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Parental exposure to hazardous agents tied to eye tumors in offspring
(Reuters Health) - Parents ’ exposure to chemicals at work might be linked to eye cancer in their children, a report from some of the world’s leading childhood cancer experts suggests. (Source: Reuters: Health)
Source: Reuters: Health - November 7, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Aqueous Humor May Serve as Surrogate Tumor Biopsy for Retinoblastoma Aqueous Humor May Serve as Surrogate Tumor Biopsy for Retinoblastoma
Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 20, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Genetic testing recommended for children considered at risk for most common eye cancer
(American Academy of Ophthalmology) Children who are considered to be at risk of developing eye cancer should receive genetic counseling and testing as soon as possible to clarify risk for the disease. This is the consensus of leading ophthalmologists, pathologists and geneticists, who worked for two years to develop the first U.S. guidelines on how to screen for the most common eye tumor affecting children. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 18, 2017 Category: Cancer & Oncology Source Type: news

' Liquid Biopsy' May Stand in for Tumor Samples in Kids' Eye Cancer (CME/CE)
(MedPage Today) -- Study found tumor DNA in aqueous humor of three children (Source: MedPage Today Ophthalmology)
Source: MedPage Today Ophthalmology - October 13, 2017 Category: Opthalmology Source Type: news

A liquid biopsy for retinoblastoma
(Children's Hospital Los Angeles) A recent study by a team of investigators at Children's Hospital Los Angeles and Keck Medicine of USC, provides proof of concept for a safe and effective way to derive genetic information from a retinoblastoma tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 12, 2017 Category: Cancer & Oncology Source Type: news

Indian boy is going blind due to his protruding eyes
Jailian Kaipeng is in 'constant pain' from his protruding eyes and may have a rare eye cancer. His labourer father from rural north eastern India is now jobless and cannot afford help. (Source: the Mail online | Health)
Source: the Mail online | Health - September 25, 2017 Category: Consumer Health News Source Type: news

Life- and Eye-Saving New Treatments for Uveal Melanoma Life- and Eye-Saving New Treatments for Uveal Melanoma
Gene testing and immunotherapy have opened the door to treatments that could save the eyesight and the lives of people with uveal melanoma.Medscape Medical News (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - September 15, 2017 Category: Opthalmology Tags: Ophthalmology News Source Type: news

Breakthrough Treatments Arriving for Uveal Melanoma Breakthrough Treatments Arriving for Uveal Melanoma
Gene testing and immunotherapy have opened the door to treatments that could save the eyesight and the lives of people with uveal melanoma.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 14, 2017 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Eye-Saving New Treatment Options for Uveal Melanoma Eye-Saving New Treatment Options for Uveal Melanoma
Gene testing and immunotherapy have opened the door to treatments that could save the eyesight and the lives of people with uveal melanoma.Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - September 14, 2017 Category: Pathology Tags: Ophthalmology News Source Type: news

International eye cancer research project to improve future therapies
(University of Liverpool) A new international research project, involving the University of Liverpool's leading eye cancer research group, has identified specific subtypes of ocular melanoma that will help develop improved management strategies and therapies in the future. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 23, 2017 Category: Cancer & Oncology Source Type: news

Genetic Glitches in Uveal Melanoma: Ophthalmology Times
(MedPage Today) -- Also, the limits of anti-VEGF therapy (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - August 22, 2017 Category: Hematology Source Type: news

Georgia State's Inlighta Biosciences gets $2 million grant to develop enhanced MRI contrast agents
(Georgia State University) A local start-up, life sciences company founded by Dr. Jenny Yang, Regents' Professor of Biochemistry at Georgia State University, has received a $2 million federal grant to develop improved magnetic resonance imaging (MRI) contrast agents for the early detection of liver cancers and other cancers, such as uveal melanoma or eye cancer, that have metastasized to the liver. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 24, 2017 Category: International Medicine & Public Health Source Type: news

Mum of baby battling eye cancer: Being together and healthy is what matters to us
ONE mum tells of her baby ’s brave battle against eye cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - July 10, 2017 Category: Consumer Health News Source Type: news

Study shows biomarkers can predict which ER-positive breast cancer patients respond best to first-line therapy
(University of Texas M. D. Anderson Cancer Center) Two challenges in treating patients with estrogen-positive breast cancer (ER+) have been an inability to predict who will respond to standard therapies and adverse events leading to therapy discontinuation. A study at The University of Texas MD Anderson Cancer Center revealed new information about how the biomarkers retinoblastoma protein (Rb) and cytoplasmic cyclin E could indicate which patients will respond best to current first-line therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 27, 2017 Category: Cancer & Oncology Source Type: news

Boy's parents tried to cure eye tumour using black magic
Bongre Anton Peter, from Papua New Guinea, had signs of retinoblastoma when he was a year old. Eye drops and painkillers failed to help, as his desperate parents turned to traditional tribal beliefs. (Source: the Mail online | Health)
Source: the Mail online | Health - May 31, 2017 Category: Consumer Health News Source Type: news

Genetic risk factor for equine eye cancer identified
(University of California - Davis) UC Davis researchers have identified a genetic mutation in horses that should help identify horses that are at risk for squamous cell carcinoma of the eye and enable horse owners to make informed breeding decisions. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 24, 2017 Category: Cancer & Oncology Source Type: news

Adoptive T-Cell Therapy Induced Response in Metastatic Uveal Melanoma
More than one-third of patients with metastatic uveal melanoma had objective tumor regression when treated with adoptive transfer of autologous tumor-infiltrating lymphocytes. (Source: CancerNetwork)
Source: CancerNetwork - May 16, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Melanoma News Source Type: news

Visunex Medical raises $20m Series B for PanoCam neonate eye scanners
Visunex Medical Systems said last week that it raised a $20 million Series B round for its PanoCam line of neonatal eye imaging systems. Fremont, Calif.-based Visunex said the PanoCam line includes the LT and Pro wireless systems and a 3rd system set to debut in June. “The interest in the medical investment community to be part of this funding round turned out to be much more than we had anticipated,” founder & CEO Wei Su said in prepared remarks. “This new round of funding brings the total investment into Visunex Medical to $32 million, and will allow the company to expa...
Source: Mass Device - May 8, 2017 Category: Medical Equipment Authors: Brad Perriello Tags: Funding Roundup Optical/Ophthalmic Wall Street Beat Visunex Source Type: news

Emerging Therapies for Uveal Melanoma: Ophthalmology Times
(MedPage Today) -- Also: avoiding ruptures during deep anterior lamellar keratoplasty (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 2, 2017 Category: American Health Source Type: news

RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis
To produce seeds, flowering plants need to specify somatic cells to undergo meiosis. Here, we reveal a regulatory cascade that controls the entry into meiosis starting with a group of redundantly acting cyclin-dependent kinase (CDK) inhibitors of the KIP-RELATED PROTEIN (KRP) class. KRPs function by restricting CDKA;1–dependent inactivation of the Arabidopsis Retinoblastoma homolog RBR1. In rbr1 and krp triple mutants, designated meiocytes undergo several mitotic divisions, resulting in the formation of supernumerary meiocytes that give rise to multiple reproductive units per future seed. One function of RBR1 is the ...
Source: ScienceNOW - April 27, 2017 Category: Science Authors: Zhao, X., Bramsiepe, J., Van Durme, M., Komaki, S., Prusicki, M. A., Maruyama, D., Forner, J., Medzihradszky, A., Wijnker, E., Harashima, H., Lu, Y., Schmidt, A., Guthörl, D., Logrono, R. S., Guan, Y., Pochon, G., Grossniklaus, U., Laux, T., Higas Tags: Botany, Online Only r-articles Source Type: news

What Causes Uveitis?
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and> 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increase...
Source: PediatricEducation.org - April 3, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Of Course Cancer Isn't Random
Despite the study in one of the world’s most prestigious scientific journals, and the high-profile media coverage of it: no, cancer is absolutely NOT mostly random and a product of “bad luck.” It wasn’t true when these same investigators published very similar work generating very similar media hype and nonsense two years ago, and it isn’t true now.  That’s what I want to talk about, but must hasten to append the obvious proviso: cancer can, rarely, be or at least seem utterly random. But to call cancer random because a child rarely gets retinoblastoma or glioblastoma, or ...
Source: Healthy Living - The Huffington Post - March 30, 2017 Category: Consumer Health News Source Type: news

New clinical trial for early-stage eye melanoma offers study of targeted therapy
(Wills Eye Hospital) A first-of-its-kind, potentially groundbreaking new option for treating a form of eye cancer is now in its first phase-1 clinical research trial at Wills Eye Hospital in Philadelphia. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 30, 2017 Category: Global & Universal Source Type: news

Aqueous Humor Can Serve as Surrogate Tumor Biopsy
In eyes of children with retinoblastoma, AH has sufficient tumor - derived DNA for genetic analyses (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 28, 2017 Category: Cancer & Oncology Tags: Oncology, Ophthalmology, Pathology, Pediatrics, Journal, Source Type: news

Metastatic Disease From Uveal Melanoma Metastatic Disease From Uveal Melanoma
What treatment options are available for patients who develop metastatic disease from this type of ocular melanoma?The British Journal of Ophthalmology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 27, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Namibia: Eye Surgeon Says Girl's Eye Cancer Can Spread to the Brain
[Namibian] AN EYE surgeon yesterday said the Windhoek toddler whose eye was removed and who looks likely to lose the other one as well suffers from retinolblastoma, a rare malignant tumour of the retina which affects young children. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 19, 2017 Category: African Health Source Type: news

For Group D Retinoblastoma, Intra-arterial May Beat IV Chemo For Group D Retinoblastoma, Intra-arterial May Beat IV Chemo
For children with group D retinoblastoma, first-line intra-arterial chemo may be better than first-line intravenous chemo , a retrospective study from Switzerland suggests.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 27, 2016 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Groundbreaking discovery has potential to improve therapies for cancer and other diseases
The Retinoblastoma protein (pRB) has long been studied for its role in cell growth and the prevention of cancer. Scientists have now discovered that pRB plays another, larger role with the potential to enhance therapies for cancer and other diseases such as HIV. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 15, 2016 Category: Science Source Type: news

Girl diagnosed with retinoblastoma after mother noticed white glow behind her pupil
Tyraah Bell-Lama, from Reading, was just eight months old when she was taken to the doctor with a white glow behind her baby's eye. Tests revealed she had retinoblastoma. (Source: the Mail online | Health)
Source: the Mail online | Health - December 15, 2016 Category: Consumer Health News Source Type: news

Groundbreaking discovery has potential to improve therapies for cancer and other diseases
(Lawson Health Research Institute) The Retinoblastoma protein (pRB) has long been studied for its role in cell growth and the prevention of cancer. In a new study by Lawson Health Research Institute, scientists have discovered that pRB plays another, larger role with the potential to enhance therapies for cancer and other diseases such as HIV. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 15, 2016 Category: Cancer & Oncology Source Type: news

Protein that promotes'cell-suicide' could revolutionize eye cancer treatment
New research has identified the role of a specific protein in the human body that can help prevent the survival and spread of eye cancer, by initiating cancer'cell-suicide.'(Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 6, 2016 Category: Science Source Type: news

Protein that promotes 'cell-suicide' could revolutionize eye cancer treatment
(University of Liverpool) New research from the University of Liverpool has identified the role of a specific protein in the human body that can help prevent the survival and spread of eye cancer, by initiating cancer 'cell-suicide.' (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 6, 2016 Category: Global & Universal Source Type: news

More boys are diagnosed with cancer than girls worldwide - why?
This article was originally published on The Conversation. Read the original article. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Science - The Huffington Post)
Source: Science - The Huffington Post - November 25, 2016 Category: Science Source Type: news

Increased eye cancer risk linked to pigmentation genes that dictate eye color
New research links specific inherited genetic differences to an increased risk for eye (uveal) melanoma, a rare form of melanoma that arises from pigment cells that determine eye color. scientists report the first evidence of a strong association between genes linked to eye color and development of uveal melanoma. Reported data suggests that inherited genetic factors associated with eye and skin pigmentation could increase a person's risk for uveal melanoma. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 19, 2016 Category: Science Source Type: news

Increased eye cancer risk linked to pigmentation genes that dictate eye color
(Ohio State University Wexner Medical Center) New research links specific inherited genetic differences to an increased risk for eye (uveal) melanoma, a rare form of melanoma that arises from pigment cells that determine eye color. scientists report the first evidence of a strong association between genes linked to eye color and development of uveal melanoma. Reported data suggests that inherited genetic factors associated with eye and skin pigmentation could increase a person's risk for uveal melanoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 19, 2016 Category: Global & Universal Source Type: news

Pediatric ophthalmology
Childhood glaucomaEye movement disordersEye cancerOptic nerve disorders We use the latest advances in pediatric ophthalmology to optimize your child ’s vision and eye health.Diagnosis and treatment of pediatric eye diseasesPrompt identification of childhood eye and vision problems is often the best way to preserve or regain vision.   This applies to common pediatric eye conditions such as refractive error requiring eyeglasses, amblyopia (or lazy eye) and strabismus (eyes that are not straight), as well as serious eye conditions such as childhood cataract, glaucoma, retinopathy of prematurity, and an eye tumor c...
Source: dukehealth.org: Duke Health News - August 8, 2016 Category: Consumer Health News Authors: dg62 at duke.edu Source Type: news

Dr. Alfred G. Knudson, the ‘Mendel of Cancer Genetics,’ Dies at 93
A 1971 theory on the inheritable nature of retinoblastoma in children, proved in 1986, is credited with helping advance the framework of how cancers are studied. (Source: NYT Health)
Source: NYT Health - July 15, 2016 Category: Consumer Health News Authors: KENNETH CHANG Tags: Deaths (Obituaries) Genetics and Heredity Research Cancer Knudson, Alfred G Philadelphia (Pa) Source Type: news

European H2020 grant to fight eye cancer for the next 5 years
(JLM&A, SA ) UM Cure 2020 is a new European Consortium to foster research on metastatic uveal melanoma and identify new treatments for this serious disease.Under the coordination of Institut Curie in Paris, the Consortium involving 12 partners has received 6 million euros of funding from the European Union's Horizon 2020 research and innovation program to identify new therapeutic approaches to treat metastatic uveal melanoma in a five-year project. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 12, 2016 Category: Global & Universal Source Type: news

Eye-Preserving Retinoblastoma Therapy Can Compromise SurvivalEye-Preserving Retinoblastoma Therapy Can Compromise Survival
The goal of preserving vision and the risk of reduced long-term overall survival must be balanced against each other when treating heritable retinoblastoma, say researchers from Germany. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 11, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Baby Everett Pepin who developed cancer in the WOMB survives aggressive treatment
Doctors discovered Everett Pepin had a type of eye cancer, during a scan at two weeks old. He started chemotherapy days later under care of a doctor who treated his mother for the same disease. (Source: the Mail online | Health)
Source: the Mail online | Health - July 8, 2016 Category: Consumer Health News Source Type: news

What Are The Most Common Pediatric Cancers?
Discussion Cancer occurs in all ages including children. Fortunately cancer is much less common in the pediatric age group accounting for
Source: PediatricEducation.org - July 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

[Editors' Choice] One target to quench many
Inhibiting the GTPase ARF6 chokes the diverse output of mutant Gαq proteins in uveal melanoma. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - June 29, 2016 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

Rare eye disease that struck Oliver Sacks gives rise to new cancer treatment strategy
(University of Utah Health Sciences) Eye cancer took the life of author and neurologist Oliver Sacks last year, bringing attention to the rare, hard-to-treat disease. Now, a team led by scientists at Huntsman Cancer Institute at the University of Utah report in Cancer Cell that a mutation that causes the cancer relies on a protein, ARF6, to distribute cancer-promoting signals. Further, treatment with a drug made against the protein inhibits eye tumors formation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 2, 2016 Category: Cancer & Oncology Source Type: news

Pond scum and the gene pool: One critical gene in green algae responsible for multicellular evolution, understanding of cancer origin
A single gene is responsible for the evolution of multicellular organisms, new research indicates. Scientists were looking for what caused single-celled organisms to evolve into multicellular organisms when they discovered the importance of a single gene, retinoblastoma, or RB. RB, known for being defective in cancer patients, is a critical gene necessary for multicellular life; previous theories have indicated that multiple genes might be responsible for multicellularity. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 5, 2016 Category: Science Source Type: news

Researchers Make Progress in Unraveling Uveal MelanomaResearchers Make Progress in Unraveling Uveal Melanoma
Two studies from the University of Miami Miller School of Medicine shed light on physiological and genetic factors associated with uveal melanoma (UM). Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 4, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Study: Combination therapy improves retinoblastoma outcome
Stephen FellerLOS ANGELES, April 15 (UPI) -- Researchers found a combination of chemotherapy and a protein inhibitor improves the outcome of children with retinoblastoma, according to a recent study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 15, 2016 Category: Consumer Health News Source Type: news

Combination therapy may offer better outcomes for patients with retinoblastoma
Targeting survivin -- a protein that inhibits apoptosis or cell death -- enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumor of the eye in children, researchers report. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 15, 2016 Category: Science Source Type: news

Combination therapy may offer better outcomes for patients with retinoblastoma
(Children's Hospital Los Angeles) Researchers at The Saban Research Institute of Children's Hospital Los Angeles (CHLA) have demonstrated that targeting survivin -- a protein that inhibits apoptosis or cell death -- enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumor of the eye in children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 14, 2016 Category: Global & Universal Source Type: news

UK’s Immunocore begins Phase I trial of uveal melanoma drug IMCgp100
UK-based biotechnology company Immunocore has started its Phase I monotherapy trial of its lead programme, IMCgp100, to treat patients with uveal melanoma. (Source: Drug Development Technology)
Source: Drug Development Technology - March 29, 2016 Category: Pharmaceuticals Source Type: news

New biomarker identifies uveal melanoma patients at high risk for metastasis
(University of Miami Miller School of Medicine) A study by J. William Harbour, M.D., associate director for Basic Research and leader of the Eye Cancer Site Disease Group at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and colleagues published today in Clinical Cancer Research details the discovery of a biomarker that puts patients at a higher risk for metastasis of uveal melanoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 1, 2016 Category: Cancer & Oncology Source Type: news