Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1
Malignancies arising from mutation of tumor suppressors have unexplained tissue proclivity. For example, BAP1 encodes a widely expressed deubiquitinase for histone H2A, but germline mutations are predominantly associated with uveal melanomas and mesotheliomas. We show that BAP1 inactivation causes apoptosis in mouse embryonic stem cells, fibroblasts, liver, and pancreatic tissue but not in melanocytes and mesothelial cells. Ubiquitin ligase RNF2, which silences genes by monoubiquitinating H2A, promoted apoptosis in BAP1-deficient cells by suppressing expression of the prosurvival genes Bcl2 and Mcl1. In contrast, BAP1 loss...
Source: ScienceNOW - April 18, 2019 Category: Science Authors: He, M., Chaurushiya, M. S., Webster, J. D., Kummerfeld, S., Reja, R., Chaudhuri, S., Chen, Y.-J., Modrusan, Z., Haley, B., Dugger, D. L., Eastham-Anderson, J., Lau, S., Dey, A., Caothien, R., Roose-Girma, M., Newton, K., Dixit, V. M. Tags: Genetics, Medicine, Diseases reports Source Type: news

Girl, 5, has her eye removed the day after doctors found 10 tumours in it
Gracie Corrigan, from Oregon, was diagnosed with the rare eye cancer retinoblastoma when doctors found 10 tumours around her right eye after her mother noticed it looked odd in a photo. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2019 Category: Consumer Health News Source Type: news

Medical News Today: Plant compound could fight eye cancer
A toxin present in the coralberry plant can stop the division of cancer cells, a new study has found. The findings may lead to enhanced treatment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 28, 2019 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Targeting a common eye cancer
(Source: ScienceNOW)
Source: ScienceNOW - March 21, 2019 Category: Science Authors: Foley, J. F. Tags: twis Source Type: news

Mother, 23, detects her baby's eye cancer after seeing a bizarre spot in his pupil in a photograph
Specialists diagnosed Jaxson, then 11 months old, with a rare children's eye cancer. He needed surgery and chemo, but now, age three, he is in a stable condition. (Source: the Mail online | Health)
Source: the Mail online | Health - March 20, 2019 Category: Consumer Health News Source Type: news

Active substance from plant slows down aggressive eye cancer
(University of Bonn) An active substance that has been known for 30 years could unexpectedly turn into a ray of hope against eye tumors. This is shown by a study conducted by researchers from the Universities of Bonn and Magdeburg together with US colleagues. The results are published in the renowned journal 'Science Signaling'. The plant leaves of which contain the tested substance is anything but rare: At Christmas time you can find it in every well-assorted garden center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 20, 2019 Category: Cancer & Oncology Source Type: news

Direct targeting of G{alpha}q and G{alpha}11 oncoproteins in cancer cells
Somatic gain-of-function mutations of GNAQ and GNA11, which encode α subunits of heterotrimeric Gαq/11 proteins, occur in about 85% of cases of uveal melanoma (UM), the most common cancer of the adult eye. Molecular therapies to directly target these oncoproteins are lacking, and current treatment options rely on radiation, surgery, or inhibition of effector molecules downstream of these G proteins. A hallmark feature of oncogenic Gαq/11 proteins is their reduced intrinsic rate of hydrolysis of guanosine triphosphate (GTP), which results in their accumulation in the GTP-bound, active state. Here, we repor...
Source: Signal Transduction Knowledge Environment - March 19, 2019 Category: Science Authors: Annala, S., Feng, X., Shridhar, N., Eryilmaz, F., Patt, J., Yang, J., Pfeil, E. M., Cervantes-Villagrana, R. D., Inoue, A., Häberlein, F., Slodczyk, T., Reher, R., Kehraus, S., Monteleone, S., Schrage, R., Heycke, N., Rick, U., Engel, S., Pfeifer, Tags: STKE Research Articles Source Type: news

What makes a cell turn cancerous?
(Children's Hospital Los Angeles) CHLA researcher David Cobrinik, MD, PhD receives $1.6M grant to study how genetic changes cause retinoblastoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 14, 2019 Category: International Medicine & Public Health Source Type: news

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential
The C-terminal guanine nucleotide exchange factor (GEF) module of Trio (TrioC) transfers signals from the Gαq/11 subfamily of heterotrimeric G proteins to the small guanosine triphosphatase (GTPase) RhoA, enabling Gαq/11-coupled G protein–coupled receptors (GPCRs) to control downstream events, such as cell motility and gene transcription. This conserved signal transduction axis is crucial for tumor growth in uveal melanoma. Previous studies indicate that the GEF activity of the TrioC module is autoinhibited, with release of autoinhibition upon Gαq/11 binding. Here, we determined the crystal structur...
Source: Signal Transduction Knowledge Environment - February 19, 2019 Category: Science Authors: Bandekar, S. J., Arang, N., Tully, E. S., Tang, B. A., Barton, B. L., Li, S., Gutkind, J. S., Tesmer, J. J. G. Tags: STKE Research Articles Source Type: news

Virus-based therapy targets a pediatric eye cancer
(American Association for the Advancement of Science) A cancer-killing, virus-based therapy showed promising effects against retinoblastoma -- a tumor of the retina that affects mainly children -- in mouse models and a pilot clinical trial. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 23, 2019 Category: Cancer & Oncology Source Type: news

Twin baby girls were both diagnosed with a rare eye cancer just DAYS after being born
Twins Ella and Eve, of  Pennsylvania, were diagnosed with bilateral retinoblastoma by the time they were one-month-old. Although off chemo for now, the disease could return at any time. (Source: the Mail online | Health)
Source: the Mail online | Health - January 21, 2019 Category: Consumer Health News Source Type: news

'Christmas berry' plant compound could fight Uveal melanoma
(Thomas Jefferson University) A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 3, 2019 Category: Cancer & Oncology Source Type: news

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Molecularly targeted therapies aim to obstruct cell autonomous programs required for tumor growth. We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to suppress the proliferation of KRAS-mutant lung cancer cells while simultaneously provoking a natural killer (NK) cell surveillance program leading to tumor cell death. The drug combination, but neither agent alone, promotes retinoblastoma (RB) protein-mediated cellular senescence and activation of the immunomodulatory senescence-associated secretory phenotype (SASP). SASP components tumor necrosis factor&ndash...
Source: ScienceNOW - December 20, 2018 Category: Science Authors: Ruscetti, M., Leibold, J., Bott, M. J., Fennell, M., Kulick, A., Salgado, N. R., Chen, C.-C., Ho, Y.-j., Sanchez-Rivera, F. J., Feucht, J., Baslan, T., Tian, S., Chen, H.-A., Romesser, P. B., Poirier, J. T., Rudin, C. M., de Stanchina, E., Manchado, E., S Tags: Immunology, Medicine, Diseases reports Source Type: news

Eye cancer symptoms: Seven warning signs you have the deadly disease in your eyes
EYE CANCER symptoms are not always obvious and they may only be picked up during a routine eye test. But it ’s important to recognise any warning signs before the disease progresses. There are seven to watch out for. (Source: Daily Express - Health)
Source: Daily Express - Health - November 18, 2018 Category: Consumer Health News Source Type: news

Spread of deadly eye cancer halted in cells and animals
(Johns Hopkins Medicine) By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 12, 2018 Category: International Medicine & Public Health Source Type: news

Toddler loses her eye to a rare form of cancer after her mother noticed she couldn't see
Alice Taylor, from Poole, Dorset, was diagnosed with the aggressive eye cancer retinoblastoma in May last year when she was just two years old. She had been going blind in her left eye for months. (Source: the Mail online | Health)
Source: the Mail online | Health - October 11, 2018 Category: Consumer Health News Source Type: news

CHLA team identifies developmental stage for no. 1 eye tumor in children
(Children's Hospital Los Angeles) Investigators at Children's Hospital Los Angeles have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the door for future interventions in retinoblastoma (RB), a tumor of the retina that affects children under five years of age. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2018 Category: International Medicine & Public Health Source Type: news

Eye cancer signs: Watch out for this symptom on the coloured part of your eye
EYE CANCER is not a common type of cancer but noticing certain signs as early as possible will help with your outlook. One of the symptoms to watch out for will appear on the coloured part of the eye, otherwise known as the iris. (Source: Daily Express - Health)
Source: Daily Express - Health - September 7, 2018 Category: Consumer Health News Source Type: news

Scientists identify weak point in deadly eye melanoma
(Washington University School of Medicine) A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School of Medicine in St. Louis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 5, 2018 Category: Cancer & Oncology Source Type: news

Targeting nucleotide exchange to inhibit constitutively active G protein {alpha} subunits in cancer cells
Constitutively active G protein α subunits cause cancer, cholera, Sturge-Weber syndrome, and other disorders. Therapeutic intervention by targeted inhibition of constitutively active Gα subunits in these disorders has yet to be achieved. We found that constitutively active Gαq in uveal melanoma (UM) cells was inhibited by the cyclic depsipeptide FR900359 (FR). FR allosterically inhibited guanosine diphosphate–for–guanosine triphosphate (GDP/GTP) exchange to trap constitutively active Gαq in inactive, GDP-bound Gαβ heterotrimers. Allosteric inhibition of other Gα subunits...
Source: Signal Transduction Knowledge Environment - September 4, 2018 Category: Science Authors: Onken, M. D., Makepeace, C. M., Kaltenbronn, K. M., Kanai, S. M., Todd, T. D., Wang, S., Broekelmann, T. J., Rao, P. K., Cooper, J. A., Blumer, K. J. Tags: STKE Research Articles Source Type: news

Two-year-old boy battling rare cancer risks blindness as painful mass grows over his eye
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five. (Source: the Mail online | Health)
Source: the Mail online | Health - August 16, 2018 Category: Consumer Health News Source Type: news

Ocular oncologist Renelle Lim on the importance of regular eye exams
The Yale Medicine ophthalmologist says eye cancer treatments work best when the cancer is caught early. (Source: Yale Science and Health News)
Source: Yale Science and Health News - July 25, 2018 Category: Universities & Medical Training Source Type: news

Eye Cancer Intraocular Uveal Melanoma Treatment
Eye Cancer: Intraocular (Uveal) Melanoma Treatment (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 20, 2018 Category: General Medicine Source Type: news

International conference brings together world leaders in eye cancer
(Champalimaud Centre for the Unknown) The world's leading ocular oncology scientists and clinicians meet to discuss the latest research and treatment developments in eye cancer. The Ocular Oncogenesis and Oncology Conference (OOO) is held by the Association for Research in Vision and Ophthalmology (ARV0) in partnership with the Champalimaud Foundation, July 18-21 at the Champalimaud Centre in Lisbon, Portugal. The conference features international experts from ophthalmic and cancer centers from around the world, including the Americas, Asia and Europe. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 12, 2018 Category: Cancer & Oncology Source Type: news

Ocular Melanoma (Intraocular Melanoma or Uveal Melanoma)
Title: Ocular Melanoma (Intraocular Melanoma or Uveal Melanoma)Category: Diseases and ConditionsCreated: 5/8/2018 12:00:00 AMLast Editorial Review: 6/19/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - June 19, 2018 Category: Cancer & Oncology Source Type: news

Mayo Clinic Q and A: Melanoma can begin in the eye
DEAR MAYO CLINIC: Is it true that melanoma can develop in the eyes? If so, how common is it? How is it treated? ANSWER:?Melanoma can begin in the eye ? a condition called intraocular melanoma. Treatment for intraocular melanoma used to primarily involve removing the affected eye. Now, however, radiation therapy often can be used [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 19, 2018 Category: Databases & Libraries Source Type: news

Uveal Melanoma: Better Survival With Liver-Directed Therapy Uveal Melanoma: Better Survival With Liver-Directed Therapy
Treatment for liver metastases in uveal cancer has changed over 50 years. At ASCO, one study charted the survival benefits seen with newer localized therapies; the other showed benefits of radioembolization.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 12, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Sidney Kimmel Cancer Center scientists to present at ASCO Annual Meeting
(Thomas Jefferson University) Scientists from the Sidney Kimmel Cancer Center (SKCC) at Jefferson Health will be presenting research and leading discussions on various topics, including metastatic uveal melanoma, genetic counseling in men, immunotherapy in early stage lung cancer and solid tumors, quality of life among patients receiving treatment for T cell lymphoma and updates on the Cancer Moonshot during the Biden Cancer Initiative Colloquium at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, being held June 1-5 in Chicago. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 1, 2018 Category: Cancer & Oncology Source Type: news

FDA OKs First Artificial Iris for Aniridia, Other Iris Defects FDA OKs First Artificial Iris for Aniridia, Other Iris Defects
The CustomFlex Artificial Iris treats adults and children with congenital aniridia or iris defects due to other reasons or conditions, such as albinism, traumatic injury, or surgical removal due to melanoma.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 30, 2018 Category: Consumer Health News Tags: Ophthalmology News Alert Source Type: news

FDA clears first artificial iris from HumanOptics
The FDA today granted pre-market approval and a breakthrough device designation for HumanOptics‘ CustomFlex artificial iris, touting it as the first stand-alone prosthetic iris to win approval in the US. The CustomFlex artificial iris is designed to be surgically implanted in adults and children to treat individuals whose iris is completely missing or damaged due to either a congenital condition called aniridia or other damage to the eye, according to an FDA release. The newly cleared device is also indicated to treat iris defects due to other reasons or conditions, such as albinism, traumatic injury or surgical remo...
Source: Mass Device - May 30, 2018 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Optical/Ophthalmic Pre-Market Approval (PMA) Regulatory/Compliance humanoptics Source Type: news

FDA Approves First Artificial Iris
A German company has become the first to score FDA approval for a stand-alone prosthetic iris in the United States. The agency said Wednesday afternoon that it approved the CustomFlex Artificial Iris, made by Erlangen, Germany-based HumanOptics. The device, which is surgically implanted, is approved to treat adults and children whose iris is completely missing or damaged due to a congenital condition called aniridia or other damage to the eye. “Patients with iris defects may experience severe vision problems, as well as dissatisfaction with the appearance of their eye,” said Malvina Eydelman, MD, dire...
Source: MDDI - May 30, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Source Type: news

Parents of two children who died of a cancer that 95% survive are suing doctor
Damian Creed and Salette Ruiz were both diagnosed with retinoblastoma aged two in Miami, Florida. Though 95 percent of sufferers survive, Damian and Salette died the same week in 2016. (Source: the Mail online | Health)
Source: the Mail online | Health - May 19, 2018 Category: Consumer Health News Source Type: news

Tanzania:Eye Cancer - Save Children
[Citizen] Recent revelations that more than half of the children under the age of 5, who are diagnosed with eye cancer in the country die, should worry everyone and jolt the authorities to action. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 18, 2018 Category: African Health Source Type: news

Jarrow toddler diagnosed with deadly eye cancer from a photograph
During a family trip to Tenerife in January 2017, a photographer snapped Presley, who was just seven months old at the time. The photographer, noticed Presley had one white eye in the picture. (Source: the Mail online | Health)
Source: the Mail online | Health - May 18, 2018 Category: Consumer Health News Source Type: news

Toddler, two, was diagnosed with deadly eye cancer from a photograph
During a family trip to Tenerife in January 2017, a photographer snapped Presley, who was just seven months old at the time. The photographer, noticed Presley had one white eye in the picture. (Source: the Mail online | Health)
Source: the Mail online | Health - May 18, 2018 Category: Consumer Health News Source Type: news

Tanzania:Eye Cancer in Children 'Worrying'
[Citizen] Dar es Salaam -Experts in Tanzania have raised concerns about rising cases of eye cancer also known as Retinoblastoma, which commonly affects children. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 17, 2018 Category: African Health Source Type: news

Doctors Stumped By Rare Eye Cancer Cases In North Carolina, Alabama
Ocular melanoma typically affects six out of every 1 million people, but doctors have found dozens of cases where the patients have connections to either Huntersville, N.C., or Auburn, Ala. (Image credit: Karen Bleier/AFP/Getty Images) (Source: NPR Health and Science)
Source: NPR Health and Science - May 4, 2018 Category: Consumer Health News Authors: Samantha Raphelson Source Type: news

CBS News report on rare eye cancer gets widespread response
A CBS News report about a rare eye cancer affecting people in Georgia and North Carolina is getting reaction from around the world. Many people say they or someone they know has also been diagnosed with ocular melanoma. CBS News correspondent Anna Werner has the latest. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 4, 2018 Category: Consumer Health News Source Type: news

After CBS News report on rare eye cancer mystery, hundreds share similar stories
Doctors are intensifying efforts to find out what caused groups of people in two different cities to mysteriously develop ocular melanoma (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 3, 2018 Category: Consumer Health News Source Type: news

After CBS News report on rare eye cancer mystery, hundreds share stories
Doctors are intensifying efforts to find out what caused groups of people in two different cities to mysteriously develop a rare eye cancer. Ocular melanoma typically occurs in just six out of every one million people. After our report Monday, hundreds of people reached out to say they or someone they know have had this same rare cancer. Anna Werner reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 3, 2018 Category: Consumer Health News Source Type: news

In Retinoblastoma Survivors, Oculo - Visual Issues Tied to QoL
Oculo - visual problems associated with functional status, vision - targeted health - related quality of life (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 2, 2018 Category: Cancer & Oncology Tags: Oncology, Ophthalmology, Journal, Source Type: news

Morning Break: Stolen Trump Records; Gyns in Trouble; Eye Cancer Cluster?
(MedPage Today) -- Health news and commentary from around the Web gathered by the MedPage Today staff (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 2, 2018 Category: American Health Source Type: news

In Retinoblastoma Survivors, Oculo-Visual Issues Tied to QoL
WEDNESDAY, May 2, 2018 -- Oculo-visual problems among adult retinoblastoma survivors are associated with patient-reported vision-targeted health-related quality of life (HRQoL), according to a study published online April 26 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 2, 2018 Category: Pharmaceuticals Source Type: news

Group of rare eye cancer cases baffles experts
A group of patients with a rare type of eye cancer called ocular melanoma has researchers and epidemiologists stumped. (Source: CNN.com - Health)
Source: CNN.com - Health - May 2, 2018 Category: Consumer Health News Source Type: news

Doctors Fret Over Cases of Rare Eye Cancer
Ocular melanoma typically occurs in just six of every one million people, but has been diagnosed in a group of 18 patients in North Carolina and Alabama. (Source: WebMD Health)
Source: WebMD Health - May 1, 2018 Category: Consumer Health News Source Type: news

Diseases spread by ticks, mosquitoes and fleas more than tripled in the U.S.
The warmer weather of spring and summer means the start of tick and mosquito season and the diseases they transmit, including Lyme disease, Rocky Mountain spotted fever, West Nile and Zika. A new report from the Centers for Disease Control and Prevention has found that illnesses from mosquito, tick and flea bites more than tripled in […]Related:Liquid nicotine for e-cigs looks like kids’ juice boxes and candy, government saysShe modeled in New York and worked for the Navy. At 93, parasites ate her alive at a nursing home.A rare eye cancer showed up in three friends. Doctors want to know if the cases are c...
Source: Washington Post: To Your Health - May 1, 2018 Category: Consumer Health News Source Type: news

Medical mystery shines light on rare eye cancer
A closer look at ocular melanoma, an extremely rare form of cancer that has been identified in groups of patients in two states (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 1, 2018 Category: Consumer Health News Source Type: news

She modeled in New York and worked for the Navy. At 93, parasites ate her alive at a nursing home.
Pictures of Rebecca Zeni during her younger years showed her with flawless skin, well-defined eyebrows and long, thick lashes. Her hair, parted in the middle, was neatly tied with a bow behind her ear. Her beauty could capture a room, her daughter said, but she was more than just a beautiful face. She was a modern-day […]Related:A rare eye cancer showed up in three friends. Doctors want to know if the cases are connected.CDC director asks that his $375,000 salary be cut after questions raisedA scientist just turned 104. His birthday wish is to die. (Source: Washington Post: To Your Health)
Source: Washington Post: To Your Health - May 1, 2018 Category: Consumer Health News Source Type: news