Vimentin at the core of wound healing

Trends Cell Biol. 2023 Sep 23:S0962-8924(23)00168-X. doi: 10.1016/j.tcb.2023.08.004. Online ahead of print.ABSTRACTAs a member of the large family of intermediate filaments (IFs), vimentin has emerged as a highly dynamic and versatile cytoskeletal protein involved in many key processes of wound healing. It is well established that vimentin is involved in epithelial-mesenchymal transition (EMT) during wound healing and metastasis, during which epithelial cells acquire more dynamic and motile characteristics. Moreover, vimentin participates in multiple cellular activities supporting growth, proliferation, migration, cell survival, and stress resilience. Here, we explore the role of vimentin at each phase of wound healing, with focus on how it integrates different signaling pathways and protects cells in the fluctuating and challenging environments that characterize a healing tissue.PMID:37748934 | DOI:10.1016/j.tcb.2023.08.004
Source: Trends in Cell Biology - Category: Cytology Authors: Source Type: research