The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research
The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research
The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research
The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research
The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research
Tetraspanins: structure, dynamics, and principles of partner-protein recognition
Trends Cell Biol. 2023 Sep 30:S0962-8924(23)00195-2. doi: 10.1016/j.tcb.2023.09.003. Online ahead of print.ABSTRACTTetraspanins are a large, highly conserved family of four-pass transmembrane (TM) proteins that play critical roles in a variety of essential cellular functions, including cell migration, protein trafficking, maintenance of membrane integrity, and regulation of signal transduction. Tetraspanins carry out these biological functions primarily by interacting with partner proteins. Here, we summarize significant advances that have revealed fundamental principles underpinning structure-function relationships in tet...
Source: Trends in Cell Biology - October 2, 2023 Category: Cytology Authors: Katherine J Susa Andrew C Kruse Stephen C Blacklow Source Type: research
Tetraspanins: structure, dynamics, and principles of partner-protein recognition
Trends Cell Biol. 2023 Sep 30:S0962-8924(23)00195-2. doi: 10.1016/j.tcb.2023.09.003. Online ahead of print.ABSTRACTTetraspanins are a large, highly conserved family of four-pass transmembrane (TM) proteins that play critical roles in a variety of essential cellular functions, including cell migration, protein trafficking, maintenance of membrane integrity, and regulation of signal transduction. Tetraspanins carry out these biological functions primarily by interacting with partner proteins. Here, we summarize significant advances that have revealed fundamental principles underpinning structure-function relationships in tet...
Source: Trends in Cell Biology - October 2, 2023 Category: Cytology Authors: Katherine J Susa Andrew C Kruse Stephen C Blacklow Source Type: research
Tetraspanins: structure, dynamics, and principles of partner-protein recognition
Trends Cell Biol. 2023 Sep 30:S0962-8924(23)00195-2. doi: 10.1016/j.tcb.2023.09.003. Online ahead of print.ABSTRACTTetraspanins are a large, highly conserved family of four-pass transmembrane (TM) proteins that play critical roles in a variety of essential cellular functions, including cell migration, protein trafficking, maintenance of membrane integrity, and regulation of signal transduction. Tetraspanins carry out these biological functions primarily by interacting with partner proteins. Here, we summarize significant advances that have revealed fundamental principles underpinning structure-function relationships in tet...
Source: Trends in Cell Biology - October 2, 2023 Category: Cytology Authors: Katherine J Susa Andrew C Kruse Stephen C Blacklow Source Type: research
Tetraspanins: structure, dynamics, and principles of partner-protein recognition
Trends Cell Biol. 2023 Sep 30:S0962-8924(23)00195-2. doi: 10.1016/j.tcb.2023.09.003. Online ahead of print.ABSTRACTTetraspanins are a large, highly conserved family of four-pass transmembrane (TM) proteins that play critical roles in a variety of essential cellular functions, including cell migration, protein trafficking, maintenance of membrane integrity, and regulation of signal transduction. Tetraspanins carry out these biological functions primarily by interacting with partner proteins. Here, we summarize significant advances that have revealed fundamental principles underpinning structure-function relationships in tet...
Source: Trends in Cell Biology - October 2, 2023 Category: Cytology Authors: Katherine J Susa Andrew C Kruse Stephen C Blacklow Source Type: research
The emerging role of receptor tyrosine kinase phase separation in cancer
Trends Cell Biol. 2023 Sep 28:S0962-8924(23)00194-0. doi: 10.1016/j.tcb.2023.09.002. Online ahead of print.ABSTRACTReceptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of signals from plasma membrane-bound RTKs is subjected to multiple regulatory mechanisms that control downstream effector protein recruitment and function. The high propensity of RTKs to condense via liquid-liquid phase separation (LLPS) into membraneless organelles with downstream effecto...
Source: Trends in Cell Biology - September 30, 2023 Category: Cytology Authors: Chi-Chuan Lin Kin Man Suen Jessica Lidster John E Ladbury Source Type: research
The emerging role of receptor tyrosine kinase phase separation in cancer
Trends Cell Biol. 2023 Sep 28:S0962-8924(23)00194-0. doi: 10.1016/j.tcb.2023.09.002. Online ahead of print.ABSTRACTReceptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of signals from plasma membrane-bound RTKs is subjected to multiple regulatory mechanisms that control downstream effector protein recruitment and function. The high propensity of RTKs to condense via liquid-liquid phase separation (LLPS) into membraneless organelles with downstream effecto...
Source: Trends in Cell Biology - September 30, 2023 Category: Cytology Authors: Chi-Chuan Lin Kin Man Suen Jessica Lidster John E Ladbury Source Type: research
The emerging role of receptor tyrosine kinase phase separation in cancer
Trends Cell Biol. 2023 Sep 28:S0962-8924(23)00194-0. doi: 10.1016/j.tcb.2023.09.002. Online ahead of print.ABSTRACTReceptor tyrosine kinase (RTK)-mediated signal transduction is fundamental to cell function and drives important cellular outcomes which, when dysregulated, can lead to malignant tumour growth and metastasis. The initiation of signals from plasma membrane-bound RTKs is subjected to multiple regulatory mechanisms that control downstream effector protein recruitment and function. The high propensity of RTKs to condense via liquid-liquid phase separation (LLPS) into membraneless organelles with downstream effecto...
Source: Trends in Cell Biology - September 30, 2023 Category: Cytology Authors: Chi-Chuan Lin Kin Man Suen Jessica Lidster John E Ladbury Source Type: research
Regulatory architecture of cell identity genes and housekeeping genes
Trends Cell Biol. 2023 Sep 27:S0962-8924(23)00178-2. doi: 10.1016/j.tcb.2023.08.007. Online ahead of print.ABSTRACTGene regulation and chromosome architecture are intimately linked. Genes with prominent roles in cell identity are often regulated by clusters of enhancer elements. By contrast, a recent study shows housekeeping genes are often regulated through clustering of promoters. We discuss here new regulatory insights for these two types of genes.PMID:37775397 | DOI:10.1016/j.tcb.2023.08.007 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - September 29, 2023 Category: Cytology Authors: Alessandra Dall'Agnese Richard Young Source Type: research
The ubiquitous role of ubiquitination in lipid metabolism
Trends Cell Biol. 2023 Sep 26:S0962-8924(23)00192-7. doi: 10.1016/j.tcb.2023.09.001. Online ahead of print.ABSTRACTLipids are essential molecules that play key roles in cell physiology by serving as structural components, for storage of energy, and in signal transduction. Hence, efficient regulation and maintenance of lipid homeostasis are crucial for normal cellular and tissue function. In the past decade, increasing research has shown the importance of ubiquitination in regulating the stability of key players in different aspects of lipid metabolism. This review describes recent insights into the regulation of lipid meta...
Source: Trends in Cell Biology - September 28, 2023 Category: Cytology Authors: Melanie Loix Noam Zelcer Jeroen F J Bogie Jerome J A Hendriks Source Type: research
The ubiquitous role of ubiquitination in lipid metabolism
Trends Cell Biol. 2023 Sep 26:S0962-8924(23)00192-7. doi: 10.1016/j.tcb.2023.09.001. Online ahead of print.ABSTRACTLipids are essential molecules that play key roles in cell physiology by serving as structural components, for storage of energy, and in signal transduction. Hence, efficient regulation and maintenance of lipid homeostasis are crucial for normal cellular and tissue function. In the past decade, increasing research has shown the importance of ubiquitination in regulating the stability of key players in different aspects of lipid metabolism. This review describes recent insights into the regulation of lipid meta...
Source: Trends in Cell Biology - September 28, 2023 Category: Cytology Authors: Melanie Loix Noam Zelcer Jeroen F J Bogie Jerome J A Hendriks Source Type: research
