Patterns in the tapestry of chromatin-bound RB

Trends Cell Biol. 2023 Aug 28:S0962-8924(23)00156-3. doi: 10.1016/j.tcb.2023.07.012. Online ahead of print.ABSTRACTThe retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's requirement in animal development, is tissue-specific, context-specific, and sometimes appears uncoupled from cell proliferation. Detailed new information about RB's genomic distribution provides a new perspective on the complexity of RB function, suggesting that some of its functional specificity results from context-specific RB association with chromatin. Here we summarize recent evidence showing that RB targets different types of chromatin regulatory elements at different cell cycle stages. RB controls traditional RB/E2F targets prior to S-phase, but, when cells proliferate, RB redistributes to cell type-specific chromatin loci. We discuss the broad implications of the new data for RB research.PMID:37648594 | DOI:10.1016/j.tcb.2023.07.012

Source: Trends in Cell Biology - August 30, 2023 Category: Cytology Authors: Ioannis Sanidas Michael S Lawrence Nicholas J Dyson Source Type: research