The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond
Trends Cell Biol. 2024 Apr 12:S0962-8924(24)00052-7. doi: 10.1016/j.tcb.2024.03.003. Online ahead of print.ABSTRACTH3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone...
Source: Trends in Cell Biology - April 13, 2024 Category: Cytology Authors: Lea R Z Cohen Eran Meshorer Source Type: research
The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond
Trends Cell Biol. 2024 Apr 12:S0962-8924(24)00052-7. doi: 10.1016/j.tcb.2024.03.003. Online ahead of print.ABSTRACTH3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone...
Source: Trends in Cell Biology - April 13, 2024 Category: Cytology Authors: Lea R Z Cohen Eran Meshorer Source Type: research
The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond
Trends Cell Biol. 2024 Apr 12:S0962-8924(24)00052-7. doi: 10.1016/j.tcb.2024.03.003. Online ahead of print.ABSTRACTH3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone...
Source: Trends in Cell Biology - April 13, 2024 Category: Cytology Authors: Lea R Z Cohen Eran Meshorer Source Type: research
The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond
Trends Cell Biol. 2024 Apr 12:S0962-8924(24)00052-7. doi: 10.1016/j.tcb.2024.03.003. Online ahead of print.ABSTRACTH3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone...
Source: Trends in Cell Biology - April 13, 2024 Category: Cytology Authors: Lea R Z Cohen Eran Meshorer Source Type: research
The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond
Trends Cell Biol. 2024 Apr 12:S0962-8924(24)00052-7. doi: 10.1016/j.tcb.2024.03.003. Online ahead of print.ABSTRACTH3.3 is a highly conserved nonreplicative histone variant. H3.3 is enriched in promoters and enhancers of active genes, but it is also found within suppressed heterochromatin, mostly around telomeres. Accordingly, H3.3 is associated with seemingly contradicting functions: It is involved in development, differentiation, reprogramming, and cell fate, as well as in heterochromatin formation and maintenance, and the silencing of developmental genes. The emerging view is that different cellular contexts and histone...
Source: Trends in Cell Biology - April 13, 2024 Category: Cytology Authors: Lea R Z Cohen Eran Meshorer Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
