Multiplicity of stem cell memories of inflammation and tissue repair in epithelia
Trends Cell Biol. 2023 Nov 6:S0962-8924(23)00212-X. doi: 10.1016/j.tcb.2023.10.008. Online ahead of print.ABSTRACTAdaptation enables cells to change their behavior in response to transient stimuli. While adaptive programs of immune cells have been widely described, it has recently emerged that epithelial cells also acquire memories in vivo. Here, we discuss and classify the adaptations identified in epithelia and describe the associated long-term consequences.PMID:37940416 | DOI:10.1016/j.tcb.2023.10.008 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - November 8, 2023 Category: Cytology Authors: Chiara Levra Levron Giacomo Donati Source Type: research
Fumarate hydratase as a metabolic regulator of immunity
Trends Cell Biol. 2023 Nov 6:S0962-8924(23)00209-X. doi: 10.1016/j.tcb.2023.10.005. Online ahead of print.ABSTRACTTricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells. Notable examples include succinate and itaconate, which have pro- and anti-inflammatory roles, respectively. Recently, fumarate has emerged as having specific roles in macrophage activation, regulating the production of such cytokines as interleukin (IL)-10 and type I interferons (IFNs). Fumarate hydratase (FH) has been identified as a control point. Notably, FH loss in different models and cell ty...
Source: Trends in Cell Biology - November 8, 2023 Category: Cytology Authors: Christian G Peace Shane M O'Carroll Luke A J O'Neill Source Type: research
Mitochondrial regulation in stem cells
Trends Cell Biol. 2023 Oct 31:S0962-8924(23)00207-6. doi: 10.1016/j.tcb.2023.10.003. Online ahead of print.ABSTRACTStem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and metabolites as signaling molecules. Concomitant mitochondrial stress can lead to loss of stem cell self-renewal ...
Source: Trends in Cell Biology - November 2, 2023 Category: Cytology Authors: Yifei Wang Marine Barthez Danica Chen Source Type: research
Mitochondrial regulation in stem cells
Trends Cell Biol. 2023 Oct 31:S0962-8924(23)00207-6. doi: 10.1016/j.tcb.2023.10.003. Online ahead of print.ABSTRACTStem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and metabolites as signaling molecules. Concomitant mitochondrial stress can lead to loss of stem cell self-renewal ...
Source: Trends in Cell Biology - November 2, 2023 Category: Cytology Authors: Yifei Wang Marine Barthez Danica Chen Source Type: research
Mitochondrial regulation in stem cells
Trends Cell Biol. 2023 Oct 31:S0962-8924(23)00207-6. doi: 10.1016/j.tcb.2023.10.003. Online ahead of print.ABSTRACTStem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and metabolites as signaling molecules. Concomitant mitochondrial stress can lead to loss of stem cell self-renewal ...
Source: Trends in Cell Biology - November 2, 2023 Category: Cytology Authors: Yifei Wang Marine Barthez Danica Chen Source Type: research
Mitochondrial regulation in stem cells
Trends Cell Biol. 2023 Oct 31:S0962-8924(23)00207-6. doi: 10.1016/j.tcb.2023.10.003. Online ahead of print.ABSTRACTStem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and metabolites as signaling molecules. Concomitant mitochondrial stress can lead to loss of stem cell self-renewal ...
Source: Trends in Cell Biology - November 2, 2023 Category: Cytology Authors: Yifei Wang Marine Barthez Danica Chen Source Type: research
Mitochondrial regulation in stem cells
Trends Cell Biol. 2023 Oct 31:S0962-8924(23)00207-6. doi: 10.1016/j.tcb.2023.10.003. Online ahead of print.ABSTRACTStem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and metabolites as signaling molecules. Concomitant mitochondrial stress can lead to loss of stem cell self-renewal ...
Source: Trends in Cell Biology - November 2, 2023 Category: Cytology Authors: Yifei Wang Marine Barthez Danica Chen Source Type: research
Mitochondrial regulation in stem cells
Trends Cell Biol. 2023 Oct 31:S0962-8924(23)00207-6. doi: 10.1016/j.tcb.2023.10.003. Online ahead of print.ABSTRACTStem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and metabolites as signaling molecules. Concomitant mitochondrial stress can lead to loss of stem cell self-renewal ...
Source: Trends in Cell Biology - November 2, 2023 Category: Cytology Authors: Yifei Wang Marine Barthez Danica Chen Source Type: research
Mitochondrial complexome and import network
Trends Cell Biol. 2023 Oct 30:S0962-8924(23)00208-8. doi: 10.1016/j.tcb.2023.10.004. Online ahead of print.ABSTRACTMitochondria perform crucial functions in cellular metabolism, protein and lipid biogenesis, quality control, and signaling. The systematic analysis of protein complexes and interaction networks provided exciting insights into the structural and functional organization of mitochondria. Most mitochondrial proteins do not act as independent units, but are interconnected by stable or dynamic protein-protein interactions. Protein translocases are responsible for importing precursor proteins into mitochondria and f...
Source: Trends in Cell Biology - November 1, 2023 Category: Cytology Authors: Fabian den Brave Uwe Schulte Bernd Fakler Nikolaus Pfanner Thomas Becker Source Type: research
Lysosomal cystine: an unexpected alarm bell for cysteine scarcity
Trends Cell Biol. 2023 Oct 23:S0962-8924(23)00213-1. doi: 10.1016/j.tcb.2023.10.009. Online ahead of print.ABSTRACTCells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.PMID:37880057 | DOI:10.1016/j.tcb.2023.10.009 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 25, 2023 Category: Cytology Authors: Fabio Hecht Isaac S Harris Source Type: research
Lysosomal cystine: an unexpected alarm bell for cysteine scarcity
Trends Cell Biol. 2023 Oct 23:S0962-8924(23)00213-1. doi: 10.1016/j.tcb.2023.10.009. Online ahead of print.ABSTRACTCells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.PMID:37880057 | DOI:10.1016/j.tcb.2023.10.009 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 25, 2023 Category: Cytology Authors: Fabio Hecht Isaac S Harris Source Type: research
Lysosomal cystine: an unexpected alarm bell for cysteine scarcity
Trends Cell Biol. 2023 Oct 23:S0962-8924(23)00213-1. doi: 10.1016/j.tcb.2023.10.009. Online ahead of print.ABSTRACTCells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.PMID:37880057 | DOI:10.1016/j.tcb.2023.10.009 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 25, 2023 Category: Cytology Authors: Fabio Hecht Isaac S Harris Source Type: research
Lysosomal cystine: an unexpected alarm bell for cysteine scarcity
Trends Cell Biol. 2023 Oct 23:S0962-8924(23)00213-1. doi: 10.1016/j.tcb.2023.10.009. Online ahead of print.ABSTRACTCells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.PMID:37880057 | DOI:10.1016/j.tcb.2023.10.009 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 25, 2023 Category: Cytology Authors: Fabio Hecht Isaac S Harris Source Type: research
Lysosomal cystine: an unexpected alarm bell for cysteine scarcity
Trends Cell Biol. 2023 Oct 23:S0962-8924(23)00213-1. doi: 10.1016/j.tcb.2023.10.009. Online ahead of print.ABSTRACTCells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.PMID:37880057 | DOI:10.1016/j.tcb.2023.10.009 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 25, 2023 Category: Cytology Authors: Fabio Hecht Isaac S Harris Source Type: research
Lysosomal cystine: an unexpected alarm bell for cysteine scarcity
Trends Cell Biol. 2023 Oct 23:S0962-8924(23)00213-1. doi: 10.1016/j.tcb.2023.10.009. Online ahead of print.ABSTRACTCells respond to amino acid depletion by activating stress responses. A recent study by Swanda et al. reveals that a decrease in lysosomal cystine triggers a novel stress response that transcriptionally activates ATF4 and protects cells from ferroptosis. A synthetic mRNA, CysRx, can prevent ATF4 activation and enhance antitumor effects.PMID:37880057 | DOI:10.1016/j.tcb.2023.10.009 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 25, 2023 Category: Cytology Authors: Fabio Hecht Isaac S Harris Source Type: research
