Comment on “The association between race and age of diagnosis of retinoblastoma in United States children”
(Source: Journal of AAPOS)
Source: Journal of AAPOS - May 6, 2024 Category: Opthalmology Authors: Francisco Altamirano-Lamarque, Efren Gonzalez, Isdin Oke Tags: Letter to the Editor Source Type: research
Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids
CONCLUSION: The study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.PMID:38704498 | DOI:10.1007/s11033-024-09564-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 4, 2024 Category: Molecular Biology Authors: Ambily Vincent Subramanian Krishnakumar Sowmya Parameswaran Source Type: research
Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids
CONCLUSION: The study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.PMID:38704498 | DOI:10.1007/s11033-024-09564-9 (Source: Molecular Medicine)
Source: Molecular Medicine - May 4, 2024 Category: Molecular Biology Authors: Ambily Vincent Subramanian Krishnakumar Sowmya Parameswaran Source Type: research
Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids
CONCLUSION: The study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.PMID:38704498 | DOI:10.1007/s11033-024-09564-9 (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 4, 2024 Category: Molecular Biology Authors: Ambily Vincent Subramanian Krishnakumar Sowmya Parameswaran Source Type: research
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
CONCLUSION: This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.PMID:38687926 | DOI:10.4103/jcrt.jcrt_1504_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yulu Chen Xi Xiao Guanghui Hu Rengyun Liu Junyu Xue Source Type: research
Advanced intraocular retinoblastoma: evolving criteria for group E disease (1)
Can J Ophthalmol. 2024 Apr 27:S0008-4182(24)00068-1. doi: 10.1016/j.jcjo.2024.03.005. Online ahead of print.ABSTRACTWith evolving criteria for classifying intraocular retinoblastoma (RB) from International Intraocular Retinoblastoma Classification (IIRC, 2005) to International Classification of Retinoblastoma (ICRB, 2006), there have been changes in the inclusion criteria for groups E eyes that have not been widely recognized. This brief review highlights issues with the current classification systems (ICRB and IIRC) and layouts a theoretical framework arguing for merging of 2 existing classifications into 1 and subdividin...
Source: Canadian Journal of Ophthalmology - April 30, 2024 Category: Opthalmology Authors: Ahad Sedaghat Vishal Raval Renbing Jia Xianqun Fan Arun D Singh Source Type: research
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
CONCLUSION: This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.PMID:38687926 | DOI:10.4103/jcrt.jcrt_1504_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yulu Chen Xi Xiao Guanghui Hu Rengyun Liu Junyu Xue Source Type: research
Advanced intraocular retinoblastoma: evolving criteria for group E disease (1)
Can J Ophthalmol. 2024 Apr 27:S0008-4182(24)00068-1. doi: 10.1016/j.jcjo.2024.03.005. Online ahead of print.ABSTRACTWith evolving criteria for classifying intraocular retinoblastoma (RB) from International Intraocular Retinoblastoma Classification (IIRC, 2005) to International Classification of Retinoblastoma (ICRB, 2006), there have been changes in the inclusion criteria for groups E eyes that have not been widely recognized. This brief review highlights issues with the current classification systems (ICRB and IIRC) and layouts a theoretical framework arguing for merging of 2 existing classifications into 1 and subdividin...
Source: Canadian Journal of Ophthalmology - April 30, 2024 Category: Opthalmology Authors: Ahad Sedaghat Vishal Raval Renbing Jia Xianqun Fan Arun D Singh Source Type: research
Advanced intraocular retinoblastoma: evolving criteria for group E disease (1)
Can J Ophthalmol. 2024 Apr 27:S0008-4182(24)00068-1. doi: 10.1016/j.jcjo.2024.03.005. Online ahead of print.ABSTRACTWith evolving criteria for classifying intraocular retinoblastoma (RB) from International Intraocular Retinoblastoma Classification (IIRC, 2005) to International Classification of Retinoblastoma (ICRB, 2006), there have been changes in the inclusion criteria for groups E eyes that have not been widely recognized. This brief review highlights issues with the current classification systems (ICRB and IIRC) and layouts a theoretical framework arguing for merging of 2 existing classifications into 1 and subdividin...
Source: Canadian Journal of Ophthalmology - April 30, 2024 Category: Opthalmology Authors: Ahad Sedaghat Vishal Raval Renbing Jia Xianqun Fan Arun D Singh Source Type: research
Advanced intraocular retinoblastoma: evolving criteria for group E disease (1)
Can J Ophthalmol. 2024 Apr 27:S0008-4182(24)00068-1. doi: 10.1016/j.jcjo.2024.03.005. Online ahead of print.ABSTRACTWith evolving criteria for classifying intraocular retinoblastoma (RB) from International Intraocular Retinoblastoma Classification (IIRC, 2005) to International Classification of Retinoblastoma (ICRB, 2006), there have been changes in the inclusion criteria for groups E eyes that have not been widely recognized. This brief review highlights issues with the current classification systems (ICRB and IIRC) and layouts a theoretical framework arguing for merging of 2 existing classifications into 1 and subdividin...
Source: Canadian Journal of Ophthalmology - April 30, 2024 Category: Opthalmology Authors: Ahad Sedaghat Vishal Raval Renbing Jia Xianqun Fan Arun D Singh Source Type: research
Advanced intraocular retinoblastoma: evolving criteria for group E disease (1)
Can J Ophthalmol. 2024 Apr 27:S0008-4182(24)00068-1. doi: 10.1016/j.jcjo.2024.03.005. Online ahead of print.ABSTRACTWith evolving criteria for classifying intraocular retinoblastoma (RB) from International Intraocular Retinoblastoma Classification (IIRC, 2005) to International Classification of Retinoblastoma (ICRB, 2006), there have been changes in the inclusion criteria for groups E eyes that have not been widely recognized. This brief review highlights issues with the current classification systems (ICRB and IIRC) and layouts a theoretical framework arguing for merging of 2 existing classifications into 1 and subdividin...
Source: Canadian Journal of Ophthalmology - April 30, 2024 Category: Opthalmology Authors: Ahad Sedaghat Vishal Raval Renbing Jia Xianqun Fan Arun D Singh Source Type: research
'Its not meant to be for life, but it carries on: a qualitative investigation into the psychosocial needs of young retinoblastoma survivors
Conclusions
This study provides in-depth insight into the experiences of life beyond Rb. Findings highlight the need for specific psychosocial interventions informed by codesign. (Source: BMJ Open)
Source: BMJ Open - April 30, 2024 Category: General Medicine Authors: O'Donnell, N., Phillips, B., Morgan, J. E., Howell, D. Tags: Open access, Oncology Source Type: research
Therapeutic Strategies for RB1-Deficient Cancers: Intersecting Gene Regulation and Targeted Therapy
Cancers (Basel). 2024 Apr 19;16(8):1558. doi: 10.3390/cancers16081558.ABSTRACTThe retinoblastoma (RB) transcriptional corepressor 1 (RB1) is a critical tumor suppressor gene, governing diverse cellular processes implicated in cancer biology. Dysregulation or deletion in RB1 contributes to the development and progression of various cancers, making it a prime target for therapeutic intervention. RB1's canonical function in cell cycle control and DNA repair mechanisms underscores its significance in restraining aberrant cell growth and maintaining genomic stability. Understanding the complex interplay between RB1 and cellular...
Source: Cancer Control - April 27, 2024 Category: Cancer & Oncology Authors: Mo-Fan Huang Yuan-Xin Wang Yu-Ting Chou Dung-Fang Lee Source Type: research
Probing the Effects of Retinoblastoma Binding Protein 6 (RBBP6) Knockdown on the Sensitivity of Cisplatin in Cervical Cancer Cells
Cells. 2024 Apr 18;13(8):700. doi: 10.3390/cells13080700.ABSTRACTCervical cancer is a major cause of death in women despite the advancement of current treatment modalities. The conventional therapeutic agent, cisplatin (CCDP), is the standard treatment for CC; however, resistance often develops due to the cancer's heterogeneity. Therefore, a detailed elucidation of the specific molecular mechanisms driving CC is crucial for the development of targeted therapeutic strategies. Retinoblastoma binding protein 6 (RBBP6) is a potential biomarker associated with cell proliferation and is upregulated in cervical cancer sites, exhi...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Harshini Mehta Melvin Anyasi Ambele Ntlotlang Mokgautsi Pontsho Moela Source Type: research
Cancers, Vol. 16, Pages 1656: Gastric Inhibitory Polypeptide Receptor (GIPR) Overexpression Reduces the Tumorigenic Potential of Retinoblastoma Cells
e Dünker
Retinoblastoma (RB) is the most common malignant intraocular tumor in early childhood. Gene expression profiling revealed that the gastric inhibitory polypeptide receptor (GIPR) is upregulated following trefoil factor family peptide 1 (TFF1) overexpression in RB cells. In the study presented, we found this G protein-coupled transmembrane receptor to be co-expressed with TFF1, a new diagnostic and prognostic RB biomarker for advanced subtype 2 RBs. Functional analyses in two RB cell lines revealed a significant reduction in cell viability and growth and a concomitant increase in apoptosis following stable, len...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Andr é Haase Emily Alefeld Fatma Yalinci Dario Van Meenen Maike Anna Busch Nicole D ünker Tags: Article Source Type: research
