the appendix. Their study, 'Molecular Profiling of Appendiceal Epithelial Tumors Using Massively Parallel Sequencing to Identify Somatic Mutations,' was published in the journal Clinical Chemistry today. When specific mutations for a cancer type are identified, patients can be treated with chemotherapy or other targeted agents that work on those mutations. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 12, 2014 Category: Cancer & Oncology Source Type: news
NIH study demonstrates that a new cancer immunotherapy method could be effective against a wide range of cancers
Human immune system could attack cancers that begin in epithelial cells. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - May 8, 2014 Category: American Health Source Type: news
VentiRx Pharma completes enrolment in Phase II study of ovarian cancer drug
US-based VentiRx Pharmaceuticals has announced the completion of patient enrollment in GOG-3003, a Phase II study of VTX-2337 in combination with pegylated liposomal doxorubicin (PLD) in patients with recurrent or persistent epithelial ovarian, fallo… (Source: Drug Development Technology)
Source: Drug Development Technology - April 22, 2014 Category: Pharmaceuticals Source Type: news
Research yields potential target for epithelial ovarian cancer treatment
(Fox Chase Cancer Center) Fox Chase Cancer Center researchers who are investigating the biological mechanisms behind metastatic epithelial ovarian cancer recently found that an enzyme called focal adhesive kinase can play a critical -- and previously unstudied -- role in the growth and spread of the disease. The research will be presented on Monday, Apr. 7, at the American Association for Cancer Research Annual Meeting 2014. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 7, 2014 Category: Cancer & Oncology Source Type: news
Scaffolding protein promotes growth, metastases of epithelial ovarian cancer
A scaffolding protein responsible for regulating signaling pathways in the cell promotes the growth and spread of epithelial ovarian cancer, research has determined. The researchers note that even though this study looked at the ovarian cancer in mice, some of the genes that turned up in the gene expression analysis can be further evaluated in human cell lines and tumors. "We want to make sure we're studying something that's not only important in mice but can also give us clues about human cancers." (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 7, 2014 Category: Science Source Type: news
Scaffolding protein promotes growth and metastases of epithelial ovarian cancer
(Fox Chase Cancer Center) Researchers from Fox Chase Cancer Center have shown that NEDD9, a scaffolding protein responsible for regulating signaling pathways in the cell, promotes the growth and spread of epithelial ovarian cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 6, 2014 Category: Cancer & Oncology Source Type: news
Bacterial gut biome may guide colon cancer progression
Gut bacteria can change the microenvironment in a way that promotes the growth and spread of tumors, research demonstrates. The results suggest that bacterial virulence proteins may suppress DNA repair proteins within the epithelial cells that line the colon. "There is a drastic, unmet need to look at new ways to define exactly how colon cancer forms in the gut and what triggers its progression into a lethal form," said the lead researcher. "We suggest that some bacterial proteins can promote genetic changes that create conditions in the gut that would favor the progression of colon cancer." (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 4, 2014 Category: Science Source Type: news
Bacterial gut biome may guide colon cancer progression
(The Wistar Institute) At the 2014 American Association for Cancer Research Annual Meeting in San Diego, researchers from The Wistar Institute present findings that suggest that gut bacteria can change the microenvironment in a way that promotes the growth and spread of tumors. Their results suggest that bacterial virulence proteins may suppress DNA repair proteins within the epithelial cells that line the colon. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 4, 2014 Category: Biology Source Type: news
'Glue' holding together skin cells & other epithelial tissue more active than realized
The strong mechanical attachments - the "glue" - that hold together the cells of the skin and the other epithelial tissues of the body are the adherens junctions.These junctions are responsible for maintaining the shape and integrity of the sheets of epithelial cells that line such body cavities as the digestive tract, as well as the surfaces of structures such as the heart. Defects in the proteins of these attachments have been implicated as potential contributors to the development and spread of cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 26, 2014 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
