Morris Animal Foundation awards nearly $1M in grants for new studies for equine health
(Morris Animal Foundation) Morris Animal Foundation, a leader in advancing animal health, has awarded nearly $1 million in large animal health research grants, supporting 14 projects. The studies will help veterinary scientists improve the well-being of horses through improved prevention and treatment of numerous health challenges, including eye cancer, heart arrhythmias and risks for injury from air transport. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 17, 2020 Category: International Medicine & Public Health Source Type: news

Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division
Cell size is fundamental to cell physiology. For example, cell size determines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis. Although some genes that affect mammalian cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive. We show that cell growth during the G1 phase of the cell division cycle dilutes the cell cycle inhibitor Retinoblastoma protein (Rb) to trigger division in human cells. RB overexpression increased cell size and G1 duration, whereas RB deletion decreased cell size and removed the inverse ...
Source: ScienceNOW - July 23, 2020 Category: Science Authors: Zatulovskiy, E., Zhang, S., Berenson, D. F., Topacio, B. R., Skotheim, J. M. Tags: Cell Biology, Engineering reports Source Type: news

Ophthalmologists Called to Catch Cancers Earlier Ophthalmologists Called to Catch Cancers Earlier
Advances in the management of common eye cancers have highlighted the need for early treatment, experts say.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 17, 2020 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Missing BAP1 gene associated with immunosuppressive molecules in uveal melanoma
(University of Turku) New study from researchers in Finland and the United Kingdom reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). The researchers also discovered that when BAP1 is lost, other molecules will be present in order to support cancer growth. Luckily, some of these molecules can be targeted with existing drugs, which can lead to the development of novel immunotherapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 9, 2020 Category: Cancer & Oncology Source Type: news

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Three brothers under the age of five have been diagnosed with a type of rare eye cancer. HLN's Lynn Smith talks to the Rush family about how the boys are doing. (Source: CNN.com - Health)
Source: CNN.com - Health - February 12, 2020 Category: Consumer Health News Source Type: news

3 Brothers Have the Same Rare Cancer
The Rush brothers, ages 5 years, 4 years, and 7 months, share something that most brothers don’t: bilateral retinoblastoma, a rare eye cancer. See how their mother, who was also born with the disease, handles treatments, daily life, and facing the unknown. (Source: WebMD Health)
Source: WebMD Health - February 11, 2020 Category: Consumer Health News Source Type: news

Combination Treatments May Improve Survival for Patients with Metastatic Uveal Melanoma
The authors indicated that prospective clinical trials investigating DTIC-based systemic chemotherapies and liver-directed treatments are necessary to validate their findings. (Source: CancerNetwork)
Source: CancerNetwork - February 6, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Three Georgia brothers under six are all battling the same rare eye cancer
Brothers Tristan Rush, five; Caison Rush, three; and Carter Rush. six months, from Marietta, Georgia have all been diagnosed with retinoblastoma, a rare form of eye cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2020 Category: Consumer Health News Source Type: news

Shift in treatment modalities associated with improved outcomes in uveal melanoma patients with live
(Thomas Jefferson University) New retrospective study indicates that the shift of treatment from systemic chemotherapies to liver-directed therapies provides survival benefits. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 3, 2020 Category: Cancer & Oncology Source Type: news

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition
The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). Under some circumstances, p27 is associated with active CDK4, but no mechanism for activation has been described. We found that p27, when phosphorylated by tyrosine kinases, allosterically activated CDK4 in complex with cyclin D1 (CDK4-CycD1). Structural and biochemical data revealed that binding of phosphorylated p27 (phosp27) to CDK4 altered the kinase adenosine triphosphate site to promote phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and other substrates. Surpri...
Source: ScienceNOW - December 12, 2019 Category: Science Authors: Guiley, K. Z., Stevenson, J. W., Lou, K., Barkovich, K. J., Kumarasamy, V., Wijeratne, T. U., Bunch, K. L., Tripathi, S., Knudsen, E. S., Witkiewicz, A. K., Shokat, K. M., Rubin, S. M. Tags: Biochemistry, Medicine, Diseases, Online Only r-articles Source Type: news

Boy's rare eye cancer spotted in photograph
Noah Blanks, aged six, had an eye removed after being diagnosed with a rare form of cancer. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 10, 2019 Category: Consumer Health News Source Type: news

Top Miami doctor is sued by three families of children whose eye cancer spread to their brains
Damian Creed and Salette Ruiz, patients of Dr Timothy Murray, died aged four and five in 2016 after their cancers spread. Jayden Alvarenga, six, now has brain damage after his cancer spread. (Source: the Mail online | Health)
Source: the Mail online | Health - November 27, 2019 Category: Consumer Health News Source Type: news

Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma
The risk of bone and soft-tissue sarcoma is markedly elevated in long-term survivors of hereditary retinoblastoma treated with radiation, researchers report.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - November 26, 2019 Category: Orthopaedics Tags: Hematology-Oncology News Source Type: news

An App That Can Catch Early Signs Of Eye Disease In A Flash
After his son developed a rare eye cancer, a chemist in Texas developed a smart phone app that uses a camera and artificial intelligence to detect early signs of eye disease.(Image credit: Munson et al., Sci. Adv. 2019; 5 eaax 6363) (Source: NPR Health and Science)
Source: NPR Health and Science - October 7, 2019 Category: Consumer Health News Authors: Joe Palca Source Type: news

Free app automatically looks for the 'white eye' cancer symptom in your phone's pictures
Scientists from Baylor University in Waco, Texas, ran the app on more than 52,000 'casual photographs' of 20 children with a range of eye conditions and 20 healthy controls. (Source: the Mail online | Health)
Source: the Mail online | Health - October 2, 2019 Category: Consumer Health News Source Type: news

How Wearing Sunglasses Actually Impacts Your Eyes, According to Science
When most people think about sun-related damage, they probably worry about their skin. But the sun’s ultraviolet rays also pose a threat to a person’s eyes. According to a 2014 study funded by the U.S. National Eye Institute, part of the National Institutes of Health, UV radiation can damage proteins in the eye’s lens. Over time, this damage can raise a person’s risk for cataracts, which impair vision. “When you don’t wear protection, ultraviolet radiation you cannot see is penetrating the eye, and the eye structures are very sensitive to it,” says Dr. Rebecca Taylor, a Nashville-b...
Source: TIME: Health - August 26, 2019 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Lifestyle Source Type: news

Coralberry: Natural treatment for eye cancer
(Natural News) Researchers in Germany found a way to slow down the progression of eye cancer. This may be possible through a substance found in the coralberry plant. Originating in Korea, the coralberry plant bears bright red fruits that make it a great ornamental plant. Its leaves contain bacteria that produce a natural insecticide called... (Source: NaturalNews.com)
Source: NaturalNews.com - August 19, 2019 Category: Consumer Health News Source Type: news

Moffitt researchers identify effective drug combination against uveal melanoma
(H. Lee Moffitt Cancer Center& Research Institute) Moffitt Cancer Center researchers have identified a new drug combination that is effective against metastatic uveal melanoma cells in preclinical studies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 8, 2019 Category: Cancer & Oncology Source Type: news

Tanzania: Medics Warn of Eye Cancer
[Daily News] MEDICAL experts in the country have raised considerable concern over raising cases of retinoblastoma, an eye cancer that develops in early childhood. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 20, 2019 Category: African Health Source Type: news

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1
Malignancies arising from mutation of tumor suppressors have unexplained tissue proclivity. For example, BAP1 encodes a widely expressed deubiquitinase for histone H2A, but germline mutations are predominantly associated with uveal melanomas and mesotheliomas. We show that BAP1 inactivation causes apoptosis in mouse embryonic stem cells, fibroblasts, liver, and pancreatic tissue but not in melanocytes and mesothelial cells. Ubiquitin ligase RNF2, which silences genes by monoubiquitinating H2A, promoted apoptosis in BAP1-deficient cells by suppressing expression of the prosurvival genes Bcl2 and Mcl1. In contrast, BAP1 loss...
Source: ScienceNOW - April 18, 2019 Category: Science Authors: He, M., Chaurushiya, M. S., Webster, J. D., Kummerfeld, S., Reja, R., Chaudhuri, S., Chen, Y.-J., Modrusan, Z., Haley, B., Dugger, D. L., Eastham-Anderson, J., Lau, S., Dey, A., Caothien, R., Roose-Girma, M., Newton, K., Dixit, V. M. Tags: Genetics, Medicine, Diseases reports Source Type: news

Girl, 5, has her eye removed the day after doctors found 10 tumours in it
Gracie Corrigan, from Oregon, was diagnosed with the rare eye cancer retinoblastoma when doctors found 10 tumours around her right eye after her mother noticed it looked odd in a photo. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2019 Category: Consumer Health News Source Type: news

Medical News Today: Plant compound could fight eye cancer
A toxin present in the coralberry plant can stop the division of cancer cells, a new study has found. The findings may lead to enhanced treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 28, 2019 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Targeting a common eye cancer
(Source: ScienceNOW)
Source: ScienceNOW - March 21, 2019 Category: Science Authors: Foley, J. F. Tags: twis Source Type: news

Mother, 23, detects her baby's eye cancer after seeing a bizarre spot in his pupil in a photograph
Specialists diagnosed Jaxson, then 11 months old, with a rare children's eye cancer. He needed surgery and chemo, but now, age three, he is in a stable condition. (Source: the Mail online | Health)
Source: the Mail online | Health - March 20, 2019 Category: Consumer Health News Source Type: news

Active substance from plant slows down aggressive eye cancer
(University of Bonn) An active substance that has been known for 30 years could unexpectedly turn into a ray of hope against eye tumors. This is shown by a study conducted by researchers from the Universities of Bonn and Magdeburg together with US colleagues. The results are published in the renowned journal 'Science Signaling'. The plant leaves of which contain the tested substance is anything but rare: At Christmas time you can find it in every well-assorted garden center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 20, 2019 Category: Cancer & Oncology Source Type: news

Direct targeting of G{alpha}q and G{alpha}11 oncoproteins in cancer cells
Somatic gain-of-function mutations of GNAQ and GNA11, which encode α subunits of heterotrimeric Gαq/11 proteins, occur in about 85% of cases of uveal melanoma (UM), the most common cancer of the adult eye. Molecular therapies to directly target these oncoproteins are lacking, and current treatment options rely on radiation, surgery, or inhibition of effector molecules downstream of these G proteins. A hallmark feature of oncogenic Gαq/11 proteins is their reduced intrinsic rate of hydrolysis of guanosine triphosphate (GTP), which results in their accumulation in the GTP-bound, active state. Here, we repor...
Source: Signal Transduction Knowledge Environment - March 19, 2019 Category: Science Authors: Annala, S., Feng, X., Shridhar, N., Eryilmaz, F., Patt, J., Yang, J., Pfeil, E. M., Cervantes-Villagrana, R. D., Inoue, A., Häberlein, F., Slodczyk, T., Reher, R., Kehraus, S., Monteleone, S., Schrage, R., Heycke, N., Rick, U., Engel, S., Pfeifer, Tags: STKE Research Articles Source Type: news

What makes a cell turn cancerous?
(Children's Hospital Los Angeles) CHLA researcher David Cobrinik, MD, PhD receives $1.6M grant to study how genetic changes cause retinoblastoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 14, 2019 Category: International Medicine & Public Health Source Type: news

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential
The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gαq/11 subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gαq/11-coupled G protein–coupled receptors (GPCRs) to control downstream events, such as cell motility and gene transcription. This conserved signal transduction axis is crucial for tumor growth in uveal melanoma. Previous studies indicate that the GEF activity of the TrioC module is autoinhibited, with release of autoinhibition upon Gαq/11 binding. Here, we determined the crystal structur...
Source: Signal Transduction Knowledge Environment - February 19, 2019 Category: Science Authors: Bandekar, S. J., Arang, N., Tully, E. S., Tang, B. A., Barton, B. L., Li, S., Gutkind, J. S., Tesmer, J. J. G. Tags: STKE Research Articles Source Type: news

Virus-based therapy targets a pediatric eye cancer
(American Association for the Advancement of Science) A cancer-killing, virus-based therapy showed promising effects against retinoblastoma -- a tumor of the retina that affects mainly children -- in mouse models and a pilot clinical trial. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 23, 2019 Category: Cancer & Oncology Source Type: news

Twin baby girls were both diagnosed with a rare eye cancer just DAYS after being born
Twins Ella and Eve, of  Pennsylvania, were diagnosed with bilateral retinoblastoma by the time they were one-month-old. Although off chemo for now, the disease could return at any time. (Source: the Mail online | Health)
Source: the Mail online | Health - January 21, 2019 Category: Consumer Health News Source Type: news

'Christmas berry' plant compound could fight Uveal melanoma
(Thomas Jefferson University) A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 3, 2019 Category: Cancer & Oncology Source Type: news

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Molecularly targeted therapies aim to obstruct cell autonomous programs required for tumor growth. We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to suppress the proliferation of KRAS-mutant lung cancer cells while simultaneously provoking a natural killer (NK) cell surveillance program leading to tumor cell death. The drug combination, but neither agent alone, promotes retinoblastoma (RB) protein-mediated cellular senescence and activation of the immunomodulatory senescence-associated secretory phenotype (SASP). SASP components tumor necrosis factor&ndash...
Source: ScienceNOW - December 20, 2018 Category: Science Authors: Ruscetti, M., Leibold, J., Bott, M. J., Fennell, M., Kulick, A., Salgado, N. R., Chen, C.-C., Ho, Y.-j., Sanchez-Rivera, F. J., Feucht, J., Baslan, T., Tian, S., Chen, H.-A., Romesser, P. B., Poirier, J. T., Rudin, C. M., de Stanchina, E., Manchado, E., S Tags: Immunology, Medicine, Diseases reports Source Type: news

Eye cancer symptoms: Seven warning signs you have the deadly disease in your eyes
EYE CANCER symptoms are not always obvious and they may only be picked up during a routine eye test. But it ’s important to recognise any warning signs before the disease progresses. There are seven to watch out for. (Source: Daily Express - Health)
Source: Daily Express - Health - November 18, 2018 Category: Consumer Health News Source Type: news

Spread of deadly eye cancer halted in cells and animals
(Johns Hopkins Medicine) By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 12, 2018 Category: International Medicine & Public Health Source Type: news

Toddler loses her eye to a rare form of cancer after her mother noticed she couldn't see
Alice Taylor, from Poole, Dorset, was diagnosed with the aggressive eye cancer retinoblastoma in May last year when she was just two years old. She had been going blind in her left eye for months. (Source: the Mail online | Health)
Source: the Mail online | Health - October 11, 2018 Category: Consumer Health News Source Type: news

CHLA team identifies developmental stage for no. 1 eye tumor in children
(Children's Hospital Los Angeles) Investigators at Children's Hospital Los Angeles have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the door for future interventions in retinoblastoma (RB), a tumor of the retina that affects children under five years of age. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2018 Category: International Medicine & Public Health Source Type: news

Eye cancer signs: Watch out for this symptom on the coloured part of your eye
EYE CANCER is not a common type of cancer but noticing certain signs as early as possible will help with your outlook. One of the symptoms to watch out for will appear on the coloured part of the eye, otherwise known as the iris. (Source: Daily Express - Health)
Source: Daily Express - Health - September 7, 2018 Category: Consumer Health News Source Type: news

Scientists identify weak point in deadly eye melanoma
(Washington University School of Medicine) A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School of Medicine in St. Louis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 5, 2018 Category: Cancer & Oncology Source Type: news

Targeting nucleotide exchange to inhibit constitutively active G protein {alpha} subunits in cancer cells
Constitutively active G protein α subunits cause cancer, cholera, Sturge-Weber syndrome, and other disorders. Therapeutic intervention by targeted inhibition of constitutively active Gα subunits in these disorders has yet to be achieved. We found that constitutively active Gαq in uveal melanoma (UM) cells was inhibited by the cyclic depsipeptide FR900359 (FR). FR allosterically inhibited guanosine diphosphate–for–guanosine triphosphate (GDP/GTP) exchange to trap constitutively active Gαq in inactive, GDP-bound Gαβ heterotrimers. Allosteric inhibition of other Gα subunits...
Source: Signal Transduction Knowledge Environment - September 4, 2018 Category: Science Authors: Onken, M. D., Makepeace, C. M., Kaltenbronn, K. M., Kanai, S. M., Todd, T. D., Wang, S., Broekelmann, T. J., Rao, P. K., Cooper, J. A., Blumer, K. J. Tags: STKE Research Articles Source Type: news

Two-year-old boy battling rare cancer risks blindness as painful mass grows over his eye
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five. (Source: the Mail online | Health)
Source: the Mail online | Health - August 16, 2018 Category: Consumer Health News Source Type: news

Ocular oncologist Renelle Lim on the importance of regular eye exams
The Yale Medicine ophthalmologist says eye cancer treatments work best when the cancer is caught early. (Source: Yale Science and Health News)
Source: Yale Science and Health News - July 25, 2018 Category: Universities & Medical Training Source Type: news

Eye Cancer Intraocular Uveal Melanoma Treatment
Eye Cancer: Intraocular (Uveal) Melanoma Treatment (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 20, 2018 Category: General Medicine Source Type: news

International conference brings together world leaders in eye cancer
(Champalimaud Centre for the Unknown) The world's leading ocular oncology scientists and clinicians meet to discuss the latest research and treatment developments in eye cancer. The Ocular Oncogenesis and Oncology Conference (OOO) is held by the Association for Research in Vision and Ophthalmology (ARV0) in partnership with the Champalimaud Foundation, July 18-21 at the Champalimaud Centre in Lisbon, Portugal. The conference features international experts from ophthalmic and cancer centers from around the world, including the Americas, Asia and Europe. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 12, 2018 Category: Cancer & Oncology Source Type: news

Ocular Melanoma (Intraocular Melanoma or Uveal Melanoma)
Title: Ocular Melanoma (Intraocular Melanoma or Uveal Melanoma)Category: Diseases and ConditionsCreated: 5/8/2018 12:00:00 AMLast Editorial Review: 6/19/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - June 19, 2018 Category: Cancer & Oncology Source Type: news

Mayo Clinic Q and A: Melanoma can begin in the eye
DEAR MAYO CLINIC: Is it true that melanoma can develop in the eyes? If so, how common is it? How is it treated? ANSWER:?Melanoma can begin in the eye ? a condition called intraocular melanoma. Treatment for intraocular melanoma used to primarily involve removing the affected eye. Now, however, radiation therapy often can be used [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 19, 2018 Category: Databases & Libraries Source Type: news

Uveal Melanoma: Better Survival With Liver-Directed Therapy Uveal Melanoma: Better Survival With Liver-Directed Therapy
Treatment for liver metastases in uveal cancer has changed over 50 years. At ASCO, one study charted the survival benefits seen with newer localized therapies; the other showed benefits of radioembolization.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Sidney Kimmel Cancer Center scientists to present at ASCO Annual Meeting
(Thomas Jefferson University) Scientists from the Sidney Kimmel Cancer Center (SKCC) at Jefferson Health will be presenting research and leading discussions on various topics, including metastatic uveal melanoma, genetic counseling in men, immunotherapy in early stage lung cancer and solid tumors, quality of life among patients receiving treatment for T cell lymphoma and updates on the Cancer Moonshot during the Biden Cancer Initiative Colloquium at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, being held June 1-5 in Chicago. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 1, 2018 Category: Cancer & Oncology Source Type: news

FDA OKs First Artificial Iris for Aniridia, Other Iris Defects FDA OKs First Artificial Iris for Aniridia, Other Iris Defects
The CustomFlex Artificial Iris treats adults and children with congenital aniridia or iris defects due to other reasons or conditions, such as albinism, traumatic injury, or surgical removal due to melanoma.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 30, 2018 Category: Consumer Health News Tags: Ophthalmology News Alert Source Type: news