Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division
Cell size is fundamental to cell physiology. For example, cell size determines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis. Although some genes that affect mammalian cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive. We show that cell growth during the G1 phase of the cell division cycle dilutes the cell cycle inhibitor Retinoblastoma protein (Rb) to trigger division in human cells. RB overexpression increased cell size and G1 duration, whereas RB deletion decreased cell size and removed the inverse ...
Source: ScienceNOW - July 23, 2020 Category: Science Authors: Zatulovskiy, E., Zhang, S., Berenson, D. F., Topacio, B. R., Skotheim, J. M. Tags: Cell Biology, Engineering reports Source Type: news

3 Brothers Have the Same Rare Cancer
The Rush brothers, ages 5 years, 4 years, and 7 months, share something that most brothers don’t: bilateral retinoblastoma, a rare eye cancer. See how their mother, who was also born with the disease, handles treatments, daily life, and facing the unknown. (Source: WebMD Health)
Source: WebMD Health - February 11, 2020 Category: Consumer Health News Source Type: news

Three Georgia brothers under six are all battling the same rare eye cancer
Brothers Tristan Rush, five; Caison Rush, three; and Carter Rush. six months, from Marietta, Georgia have all been diagnosed with retinoblastoma, a rare form of eye cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2020 Category: Consumer Health News Source Type: news

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition
The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). Under some circumstances, p27 is associated with active CDK4, but no mechanism for activation has been described. We found that p27, when phosphorylated by tyrosine kinases, allosterically activated CDK4 in complex with cyclin D1 (CDK4-CycD1). Structural and biochemical data revealed that binding of phosphorylated p27 (phosp27) to CDK4 altered the kinase adenosine triphosphate site to promote phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and other substrates. Surpri...
Source: ScienceNOW - December 12, 2019 Category: Science Authors: Guiley, K. Z., Stevenson, J. W., Lou, K., Barkovich, K. J., Kumarasamy, V., Wijeratne, T. U., Bunch, K. L., Tripathi, S., Knudsen, E. S., Witkiewicz, A. K., Shokat, K. M., Rubin, S. M. Tags: Biochemistry, Medicine, Diseases, Online Only r-articles Source Type: news

Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma
The risk of bone and soft-tissue sarcoma is markedly elevated in long-term survivors of hereditary retinoblastoma treated with radiation, researchers report.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - November 26, 2019 Category: Orthopaedics Tags: Hematology-Oncology News Source Type: news

Tanzania: Medics Warn of Eye Cancer
[Daily News] MEDICAL experts in the country have raised considerable concern over raising cases of retinoblastoma, an eye cancer that develops in early childhood. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 20, 2019 Category: African Health Source Type: news

Girl, 5, has her eye removed the day after doctors found 10 tumours in it
Gracie Corrigan, from Oregon, was diagnosed with the rare eye cancer retinoblastoma when doctors found 10 tumours around her right eye after her mother noticed it looked odd in a photo. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2019 Category: Consumer Health News Source Type: news

What makes a cell turn cancerous?
(Children's Hospital Los Angeles) CHLA researcher David Cobrinik, MD, PhD receives $1.6M grant to study how genetic changes cause retinoblastoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 14, 2019 Category: International Medicine & Public Health Source Type: news

Virus-based therapy targets a pediatric eye cancer
(American Association for the Advancement of Science) A cancer-killing, virus-based therapy showed promising effects against retinoblastoma -- a tumor of the retina that affects mainly children -- in mouse models and a pilot clinical trial. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 23, 2019 Category: Cancer & Oncology Source Type: news

Twin baby girls were both diagnosed with a rare eye cancer just DAYS after being born
Twins Ella and Eve, of  Pennsylvania, were diagnosed with bilateral retinoblastoma by the time they were one-month-old. Although off chemo for now, the disease could return at any time. (Source: the Mail online | Health)
Source: the Mail online | Health - January 21, 2019 Category: Consumer Health News Source Type: news

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Molecularly targeted therapies aim to obstruct cell autonomous programs required for tumor growth. We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to suppress the proliferation of KRAS-mutant lung cancer cells while simultaneously provoking a natural killer (NK) cell surveillance program leading to tumor cell death. The drug combination, but neither agent alone, promotes retinoblastoma (RB) protein-mediated cellular senescence and activation of the immunomodulatory senescence-associated secretory phenotype (SASP). SASP components tumor necrosis factor&ndash...
Source: ScienceNOW - December 20, 2018 Category: Science Authors: Ruscetti, M., Leibold, J., Bott, M. J., Fennell, M., Kulick, A., Salgado, N. R., Chen, C.-C., Ho, Y.-j., Sanchez-Rivera, F. J., Feucht, J., Baslan, T., Tian, S., Chen, H.-A., Romesser, P. B., Poirier, J. T., Rudin, C. M., de Stanchina, E., Manchado, E., S Tags: Immunology, Medicine, Diseases reports Source Type: news

Toddler loses her eye to a rare form of cancer after her mother noticed she couldn't see
Alice Taylor, from Poole, Dorset, was diagnosed with the aggressive eye cancer retinoblastoma in May last year when she was just two years old. She had been going blind in her left eye for months. (Source: the Mail online | Health)
Source: the Mail online | Health - October 11, 2018 Category: Consumer Health News Source Type: news

CHLA team identifies developmental stage for no. 1 eye tumor in children
(Children's Hospital Los Angeles) Investigators at Children's Hospital Los Angeles have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the door for future interventions in retinoblastoma (RB), a tumor of the retina that affects children under five years of age. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2018 Category: International Medicine & Public Health Source Type: news

Two-year-old boy battling rare cancer risks blindness as painful mass grows over his eye
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five. (Source: the Mail online | Health)
Source: the Mail online | Health - August 16, 2018 Category: Consumer Health News Source Type: news

Parents of two children who died of a cancer that 95% survive are suing doctor
Damian Creed and Salette Ruiz were both diagnosed with retinoblastoma aged two in Miami, Florida. Though 95 percent of sufferers survive, Damian and Salette died the same week in 2016. (Source: the Mail online | Health)
Source: the Mail online | Health - May 19, 2018 Category: Consumer Health News Source Type: news

Tanzania:Eye Cancer in Children 'Worrying'
[Citizen] Dar es Salaam -Experts in Tanzania have raised concerns about rising cases of eye cancer also known as Retinoblastoma, which commonly affects children. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 17, 2018 Category: African Health Source Type: news

In Retinoblastoma Survivors, Oculo - Visual Issues Tied to QoL
Oculo - visual problems associated with functional status, vision - targeted health - related quality of life (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 2, 2018 Category: Cancer & Oncology Tags: Oncology, Ophthalmology, Journal, Source Type: news

In Retinoblastoma Survivors, Oculo-Visual Issues Tied to QoL
WEDNESDAY, May 2, 2018 -- Oculo-visual problems among adult retinoblastoma survivors are associated with patient-reported vision-targeted health-related quality of life (HRQoL), according to a study published online April 26 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 2, 2018 Category: Pharmaceuticals Source Type: news

Retinoblastoma Eye Cancer
Retinoblastoma (Eye Cancer) (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - February 20, 2018 Category: General Medicine Source Type: news

Boston Doctors Try To Save Girl ’ s Vision Using New Cancer Treatment
BOSTON (CBS) – It’s a parent’s worst nightmare, hearing not only that your child has cancer but that she might also lose her eye. That’s exactly what happened to an Andover family and their 3-year-old daughter. But as Dr. Mallika Marshall reports, doctors at Boston Children’s Hospital are using a revolutionary technique to try to save her vision and her life. A little over a year ago Dania Snyder was a typical toddler until her parents noticed something unusual about her right eye. “You could see a little flash of a fleshy piece sort of through her pupil,” explains PJ, Dania’...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 23, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Syndicated Local Boston Children's Hospital Cancer Dr. Mallika Marshall Source Type: news

Intravitreous Chemo Poses Minimal Extraocular Extension Risk in Retinoblastoma Intravitreous Chemo Poses Minimal Extraocular Extension Risk in Retinoblastoma
Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 8, 2017 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Aqueous Humor May Serve as Surrogate Tumor Biopsy for Retinoblastoma Aqueous Humor May Serve as Surrogate Tumor Biopsy for Retinoblastoma
Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 20, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news

A liquid biopsy for retinoblastoma
(Children's Hospital Los Angeles) A recent study by a team of investigators at Children's Hospital Los Angeles and Keck Medicine of USC, provides proof of concept for a safe and effective way to derive genetic information from a retinoblastoma tumor. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 12, 2017 Category: Cancer & Oncology Source Type: news

Study shows biomarkers can predict which ER-positive breast cancer patients respond best to first-line therapy
(University of Texas M. D. Anderson Cancer Center) Two challenges in treating patients with estrogen-positive breast cancer (ER+) have been an inability to predict who will respond to standard therapies and adverse events leading to therapy discontinuation. A study at The University of Texas MD Anderson Cancer Center revealed new information about how the biomarkers retinoblastoma protein (Rb) and cytoplasmic cyclin E could indicate which patients will respond best to current first-line therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 27, 2017 Category: Cancer & Oncology Source Type: news

Boy's parents tried to cure eye tumour using black magic
Bongre Anton Peter, from Papua New Guinea, had signs of retinoblastoma when he was a year old. Eye drops and painkillers failed to help, as his desperate parents turned to traditional tribal beliefs. (Source: the Mail online | Health)
Source: the Mail online | Health - May 31, 2017 Category: Consumer Health News Source Type: news

Visunex Medical raises $20m Series B for PanoCam neonate eye scanners
Visunex Medical Systems said last week that it raised a $20 million Series B round for its PanoCam line of neonatal eye imaging systems. Fremont, Calif.-based Visunex said the PanoCam line includes the LT and Pro wireless systems and a 3rd system set to debut in June. “The interest in the medical investment community to be part of this funding round turned out to be much more than we had anticipated,” founder & CEO Wei Su said in prepared remarks. “This new round of funding brings the total investment into Visunex Medical to $32 million, and will allow the company to expa...
Source: Mass Device - May 8, 2017 Category: Medical Equipment Authors: Brad Perriello Tags: Funding Roundup Optical/Ophthalmic Wall Street Beat Visunex Source Type: news

RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis
To produce seeds, flowering plants need to specify somatic cells to undergo meiosis. Here, we reveal a regulatory cascade that controls the entry into meiosis starting with a group of redundantly acting cyclin-dependent kinase (CDK) inhibitors of the KIP-RELATED PROTEIN (KRP) class. KRPs function by restricting CDKA;1–dependent inactivation of the Arabidopsis Retinoblastoma homolog RBR1. In rbr1 and krp triple mutants, designated meiocytes undergo several mitotic divisions, resulting in the formation of supernumerary meiocytes that give rise to multiple reproductive units per future seed. One function of RBR1 is the ...
Source: ScienceNOW - April 27, 2017 Category: Science Authors: Zhao, X., Bramsiepe, J., Van Durme, M., Komaki, S., Prusicki, M. A., Maruyama, D., Forner, J., Medzihradszky, A., Wijnker, E., Harashima, H., Lu, Y., Schmidt, A., Guthörl, D., Logrono, R. S., Guan, Y., Pochon, G., Grossniklaus, U., Laux, T., Higas Tags: Botany, Online Only r-articles Source Type: news

What Causes Uveitis?
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and> 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increase...
Source: PediatricEducation.org - April 3, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Of Course Cancer Isn't Random
Despite the study in one of the world’s most prestigious scientific journals, and the high-profile media coverage of it: no, cancer is absolutely NOT mostly random and a product of “bad luck.” It wasn’t true when these same investigators published very similar work generating very similar media hype and nonsense two years ago, and it isn’t true now.  That’s what I want to talk about, but must hasten to append the obvious proviso: cancer can, rarely, be or at least seem utterly random. But to call cancer random because a child rarely gets retinoblastoma or glioblastoma, or ...
Source: Healthy Living - The Huffington Post - March 30, 2017 Category: Consumer Health News Source Type: news

Aqueous Humor Can Serve as Surrogate Tumor Biopsy
In eyes of children with retinoblastoma, AH has sufficient tumor - derived DNA for genetic analyses (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 28, 2017 Category: Cancer & Oncology Tags: Oncology, Ophthalmology, Pathology, Pediatrics, Journal, Source Type: news

For Group D Retinoblastoma, Intra-arterial May Beat IV Chemo For Group D Retinoblastoma, Intra-arterial May Beat IV Chemo
For children with group D retinoblastoma, first-line intra-arterial chemo may be better than first-line intravenous chemo , a retrospective study from Switzerland suggests.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 27, 2016 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Groundbreaking discovery has potential to improve therapies for cancer and other diseases
The Retinoblastoma protein (pRB) has long been studied for its role in cell growth and the prevention of cancer. Scientists have now discovered that pRB plays another, larger role with the potential to enhance therapies for cancer and other diseases such as HIV. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 15, 2016 Category: Science Source Type: news

Girl diagnosed with retinoblastoma after mother noticed white glow behind her pupil
Tyraah Bell-Lama, from Reading, was just eight months old when she was taken to the doctor with a white glow behind her baby's eye. Tests revealed she had retinoblastoma. (Source: the Mail online | Health)
Source: the Mail online | Health - December 15, 2016 Category: Consumer Health News Source Type: news

Groundbreaking discovery has potential to improve therapies for cancer and other diseases
(Lawson Health Research Institute) The Retinoblastoma protein (pRB) has long been studied for its role in cell growth and the prevention of cancer. In a new study by Lawson Health Research Institute, scientists have discovered that pRB plays another, larger role with the potential to enhance therapies for cancer and other diseases such as HIV. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 15, 2016 Category: Cancer & Oncology Source Type: news

More boys are diagnosed with cancer than girls worldwide - why?
This article was originally published on The Conversation. Read the original article. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Science - The Huffington Post)
Source: Science - The Huffington Post - November 25, 2016 Category: Science Source Type: news

Pediatric ophthalmology
Childhood glaucomaEye movement disordersEye cancerOptic nerve disorders We use the latest advances in pediatric ophthalmology to optimize your child ’s vision and eye health.Diagnosis and treatment of pediatric eye diseasesPrompt identification of childhood eye and vision problems is often the best way to preserve or regain vision.   This applies to common pediatric eye conditions such as refractive error requiring eyeglasses, amblyopia (or lazy eye) and strabismus (eyes that are not straight), as well as serious eye conditions such as childhood cataract, glaucoma, retinopathy of prematurity, and an eye tumor c...
Source: dukehealth.org: Duke Health News - August 8, 2016 Category: Consumer Health News Authors: dg62 at duke.edu Source Type: news

Dr. Alfred G. Knudson, the ‘Mendel of Cancer Genetics,’ Dies at 93
A 1971 theory on the inheritable nature of retinoblastoma in children, proved in 1986, is credited with helping advance the framework of how cancers are studied. (Source: NYT Health)
Source: NYT Health - July 15, 2016 Category: Consumer Health News Authors: KENNETH CHANG Tags: Deaths (Obituaries) Genetics and Heredity Research Cancer Knudson, Alfred G Philadelphia (Pa) Source Type: news

Eye-Preserving Retinoblastoma Therapy Can Compromise SurvivalEye-Preserving Retinoblastoma Therapy Can Compromise Survival
The goal of preserving vision and the risk of reduced long-term overall survival must be balanced against each other when treating heritable retinoblastoma, say researchers from Germany. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 11, 2016 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

What Are The Most Common Pediatric Cancers?
Discussion Cancer occurs in all ages including children. Fortunately cancer is much less common in the pediatric age group accounting for
Source: PediatricEducation.org - July 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Pond scum and the gene pool: One critical gene in green algae responsible for multicellular evolution, understanding of cancer origin
A single gene is responsible for the evolution of multicellular organisms, new research indicates. Scientists were looking for what caused single-celled organisms to evolve into multicellular organisms when they discovered the importance of a single gene, retinoblastoma, or RB. RB, known for being defective in cancer patients, is a critical gene necessary for multicellular life; previous theories have indicated that multiple genes might be responsible for multicellularity. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 5, 2016 Category: Science Source Type: news

Study: Combination therapy improves retinoblastoma outcome
Stephen FellerLOS ANGELES, April 15 (UPI) -- Researchers found a combination of chemotherapy and a protein inhibitor improves the outcome of children with retinoblastoma, according to a recent study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 15, 2016 Category: Consumer Health News Source Type: news

Combination therapy may offer better outcomes for patients with retinoblastoma
Targeting survivin -- a protein that inhibits apoptosis or cell death -- enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumor of the eye in children, researchers report. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 15, 2016 Category: Science Source Type: news

Combination therapy may offer better outcomes for patients with retinoblastoma
(Children's Hospital Los Angeles) Researchers at The Saban Research Institute of Children's Hospital Los Angeles (CHLA) have demonstrated that targeting survivin -- a protein that inhibits apoptosis or cell death -- enhances the effectiveness of chemotherapy in cells and mouse models of retinoblastoma (Rb), the most common malignant tumor of the eye in children. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 14, 2016 Category: Global & Universal Source Type: news

Mother Gemma Edgar and son Noah are BOTH battling cancer
Gemma Edgar, 30, of Colchester, had surgery to cut out her glioblastoma multiforme. But later that year her son Noah, 18 months, was found to have retinoblastoma - a rare type of eye cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - February 27, 2016 Category: Consumer Health News Source Type: news

Catching up with Poppy: Life after an eye tumor
Poppy with her little sister Hazel (Courtesy of Dana Biagini) When Poppy Biagini was just four months old, her family got news no parent wants to hear — that she had a rare, rapidly growing tumor in her right eye called a retinoblastoma. That was almost three years ago. But if you looked at Poppy today, you’d be hard pressed to tell that she’s anything other than your average 3-year-old who loves Curious George, swim class and playing dress-up. “She knows that there’s something a little different with her eye than everyone else’s,” her father Dana says. “But she’s handl...
Source: Thrive, Children's Hospital Boston - February 9, 2016 Category: Pediatrics Authors: Tom Ulrich Tags: Diseases & Conditions Our Patients’ Stories Ankoor Shah Dana-Farber/Boston Children's Cancer and Blood Disorders Center Darren Orbach eye tumor intra-arterial chemotherapy retinoblastoma Source Type: news

Medical News Today: What are the long-term implications for children with cancers affecting vision?
Retinoblastoma is the most common childhood cancer of the eye. New research investigates the health implications for survivors over the ensuing decades. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 11, 2016 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Simple test predicts response to chemotherapy in lung cancer patients
(Lawson Health Research Institute) Scientists at Lawson Health Research Institute have found that adenocarcinoma patients who undergo chemotherapy and surgery experience significantly improved survival rates when their tumor is lacking the retinoblastoma tumor suppressor protein. This new information is very useful as it may predict which patients will respond best to chemotherapy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 3, 2015 Category: Biology Source Type: news

InfantSEE: Vision For Your Baby's Future
Your baby's eyes developed in utero as an extension of the brain. At birth, your baby could see light and dark, but not colors or details. Outside stimuli began to interact with your newborn's eyes and vision began to form. View image | gettyimages.com Vision and the way the brain uses visual information, are skills that a baby learns over time. The greatest amount of growth in vision and processing visual information occurs during your baby's first year of life. During this time, your baby will learn how to focus on an object and how to move the eyes in response to stimuli. All of these vision milestones will allow your ...
Source: Healthy Living - The Huffington Post - October 9, 2015 Category: Consumer Health News Source Type: news