Gene Set Enrichment Analyses Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy
Purpose: To identify functionally related genes associated with diabetic retinopathy (DR) risk using gene set enrichment analyses (GSEA) applied to genome-wide association study (GWAS) meta-analyses.Methods: We analyzed DR GWAS meta-analyses performed on 3,246 Europeans and 2,611 African Americans with type 2 diabetes. Gene sets relevant to five key DR pathophysiology processes were investigated: tissue injury, vascular events, metabolic events and glial dysregulation, neuronal dysfunction, and inflammation. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 20, 2021 Category: Opthalmology Authors: Lucia Sobrin, Gayatri Susarla, Lynn Stanwyck, John M. Rouhana, Ashley Li, Samuela Pollack, Robert P. Igo, Richard A. Jensen, Xiaohui Li, Maggie C.Y. Ng, Albert V. Smith, Jane Z. Kuo, Kent D. Taylor, Barry I. Freedman, Donald W. Bowden, Alan Penman, Ching Tags: Original Articles Source Type: research

Vision, Eye Disease, and the Onset of Balance Problems: The Canadian Longitudinal Study on Aging
Balance is critical to successful aging as studies have found that poor balance is associated with an increased risk of falls, nursing home admission, and mortality 1-3. Balance is regulated by multiple systems including the visual system, the vestibular system, and the proprioceptive system. Studies have reported that the visual system takes on a more important role in maintaining postural control in older age 4,5. Yet, visual impairment becomes much more common in older age, 6 which may leave visually impaired older adults without adequate postural control. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 19, 2021 Category: Opthalmology Authors: Zaina Kahiel, Alyssa Grant, Marie-Jos ée Aubin, Ralf Buhrmann, Marie-Jeanne Kergoat, Ellen E. Freeman Tags: Original Articles Source Type: research

Anti-inflammatory Pharmacotherapy for the Prevention of Cystoid Macular Edema after Cataract Surgery
: To elucidate strategies for and controversies surrounding the use of anti-inflammatory medications after uneventful cataract surgery, with a focus on the prevention of irreversible vision loss due to cystoid macular edema (CME). (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 19, 2021 Category: Opthalmology Authors: Kenneth J. Taubenslag, Stephen J. Kim, Andrzej Grzybowski Tags: Anti-inflammatory Pharmacotherapy for Cataract Surgery Source Type: research

Describing the Structural Phenotype of the Glaucomatous Optic Nerve Head Using Artificial Intelligence
To develop a novel deep-learning approach that can describe the structural phenotype of the glaucomatous ONH and can be used as a robust glaucoma diagnosis tool. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 19, 2021 Category: Opthalmology Authors: Satish K. Panda, Haris Cheong, Tin A. Tun, Sripad K. Devella, Vijayalakshmi Senthil, Ramaswami Krishnadas, Martin L. Buist, Shamira Perera, Ching-Yu Cheng, Tin Aung, Alexandre H. Thi éry, Michaël J.A. Girard Tags: Structural Phenotype of the Glaucomatous Optic Nerve Head Source Type: research

Factors influencing career decisions and satisfaction among newly practicing ophthalmologists
To describe the career choices of newly practicing ophthalmologists and explore factors influencing career decisions and satisfaction. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 19, 2021 Category: Opthalmology Authors: Steven J. Gedde, William J. Feuer, Ashley M. Crane, Wei Shi Source Type: research

Long term outcomes in fellow eyes comparing DSAEK and DMEK for treatment of Fuchs Corneal Dystrophy
: To compare the long term results of Descemet's stripping automated endothelial keratoplasty (DSAEK) and Descemet's membrane endothelial keratoplasty (DMEK) in fellow eyes for treatment of Fuchs endothelial corneal dystrophy (FED). (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 18, 2021 Category: Opthalmology Authors: Robert W. Weisenthal, Han Y. Yin, Allison R. Jarstad, Dongliang Wang, David D. Verdier Source Type: research

Clinical features of advanced glaucoma with optic nerve head prelaminar schisis Prelaminar schisis in advanced glaucoma
The optic nerve head (ONH) is the posterior ocular structure that enables the exit of retinal ganglion cell axons, and consists of nerve fibers and glial and vascular tissue. The scleral portion of the ONH neural canal is spanned by connective tissue beams of the lamina cribrosa (LC), which enter the peripapillary scleral circumferential collagen fibers through the scleral canal wall. LC is supposedly the key site of pressure-related retinal ganglion cell axonal insult in glaucoma.1,2 Thus, glaucoma is characterized by a range of morphological changes in the ONH, including a narrowing of the neuroretinal rim, an enlargemen...
Source: American Journal of Ophthalmology - June 18, 2021 Category: Opthalmology Authors: Mi Sun Sung, Hyung Nam Jin, Sang Woo Park Source Type: research

Long-Term Outcomes of Selective Laser Trabeculoplasty for Open-Angle Glaucoma in the Caribbean
To characterize long-term clinical outcomes of monotherapy selective laser trabeculoplasty (SLT) in Afro-Caribbean patients with open-angle glaucoma (OAG). (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 18, 2021 Category: Opthalmology Authors: Tony Realini, Hazel Shillingford-Ricketts, Darra Burt, Goundappa K. Balasubramani Tags: Original Articles Source Type: research

Ultrastructural Alterations of Grafted Corneal Buttons: The Anatomic Basis for Stromal Peeling along a Natural Plane of Separation
To examine the ultrastructure of the natural plane of separation in grafted corneas and evaluate the outcomes of stromal peeling. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 9, 2021 Category: Opthalmology Authors: Massimo Busin, Cristina Bovone, Vincenzo Scorcia, Erika Rimondi, Yoav Nahum, James Myerscough, Angeli Christy Yu Source Type: research

Outcomes of a Modified Treatment Ladder Algorithm using Retrobulbar Amphotericin B for Invasive Fungal Rhino-Orbital Sinusitis.
: To assess whether a modified treatment ladder algorithm incorporating transcutaneous retrobulbar amphotericin B (TRAMB) for invasive fungal rhino-orbital sinusitis (IFROS) can reduce the risk of exenteration without compromising survival. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 8, 2021 Category: Opthalmology Authors: Davin C. Ashraf, Oluwatobi O. Idowu, Kristin E. Hirabayashi, Evan Kalin-Hajdu, Seanna R. Grob, Bryan J. Winn, M. Reza Vagefi, Robert C. Kersten Source Type: research

Comparative Accuracy of Barrett Toric Calculator with and without Posterior Corneal Astigmatism Measurements and the Kane Toric Formula
: To compare the accuracy of the Barrett toric calculator with and without posterior corneal astigmatism and the Kane toric calculator. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 8, 2021 Category: Opthalmology Authors: Soonwon Yang, Yong-Soo Byun, Hyun Seung Kim, So-Hyang Chung Source Type: research

Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy
To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 8, 2021 Category: Opthalmology Authors: Danny Siu-Chun Ng, Mary Ho, Li Jia Chen, Fanny Lai-Ting Yip, Wee Min Teh, Linbin Zhou, Shaheeda Mohamed, Chi Wai Tsang, M årten Erik Brelén, Haoyu Chen, Chi Pui Pang, Timothy Y.Y. Lai Source Type: research

Rotational Stability of Intraocular Lenses: A Standardized Method for More Accurate Measurements in Future Studies
To assess the reliability and reproducibility of a new semi automated evaluation method Rotix for intraocular lens rotation (IOL) and to define a standardized evaluation method for future toric IOL studies. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 8, 2021 Category: Opthalmology Authors: Daniel Schartm üller, Luca Schwarzenbacher, Sabine Schriefl, Veronika Röggla, Irene Steiner, Claudette Abela-Formanek, Christina Leydolt, Rupert Menapace Source Type: research

Characteristics of Central Visual Field Progression in Eyes with Optic Disc Hemorrhage
Purpose: To investigate the characteristics and rate of central visual field loss after optic disc hemorrhages (DH).Design: Prospective cohort study.Methods: 343 eyes of 220 subjects who had at least 3 years of follow-up with minimum of 5 visits with 10-2 and 24-2 visual field (VF) were recruited. Rates of 10-2 mean deviation (MD) loss in each hemifield and pre-defined zones were compared using linear mixed-effects model in DH and non-DH eyes. Clustered pointwise regression analysis was also used to define central VF progressors and compared to 24-2 VF loss using Guided Progression Analysis. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 6, 2021 Category: Opthalmology Authors: Ryan Caezar C. David, Sasan Moghimi, Jiun L. Do, Huiyuan Hou, James Proudfoot, Linda M. Zangwill, Alireza Kamalipour, Takashi Nishida, Carlos Gustavo De Moraes, Christopher A. Girkin, Jeffrey M. Liebmann, Robert N. Weinreb Source Type: research

Comments on “Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis”
We read with interest the article “Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis” by Thulasi et al.1 In this retrospective analysis, the authors have attempted to identify the role of systemic Miltefosine in cases of recalcitrant/ resistant Acanthamoeba Keratitis. We had some queries and hope that the authors would answer them. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 6, 2021 Category: Opthalmology Authors: Amanjot Kaur, Srikant Kumar Sahu Tags: LETTER TO EDITOR Source Type: research

Automated Quantification of Choriocapillaris Lesion Area in Patients with Posterior Uveitis
: To validate a custom algorithm for automated identification and quantification of clinically relevant inflammatory choriocapillaris (CC) lesions from en face swept source optical coherence tomography (SS-OCTA) images. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 6, 2021 Category: Opthalmology Authors: K. Matthew McKay, Zhongdi Chu, Joon-Bom Kim, Alex Legocki, Xiao Zhou, Meng Tian, Marion R. Munk, Ruikang K. Wang, Kathryn L. Pepple Source Type: research

Efficacy of a Single Administration of 5% Povidone-Iodine in the Treatment of Adenoviral Conjunctivitis
Human adenoviruses are estimated to account for approximately 65% to 90% of the viral conjunctivitis cases.1 Adenoviral conjunctivitis (Ad-Cs) is typically associated with significant discomfort, tearing, discharge, lid swelling and photophobia. More rarely, there can be permanent corneal scarring due to inflammation. Ad-Cs is highly contagious as the virus is resistant to standard disinfectants including 70% isopropyl alcohol and 3% hydrogen peroxide and can persist on fomites at room temperature for five to seven weeks. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Tammy Than, Christina E. Morettin, Jennifer S. Harthan, Andrew T.E. Hartwick, Julia B. Huecker, Spencer D. Johnson, Mary K. Migneco, Ellen Shorter, Meredith Whiteside, Mathew S. Margolis, Christian K. Olson, Christopher S. Alferez, Tav é van Zyl, Bojana Source Type: research

Gender of Award Recipients in Major Ophthalmology Societies
With women outnumbering men among newly admitted medical students,1 the gender gap in ophthalmology has progressively diminished in the past decade. Women compose approximately a quarter of the ophthalmology workforce and nearly half of the ophthalmology residents.2,3 Prior research has shown an increase in the number of women presenting at conferences,4 publishing in ophthalmology journals,5 and working in academic centers.6 Despite these positive trends, women ophthalmologists are underrepresented at senior academic ranks,7 editorial board positions,5 and compensation. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Anne Xuan-Lan Nguyen, Sanyam Ratan, Ankita Biyani, Xuan-Vi Trinh, Solin Saleh, Yang Sun, Albert Y. Wu Source Type: research

Long-term outcome after superficial keratectomy of the abnormal epithelium for partial limbal stem cell deficiency
The destruction of limbal stem cells (LSCs) and/or the stem cell niche leads to their dysfunction or deficiency.1,2 Limbal stem cell deficiency (LSCD) is characterized by conjunctivalization, persistent or recurrent epithelial defects, ocular surface inflammation, neovascularization, and scarring.2,3 LSCD is one of the causes of corneal blindness,1 particularly in severe cases, such as total LSCD. Researchers have proposed various surgical treatments in combination with corneal transplantation, including the direct transplantation of limbal tissues,4,5 transplantation of ex vivo/in vivo expanded LSCs,6 –9 transplanta...
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Takehiro Matsumura, Takefumi Yamaguchi, Kazunari Higa, Masaru Inatani, Jun Shimazaki Source Type: research

COVID-19 morbidity and severity in patients with age-related macular degeneration: a Korean nationwide cohort study
Coronavirus disease 2019 (COVID-19) resulting from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a global emergency.1 Recent studies on factors that increase susceptibility to COVID-19 or worsen clinical outcomes of this disease have focused on common diseases and conditions such as cardiopulmonary disorders, cancer, and diabetes mellitus.2, 3 Although little attention has been paid to extrapulmonary comorbidities, associations between chronic central nervous system comorbidity and COVID-19 outcomes have been reported. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Jee Myung Yang, Sung Yong Moon, Joo Young Lee, Dritan Agalliu, Dong Keon Yon, Seung Won Lee Source Type: research

Vitreoretinal Complications in Boston Keratoprosthesis Type 1.
: To evaluate the incidence of vitreoretinal complications, treatment modalities, and the visual outcomes in a large cohort of eyes that underwent Boston Keratoprosthesis (KPro) implantation. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Diana Khair, Ali Salimi, Mona Harissi-Dagher Source Type: research

Association of Optic Disc Tilt and Torsion with Open-Angle Glaucoma-Progression Risk: Meta-Analysis and Meta-Regression Analysis
: To evaluate the association of optic disc deformation with open-angle glaucoma (OAG)-progression risk. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Ahnul Ha, Woosuk Chung, Sung Ryul Shim, Chung Young Kim, In Boem Chang, Young Kook Kim, Ki Ho Park Source Type: research

Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes
To investigate hemiretinal asymmetry in radial peripapillary capillary vessel area density (VAD) of healthy, glaucoma suspect, and glaucoma eyes of varying severity and its diagnostic utility for glaucoma. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Kendra L. Hong, Bruce Burkemper, Anna L. Urrea, Brenda R. Chang, Jae C. Lee, Vivian H. LeTran, Zhongdi Chu, Xiao Zhou, Benjamin Y. Xu, Brandon J. Wong, Brian J. Song, Xuejuan Jiang, Ruikang K. Wang, Rohit Varma, Grace M. Richter Source Type: research

Corneal Endothelium:A Promising Quantitative Index for Graves Ophthalmopathy Activity Evaluation
To investigate the corneal endothelium damage in Graves ophthalmopathy (GO) and its role as a promising quantitative index to evaluate GO activity. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Min Zhou, Dide Wu, Fenfen Yu, Shubin Hong, Jiacheng Ye, Congyao Wang, Ye Li, Miao Du, Haipeng Xiao, Pengxia Wan Source Type: research

Long-Term Outcomes of Boston Type I Keratoprosthesis, and Efficacy of Amphotericin B and Povidone-Iodine in Infection Prophylaxis
To evaluate the long-term outcomes, anatomical retention and complications of Boston type I keratoprosthesis (KPro). (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 5, 2021 Category: Opthalmology Authors: Pinnita Prabhasawat, Suksri Chotikavanich, Panotsom Ngowyutagon, Warinyupa Pinitpuwadol Source Type: research

Differences in self-rated versus parent proxy-rated vision-related quality of life and functional vision of visually impaired children
Health-related quality of life (HRQoL) describes the subjective experience of living with a health condition and its associated impact on everyday life,1 and is captured using validated patient-reported outcome measures (PROMs). PROMs are now widely used as part of routine clinical practice, and as primary outcomes in clinical trials of new therapies.2 Using age-appropriate PROMs, children as young as 5 years can be reliable informants of their HRQoL, as well as other aspects of their physical and mental health. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 4, 2021 Category: Opthalmology Authors: Alexandra O Robertson, Valerija Tadi ć, Lisanne A. Horvat-Gitsels, Mario Cortina-Borja, Jugnoo S Rahi, for the Child Vision PROMs group Source Type: research

Detection of Longitudinal GCIPL Change: Comparison of Two Spectral Domain Optical Coherence Tomography Devices
Glaucoma is a slowly progressive optic neuropathy characterized by damage to the retinal ganglion cell (RGC) axons at the level of the optic nerve head (ONH) and subsequent loss of RGCs across the retina.1 The irreversible nature of damage in glaucoma makes early detection of the disease or its progression essential.2 Optical coherence tomography (OCT) is now considered a standard tool for monitoring structural findings in glaucoma.3,4 Early perimetric glaucoma can be detected with ganglion cell/inner plexiform layer (GCIPL) thickness measurements as well as with retinal nerve fiber layer (RNFL) or ONH measurements. (Sourc...
Source: American Journal of Ophthalmology - June 4, 2021 Category: Opthalmology Authors: Golnoush Mahmoudinezhad, Vahid Mohammadzadeh, Navid Amini, Kevin Delao, Bingnan Zhou, Tae Hong, Sepideh Heydar Zadeh, Esteban Morales, Jack Martinyan, Simon K. Law, Anne L. Coleman, Joseph Caprioli, Kouros Nouri-Mahdavi Source Type: research

Editorial Board
(Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 3, 2021 Category: Opthalmology Source Type: research

Table of Contents
(Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - June 3, 2021 Category: Opthalmology Source Type: research

Outer retinal layer thickening predicts the onset of exudative neovascular age related macular degeneration
The sooner macular neovascularization in age-related macular degeneration is detected the better the outcomes of treatment.1,2 This is especially significant in second-affected eyes because the patients have so much more to lose. 3,4 With serial clinical examination and optical coherence tomography (OCT) scans, clinicians may be able to detect early onset of active or exudative nAMD, however frequent monitoring visits contribute to a significant burden of care. Patients undergoing treatment for nAMD in one eye have “opportunistic” monitoring visits for their fellow eye, however these monitoring intervals may be...
Source: American Journal of Ophthalmology - May 27, 2021 Category: Opthalmology Authors: Alessandro Invernizzi, Salvatore Parrulli, Davide Monteduro, Matteo G. Cereda, Vuong Nguyen, Giovanni Staurenghi, Chui Ming Gemmy Cheung, Mark Gillies, Kelvin Yi Chong Teo Source Type: research

Retinal Vein Occlusion and Risk of Dementia: A Nationwide Population-Based Cohort Study
Response to comment to “ Retinal vein occlusion and the risk of dementia: A nationwide cohort study.”We thank Dr. Hayreh for his thoughtful comments as retinal vein occlusion is a field that his name is synonymous with due to his extensive contributions. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 26, 2021 Category: Opthalmology Authors: Ga Eun Nam, Kyungdo Han, Sang Hyun Park, Kyung Hwan Cho, Su Jeong Song Source Type: research

Comment on: Retinal vein occlusion and the risk of dementia: A nationwide cohort study
Dear Editor, (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 26, 2021 Category: Opthalmology Authors: Sohan Singh Hayreh Tags: Correspondence Source Type: research

Steps to Measurement Floor of an Optical Microangiography Device in Glaucoma
Glaucoma is one of the leading causes of permanent vision loss worldwide.1 Monitoring for disease progression and adjusting intraocular pressure (IOP) lowering treatment accordingly is a vital component of minimizing vision loss due to glaucoma.1 The structure-function relationship linking decreased peripapillary microvascular density, as measured by optical coherence tomography angiography (OCTA), and reduced visual field mean deviation in eyes with glaucoma has been well-established.2,3 In addition, a decrease in retinal microvasculature density in individuals with glaucoma has been shown to occur before loss of peripher...
Source: American Journal of Ophthalmology - May 26, 2021 Category: Opthalmology Authors: Mark J. Phillips, Duyen Dinh-Dang, Kyle Bolo, Bruce Burkemper, Jae C. Lee, Vivian H. LeTran, Brenda R. Chang, Dominic J. Grisafe, Zhongdi Chu, Xiao Zhou, Brian J. Song, Benjamin Y. Xu, Brandon Wong, Ruikang K. Wang, Grace M. Richter Source Type: research

Unplanned Return to the Operating Room after Tube Shunt Surgery
Studies of unplanned return to the operating room (OR) within ophthalmology have almost exclusively focused on resident-performed surgeries, most commonly cataract and vitreoretinal surgeries1 –4. Among glaucoma surgeries, Hsia and colleagues examined complication and reoperation rates after resident-performed glaucoma procedures5, and our group has recently reported on unplanned return to the operating room after attending- and fellow-performed trabeculectomy6. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 25, 2021 Category: Opthalmology Authors: Nur Cardakli, David S. Friedman, Michael V. Boland Source Type: research

Vertical position of the central retinal vessel in the optic disc and its association with the site of visual field defects in glaucoma
The optic nerve head (ONH) presents with characteristic deformations in glaucoma, and ocular structures that consist of the ONH change their shape along with it. The lamina cribrosa (LC) is one of these structures,1-4 and it is reported to exhibit deformations such as posterior displacement,5,6 posterior migration at its insertion point,7,8 and thinning.9 Enlargement of the ONH area has also been reported in glaucoma, including expansion of the Bruch's membrane opening (BMO) and the anterior scleral canal opening. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 25, 2021 Category: Opthalmology Authors: Yu Sawada, Makoto Araie, Hitomi Shibata Source Type: research

Predictors of Receiving Keratoplasty for Keratoconus
To identify sociodemographic factors and comorbid conditions associated with receiving keratoplasty for keratoconus (KCN) (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 25, 2021 Category: Opthalmology Authors: Chanon Thanitcul, Varshini Varadaraj, Joseph K. Canner, Fasika A. Woreta, Uri S. Soiberman, Divya Srikumaran Tags: Original Articles Source Type: research

Mucopolysaccharidosis type I associated corneal disease: A clinicopathologic study
To report the anterior segment clinical features as well as histopathologic and histochemical characteristics of corneal findings associated with the largest reported cohort of patients with Hurler Syndrome and other variants of mucopolysaccharidosis (MPS) I undergoing corneal transplantation. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 25, 2021 Category: Opthalmology Authors: Imani M. Williams, Roberto Pineda, Vamsee K. Neerukonda, Anna M. Stagner Tags: Original Articles Source Type: research

Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus: findings from a Cochrane Systematic Review
To summarize key findings from a systematic review of the effectiveness and safety of transepithelial corneal crosslinking (CXL) compared with versus epithelium-off CXL for progressive keratoconus. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 25, 2021 Category: Opthalmology Authors: Sueko M. Ng, Barbara S. Hawkins, Irene C. Kuo Source Type: research

Presence of SARS-CoV-2 Viral RNA in Aqueous Humor of Asymptomatic Individuals
: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is detectable in the aqueous of asymptomatic individuals presenting for ophthalmic surgery. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 19, 2021 Category: Opthalmology Authors: Ellen H. Koo, Allen O. Eghrari, Daliya Dzhaber, Amar Shah, Elizabeth Fout, Sander Dubovy, Jorge Maestre-Mesa, Darlene Miller Source Type: research

PeriorbitAI: Artificial intelligence automation of eyelid and periorbital measurements
To develop a deep learning semantic segmentation network to automate the assessment of eight periorbital measurements. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 16, 2021 Category: Opthalmology Authors: Alexandra Van Brummen, Julia P. Owen, Theodore Spaide, Colin Froines, Randy Lu, Megan Lacy, Marian Blazes, Emily Li, Cecilia S. Lee, Aaron Y. Lee, Matthew Zhang Tags: Original Articles Source Type: research

Assessing photoreceptor status in retinal dystrophies: from high resolution imaging to functional vision
Describe the value of integrating phenotype/genotype data, disease staging and evaluation of functional vision in patient-centered management of retinal dystrophies. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 13, 2021 Category: Opthalmology Authors: Jos é-Alain Sahel, Kate Grieve, Chloé Pagot, Colas Authié, Saddek Mohand-Said, Michel Paques, Isabelle Audo, Karine Becker, Anne-Elisabeth Chaumet-Riffaud, Line Azoulay, Emmanuel Gutman, Thierry Léveillard, Christina Zeitz, Serge Picaud, Deniz Dalkara Source Type: research

Addressing structural racism: Towards an organization-theoretical approach
Since March 2020, much of the public has awoken to the need to combat structural racism. The immediate triggers were the deaths of George Floyd and Breonna Taylor, the newest victims (at the time) in a long string of fatalities due to police brutality and injustice. But a disproportionate number of Black, Indigenous, and People of Color (BIPOC) who fell victim to the ongoing coronavirus infection also played an important role. As the pandemic rages on, disproportionately affecting BIPOC, and the presence of white nationalism in mainstream politics grows, it feels important to continue and expand upon the discussion of stru...
Source: American Journal of Ophthalmology - May 13, 2021 Category: Opthalmology Authors: Deonna Vaughn, Angela Elam Tags: Editorial Source Type: research

Effects of Lipiflow Treatment Prior to Cataract Surgery: A Prospective, Randomized, Controlled Study
To investigate the effects of preoperative Lipiflow (Johnson& Johnson, USA) treatment prior to cataract surgery on meibomian gland dysfunction (MGD) and dry eye induced by surgery. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 13, 2021 Category: Opthalmology Authors: Jongyeop Park, Young-Sik Yoo, Kyungyoon Shin, Gyule Han, Reiko Arita, Dong Hui Lim, Tae-Young Chung Source Type: research

Importance and severity dependence of physical activity by GPS-tracked location in glaucoma patients
: To quantify the association of visual field (VF) damage on physical activity away-from-home, per away-from-home excursion, and at home. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 13, 2021 Category: Opthalmology Authors: Jian-Yu E, Aleksandra Mihailovic, Catalina Garzon, Jennifer A. Schrack, Tianjing Li, Sheila K. West, David S. Friedman, Laura N. Gitlin, Pradeep Y. Ramulu Tags: Original Articles Source Type: research

Identifying Characteristics Predictive of Lost-to-follow-up (LTFU) Status in Amblyopia
To identify demographic and disease-related characteristics predictive of LTFU status in amblyopia treatment and create a risk model for predicting LTFU status. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 13, 2021 Category: Opthalmology Authors: Talia N. Shoshany, Ryan N. Chinn, Steven J. Staffa, Kaila Bishop, Suzanne Michalak, David G. Hunter Source Type: research

Here comes the SUN (Part 2): Standardization of uveitis nomenclature for disease classification criteria
“Nosology is not a sport for the timid” - Sherwin B. Nuland, MD (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 13, 2021 Category: Opthalmology Authors: Russell N. Van Gelder, Nida Sen, Adnan Tufail, Aaron Y. Lee Tags: Editorial Source Type: research

The Heritability of Primary Angle Closure Anatomic Traits and Predictors of Angle Closure in South Indian Siblings
The number of people worldwide with primary angle closure glaucoma (PACG) in 2020 is estimated to be 23.4 million with 76.9% of PACG cases occurring in Asia.1 South India, in particular, has a high prevalence of PACG, ranging from 0.5% to 2.75%.2-6 Angle closure is known to be highly heritable with family history being an important risk factor for angle closure disease.7-9 Heritability can be defined as the proportion of variance attributable to genetic effects. The overall heritability of PACG is estimated at 60%, and siblings of patients with primary angle closure (PAC)/PACG probands have been shown to have nearly 14-fol...
Source: American Journal of Ophthalmology - May 13, 2021 Category: Opthalmology Authors: Elizabeth C. Ciociola, Srinivasan Kavitha, Sabyasachi Sengupta, Janey L. Wiggs, Mohideen Abdul Kader, Ganesh V Raman, Sharmila Rajendrababu, Pradeep Y. Ramulu, Rengaraj Venkatesh, Nazlee Zebardast Source Type: research

The PEARL-DGS formula: the development of an open-source machine learning-based thick IOL calculation formula
To describe an open-source, reproducible, step-by-step method to design sum-of-segments thick-lens intraocular lens (IOL) calculation formulas, and to evaluate a formula built using this methodology. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 12, 2021 Category: Opthalmology Authors: Guillaume Debellemani ère, Mathieu Dubois, Mathieu Gauvin, Avi Wallerstein, F. Brenner Luis, RampatRadhika, Alain Saad, Damien Gatinel Source Type: research

Timing of Ocular Hypertension After Pediatric Closed-Globe Traumatic Hyphema: Implications for Surveillance
Traumatic hyphema is defined as a collection of blood in the anterior chamber following injury.1 It commonly occurs secondary to closed-globe injury (CGI),2 as this mechanism of injury results in the transmission of significant force to the eye.1 This force causes a contraction and re-expansion of the globe, which can shear iris and ciliary vessels leading to bleeding in the anterior chamber.3 Traumatic hyphemas are relatively common among children and are often caused by injuries sustained during sports or play. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 12, 2021 Category: Opthalmology Authors: Theodore Bowe, Anthony Serina, Mikhayla Armstrong, Jennifer Welcher, Olumuyiwa Adebona, Charlotte Gore, Steven J. Staffa, David Zurakowski, Ankoor S. Shah Tags: Original Articles Source Type: research

Descemet membrane endothelial keratoplasty (DMEK) in eyes with chronic ocular hypotony following glaucoma surgery
: To assess the outcomes of Descemet membrane endothelial keratoplasty (DMEK) in patients with ocular hypotony following glaucoma surgery. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - May 12, 2021 Category: Opthalmology Authors: Eitan Livny, Michael Mimouni, Nir Sorkin, Irit Bahar, David S. Rootman, Yoav Nahum Tags: Original Articles Source Type: research