Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
Blebology: principles of bleb-based migration
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00032-1. doi: 10.1016/j.tcb.2024.02.009. Online ahead of print.ABSTRACTBleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex int...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Juan Manuel Garc ía-Arcos Ankita Jha Clare M Waterman Matthieu Piel Source Type: research
Interplay between hormonal and mechanical signals in mammary morphodynamics
Trends Cell Biol. 2024 Mar 26:S0962-8924(24)00053-9. doi: 10.1016/j.tcb.2024.03.004. Online ahead of print.ABSTRACTMammographic density is a well-established risk factor for breast cancer. In a recent study, Northey et al. reveal that the associated increase in tissue stiffness elevates extracellular signal-regulated kinase (ERK) activity, promoting progesterone receptor-dependent receptor activator of nuclear factor κβ (RANK) signaling. Thus, stiffness alters the context of hormonal signaling and increases mammary stem cells. This mechanism suggests potential treatments for breast cancer.PMID:38538440 | DOI:10.1016/j.tc...
Source: Trends in Cell Biology - March 27, 2024 Category: Cytology Authors: Ali şya A Anlaş Celeste M Nelson Source Type: research
