The ubiquitous role of ubiquitination in lipid metabolism

Trends Cell Biol. 2023 Sep 26:S0962-8924(23)00192-7. doi: 10.1016/j.tcb.2023.09.001. Online ahead of print.ABSTRACTLipids are essential molecules that play key roles in cell physiology by serving as structural components, for storage of energy, and in signal transduction. Hence, efficient regulation and maintenance of lipid homeostasis are crucial for normal cellular and tissue function. In the past decade, increasing research has shown the importance of ubiquitination in regulating the stability of key players in different aspects of lipid metabolism. This review describes recent insights into the regulation of lipid metabolism by ubiquitin signaling, discusses how ubiquitination can be targeted in diseases characterized by lipid dysregulation, and identifies areas that require further research.PMID:37770289 | DOI:10.1016/j.tcb.2023.09.001

Source: Trends in Cell Biology - September 28, 2023 Category: Cytology Authors: Melanie Loix Noam Zelcer Jeroen F J Bogie Jerome J A Hendriks Source Type: research