Ocular and Orbital Tumors in Childhood
Pediatric tumors of the eye and orbit can be benign or malignant as well as congenital or acquired and are usually distinctively different than those seen in adults.1 Although most of these neoplasms are benign (e.g. dermoid cyst, chalazion or molluscum), their location near and within a vital organ can result in serious dermatologic and ophthalmologic sequelae. Lesions discussed include vascular lesions, retinoblastomas (the most common primary pediatric intraocular malignancy), rhabdomyosarcoma (the most common primary pediatric orbital malignancy), Langerhans cell histiocytosis, and metastatic lesions to the orbit (neur...
Source: Clinics in Dermatology - January 30, 2024 Category: Dermatology Authors: Kathryn Bentivegna, Nicholas J. Saba, Roman Shinder, Jane M. Grant-Kels Source Type: research
When the second comes first – rhabdomyosarcoma preceding heritable retinoblastoma– a case report
Retinoblastoma (rb) is the most frequent intraocular tumor, accounting for 3% of all childhood cancers. Heritable rb survivors are germline carriers for an RB1 mutation and have a lifelong risk to develop non-... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Devjyoti Tripathy, Alexandre Moulin, Jacques Bijon, Carole Gengler, Maja Beck-Popovic, Francis L. Munier and Christina Stathopoulos Tags: Case Report Source Type: research
Distribution and causes of blindness and severe visual impairment in children at a tertiary referral centre in Rwanda
Conclusion
The high number of avoidable causes for SVI/BL may be reduced through several cost-effective ways. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 29, 2024 Category: Opthalmology Authors: El-Khoury, S., Strittmatter, S., Tuyisabe, T., Preussner, P.-R., Abdelmassih, Y. Tags: Paediatric ophthalmology Source Type: research
Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1
ConclusionThese data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1, implying that Prox1 could be a potential therapeutic target for RB. (Source: Journal of Huazhong University of Science and Technology -- Medical Sciences --)
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - January 26, 2024 Category: Research Source Type: research
Clinico-Microbiological Correlation in < em > Salmonella < /em > Endophthalmitis: Case Series and Review of Literature
CONCLUSIONS: Salmonella endophthalmitis, though rare, leads to poor visual outcomes despite early recognition and aggressive management and may be confused with other infections or non-infectious entities such as necrotizing retinoblastoma in babies, in the absence of clear systemic signs of the disease.PMID:38254268 | DOI:10.1080/08820538.2024.2308802 (Source: Seminars in Ophthalmology)
Source: Seminars in Ophthalmology - January 23, 2024 Category: Opthalmology Authors: Sanchita Mitra Bhagyashree Meshram Subhadra Jalali Soumyava Basu Source Type: research
Identification of dysregulation of sphingolipids in retinoblastoma using liquid chromatography-mass spectrometry
Exp Eye Res. 2024 Jan 19:109798. doi: 10.1016/j.exer.2024.109798. Online ahead of print.ABSTRACTRetinoblastoma (RB) is a rare ocular cancer seen in children that counts for approximately 3% of all childhood cancers. It is found that mutation in RB1, a tumour Suppressor Gene on chromosome 13 as the cause of malignancy. Retinoblastoma protein is the target for ceramide to cause apoptosis. We studied lipidomics of two RB cell lines, one aggressive cell line (NCC-RbC-51) derived from a metastatic site and one non aggressive cell line (WERI-Rb1) in comparison with a control cell line (MIO-M1). Lipid profiles of all the cell lin...
Source: Experimental Eye Research - January 21, 2024 Category: Opthalmology Authors: Omkar Surendra Khade Sruthy Sasidharan Ankit Jain Bhavani Shankar Maradani Amit Chatterjee Divya Gopal Ranjith Kumar Ravi Kumar Subramaniyan Krishnakumar Akhilesh Pandey Narayanan Janakiraman Sailaja V Elchuri Seetaramanjaneyulu Gundimeda Source Type: research
Retinoblastoma treatment in a Brazilian population. Presentation and long ‐term results
ConclusionsTreatment of retinoblastoma with conservative systemic-based chemotherapy was associated with an excellent survival rate (92%). Albeit the low overall globe salvage rate, in BIL patients, approximately half the eyes were conserved, and a satisfactory functional visual result was achieved The evaluated protocol is an important treatment option, especially in developing countries. (Source: Cancer Medicine)
Source: Cancer Medicine - January 20, 2024 Category: Cancer & Oncology Authors: Maria Teresa Brizzi Chizzotti Bonanomi,
Maria Tereza A. de Almeida,
Marianna A. Hollaender,
Roberta Chizzotti Bonanomi,
Mario Luiz Ribeiro Monteiro Tags: RESEARCH ARTICLE Source Type: research
Use of Pharmacokinetic and Pharmacodynamic Data to Develop the CDK4/6 Inhibitor Ribociclib for Patients with Advanced Breast Cancer
AbstractRibociclib is an orally bioavailable, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. CDK4/6 inhibition by ribociclib leads to retinoblastoma tumor suppressor protein (Rb) reactivation, thereby restoring Rb-mediated cell cycle arrest. Ribociclib is approved for the treatment of patients with hormone receptor-positive/human epidermal growth factor receptor-2-negative (HR+/HER2−) advanced breast cancer (ABC), at the dose of 600 mg once daily (QD) during cycles of 21 days on/7 days off, with optional dose reduction to 400 mg and 200 mg. Ribociclib is rapidly absorbed with a median time to reach ...
Source: Clinical Pharmacokinetics - January 20, 2024 Category: Drugs & Pharmacology Source Type: research
Targeted therapies in retinoblastoma: GD2-directed immunotherapy following autologous stem cell transplantation and evaluation of alternative target B7-H3
ConclusionAnti-GD2-directed immunotherapy represents an additional therapeutic option in high-risk metastasized RB. Moreover, CD276 is another target of interest. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - January 19, 2024 Category: Cancer & Oncology Source Type: research
Clinical considerations of CDK4/6 inhibitors in HER2 positive breast cancer
Deregulation of cell cycles can result in a variety of cancers, including breast cancer (BC). In fact, abnormal regulation of cell cycle pathways is often observed in breast cancer, leading to malignant cell proliferation. CDK4/6 inhibitors (CDK4/6i) can block the G1 cell cycle through the cyclin D-cyclin dependent kinase 4/6-inhibitor of CDK4-retinoblastoma (cyclinD-CDK4/6-INK4-RB) pathway, thus blocking the proliferation of invasive cells, showing great therapeutic potential to inhibit the spread of BC. So far, three FDA-approved drugs have been shown to be effective in the management of advanced hormone receptor positiv...
Source: Frontiers in Oncology - January 16, 2024 Category: Cancer & Oncology Source Type: research
The association between race and age of diagnosis of retinoblastoma in United States children
To explore the associations between race and retinoblastoma diagnosis in United States children. (Source: Journal of AAPOS)
Source: Journal of AAPOS - January 16, 2024 Category: Opthalmology Authors: Alexander K. Black, Amanda E. Kahn, Chrisnel Lamy, Roberto Warman, No ël C. Barengo Tags: Major Article Source Type: research
The apoptotic and anti-proliferative effect of Lysyl oxidase propeptide in Y79 human retinoblastoma cells
CONCLUSIONS: Our results demonstrate the anti-tumorigenic effect of LOX-PP in Y79 RB cells by inducing apoptosis and decreasing proliferation. This effect was mediated by the downregulation of AKT signaling. These results suggest that LOX-PP can be explored as a therapeutic molecule in RB.PMID:38222455 | PMC:PMC10784223 (Source: Molecular Vision)
Source: Molecular Vision - January 15, 2024 Category: Molecular Biology Authors: Nareshkumar Ragavachetty Nagaraj Sulochana Konerirajapuram Natarajan Coral Karunakaran Source Type: research
Association of Neighborhood Opportunity with Severity of Retinoblastoma at Presentation
To examine the relationship between the Child Opportunity Index (COI) and severity of retinoblastoma at presentation. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - January 15, 2024 Category: Opthalmology Authors: Francisco Altamirano-Lamarque, Caleb Lim, Ankoor S. Shah, Deborah K. VanderVeen, Efren Gonzalez, Isdin Oke Tags: Original Articles Source Type: research
Post-chemotherapy changes in retinal pigment epithelium in retinoblastoma eyes
CONCLUSION: The study highlights the characteristic histopathological RPE changes after systemic chemotherapy in RB cases. These changes may be attributable to cell nucleus damage after chemotherapy.PMID:38219790 | DOI:10.1016/j.jcjo.2023.12.006 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - January 14, 2024 Category: Opthalmology Authors: Dipankar Das Obaidur Rehman Kasturi Bhattacharjee Manab Jyoti Barman Harsha Bhattacharjee Munlima Hazarika Bidhan Chandra Das Vatsalya Venkatraman Deepak Soni Jessica Basumatary Apurba Deka Source Type: research
