Epstein-barr virus infections induce aberrant osteoclastogenesis in immune system-humanized NOD/Shi-scid/IL-2R γC < sup > null < /sup > mice
Biochem Biophys Res Commun. 2024 Apr 23;715:149984. doi: 10.1016/j.bbrc.2024.149984. Online ahead of print.ABSTRACTEpstein-Barr virus (EBV) and other viral infections are possible triggers of autoimmune diseases, such as rheumatoid arthritis (RA). To analyze the causative relationship between EBV infections and RA development, we performed experiment on humanized NOD/Shi-scid/IL-2RγCnull (hu-NOG) mice reconstituted human immune system components and infected with EBV. In EBV-infected hu-NOG mice, breakdown of knee joint bones was found to be accompanied by the accumulation of receptor activator of nuclear factor-κB (NF-Î...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yasuko Nagatsuka Mitsuhiro Iwata Yosuke Nagasawa Hiroshi Tsuzuki Noboru Kitamura Atsushi Komatsu Kei Kawana Ryoji Ito Shigeyoshi Fujiwara Hideki Nakamura Masami Takei Source Type: research
Potential roles of PIWI-interacting RNAs in breast cancer, a new therapeutic strategy
Pathol Res Pract. 2024 Apr 17;257:155318. doi: 10.1016/j.prp.2024.155318. Online ahead of print.ABSTRACTBreast cancer (BC) has been the focus of numerous studies aimed at identifying novel biological markers for its early detection. PIWI-interacting RNAs (piRNAs), a subset of small non-coding RNAs, have emerged as potential markers due to their aberrant expression in various cancers. PiRNAs have recently gained attention due to their aberrant expression in various cancers, including BC. PiRNAs, exhibit diverse biological activities, such as epigenetic regulation of gene and protein expression and their association with cel...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Hongpeng Zhang Yanshu Li Source Type: research
Moving from insulin substitution to the treatment of the underlying autoimmune disease in type 1 diabetes
Horm Res Paediatr. 2024 Apr 30. doi: 10.1159/000539120. Online ahead of print.ABSTRACTCurrently a paradigm change occurs in type 1 diabetes from insulin substitution to the treatment of the underlying autoimmune disease. Teplizumab, a humanized monoclonal anti CD3 antibody, is the first FDA approved disease modifying treatment of preclinical stage 2 diabetes. Research of drugs like Golimumab, a monoclonal antibody specific for TNF alpha, baricitinib, a tyrosine kinase inhibitor, or frexalimab, a monoclonal antibody against the CD40-Ligand, is still ongoing. Repurposing drugs that have been used in other indications like th...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jantje Weiskorn Thomas Danne Source Type: research
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
CONCLUSION: This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.PMID:38687926 | DOI:10.4103/jcrt.jcrt_1504_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yulu Chen Xi Xiao Guanghui Hu Rengyun Liu Junyu Xue Source Type: research
Tumor-targeted gypenoside nanodrug delivery system with double protective layers
CONCLUSIONS: We have established a tumor-targeted nanodrug delivery system that can target and kill liver cancer cells and may provide a strategy for preparing new nanodrug-loaded preparations of traditional Chinese medicine.PMID:38687941 | DOI:10.4103/jcrt.jcrt_134_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Zongqiang Lai Facheng Bai Tao Pu Jun Li Lining Wu Zhou Zhou Nuo Yang Source Type: research
Immunostimulatory effects of thermal ablation: Challenges and future prospects
J Cancer Res Ther. 2024 Apr 1;20(2):531-539. doi: 10.4103/jcrt.jcrt_2484_23. Epub 2024 Apr 30.ABSTRACTThis literature explores the immunostimulatory effects of thermal ablation in the tumor microenvironment, elucidating the mechanisms such as immunogenic cell death, tumor-specific antigens, and damage-associated molecular patterns. Furthermore, it outlines critical issues associated with thermal ablation-induced immunostimulatory challenges and offers insights into future research avenues and potential therapeutic strategies.PMID:38687922 | DOI:10.4103/jcrt.jcrt_2484_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Peng Liu Zhigang Wei Xin Ye Source Type: research
Microwave ablation combined with percutaneous vertebroplasty for treating painful non-small cell lung cancer with spinal metastases under real-time temperature monitoring
CONCLUSIONS: MWA combined with PVP can significantly relieve pain and improve patients' quality of life, which implied this is an effective treatment option for painful NSCLC with spinal metastases. Additionally, its efficacy should be further verified through the mid- and long-term studies.PMID:38687923 | DOI:10.4103/jcrt.jcrt_1074_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Linlin Wu Miaomiao Hu Peishun Li Qirong Man Qianqian Yuan Xusheng Zhang Yuanyuan Qiu Lili Chen Jing Fan Kaixian Zhang Source Type: research
Chromosome fusion and programmed DNA elimination shape karyotypes of nematodes
Curr Biol. 2024 Apr 23:S0960-9822(24)00462-7. doi: 10.1016/j.cub.2024.04.022. Online ahead of print.ABSTRACTAn increasing number of metazoans undergo programmed DNA elimination (PDE), where a significant amount of DNA is selectively lost from the somatic genome during development. In some nematodes, PDE leads to the removal and remodeling of the ends of all germline chromosomes. In several species, PDE also generates internal breaks that lead to sequence loss and increased numbers of somatic chromosomes. The biological significance of these karyotype changes associated with PDE and the origin and evolution of nematode PDE ...
Source: Current Biology - April 30, 2024 Category: Biology Authors: James R Simmons Brandon Estrem Maxim V Zagoskin Ryan Oldridge Sobhan Bahrami Zadegan Jianbin Wang Source Type: research
TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes
Autophagy. 2024 Apr 30:1-21. doi: 10.1080/15548627.2024.2338576. Online ahead of print.ABSTRACTObesity is one of the most common metabolic diseases around the world, which is distinguished by the abnormal buildup of triglycerides within adipose cells. Recent research has revealed that autophagy regulates lipid mobilization to maintain energy balance. TIGAR (Trp53 induced glycolysis regulatory phosphatase) has been identified as a glycolysis inhibitor, whether it plays a role in the metabolism of lipids is unknown. Here, we found that TIGAR transgenic (TIGAR+/+) mice exhibited increased fat mass and trended to obesity pheno...
Source: Autophagy - April 30, 2024 Category: Cytology Authors: Tian Zhang Ke-Gang Linghu Jia Tan Mingming Wang Diao Chen Yan Shen Junchao Wu Mingjun Shi Yuxia Zhou Lei Tang Lirong Liu Zheng-Hong Qin Bing Guo Source Type: research
PELI1 overexpression contributes to pancreatic cancer progression through upregulating ubiquitination-mediated INPP5J degradation
In conclusion, the results suggest that INPP5J, decreased by PELI1 through ubiquitination, may promote PC progression. The PELI1-INPP5J axis represents a potential therapeutic targetable node for PC.PMID:38685520 | DOI:10.1016/j.cellsig.2024.111194 (Source: Cellular Signalling)
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Wenyang Zhou Xin Deng Liling Liu Yifeng Yuan Xiangpeng Meng Jia Ma Source Type: research
The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization
In this study, we analyzed RNA-seq data from sGBM patients' glioma tissues with or without ZM fusion,and found that stemness and macrophage markers were more highly expressed in sGBM patients harboring ZM than in those without ZM fusion. ZM enhanced the self-renewal and proliferation of GSCs, thereby accelerating glioma progression. In addition, ZM-positive GSCs facilitated the infiltration of TAMs and drove their polarization toward an immunosuppressive phenotype, which was primarily accomplished through the extracellular secretion of ISG20. Our research identified the MET-STAT3-ISG20 axis within GSCs, thus demonstrating ...
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Yuxin Wang Jinghao Suo Zhixing Wang Kunnian Ran Yuan Tian Wei Han Yanwei Liu Xiaozhong Peng Source Type: research
IRAK1 deficiency potentiates the efficacy of radiotherapy in repressing cervical cancer development
In this study, we evaluated IRAK1 expression in radiotherapy-treated cervical cancer tissues and found that IRAK1 expression is negatively associated with the efficacy of radiotherapy. Consistently, ionizing radiation (IR)-treated HeLa and SiHa cervical cancer cells express a lower level of IRAK1 than control cells. Depletion of IRAK1 resulted in reduced activation of the NF-κB pathway, decreased cell viability, downregulated colony formation efficiency, cell cycle arrest, increased apoptosis, and impaired migration and invasion in IR-treated cervical cancer cells. Conversely, overexpressing IRAK1 mitigated the anti-cance...
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Wenjuan Chen Xingyun Xie Chengying Liu Jingrong Liao Yuting Wei Rongrong Wu Jinsheng Hong Source Type: research
BPTF promotes glioma development through USP34-mediated de-ubiquitination of FOXC1
In conclusion, the BPTF/FOXC1 axis was identified as a key promotor in glioma development and may be a potential target in the inhibition of glioma development.PMID:38686761 | DOI:10.14670/HH-18-748 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 30, 2024 Category: Cytology Authors: Yanling Pan Feng Yuan Zhiren Lin Yijie Li Source Type: research
Effect of stability of PTEN on hepatocellular carcinoma
CONCLUSIONS: On the one hand, our study revealed that CRISPR-Cas12a might play an important role in the screening and prognosis of HCC as a new clinical method to detect PTEN mutation.PMID:38687946 | DOI:10.4103/jcrt.jcrt_349_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yilin Hu Hongliang Mei Tianji Luan Huiling Sun Qiping Lu Rong Liu Source Type: research
Local therapy combined with anti-PD-1 immunotherapy for advanced lung adenocarcinoma: A case report
J Cancer Res Ther. 2024 Apr 1;20(2):739-744. doi: 10.4103/jcrt.jcrt_1600_23. Epub 2024 Apr 30.ABSTRACTLung adenocarcinoma (LUAD) encompasses all lung epithelial cancers except small-cell lung cancer. Although programmed cell death protein 1 (PD-1) inhibitors, such as pembrolizumab, and other Food and Drug Administration-approved immune checkpoint inhibitors, offer new hope for LUAD treatment, LUAD's overall efficacy remains limited. Thus, the combination of immunotherapy with other therapeutic approaches has gained widespread attention. Local therapy is an optimal method for treating many advanced unresectable lung cancers...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Na Wu Xiaoxin Yang Yan Zhai Wei Lu Source Type: research
