Epigenetic control of circadian clocks by environmental signals
Trends Cell Biol. 2024 Feb 28:S0962-8924(24)00028-X. doi: 10.1016/j.tcb.2024.02.005. Online ahead of print.ABSTRACTCircadian clocks have evolved to enable organisms to respond to daily environmental changes. Maintaining a robust circadian rhythm under various perturbations and stresses is essential for the fitness of an organism. In the core circadian oscillator conserved in eukaryotes (from fungi to mammals), a negative feedback loop based on both transcription and translation drives circadian rhythms. The expression of circadian clock genes depends both on the binding of transcription activators at the promoter and on th...
Source: Trends in Cell Biology - February 29, 2024 Category: Cytology Authors: Xiao-Lan Liu Zeyu Duan Muqun Yu Xiao Liu Source Type: research
Things you should learn in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00026-6. doi: 10.1016/j.tcb.2024.02.004. Online ahead of print.ABSTRACTBecoming an academic scientist is neither linear nor formulaic. Rather, graduate education is mostly an apprenticeship without a discrete curriculum, clear sign posts of progress, or specific training metrics. In this science and society article I offer a few thoughts from my own experience for what a student beginning this journey might want to learn.PMID:38402005 | DOI:10.1016/j.tcb.2024.02.004 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
How to enjoy and thrive in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00027-8. doi: 10.1016/j.tcb.2024.02.003. Online ahead of print.ABSTRACTScientific research is an exploration of the unknown. The process is full of uncertainty, missteps, delightful surprises, painful lessons, and ultimately a measure of insight into nature. In this Science and Society article I suggest a few practical strategies that helped me navigate these challenges at the earliest stages of becoming a cell biologist.PMID:38402006 | DOI:10.1016/j.tcb.2024.02.003 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
Things you should learn in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00026-6. doi: 10.1016/j.tcb.2024.02.004. Online ahead of print.ABSTRACTBecoming an academic scientist is neither linear nor formulaic. Rather, graduate education is mostly an apprenticeship without a discrete curriculum, clear sign posts of progress, or specific training metrics. In this science and society article I offer a few thoughts from my own experience for what a student beginning this journey might want to learn.PMID:38402005 | DOI:10.1016/j.tcb.2024.02.004 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
How to enjoy and thrive in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00027-8. doi: 10.1016/j.tcb.2024.02.003. Online ahead of print.ABSTRACTScientific research is an exploration of the unknown. The process is full of uncertainty, missteps, delightful surprises, painful lessons, and ultimately a measure of insight into nature. In this Science and Society article I suggest a few practical strategies that helped me navigate these challenges at the earliest stages of becoming a cell biologist.PMID:38402006 | DOI:10.1016/j.tcb.2024.02.003 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
Things you should learn in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00026-6. doi: 10.1016/j.tcb.2024.02.004. Online ahead of print.ABSTRACTBecoming an academic scientist is neither linear nor formulaic. Rather, graduate education is mostly an apprenticeship without a discrete curriculum, clear sign posts of progress, or specific training metrics. In this science and society article I offer a few thoughts from my own experience for what a student beginning this journey might want to learn.PMID:38402005 | DOI:10.1016/j.tcb.2024.02.004 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
How to enjoy and thrive in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00027-8. doi: 10.1016/j.tcb.2024.02.003. Online ahead of print.ABSTRACTScientific research is an exploration of the unknown. The process is full of uncertainty, missteps, delightful surprises, painful lessons, and ultimately a measure of insight into nature. In this Science and Society article I suggest a few practical strategies that helped me navigate these challenges at the earliest stages of becoming a cell biologist.PMID:38402006 | DOI:10.1016/j.tcb.2024.02.003 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
Things you should learn in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00026-6. doi: 10.1016/j.tcb.2024.02.004. Online ahead of print.ABSTRACTBecoming an academic scientist is neither linear nor formulaic. Rather, graduate education is mostly an apprenticeship without a discrete curriculum, clear sign posts of progress, or specific training metrics. In this science and society article I offer a few thoughts from my own experience for what a student beginning this journey might want to learn.PMID:38402005 | DOI:10.1016/j.tcb.2024.02.004 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
How to enjoy and thrive in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00027-8. doi: 10.1016/j.tcb.2024.02.003. Online ahead of print.ABSTRACTScientific research is an exploration of the unknown. The process is full of uncertainty, missteps, delightful surprises, painful lessons, and ultimately a measure of insight into nature. In this Science and Society article I suggest a few practical strategies that helped me navigate these challenges at the earliest stages of becoming a cell biologist.PMID:38402006 | DOI:10.1016/j.tcb.2024.02.003 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
Things you should learn in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00026-6. doi: 10.1016/j.tcb.2024.02.004. Online ahead of print.ABSTRACTBecoming an academic scientist is neither linear nor formulaic. Rather, graduate education is mostly an apprenticeship without a discrete curriculum, clear sign posts of progress, or specific training metrics. In this science and society article I offer a few thoughts from my own experience for what a student beginning this journey might want to learn.PMID:38402005 | DOI:10.1016/j.tcb.2024.02.004 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
How to enjoy and thrive in graduate school
Trends Cell Biol. 2024 Feb 23:S0962-8924(24)00027-8. doi: 10.1016/j.tcb.2024.02.003. Online ahead of print.ABSTRACTScientific research is an exploration of the unknown. The process is full of uncertainty, missteps, delightful surprises, painful lessons, and ultimately a measure of insight into nature. In this Science and Society article I suggest a few practical strategies that helped me navigate these challenges at the earliest stages of becoming a cell biologist.PMID:38402006 | DOI:10.1016/j.tcb.2024.02.003 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - February 24, 2024 Category: Cytology Authors: Ramanujan S Hegde Source Type: research
Driving factors of neuronal ferroptosis
Trends Cell Biol. 2024 Feb 22:S0962-8924(24)00022-9. doi: 10.1016/j.tcb.2024.01.010. Online ahead of print.ABSTRACTFerroptosis is an oxidative form of iron-dependent cell death characterized by the accumulation of lipid peroxides on membranes. Iron and lipids containing polyunsaturated fatty acids are essential for this process. Ferroptosis is central to several neurological diseases and underlies the importance of balanced iron and polyunsaturated fatty acid metabolism in the brain, particularly in neurons. Here, we reflect on the potential links between neuronal physiology and the accumulation of iron and peroxidated lip...
Source: Trends in Cell Biology - February 23, 2024 Category: Cytology Authors: Julie Jacquemyn Isha Ralhan Maria S Ioannou Source Type: research
Chromosome compartmentalization: causes, changes, consequences, and conundrums
Trends Cell Biol. 2024 Feb 22:S0962-8924(24)00021-7. doi: 10.1016/j.tcb.2024.01.009. Online ahead of print.ABSTRACTThe spatial segregation of the genome into compartments is a major feature of 3D genome organization. New data on mammalian chromosome organization across different conditions reveal important information about how and why these compartments form and change. A combination of epigenetic state, nuclear body tethering, physical forces, gene expression, and replication timing (RT) can all influence the establishment and alteration of chromosome compartments. We review the causes and implications of genomic regions...
Source: Trends in Cell Biology - February 23, 2024 Category: Cytology Authors: Heng Li Christopher Playter Priyojit Das Rachel Patton McCord Source Type: research
ER remodeling via lipid metabolism
Trends Cell Biol. 2024 Feb 22:S0962-8924(24)00023-0. doi: 10.1016/j.tcb.2024.01.011. Online ahead of print.ABSTRACTUnlike most other organelles found in multiple copies, the endoplasmic reticulum (ER) is a unique singular organelle within eukaryotic cells. Despite its continuous membrane structure, encompassing more than half of the cellular endomembrane system, the ER is subdivided into specialized sub-compartments, including morphological, membrane contact site (MCS), and de novo organelle biogenesis domains. In this review, we discuss recent emerging evidence indicating that, in response to nutrient stress, cells underg...
Source: Trends in Cell Biology - February 23, 2024 Category: Cytology Authors: Wonyul Jang Volker Haucke Source Type: research
Functional analysis of cell plasticity using single-cell technologies
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00006-0. doi: 10.1016/j.tcb.2024.01.006. Online ahead of print.ABSTRACTMetazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the d...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Xiao Qin Christopher J Tape Source Type: research
