Vimentin at the core of wound healing
Trends Cell Biol. 2023 Sep 23:S0962-8924(23)00168-X. doi: 10.1016/j.tcb.2023.08.004. Online ahead of print.ABSTRACTAs a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial-mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell sur...
Source: Trends in Cell Biology - September 25, 2023 Category: Cytology Authors: Leila S Coelho-Rato Sepideh Parvanian Mayank Kumar Modi John E Eriksson Source Type: research
Vimentin at the core of wound healing
Trends Cell Biol. 2023 Sep 23:S0962-8924(23)00168-X. doi: 10.1016/j.tcb.2023.08.004. Online ahead of print.ABSTRACTAs a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial-mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell sur...
Source: Trends in Cell Biology - September 25, 2023 Category: Cytology Authors: Leila S Coelho-Rato Sepideh Parvanian Mayank Kumar Modi John E Eriksson Source Type: research
Vimentin at the core of wound healing
Trends Cell Biol. 2023 Sep 23:S0962-8924(23)00168-X. doi: 10.1016/j.tcb.2023.08.004. Online ahead of print.ABSTRACTAs a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial-mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell sur...
Source: Trends in Cell Biology - September 25, 2023 Category: Cytology Authors: Leila S Coelho-Rato Sepideh Parvanian Mayank Kumar Modi John E Eriksson Source Type: research
Towards solving the mystery of peroxisomal matrix protein import
Trends Cell Biol. 2023 Sep 22:S0962-8924(23)00169-1. doi: 10.1016/j.tcb.2023.08.005. Online ahead of print.ABSTRACTPeroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from the cytosol using mobile receptors. Surprisingly, the receptors can even import folded proteins, but the underlying mechanism has been a mystery. Recent results reveal how import receptors shuttle cargo into peroxisomes. The cargo-bound receptors move from the cytosol across the peroxisomal membrane completely into the matrix by a mechanism that resembles transport through the nuclear pore. The receptors then return to t...
Source: Trends in Cell Biology - September 24, 2023 Category: Cytology Authors: Michael L Skowyra Peiqiang Feng Tom A Rapoport Source Type: research
Towards solving the mystery of peroxisomal matrix protein import
Trends Cell Biol. 2023 Sep 22:S0962-8924(23)00169-1. doi: 10.1016/j.tcb.2023.08.005. Online ahead of print.ABSTRACTPeroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from the cytosol using mobile receptors. Surprisingly, the receptors can even import folded proteins, but the underlying mechanism has been a mystery. Recent results reveal how import receptors shuttle cargo into peroxisomes. The cargo-bound receptors move from the cytosol across the peroxisomal membrane completely into the matrix by a mechanism that resembles transport through the nuclear pore. The receptors then return to t...
Source: Trends in Cell Biology - September 24, 2023 Category: Cytology Authors: Michael L Skowyra Peiqiang Feng Tom A Rapoport Source Type: research
Responses of organ precursors to correct and incorrect inductive signals
Trends Cell Biol. 2023 Sep 20:S0962-8924(23)00191-5. doi: 10.1016/j.tcb.2023.08.008. Online ahead of print.ABSTRACTDuring embryonic development, the inductive molecules produced by local origins normally arrive at their target tissues in a nondirectional, diffusion manner. The target organ precursor cells must correctly interpret these inductive signals to ensure proper specification/differentiation, which is dependent on two prerequisites: (i) obtaining cell-intrinsic competence; and (ii) receiving correct inductive signals while resisting incorrect ones. Gain of intrinsic competence could avoid a large number of misinduc...
Source: Trends in Cell Biology - September 22, 2023 Category: Cytology Authors: Yun Yang Shuang Li Lingfei Luo Source Type: research
Responses of organ precursors to correct and incorrect inductive signals
Trends Cell Biol. 2023 Sep 20:S0962-8924(23)00191-5. doi: 10.1016/j.tcb.2023.08.008. Online ahead of print.ABSTRACTDuring embryonic development, the inductive molecules produced by local origins normally arrive at their target tissues in a nondirectional, diffusion manner. The target organ precursor cells must correctly interpret these inductive signals to ensure proper specification/differentiation, which is dependent on two prerequisites: (i) obtaining cell-intrinsic competence; and (ii) receiving correct inductive signals while resisting incorrect ones. Gain of intrinsic competence could avoid a large number of misinduc...
Source: Trends in Cell Biology - September 22, 2023 Category: Cytology Authors: Yun Yang Shuang Li Lingfei Luo Source Type: research
Implementing standardized diversity, equity, and inclusion approaches within scientific communities
Trends Cell Biol. 2023 Sep 18:S0962-8924(23)00170-8. doi: 10.1016/j.tcb.2023.08.006. Online ahead of print.ABSTRACTWithin the global scientific community, there are disparate approaches to diversity, equity, and inclusion (DEI) practices, leading to inequalities that hinder progress. Here, we frame this problem through historical perspectives in the global north and propose a DEI framework adaptable by institutions regardless of location, improving the academic environment for researchers globally.PMID:37730511 | DOI:10.1016/j.tcb.2023.08.006 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - September 20, 2023 Category: Cytology Authors: Aidira D Y Macias Gonzalez Sarah McCallum Jacqueline A De Lora Source Type: research
Implementing standardized diversity, equity, and inclusion approaches within scientific communities
Trends Cell Biol. 2023 Sep 18:S0962-8924(23)00170-8. doi: 10.1016/j.tcb.2023.08.006. Online ahead of print.ABSTRACTWithin the global scientific community, there are disparate approaches to diversity, equity, and inclusion (DEI) practices, leading to inequalities that hinder progress. Here, we frame this problem through historical perspectives in the global north and propose a DEI framework adaptable by institutions regardless of location, improving the academic environment for researchers globally.PMID:37730511 | DOI:10.1016/j.tcb.2023.08.006 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - September 20, 2023 Category: Cytology Authors: Aidira D Y Macias Gonzalez Sarah McCallum Jacqueline A De Lora Source Type: research
Implementing standardized diversity, equity, and inclusion approaches within scientific communities
Trends Cell Biol. 2023 Sep 18:S0962-8924(23)00170-8. doi: 10.1016/j.tcb.2023.08.006. Online ahead of print.ABSTRACTWithin the global scientific community, there are disparate approaches to diversity, equity, and inclusion (DEI) practices, leading to inequalities that hinder progress. Here, we frame this problem through historical perspectives in the global north and propose a DEI framework adaptable by institutions regardless of location, improving the academic environment for researchers globally.PMID:37730511 | DOI:10.1016/j.tcb.2023.08.006 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - September 20, 2023 Category: Cytology Authors: Aidira D Y Macias Gonzalez Sarah McCallum Jacqueline A De Lora Source Type: research
Spermidine - an old molecule with a new age-defying immune function
Trends Cell Biol. 2023 Sep 16:S0962-8924(23)00166-6. doi: 10.1016/j.tcb.2023.08.002. Online ahead of print.ABSTRACTPolyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. Recent advances in immuno-metabolism and immunotherapy shed new light on the role of spermidine in immune cell regulation and anticancer responses. Here, we review novel works demonstrating that spermidine is prod...
Source: Trends in Cell Biology - September 18, 2023 Category: Cytology Authors: Kenji Chamoto Baihao Zhang Masaki Tajima Tasuku Honjo Sidonia Fagarasan Source Type: research
Spermidine - an old molecule with a new age-defying immune function
Trends Cell Biol. 2023 Sep 16:S0962-8924(23)00166-6. doi: 10.1016/j.tcb.2023.08.002. Online ahead of print.ABSTRACTPolyamines - putrescine, spermidine, and spermine - are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine insufficiency is associated with various physio-pathological processes, such as aging and cancers. Recent advances in immuno-metabolism and immunotherapy shed new light on the role of spermidine in immune cell regulation and anticancer responses. Here, we review novel works demonstrating that spermidine is prod...
Source: Trends in Cell Biology - September 18, 2023 Category: Cytology Authors: Kenji Chamoto Baihao Zhang Masaki Tajima Tasuku Honjo Sidonia Fagarasan Source Type: research
Multifaceted collagen-DDR1 signaling in cancer
Trends Cell Biol. 2023 Sep 12:S0962-8924(23)00167-8. doi: 10.1016/j.tcb.2023.08.003. Online ahead of print.ABSTRACTIn addition to immune cells and fibroblasts, the tumor microenvironment (TME) comprises an extracellular matrix (ECM) which contains collagens (COLs) whose architecture and remodeling dictate cancer development and progression. COL receptors expressed by cancer cells sense signals generated by microenvironmental alterations in COL state to regulate cell behavior and metabolism. Discoidin domain receptor 1 (DDR1) is a key sensor of COL fiber state and composition that controls tumor cell metabolism and growth, ...
Source: Trends in Cell Biology - September 14, 2023 Category: Cytology Authors: Hua Su Michael Karin Source Type: research
Multifaceted collagen-DDR1 signaling in cancer
Trends Cell Biol. 2023 Sep 12:S0962-8924(23)00167-8. doi: 10.1016/j.tcb.2023.08.003. Online ahead of print.ABSTRACTIn addition to immune cells and fibroblasts, the tumor microenvironment (TME) comprises an extracellular matrix (ECM) which contains collagens (COLs) whose architecture and remodeling dictate cancer development and progression. COL receptors expressed by cancer cells sense signals generated by microenvironmental alterations in COL state to regulate cell behavior and metabolism. Discoidin domain receptor 1 (DDR1) is a key sensor of COL fiber state and composition that controls tumor cell metabolism and growth, ...
Source: Trends in Cell Biology - September 14, 2023 Category: Cytology Authors: Hua Su Michael Karin Source Type: research
Multifaceted collagen-DDR1 signaling in cancer
Trends Cell Biol. 2023 Sep 12:S0962-8924(23)00167-8. doi: 10.1016/j.tcb.2023.08.003. Online ahead of print.ABSTRACTIn addition to immune cells and fibroblasts, the tumor microenvironment (TME) comprises an extracellular matrix (ECM) which contains collagens (COLs) whose architecture and remodeling dictate cancer development and progression. COL receptors expressed by cancer cells sense signals generated by microenvironmental alterations in COL state to regulate cell behavior and metabolism. Discoidin domain receptor 1 (DDR1) is a key sensor of COL fiber state and composition that controls tumor cell metabolism and growth, ...
Source: Trends in Cell Biology - September 14, 2023 Category: Cytology Authors: Hua Su Michael Karin Source Type: research
