The ins-and-outs of exosome biogenesis, secretion, and internalization

Trends Cell Biol. 2023 Jul 26:S0962-8924(23)00129-0. doi: 10.1016/j.tcb.2023.06.006. Online ahead of print.ABSTRACTExosomes are specialized cargo delivery vesicles secreted from cells by fusion of multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of exosomes during physiological and pathological events has been extensively reported, there remains a lack of understanding of the mechanisms that regulate exosome biogenesis, secretion, and internalization. Recent technological and methodological advances now provide details about MVB/exosome structure as well as the pathways of exosome biogenesis, secretion, and uptake. In this review, we outline our current understanding of these processes and highlight outstanding questions following on recent discoveries in the field.PMID:37507251 | DOI:10.1016/j.tcb.2023.06.006

Source: Trends in Cell Biology - July 28, 2023 Category: Cytology Authors: Subhash B Arya Samuel P Collie Carole A Parent Source Type: research