Advancements in kidney organoids and tubuloids to study (dys)function
Trends Cell Biol. 2023 Oct 19:S0962-8924(23)00197-6. doi: 10.1016/j.tcb.2023.09.005. Online ahead of print.ABSTRACTThe rising prevalence of kidney diseases urges the need for novel therapies. Kidney organoids and tubuloids are advanced in vitro models and have recently been described as promising tools to study kidney (patho)physiology. Recent developments have shown their application in disease modeling, drug screening, and nephrotoxicity. These applications rely on their ability to mimic (dys)function in vitro including endocrine activity and drug, electrolyte, and water transport. This review provides an overview of the...
Source: Trends in Cell Biology - October 21, 2023 Category: Cytology Authors: E Dilmen I Orhon J Jansen J G J Hoenderop Source Type: research

Advancements in kidney organoids and tubuloids to study (dys)function
Trends Cell Biol. 2023 Oct 19:S0962-8924(23)00197-6. doi: 10.1016/j.tcb.2023.09.005. Online ahead of print.ABSTRACTThe rising prevalence of kidney diseases urges the need for novel therapies. Kidney organoids and tubuloids are advanced in vitro models and have recently been described as promising tools to study kidney (patho)physiology. Recent developments have shown their application in disease modeling, drug screening, and nephrotoxicity. These applications rely on their ability to mimic (dys)function in vitro including endocrine activity and drug, electrolyte, and water transport. This review provides an overview of the...
Source: Trends in Cell Biology - October 21, 2023 Category: Cytology Authors: E Dilmen I Orhon J Jansen J G J Hoenderop Source Type: research

Advancements in kidney organoids and tubuloids to study (dys)function
Trends Cell Biol. 2023 Oct 19:S0962-8924(23)00197-6. doi: 10.1016/j.tcb.2023.09.005. Online ahead of print.ABSTRACTThe rising prevalence of kidney diseases urges the need for novel therapies. Kidney organoids and tubuloids are advanced in vitro models and have recently been described as promising tools to study kidney (patho)physiology. Recent developments have shown their application in disease modeling, drug screening, and nephrotoxicity. These applications rely on their ability to mimic (dys)function in vitro including endocrine activity and drug, electrolyte, and water transport. This review provides an overview of the...
Source: Trends in Cell Biology - October 21, 2023 Category: Cytology Authors: E Dilmen I Orhon J Jansen J G J Hoenderop Source Type: research

Control of mitochondrial dynamics by a fusogenic lipid
Trends Cell Biol. 2023 Oct 17:S0962-8924(23)00210-6. doi: 10.1016/j.tcb.2023.10.006. Online ahead of print.ABSTRACTMitochondrial fusion enables cooperation between the mitochondrial population and is critical for mitochondrial function. Phosphatidic acid (PA) on the mitochondrial surface has a key role in mitochondrial fusion. A recent study by Su et al. shows that the nucleoside diphosphate (NDP) kinase NME3 recognizes PA and mediates its effects on mitochondrial dynamics.PMID:37858503 | DOI:10.1016/j.tcb.2023.10.006 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 20, 2023 Category: Cytology Authors: Zheng Yang David C Chan Source Type: research

Control of mitochondrial dynamics by a fusogenic lipid
Trends Cell Biol. 2023 Oct 17:S0962-8924(23)00210-6. doi: 10.1016/j.tcb.2023.10.006. Online ahead of print.ABSTRACTMitochondrial fusion enables cooperation between the mitochondrial population and is critical for mitochondrial function. Phosphatidic acid (PA) on the mitochondrial surface has a key role in mitochondrial fusion. A recent study by Su et al. shows that the nucleoside diphosphate (NDP) kinase NME3 recognizes PA and mediates its effects on mitochondrial dynamics.PMID:37858503 | DOI:10.1016/j.tcb.2023.10.006 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - October 20, 2023 Category: Cytology Authors: Zheng Yang David C Chan Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research

The cell biology of APOE in the brain
Trends Cell Biol. 2023 Oct 5:S0962-8924(23)00196-4. doi: 10.1016/j.tcb.2023.09.004. Online ahead of print.ABSTRACTApolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other neurodegenerative diseases, yet the molecular mechanisms by which APOE4 drives disease are still unclear. A growing collection of studies in iPSC models, knock-in mice, and human postmortem brain tissue have demonstrated that APOE4 expression in astrocytes and microglia is associated with the accumulation of cytoplasmic lipid droplets,...
Source: Trends in Cell Biology - October 7, 2023 Category: Cytology Authors: Ian A Windham Sarah Cohen Source Type: research