Sublethal engagement of apoptotic pathways in residual cancer
Trends Cell Biol. 2023 Aug 10:S0962-8924(23)00138-1. doi: 10.1016/j.tcb.2023.07.005. Online ahead of print.ABSTRACTCytotoxic chemo-, radio-, and targeted therapies frequently elicit apoptotic cancer cell death. Mitochondrial outer membrane permeabilization (MOMP) is a critical, regulated step in this apoptotic pathway. The residual cancer cells that survive treatment serve as the seeds of eventual relapse and are often functionally characterized by their transient tolerance of multiple therapeutic treatments. New studies suggest that, in these cells, a sublethal degree of MOMP, reflective of incomplete apoptotic commitment...
Source: Trends in Cell Biology - August 12, 2023 Category: Cytology Authors: Shane T Killarney Stephen W G Tait Douglas R Green Kris C Wood Source Type: research
Towards unraveling the origins of eukaryotic nuclear genome organization
Trends Cell Biol. 2023 Aug 8:S0962-8924(23)00142-3. doi: 10.1016/j.tcb.2023.07.008. Online ahead of print.ABSTRACTWith 3D genome mapping maturing over the past decade, studies exposed the differences between eukaryotic and prokaryotic genome organization. This raises the question of how the complex eukaryotic genome organization originated. Here, I explore potential pathways to answering this question, guided by our changing understanding of the origins of eukaryotes.PMID:37558594 | DOI:10.1016/j.tcb.2023.07.008 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - August 9, 2023 Category: Cytology Authors: Jolien J E van Hooff Source Type: research
The ubiquitin-proteasome system links NADPH metabolism to ferroptosis
Trends Cell Biol. 2023 Aug 7:S0962-8924(23)00136-8. doi: 10.1016/j.tcb.2023.07.003. Online ahead of print.ABSTRACTFerroptosis is the type of cell death arising from uncontrolled and excessive lipid peroxidation. NADPH is essential for ferroptosis regulation because it supplies reducing equivalents for antioxidant defense systems and contributes to the generation of reactive oxygen species. Moreover, NADPH level serves as a biomarker for predicting the sensitivity of cells to ferroptosis. The ubiquitin-proteasome system governs the stability of many ferroptosis effectors. Recent research has revealed MARCHF6, the endoplasmi...
Source: Trends in Cell Biology - August 9, 2023 Category: Cytology Authors: Jihye Yang Yoontae Lee Cheol-Sang Hwang Source Type: research
Towards unraveling the origins of eukaryotic nuclear genome organization
Trends Cell Biol. 2023 Aug 8:S0962-8924(23)00142-3. doi: 10.1016/j.tcb.2023.07.008. Online ahead of print.ABSTRACTWith 3D genome mapping maturing over the past decade, studies exposed the differences between eukaryotic and prokaryotic genome organization. This raises the question of how the complex eukaryotic genome organization originated. Here, I explore potential pathways to answering this question, guided by our changing understanding of the origins of eukaryotes.PMID:37558594 | DOI:10.1016/j.tcb.2023.07.008 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - August 9, 2023 Category: Cytology Authors: Jolien J E van Hooff Source Type: research
The ubiquitin-proteasome system links NADPH metabolism to ferroptosis
Trends Cell Biol. 2023 Aug 7:S0962-8924(23)00136-8. doi: 10.1016/j.tcb.2023.07.003. Online ahead of print.ABSTRACTFerroptosis is the type of cell death arising from uncontrolled and excessive lipid peroxidation. NADPH is essential for ferroptosis regulation because it supplies reducing equivalents for antioxidant defense systems and contributes to the generation of reactive oxygen species. Moreover, NADPH level serves as a biomarker for predicting the sensitivity of cells to ferroptosis. The ubiquitin-proteasome system governs the stability of many ferroptosis effectors. Recent research has revealed MARCHF6, the endoplasmi...
Source: Trends in Cell Biology - August 9, 2023 Category: Cytology Authors: Jihye Yang Yoontae Lee Cheol-Sang Hwang Source Type: research
Towards unraveling the origins of eukaryotic nuclear genome organization
Trends Cell Biol. 2023 Aug 8:S0962-8924(23)00142-3. doi: 10.1016/j.tcb.2023.07.008. Online ahead of print.ABSTRACTWith 3D genome mapping maturing over the past decade, studies exposed the differences between eukaryotic and prokaryotic genome organization. This raises the question of how the complex eukaryotic genome organization originated. Here, I explore potential pathways to answering this question, guided by our changing understanding of the origins of eukaryotes.PMID:37558594 | DOI:10.1016/j.tcb.2023.07.008 (Source: Trends in Cell Biology)
Source: Trends in Cell Biology - August 9, 2023 Category: Cytology Authors: Jolien J E van Hooff Source Type: research
The ubiquitin-proteasome system links NADPH metabolism to ferroptosis
Trends Cell Biol. 2023 Aug 7:S0962-8924(23)00136-8. doi: 10.1016/j.tcb.2023.07.003. Online ahead of print.ABSTRACTFerroptosis is the type of cell death arising from uncontrolled and excessive lipid peroxidation. NADPH is essential for ferroptosis regulation because it supplies reducing equivalents for antioxidant defense systems and contributes to the generation of reactive oxygen species. Moreover, NADPH level serves as a biomarker for predicting the sensitivity of cells to ferroptosis. The ubiquitin-proteasome system governs the stability of many ferroptosis effectors. Recent research has revealed MARCHF6, the endoplasmi...
Source: Trends in Cell Biology - August 9, 2023 Category: Cytology Authors: Jihye Yang Yoontae Lee Cheol-Sang Hwang Source Type: research
The many faces of the helicase RTEL1 at telomeres and beyond
Trends Cell Biol. 2023 Jul 31:S0962-8924(23)00135-6. doi: 10.1016/j.tcb.2023.07.002. Online ahead of print.ABSTRACTRegulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction, the wide spectrum of symptoms caused by germline RTEL1 mutations, and the association of RTEL1 mutations with cancers suggest that RTEL1 is a complex machine that interacts with DNA, RNA, and proteins, and functions in diverse cellular pathways. We summarize the proposed functions of RTEL1 and discuss their implications for telomere ma...
Source: Trends in Cell Biology - August 2, 2023 Category: Cytology Authors: Noa Hourvitz Aya Awad Yehuda Tzfati Source Type: research
The many faces of the helicase RTEL1 at telomeres and beyond
Trends Cell Biol. 2023 Jul 31:S0962-8924(23)00135-6. doi: 10.1016/j.tcb.2023.07.002. Online ahead of print.ABSTRACTRegulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction, the wide spectrum of symptoms caused by germline RTEL1 mutations, and the association of RTEL1 mutations with cancers suggest that RTEL1 is a complex machine that interacts with DNA, RNA, and proteins, and functions in diverse cellular pathways. We summarize the proposed functions of RTEL1 and discuss their implications for telomere ma...
Source: Trends in Cell Biology - August 2, 2023 Category: Cytology Authors: Noa Hourvitz Aya Awad Yehuda Tzfati Source Type: research
The many faces of the helicase RTEL1 at telomeres and beyond
Trends Cell Biol. 2023 Jul 31:S0962-8924(23)00135-6. doi: 10.1016/j.tcb.2023.07.002. Online ahead of print.ABSTRACTRegulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction, the wide spectrum of symptoms caused by germline RTEL1 mutations, and the association of RTEL1 mutations with cancers suggest that RTEL1 is a complex machine that interacts with DNA, RNA, and proteins, and functions in diverse cellular pathways. We summarize the proposed functions of RTEL1 and discuss their implications for telomere ma...
Source: Trends in Cell Biology - August 2, 2023 Category: Cytology Authors: Noa Hourvitz Aya Awad Yehuda Tzfati Source Type: research
The many faces of the helicase RTEL1 at telomeres and beyond
Trends Cell Biol. 2023 Jul 31:S0962-8924(23)00135-6. doi: 10.1016/j.tcb.2023.07.002. Online ahead of print.ABSTRACTRegulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction, the wide spectrum of symptoms caused by germline RTEL1 mutations, and the association of RTEL1 mutations with cancers suggest that RTEL1 is a complex machine that interacts with DNA, RNA, and proteins, and functions in diverse cellular pathways. We summarize the proposed functions of RTEL1 and discuss their implications for telomere ma...
Source: Trends in Cell Biology - August 2, 2023 Category: Cytology Authors: Noa Hourvitz Aya Awad Yehuda Tzfati Source Type: research
The many faces of the helicase RTEL1 at telomeres and beyond
Trends Cell Biol. 2023 Jul 31:S0962-8924(23)00135-6. doi: 10.1016/j.tcb.2023.07.002. Online ahead of print.ABSTRACTRegulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction, the wide spectrum of symptoms caused by germline RTEL1 mutations, and the association of RTEL1 mutations with cancers suggest that RTEL1 is a complex machine that interacts with DNA, RNA, and proteins, and functions in diverse cellular pathways. We summarize the proposed functions of RTEL1 and discuss their implications for telomere ma...
Source: Trends in Cell Biology - August 2, 2023 Category: Cytology Authors: Noa Hourvitz Aya Awad Yehuda Tzfati Source Type: research
The many faces of the helicase RTEL1 at telomeres and beyond
Trends Cell Biol. 2023 Jul 31:S0962-8924(23)00135-6. doi: 10.1016/j.tcb.2023.07.002. Online ahead of print.ABSTRACTRegulator of telomere elongation 1 (RTEL1) is known as a DNA helicase that is important for telomeres and genome integrity. However, the diverse phenotypes of RTEL1 dysfunction, the wide spectrum of symptoms caused by germline RTEL1 mutations, and the association of RTEL1 mutations with cancers suggest that RTEL1 is a complex machine that interacts with DNA, RNA, and proteins, and functions in diverse cellular pathways. We summarize the proposed functions of RTEL1 and discuss their implications for telomere ma...
Source: Trends in Cell Biology - August 2, 2023 Category: Cytology Authors: Noa Hourvitz Aya Awad Yehuda Tzfati Source Type: research
The ins-and-outs of exosome biogenesis, secretion, and internalization
Trends Cell Biol. 2023 Jul 26:S0962-8924(23)00129-0. doi: 10.1016/j.tcb.2023.06.006. Online ahead of print.ABSTRACTExosomes are specialized cargo delivery vesicles secreted from cells by fusion of multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of exosomes during physiological and pathological events has been extensively reported, there remains a lack of understanding of the mechanisms that regulate exosome biogenesis, secretion, and internalization. Recent technological and methodological advances now provide details about MVB/exosome structure as well as the pathways of exosome biogenesis, ...
Source: Trends in Cell Biology - July 28, 2023 Category: Cytology Authors: Subhash B Arya Samuel P Collie Carole A Parent Source Type: research
The ins-and-outs of exosome biogenesis, secretion, and internalization
Trends Cell Biol. 2023 Jul 26:S0962-8924(23)00129-0. doi: 10.1016/j.tcb.2023.06.006. Online ahead of print.ABSTRACTExosomes are specialized cargo delivery vesicles secreted from cells by fusion of multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of exosomes during physiological and pathological events has been extensively reported, there remains a lack of understanding of the mechanisms that regulate exosome biogenesis, secretion, and internalization. Recent technological and methodological advances now provide details about MVB/exosome structure as well as the pathways of exosome biogenesis, ...
Source: Trends in Cell Biology - July 28, 2023 Category: Cytology Authors: Subhash B Arya Samuel P Collie Carole A Parent Source Type: research
