Endogenous Protein-Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex
J Proteome Res. 2024 Apr 30. doi: 10.1021/acs.jproteome.3c00788. Online ahead of print.ABSTRACTNPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in the NPC1 gene result in Niemann-Pick disease, type C (NPC), a fatal, lysosomal storage disease. Due to the progressively expanding implications of NPC1-related disorders, we investigated endogenous NPC1 protein-protein interactions in the mouse cortex and human-derived iPSCs neuronal models of the disease through coimmunoprecipitation-coupled with LC-MS b...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Roshan Javanshad Thu T A Nguyen Ruth D Azaria Wenping Li Daisy Edmison Liang-Wei Gong Swetha Gowrishankar Andrew P Lieberman Mark L Schultz Stephanie M Cologna Source Type: research
Periodontal granulation tissue - To remove or not to remove, that is the question
J Periodontal Res. 2024 Apr 30. doi: 10.1111/jre.13261. Online ahead of print.ABSTRACTFormation of granulation tissue is a fundamental phase in periodontal wound healing with subsequent maturation leading to regeneration or repair. However, persistently inflamed granulation tissue presents in osseous defects as a result of periodontitis and is routinely disrupted and discarded with non-surgical and surgical therapy to facilitate wound healing or improve chances of regeneration. Histological assessment suggests that granulation tissue from periodontitis-affected sites is effectively a chronic inflammatory tissue resulting f...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Ye Han Sam Luigi Nibali Mandeep Ghuman Source Type: research
ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly
ERJ Open Res. 2024 Apr 29;10(2):00875-2023. doi: 10.1183/23120541.00875-2023. eCollection 2024 Mar.ABSTRACTEarly career members of Assembly 3 (Basic and Translational Sciences) of the European Respiratory Society (ERS) summarise the key messages discussed during six selected sessions that took place at the ERS International Congress 2023 in Milan, Italy. Aligned with the theme of the congress, the first session covered is "Micro- and macro-environments and respiratory health", which is followed by a summary of the "Scientific year in review" session. Next, recent advances in experimental methodologies and new technologies ...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Karosham Diren Reddy Nikoleta Bizymi Anja Schweikert Sachin Ananth Clarice X Lim Katharine M Lodge Audrey Joannes Niki Ubags Anne M van der Does Suzanne M Cloonan Arnaud Mailleux Nahal Mansouri Niki L Reynaert Irene H Heijink Sara Cuevas-Oca ña Source Type: research
Systemic Inflammatory Response Index, a Potential Inflammatory Biomarker in Disease Severity of Myasthenia Gravis: A Pilot Retrospective Study
CONCLUSION: Our findings indicate a strong independent association between SIRI and disease severity in MG, suggesting SIRI's potential as a valuable biomarker for MG with superior clinical benefit to currently utilized markers.PMID:38686359 | PMC:PMC11057634 | DOI:10.2147/JIR.S449324 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Suwen Huang Yanchu Wang Jinrong Zhu Shengqi Li Shenyi Lin Wei Xie Siyao Chen Yukai Wang Lingsheng Wang Qiaoqiao Jin Yiyun Weng Dehao Yang Source Type: research
A comparative < em > in vitro < /em > study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells
This study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors, specifically Canagliflozin (CAN), Dapagliflozin (DAP), Empagliflozin (EMP), and Doxorubicin (DOX), using in vitro experimentation. The precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin (DOX) in MCF-7 cells. Interestingly, it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their growth. Notably, when these medications were combined with DOX, there was a considerable inhibition of glucose consumption, as well as reductions in intra...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Shahid Karim Alanoud Naher Alghanmi Maha Jamal Huda Alkreathy Alam Jamal Hind A Alkhatabi Mohammed Bazuhair Aftab Ahmad Source Type: research
