The novel DNA methylation marker FIBIN suppresses non-small cell lung cancer metastasis by negatively regulating ANXA2
CONCLUSION: Our findings firstly identify FIBIN is a tumor suppressor, frequently silenced due to promoter hypermethylation. FIBIN may serve as a predictive biomarker for progression or metastasis among early-stage lung cancer patients.PMID:38697447 | DOI:10.1016/j.cellsig.2024.111197 (Source: Cellular Signalling)
Source: Cellular Signalling - May 2, 2024 Category: Cytology Authors: Mingyu Peng Li Yang Jiaxin Liao Xin Le Fengsheng Dai Ran Sun Fan Wu Yu Jiang Rui Tian Bianfei Shao Li Zhou Mingjun Wu Shuliang Guo Tingxiu Xiang Source Type: research
Identification of S100A8/A9 involved in thromboangiitis obliterans development using tandem mass tags-labeled quantitative proteomics analysis
In conclusion, our study revealed that the early activation of S100A8/A9 in the femoral artery is implicated in TAO development, targeting S100A8/A9 signaling may provide a novel approach for TAO prevention and treatment.PMID:38697446 | DOI:10.1016/j.cellsig.2024.111199 (Source: Cellular Signalling)
Source: Cellular Signalling - May 2, 2024 Category: Cytology Authors: Jing Chen Chunfang Chen Lili Wang Xinyi Feng Yinru Chen Rong Zhang Yuanyuan Cheng Zhongqiu Liu Qi Chen Source Type: research
Raman Spectroscopy Analysis of Human Amniotic Fluid Cells from fetuses with Myelomeningocele
Exp Cell Res. 2024 Apr 30:114048. doi: 10.1016/j.yexcr.2024.114048. Online ahead of print.ABSTRACTPrenatal surgery for the treatment of spina bifida (myelomeningocele, MMC) significantly enhances the neurological prognosis of the patient. To ensure better protection of the spinal cord by large defects, the application of skin grafts produced with cells gained from the amniotic fluid is presently studied. In order to determine the most appropriate cells for this purpose, we tried to shed light on the extremely complex amniotic fluid cellular composition in healthy and MMC pregnancies. We exploited the potential of micro-Ram...
Source: Experimental Cell Research - May 2, 2024 Category: Cytology Authors: Luca Pontiggia Katarzyna Michalak-Micka Nadine H ürlimann Hesham K Yosef Roland B öni Agnes S Klar Martin Ehrbar Nicole Ochsenbein-K ölble Thomas Biedermann Ueli Moehrlen Source Type: research
Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft
Protein Cell. 2024 May 2:pwae021. doi: 10.1093/procel/pwae021. Online ahead of print.NO ABSTRACTPMID:38695759 | DOI:10.1093/procel/pwae021 (Source: Protein and Cell)
Source: Protein and Cell - May 2, 2024 Category: Cytology Authors: Huaxiang Zhao Wenjie Zhong Wenbin Huang Guozhu Ning Jieni Zhang Mengqi Zhang Peiqi Meng Yunfan Zhang Qian Zhang Hongping Zhu Gulibaha Maimaitili Yi Ding Weiran Li Wei Liang Zhibo Zhou Qiang Wang Feng Chen Jiuxiang Lin Source Type: research
Notochord segmentation in zebrafish controlled by iterative mechanical signaling
Dev Cell. 2024 Apr 26:S1534-5807(24)00238-7. doi: 10.1016/j.devcel.2024.04.013. Online ahead of print.ABSTRACTIn bony fishes, patterning of the vertebral column, or spine, is guided by a metameric blueprint established in the notochord sheath. Notochord segmentation begins days after somitogenesis concludes and can occur in its absence. However, somite patterning defects lead to imprecise notochord segmentation, suggesting that these processes are linked. Here, we identify that interactions between the notochord and the axial musculature ensure precise spatiotemporal segmentation of the zebrafish spine. We demonstrate that...
Source: Developmental Cell - May 2, 2024 Category: Cytology Authors: Susan Wopat Priyom Adhyapok Bijoy Daga Janice M Crawford James Norman Jennifer Bagwell Brianna Peskin Indrasen Magre Stephanie M Fogerson Daniel S Levic Stefano Di Talia Daniel P Kiehart Patrick Charbonneau Michel Bagnat Source Type: research
Cilia as Wnt signaling organelles
Trends Cell Biol. 2024 May 1:S0962-8924(24)00071-0. doi: 10.1016/j.tcb.2024.04.001. Online ahead of print.ABSTRACTCilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and, conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are present in flagella, primary cilia, and multicilia, where they transmit an intraciliary signal that is independent of β-catenin. Intraciliary Wnt signaling promotes ciliogenesis, affecting male fertility, adipogenesis, and mucociliary clearance. Wnt also stimulates the beating of motile cilia, highlighting that these nanomotors, too, are...
Source: Trends in Cell Biology - May 2, 2024 Category: Cytology Authors: Christof Niehrs Fabio Da Silva Carina Seidl Source Type: research
Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease
This study reveals mitophagy impairment reflected in biofluid biomarkers of individuals with AD and associated with more advanced AD pathology.Abbreviation: Aβ: amyloid beta; AD: Alzheimer disease; AVs: autophagic vacuoles; BNIP3L: BCL2 interacting protein 3 like; CU: cognitively unimpaired; CSF: cerebrospinal fluid; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MCI: mild cognitive impairment; NRGN: neurogranin; NEFL: neurofilament light chain; p-MAPT/tau: phosphorylated microtubule associated protein tau; PINK1: PTEN induced kinase 1; t-MAPT/tau: total microt...
Source: Autophagy - May 2, 2024 Category: Cytology Authors: Kate řina Veverová Jan Lacz ó Al žběta Katonová Hana Hor áková Veronika Matu šková Francesco Angelucci Martina Lacz ó Zuzana Nedelsk á Jakub Hort He-Ling Wang Jianying Zhang Liu Shi Evandro Fei Fang Martin Vyhn álek Source Type: research
Statement of Retraction: Autophagic proteins regulate cigarette smoke induced apoptosis: Protective role of heme oxygenase-1
Autophagy. 2024 May 2:1. doi: 10.1080/15548627.2024.2343270. Online ahead of print.NO ABSTRACTPMID:38697775 | DOI:10.1080/15548627.2024.2343270 (Source: Autophagy)
Source: Autophagy - May 2, 2024 Category: Cytology Source Type: research
Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense
Cell Mol Life Sci. 2024 May 2;81(1):203. doi: 10.1007/s00018-024-05200-8.ABSTRACTNitrogen metabolism of M. tuberculosis is critical for its survival in infected host cells. M. tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and uptake of various amino acids from host cells for metabolic demands. Pyridoxal phosphate-dependent histidinol phosphate aminotransferase-HspAT enzyme is critically required for histidine biosynthesis. HspAT is involved in metabolic synthesis of histidine, phenylalanine, tyrosine, tryptophan, and novobiocin. We showed that M. tuberculosis Rv2231c is a conserved e...
Source: Cellular and Molecular Life Sciences : CMLS - May 2, 2024 Category: Cytology Authors: Sheeba Zarin Mohd Shariq Nilisha Rastogi Yashika Ahuja P Manjunath Anwar Alam Seyed Ehtesham Hasnain Nasreen Zafar Ehtesham Source Type: research
Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation
Cell Transplant. 2024 Jan-Dec;33:9636897241244943. doi: 10.1177/09636897241244943.ABSTRACTMultipotent mesenchymal stem cells (MSCs) have high self-renewal and multi-lineage differentiation potentials and low immunogenicity, so they have attracted much attention in the field of regenerative medicine and have a promising clinical application. MSCs originate from the mesoderm and can differentiate not only into osteoblasts, cartilage, adipocytes, and muscle cells but also into ectodermal and endodermal cell lineages across embryonic layers. To design cell therapy for replacement of damaged tissues, it is essential to understa...
Source: Cell Transplantation - May 2, 2024 Category: Cytology Authors: Mengyu Wu Junwei Mi Guo-Xin Qu Shu Zhang Yi Jian Chu Gao Qingli Cai Jing Liu Jianxin Jiang Hong Huang Source Type: research
The International System for Reporting Serous Fluid Cytopathology: A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies
Adv Anat Pathol. 2024 May 2. doi: 10.1097/PAP.0000000000000454. Online ahead of print.ABSTRACTThis is the first systematic review and meta-analysis of The International System (TIS) for reporting serous fluid cytopathology. Our aims were to present the pooled malignancy rate of each TIS reporting category and the diagnostic accuracy of cytology using this system. Database search using a predefined strategy was followed by study selection, data extraction, study quality assessment, and statistical analysis. Data derived from 16 eligible studies were pooled. The pooled rates of malignancy were as follows: 27% (95% CI; 16%-41...
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Fatima E Jamal Johannes A Vey Tanja Proctor Angela Ishak Fernando C Schmitt Ilias P Nikas Source Type: research
Characterization of cells expressing lipocalin-2 (LCN2) as a reporter
Biochem Cell Biol. 2024 May 2. doi: 10.1139/bcb-2024-0013. Online ahead of print.ABSTRACTLipocalin-2 (LCN2), an effector molecule of the innate immune system that is small enough to be tagged as a reporter molecule, can be coupled with the ferric ion through a siderophore such as enterobactin (Ent). Mintbody (modification-specific intracellular antibody) can track a posttranslational protein modification in epigenetics. We constructed plasmids expressing the LCN2 hybrid of mintbody to examine the potential of LCN2 as a novel reporter for magnetic resonance imaging (MRI). Cells expressing the LCN2 hybrid of mintbody showed ...
Source: Biochemistry and Cell Biology - May 2, 2024 Category: Biochemistry Authors: Kimihiko Sugaya Source Type: research
Assessing the impact of lubricant on liquid-based Pap smear test outcomes: a randomized clinical trial
CONCLUSION: The use of lubricant gel in patients can reduce pain in patients during examination and testing, but does not affect the cytological and pathological results of patients.PMID:38694378 | PMC:PMC11060314 | DOI:10.1097/MS9.0000000000001803 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Mansooreh Yaraghi Sarvenaz Gharavi Ayda Najafian Vajihe Hazari Source Type: research
Evaluation of differences in expression pattern of three isoforms of the transforming growth factor beta in patients with lumbosacral stenosis
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Source: Cell Cycle - May 2, 2024 Category: Cytology Authors: Dawid Soba ńskiPaweł BogdałRafał StaszkiewiczMałgorzata SobańskaMichał FilipowiczRyszard Adam CzepkoDamian StrojnyBeniamin Oskar Grabareka Department of Neurosurgery, Szpital sw. Rafala in Cracow, Cracow, Polandb Collegium Medicum, WSB University, Source Type: research
GTSE1 promotes nasopharyngeal carcinoma proliferation and angiogenesis by upregulating STMN1
Nasopharyngeal carcinoma (NPC) is a malignant tumor with poor survival rate. G2 and S phase-expressed ‐1 (GTSE1) takes part in the progression of diverse tumors as an oncogene, but its role and potential mechan... (Source: Cell Division)
Source: Cell Division - May 2, 2024 Category: Cytology Authors: Jiadi Dong, Jingjing Chen, Yidong Wu and Jiangyu Yan Tags: Research Source Type: research
