Regulatory landscape of enhancer-mediated transcriptional activation
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research
Functional analysis of cell plasticity using single-cell technologies
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00006-0. doi: 10.1016/j.tcb.2024.01.006. Online ahead of print.ABSTRACTMetazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the d...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Xiao Qin Christopher J Tape Source Type: research
Regulatory landscape of enhancer-mediated transcriptional activation
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research
Functional analysis of cell plasticity using single-cell technologies
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00006-0. doi: 10.1016/j.tcb.2024.01.006. Online ahead of print.ABSTRACTMetazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the d...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Xiao Qin Christopher J Tape Source Type: research
Regulatory landscape of enhancer-mediated transcriptional activation
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research
Functional analysis of cell plasticity using single-cell technologies
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00006-0. doi: 10.1016/j.tcb.2024.01.006. Online ahead of print.ABSTRACTMetazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the d...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Xiao Qin Christopher J Tape Source Type: research
Regulatory landscape of enhancer-mediated transcriptional activation
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research
Functional analysis of cell plasticity using single-cell technologies
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00006-0. doi: 10.1016/j.tcb.2024.01.006. Online ahead of print.ABSTRACTMetazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the d...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Xiao Qin Christopher J Tape Source Type: research
Regulatory landscape of enhancer-mediated transcriptional activation
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research
Functional analysis of cell plasticity using single-cell technologies
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00006-0. doi: 10.1016/j.tcb.2024.01.006. Online ahead of print.ABSTRACTMetazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the d...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Xiao Qin Christopher J Tape Source Type: research
Regulatory landscape of enhancer-mediated transcriptional activation
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research
Functional analysis of cell plasticity using single-cell technologies
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00006-0. doi: 10.1016/j.tcb.2024.01.006. Online ahead of print.ABSTRACTMetazoan organisms are heterocellular systems composed of hundreds of different cell types, which arise from an isogenic genome through differentiation. Cellular 'plasticity' further enables cells to alter their fate in response to exogenous cues and is involved in a variety of processes, such as wound healing, infection, and cancer. Recent advances in cellular model systems, high-dimensional single-cell technologies, and lineage tracing have sparked a renaissance in plasticity research. Here, we discuss the d...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Xiao Qin Christopher J Tape Source Type: research
Regulatory landscape of enhancer-mediated transcriptional activation
Trends Cell Biol. 2024 Feb 13:S0962-8924(24)00020-5. doi: 10.1016/j.tcb.2024.01.008. Online ahead of print.ABSTRACTEnhancers are noncoding regulatory elements that instruct spatial and temporal specificity of gene transcription in response to a variety of intrinsic and extrinsic signals during development. Although it has long been postulated that enhancers physically interact with target promoters through the formation of stable loops, recent studies have changed this static view: sequence-specific transcription factors (TFs) and coactivators are dynamically recruited to enhancers and assemble so-called transcription hubs...
Source: Trends in Cell Biology - February 14, 2024 Category: Cytology Authors: Koji Kawasaki Takashi Fukaya Source Type: research
RNA G-quadruplexes and stress: emerging mechanisms and functions
Trends Cell Biol. 2024 Feb 9:S0962-8924(24)00005-9. doi: 10.1016/j.tcb.2024.01.005. Online ahead of print.ABSTRACTRNA G-quadruplexes (rG4s) are noncanonical secondary structures formed by guanine-rich sequences that are found in different regions of RNA molecules. These structures have been implicated in diverse biological processes, including translation, splicing, and RNA stability. Recent studies have suggested that rG4s play a role in the cellular response to stress. This review summarizes the current knowledge on rG4s under stress, focusing on their formation, regulation, and potential functions in stress response pat...
Source: Trends in Cell Biology - February 10, 2024 Category: Cytology Authors: Prakash Kharel Pavel Ivanov Source Type: research
Epithelial metabolism as a rheostat for intestinal inflammation and malignancy
Trends Cell Biol. 2024 Feb 9:S0962-8924(24)00004-7. doi: 10.1016/j.tcb.2024.01.004. Online ahead of print.ABSTRACTThe gut epithelium protects the host from a potentially hostile environment while allowing nutrient uptake that is vital for the organism. To maintain this delicate task, the gut epithelium has evolved multilayered cellular functions ranging from mucus production to hormone release and orchestration of mucosal immunity. Here, we review the execution of intestinal epithelial metabolism in health and illustrate how perturbation of epithelial metabolism affects experimental gut inflammation and tumorigenesis. We a...
Source: Trends in Cell Biology - February 10, 2024 Category: Cytology Authors: Julian Schw ärzler Lisa Mayr Felix Grabherr Herbert Tilg Timon E Adolph Source Type: research
