Alterations of human CSF and serum-based mitophagy biomarkers in the continuum of Alzheimer disease

This study reveals mitophagy impairment reflected in biofluid biomarkers of individuals with AD and associated with more advanced AD pathology.Abbreviation: Aβ: amyloid beta; AD: Alzheimer disease; AVs: autophagic vacuoles; BNIP3L: BCL2 interacting protein 3 like; CU: cognitively unimpaired; CSF: cerebrospinal fluid; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MCI: mild cognitive impairment; NRGN: neurogranin; NEFL: neurofilament light chain; p-MAPT/tau: phosphorylated microtubule associated protein tau; PINK1: PTEN induced kinase 1; t-MAPT/tau: total microtubule associated protein tau; TFEB: transcription factor EB; TMT: Trail Making Test.PMID:38695174 | DOI:10.1080/15548627.2024.2340408

Source: Autophagy - May 2, 2024 Category: Cytology Authors: Kate řina Veverová Jan Lacz ó Al žběta Katonová Hana Hor áková Veronika Matu šková Francesco Angelucci Martina Lacz ó Zuzana Nedelsk á Jakub Hort He-Ling Wang Jianying Zhang Liu Shi Evandro Fei Fang Martin Vyhn álek Source Type: research