Genome-wide transcriptome analysis reveals that bisphenol A activates immune responses in skeletal muscle
Environ Res. 2024 May 1:119034. doi: 10.1016/j.envres.2024.119034. Online ahead of print.ABSTRACTCumulative human exposure to the environmental toxin, bisphenol A (BPA), has raised important health concerns in recent decades. However, the direct genomic regulation of BPA in skeletal muscles and its clinical significance are poorly understood. Therefore, we conducted a genome-wide transcriptome analysis after daily oral administration of BPA at the lowest observed adverse-effect level (LOAEL, 50 mg/kg) in male mice for six weeks to explore the gene-expression regulations in skeletal muscle induced by BPA. The primary Gene O...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Hyo Jin Gu Do-Young Kim Seung Hee Shin Md Saidur Rahman Hee-Seok Lee Myung-Geol Pang Jun-Mo Kim Buom-Yong Ryu Source Type: research
PLAU, transcriptionally negatively regulated by GATA6, promotes lung squamous carcinoma cell proliferation and migration
CONCLUSION: In this work, it was revealed that PLAU is a novel oncogene for LUSC and a new molecular regulatory mechanism of GATA6 in LUSC was unveiled. Targeting the GATA6/PLAU pathway might help in the development of novel therapeutic treatment strategies for LUSC.PMID:38702016 | DOI:10.1016/j.bbamcr.2024.119744 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Jiankun Guo Hailong Wang Changhua Huang Caihong Lai Wenli Shang Shiwen Luo Limin Chen Source Type: research
A GMP-compliant manufacturing method for Wharton's jelly-derived mesenchymal stromal cells
CONCLUSION: This study offers valuable insights into optimizing the isolation and culture of WJ-MSCs. Our scalable manufacturing processes facilitate the large-scale production of high-quality WJ-MSCs. These findings contribute to the advancement of WJ-MSCs-based therapies in regenerative medicine.PMID:38702793 | DOI:10.1186/s13287-024-03725-0 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Wanglong Chu Fen Zhang Xiuping Zeng Fangtao He Guanyan Shang Tao Guo Qingfang Wang Jianfu Wu Tongjing Li Zhen Zhong Zhong Xiao Liang Junyuan Hu Muyun Liu Source Type: research
METTL3-mediated m < sup > 6 < /sup > A methylation of SLC38A1 stimulates cervical cancer growth
In conclusion, METTL3-mediated m6A methylation of SLC38A1 stimulates cervical cancer progression. SLC38A1 inhibition is a potential therapeutic strategy for cervical cancer.PMID:38701556 | DOI:10.1016/j.bbrc.2024.150039 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Hai-Ting Liu Yun Zhao Hong-Cai Wang Qing-Ling Liu Source Type: research
Effects of different light conditions on morphological, anatomical, photosynthetic and biochemical parameters of Cypripedium macranthos Sw
In this study, the morphological (plant height, leaf length and width, stem diameter and leaf number), anatomical (epidermal cell density and thickness, Stomatal length and width), photosynthetic (net photosynthetic rate, transpiration rate, stomatal conductance, intercellular CO2 concentration, relative humidity, leaf temperature and chlorophyll fluorescence parameters) and biochemical parameters (the content of soluble sugar, soluble protein, proline, malondialdehyde and electrical conductivity) of Cypripedium macranthos Sw. in Changbai Mountain were determined under different light conditions (L10, L30, L50, L100). The ...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Yuqing Zhang Wei Liu Xi Lu Shuang Li Ying Li Yuze Shan Shizhuo Wang Yunwei Zhou Lifei Chen Source Type: research
Monocytes prevent apoptosis of iPSCs and promote differentiation of kidney organoids
CONCLUSION: Our data suggest that co-culturing of iPSCs with human monocytes strongly improves differentiation of kidney organoids. An underlying mechanism of monocytic action implies, but not limited to, an increased autophagy in CHIR-treated iPSCs. Our findings enhance the utility of kidney organoid models.PMID:38702808 | DOI:10.1186/s13287-024-03739-8 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Ekaterina Pecksen Sergey Tkachuk Cristoph Schr öder Marc Vives Enrich Anindita Neog Cory P Johnson Niko Lachmann Hermann Haller Yulia Kiyan Source Type: research
The Hansenula polymorpha mitochondrial carrier family protein Mir1 is dually localized at peroxisomes and mitochondria
Biochim Biophys Acta Mol Cell Res. 2024 May 1:119742. doi: 10.1016/j.bbamcr.2024.119742. Online ahead of print.ABSTRACTPeroxisomes are ubiquitous cell organelles involved in various metabolic pathways. In order to properly function, several cofactors, substrates and products of peroxisomal enzymes need to pass the organellar membrane. So far only a few transporter proteins have been identified. We analysed peroxisomal membrane fractions purified from the yeast Hansenula polymorpha by untargeted label-free quantitation mass spectrometry. As expected, several known peroxisome-associated proteins were enriched in the peroxiso...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Marc Pilegaard Pedersen Justina C Wolters Rinse de Boer Arjen M Krikken Ida J van der Klei Source Type: research
Exploring the epigenetic profile of ID4 in breast cancer: bioinformatic insights into methylation patterns and chromatin accessibility dynamics
CONCLUSION: This study shows the intricate epigenetic regulation of ID4 in breast cancer, highlighting subtype-specific differences in DNA methylation and chromatin accessibility.PMID:38702584 | DOI:10.1007/s10549-024-07343-5 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Daniela Nasif Sergio Laurito Sebastian Real Mar ía Teresita Branham Source Type: research
Illuminating intercellular autophagy: A comprehensive review of cell non-autonomous autophagy
Biochem Biophys Res Commun. 2024 Apr 27;716:150024. doi: 10.1016/j.bbrc.2024.150024. Online ahead of print.ABSTRACTMacro-autophagy (autophagy hereafter) is an evolutionarily conserved cellular process that has long been recognized as an intracellular mechanism for maintaining cellular homeostasis. It involves the formation of a membraned structure called the autophagosome, which carries cargo that includes toxic protein aggregates and dysfunctional organelles to the lysosome for degradation and recycling. Autophagy is primarily considered and studied as a cell-autonomous mechanism. However, recent studies have illuminated ...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Karan Selarka Bhupendra V Shravage Source Type: research
MIER2/PGC1A elicits sunitinib resistance via lipid metabolism in renal cell carcinoma
CONCLUSION: Our findings highlight MIER2 as a key player in anchoring HDAC1 and inhibiting PGC1A expression through the deacetylation of P53, thereby inducing lipid accumulation in RCC and promoting drug resistance. Lipid-rich RCC cells compensate for energy production and sustain their own growth in a glycolysis-independent manner, evading the cytotoxic effects of targeted drugs and ultimately culminating in the development of drug resistance.PMID:38702028 | DOI:10.1016/j.jare.2024.04.032 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Zhihao Wei Yuzhong Ye Chenchen Liu Qi Wang Yunxuan Zhang Kailei Chen Gong Cheng Xiaoping Zhang Source Type: research
A tale of two calcium channels: structural pharmacology of Cav2.1 and Cav3.2
Cell Res. 2024 May 3. doi: 10.1038/s41422-024-00961-0. Online ahead of print.NO ABSTRACTPMID:38702487 | DOI:10.1038/s41422-024-00961-0 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Laurent Ferron Gerald W Zamponi Source Type: research
Impact of Lithium on the Immune System: An Investigation of T-Cell Subpopulations and Cytokine Responses in Rats
In conclusion, lithium adversely impacted the cellular defense system. Furthermore, apart from its anti-inflammatory properties, lithium exhibited cytokine-mediated inflammatory activities. Therefore, lithium's potential adverse effects on the immune system should be considered in immunodeficient patients and those with an inflammatory status treated with high doses of lithium.PMID:38700635 | DOI:10.1007/s12011-024-04202-8 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Erdal Matur Sibel Akyol Selmin Toplan Semra Ozdemir Ibrahim Akyaz ı Nuran Dar ıyerli Source Type: research
The laterality of skin cancer: a retrospective study
Arch Dermatol Res. 2024 May 3;316(5):148. doi: 10.1007/s00403-024-02877-6.NO ABSTRACTPMID:38700710 | DOI:10.1007/s00403-024-02877-6 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Andrew Cho Patrick Ting Ingrid Freeny Source Type: research
Subcellular localization of circular RNAs: Where and why
Biochem Biophys Res Commun. 2024 Apr 17;715:149937. doi: 10.1016/j.bbrc.2024.149937. Online ahead of print.ABSTRACTLocalization of RNAs at specific subcellular locations regulating various local cellular events has gained much attention recently. Like most other classes of RNAs, the function of newly discovered circular RNAs (circRNAs) is predominantly determined by their association with different cellular factors in the cell. CircRNAs function as transcriptional and posttranscriptional regulators of gene expression by interacting with transcription factors, splicing regulators, RNA-binding proteins, and microRNAs or by t...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Susovan Sadhukhan Tanvi Sinha Suchanda Dey Amaresh C Panda Source Type: research
Anhydroparthenin as a dual-target inhibitor against Sterol C-24 methyltransferase and Sterol 14- α demethylase of Leishmania donovani: A comprehensive in vitro and in silico study
Int J Biol Macromol. 2024 May 1:132034. doi: 10.1016/j.ijbiomac.2024.132034. Online ahead of print.ABSTRACTParthenium hysterophorus plant has a diverse chemical profile and immense bioactive potential. It exhibits excellent pharmacological properties such as anti-cancer, anti-inflammatory, anti-malarial, microbicidal, and anti-trypanosomal. The present study aims to evaluate the anti-leishmanial potential and toxicological safety of anhydroparthenin isolated from P. hysterophorus. Anydroparthenin was extracted from the leaves of P. hysterophorus and characterized through detailed analysis of 1H, 13C NMR, and HRMS. Dye-base...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Diksha Kumari Parampreet Kour Chetan Paul Singh Rinku Choudhary Syed Mudassir Ali Sagar Bhayye Yogesh P Bharitkar Kuljit Singh Source Type: research
