Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00157-5. doi: 10.1016/j.tcb.2023.07.013. Online ahead of print.ABSTRACTThe multistep process of in vivo reprogramming, mediated by the transcription factors (TFs) Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of rejuvenating and regenerative strategies. However, most of the approaches developed so far are accompanied by a persistent risk of tumorigenicity. Here, we review the groundbreaking effects of in vivo reprogramming with a particular focus on rejuvenation and regeneration. We discuss how the activity of pioneer TFs generates cellular plasticit...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Aur élia Huyghe Aneta Trajkova Fabrice Lavial Source Type: research
Patterns in the tapestry of chromatin-bound RB
Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with...
Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research
