Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Tumor-initiating cells establish a niche to overcome isolation stress
Trends Cell Biol. 2023 Aug 26:S0962-8924(23)00165-4. doi: 10.1016/j.tcb.2023.08.001. Online ahead of print.ABSTRACTWhile the tumor microenvironment is a critical contributor to cancer progression, early steps of tumor initiation and metastasis also rely on the ability of individual tumor cells to survive and thrive at locations where tumor stroma or immune infiltration has yet to be established. In this opinion article, we use the term 'isolation stress' to broadly describe the challenges that individual tumor cells must overcome during the initiation and expansion of the primary tumor beyond permissive boundaries and meta...
Source: Trends in Cell Biology - August 28, 2023 Category: Cytology Authors: Chengsheng Wu Sara M Weis David A Cheresh Source Type: research
Tumor-initiating cells establish a niche to overcome isolation stress
Trends Cell Biol. 2023 Aug 26:S0962-8924(23)00165-4. doi: 10.1016/j.tcb.2023.08.001. Online ahead of print.ABSTRACTWhile the tumor microenvironment is a critical contributor to cancer progression, early steps of tumor initiation and metastasis also rely on the ability of individual tumor cells to survive and thrive at locations where tumor stroma or immune infiltration has yet to be established. In this opinion article, we use the term 'isolation stress' to broadly describe the challenges that individual tumor cells must overcome during the initiation and expansion of the primary tumor beyond permissive boundaries and meta...
Source: Trends in Cell Biology - August 28, 2023 Category: Cytology Authors: Chengsheng Wu Sara M Weis David A Cheresh Source Type: research
Tumor-initiating cells establish a niche to overcome isolation stress
Trends Cell Biol. 2023 Aug 26:S0962-8924(23)00165-4. doi: 10.1016/j.tcb.2023.08.001. Online ahead of print.ABSTRACTWhile the tumor microenvironment is a critical contributor to cancer progression, early steps of tumor initiation and metastasis also rely on the ability of individual tumor cells to survive and thrive at locations where tumor stroma or immune infiltration has yet to be established. In this opinion article, we use the term 'isolation stress' to broadly describe the challenges that individual tumor cells must overcome during the initiation and expansion of the primary tumor beyond permissive boundaries and meta...
Source: Trends in Cell Biology - August 28, 2023 Category: Cytology Authors: Chengsheng Wu Sara M Weis David A Cheresh Source Type: research
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production
Trends Cell Biol. 2023 Aug 23:S0962-8924(23)00137-X. doi: 10.1016/j.tcb.2023.07.004. Online ahead of print.ABSTRACTβ-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy. Following the observation that near-total β-cell ablation in adult mice triggers the reprogramming of pancreatic α-, δ-, and γ-cells into insulin (INS)-producing cells, recent studies are delving deep into the mechanisms controlling adult α-cell identity. Systematic analyses of the α-cell transcriptome and epigenome have started to pinpoint features that could be crucial for maintaining α-cell identity. Using d...
Source: Trends in Cell Biology - August 25, 2023 Category: Cytology Authors: Daniel Oropeza Pedro Luis Herrera Source Type: research
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production
Trends Cell Biol. 2023 Aug 23:S0962-8924(23)00137-X. doi: 10.1016/j.tcb.2023.07.004. Online ahead of print.ABSTRACTβ-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy. Following the observation that near-total β-cell ablation in adult mice triggers the reprogramming of pancreatic α-, δ-, and γ-cells into insulin (INS)-producing cells, recent studies are delving deep into the mechanisms controlling adult α-cell identity. Systematic analyses of the α-cell transcriptome and epigenome have started to pinpoint features that could be crucial for maintaining α-cell identity. Using d...
Source: Trends in Cell Biology - August 25, 2023 Category: Cytology Authors: Daniel Oropeza Pedro Luis Herrera Source Type: research
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production
Trends Cell Biol. 2023 Aug 23:S0962-8924(23)00137-X. doi: 10.1016/j.tcb.2023.07.004. Online ahead of print.ABSTRACTβ-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy. Following the observation that near-total β-cell ablation in adult mice triggers the reprogramming of pancreatic α-, δ-, and γ-cells into insulin (INS)-producing cells, recent studies are delving deep into the mechanisms controlling adult α-cell identity. Systematic analyses of the α-cell transcriptome and epigenome have started to pinpoint features that could be crucial for maintaining α-cell identity. Using d...
Source: Trends in Cell Biology - August 25, 2023 Category: Cytology Authors: Daniel Oropeza Pedro Luis Herrera Source Type: research
Structural perspectives on transcription in chromatin
Trends Cell Biol. 2023 Aug 16:S0962-8924(23)00155-1. doi: 10.1016/j.tcb.2023.07.011. Online ahead of print.ABSTRACTIn eukaryotes, all genetic processes take place in the cell nucleus, where DNA is packaged as chromatin in 'beads-on-a-string' nucleosome arrays. RNA polymerase II (RNAPII) transcribes protein-coding and many non-coding genes in this chromatin environment. RNAPII elongates RNA while passing through multiple nucleosomes and maintaining the integrity of the chromatin structure. Recent structural studies have shed light on the detailed mechanisms of this process, including how transcribing RNAPII progresses throu...
Source: Trends in Cell Biology - August 18, 2023 Category: Cytology Authors: Shun-Ichi Sekine Haruhiko Ehara Tomoya Kujirai Hitoshi Kurumizaka Source Type: research
Structural perspectives on transcription in chromatin
Trends Cell Biol. 2023 Aug 16:S0962-8924(23)00155-1. doi: 10.1016/j.tcb.2023.07.011. Online ahead of print.ABSTRACTIn eukaryotes, all genetic processes take place in the cell nucleus, where DNA is packaged as chromatin in 'beads-on-a-string' nucleosome arrays. RNA polymerase II (RNAPII) transcribes protein-coding and many non-coding genes in this chromatin environment. RNAPII elongates RNA while passing through multiple nucleosomes and maintaining the integrity of the chromatin structure. Recent structural studies have shed light on the detailed mechanisms of this process, including how transcribing RNAPII progresses throu...
Source: Trends in Cell Biology - August 18, 2023 Category: Cytology Authors: Shun-Ichi Sekine Haruhiko Ehara Tomoya Kujirai Hitoshi Kurumizaka Source Type: research
Structural perspectives on transcription in chromatin
Trends Cell Biol. 2023 Aug 16:S0962-8924(23)00155-1. doi: 10.1016/j.tcb.2023.07.011. Online ahead of print.ABSTRACTIn eukaryotes, all genetic processes take place in the cell nucleus, where DNA is packaged as chromatin in 'beads-on-a-string' nucleosome arrays. RNA polymerase II (RNAPII) transcribes protein-coding and many non-coding genes in this chromatin environment. RNAPII elongates RNA while passing through multiple nucleosomes and maintaining the integrity of the chromatin structure. Recent structural studies have shed light on the detailed mechanisms of this process, including how transcribing RNAPII progresses throu...
Source: Trends in Cell Biology - August 18, 2023 Category: Cytology Authors: Shun-Ichi Sekine Haruhiko Ehara Tomoya Kujirai Hitoshi Kurumizaka Source Type: research
