Examining the Correlation of Lymphangiogenesis Biomarkers with Clinical Condition in Age-Related Macular Degeneration (AMD)
Exp Eye Res. 2024 Apr 12:109891. doi: 10.1016/j.exer.2024.109891. Online ahead of print.ABSTRACTThe aim of this study is to investigate the relationship between age-related macular degeneration (AMD) and lymphangiogenesis biomarkers, namely LYVE-1, Podoplanin, VEGF-C, VEGFR-2 and VEGFR-3. This prospective and interventional study includes 30 patients with AMD which may be dry or wet type and 30 controls for whom vitrectomy and phacoemulsification was indicated due to additional pathologies (epiretinal membrane, macular hole, retinal detachment, and cataract). 0.1-0,2 ml of aqueous humor and 0.5-1 ml of vitreous sample was ...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Bagim Aycin Cakir Ince Murat Kucukevcilioglu Cigdem Yucel Ali Hakan Durukan Source Type: research
Possible Retinotoxicity of Long-term Vardenafil Treatment
Exp Eye Res. 2024 Apr 12:109890. doi: 10.1016/j.exer.2024.109890. Online ahead of print.ABSTRACTPhosphodiesterase (PDE) inhibitors - such as vardenafil - are used primarily for treating erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent studies have also demonstrated their significant cardioprotective effects in several diseases, including diabetes, upon long-term, continuous application. However, PDE inhibitors are not specific for PDE5 and also inhibit the retinal isoform. A sustained rise in cGMP in photoreceptors is known to be toxic; therefore, we hypothesized that long-term varde...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Klaudia Szab ó Bulcs ú Dékány Anna Énzsöly Rozina Ida Hajd ú Lenke Korn élia Laurik-Feuerstein Arnold Szab ó Tam ás Radovits Csaba M átyás Attila Ol áh Kriszti án András Kovács Ágoston Szél G ábor Márk Somfai Ákos Lukáts Source Type: research
Examining the Correlation of Lymphangiogenesis Biomarkers with Clinical Condition in Age-Related Macular Degeneration (AMD)
Exp Eye Res. 2024 Apr 12:109891. doi: 10.1016/j.exer.2024.109891. Online ahead of print.ABSTRACTThe aim of this study is to investigate the relationship between age-related macular degeneration (AMD) and lymphangiogenesis biomarkers, namely LYVE-1, Podoplanin, VEGF-C, VEGFR-2 and VEGFR-3. This prospective and interventional study includes 30 patients with AMD which may be dry or wet type and 30 controls for whom vitrectomy and phacoemulsification was indicated due to additional pathologies (epiretinal membrane, macular hole, retinal detachment, and cataract). 0.1-0,2 ml of aqueous humor and 0.5-1 ml of vitreous sample was ...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Bagim Aycin Cakir Ince Murat Kucukevcilioglu Cigdem Yucel Ali Hakan Durukan Source Type: research
Possible Retinotoxicity of Long-term Vardenafil Treatment
Exp Eye Res. 2024 Apr 12:109890. doi: 10.1016/j.exer.2024.109890. Online ahead of print.ABSTRACTPhosphodiesterase (PDE) inhibitors - such as vardenafil - are used primarily for treating erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent studies have also demonstrated their significant cardioprotective effects in several diseases, including diabetes, upon long-term, continuous application. However, PDE inhibitors are not specific for PDE5 and also inhibit the retinal isoform. A sustained rise in cGMP in photoreceptors is known to be toxic; therefore, we hypothesized that long-term varde...
Source: Experimental Eye Research - April 14, 2024 Category: Opthalmology Authors: Klaudia Szab ó Bulcs ú Dékány Anna Énzsöly Rozina Ida Hajd ú Lenke Korn élia Laurik-Feuerstein Arnold Szab ó Tam ás Radovits Csaba M átyás Attila Ol áh Kriszti án András Kovács Ágoston Szél G ábor Márk Somfai Ákos Lukáts Source Type: research
Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma
Exp Eye Res. 2024 Apr 10:109887. doi: 10.1016/j.exer.2024.109887. Online ahead of print.ABSTRACTThe pathophysiology of Primary Open Angle Glaucoma (POAG) remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. High resolution mass spectrometry-based TMT6plex quantitative proteomics analysis is performed on AH samples collected from POAG patients, and compared against a control group of patients with cataracts. Data are available via ProteomeXchange with identifier PXD033153. 1589 proteins...
Source: Experimental Eye Research - April 12, 2024 Category: Opthalmology Authors: Darren Mun Yoong Choy Bryan Chin Hou Ang Sunil S Adav Zheng Yu Bo Caius Jun Shyan Goh Jin Wei Arjunan Kumaran Chua Chun Hau Nicola Yian Gan Sze Siu Kwan Leonard Wai Leon Yip Source Type: research
Aqueous humour protein dysregulation in Asian eyes with primary open angle glaucoma
Exp Eye Res. 2024 Apr 10:109887. doi: 10.1016/j.exer.2024.109887. Online ahead of print.ABSTRACTThe pathophysiology of Primary Open Angle Glaucoma (POAG) remains poorly understood. Through proteomic analysis of aqueous humour (AH) from POAG patients, we aim to identify changes in protein composition of these samples compared to control samples. High resolution mass spectrometry-based TMT6plex quantitative proteomics analysis is performed on AH samples collected from POAG patients, and compared against a control group of patients with cataracts. Data are available via ProteomeXchange with identifier PXD033153. 1589 proteins...
Source: Experimental Eye Research - April 12, 2024 Category: Opthalmology Authors: Darren Mun Yoong Choy Bryan Chin Hou Ang Sunil S Adav Zheng Yu Bo Caius Jun Shyan Goh Jin Wei Arjunan Kumaran Chua Chun Hau Nicola Yian Gan Sze Siu Kwan Leonard Wai Leon Yip Source Type: research
Autophagy in dry AMD: A promising therapeutic strategy for retinal pigment epithelial cell damage
Exp Eye Res. 2024 Apr 7;242:109889. doi: 10.1016/j.exer.2024.109889. Online ahead of print.ABSTRACTDry age-related macular degeneration (AMD) is a prevalent clinical condition that leads to permanent damage to central vision and poses a significant threat to patients' visual health. Although the pathogenesis of dry AMD remains unclear, there is consensus on the role of retinal pigment epithelium (RPE) damage. Oxidative stress and chronic inflammation are major contributors to RPE cell damage, and the NOD-like receptor thermoprotein structural domain-associated protein 3 (NLRP3) inflammasome mediates the inflammatory respon...
Source: Experimental Eye Research - April 9, 2024 Category: Opthalmology Authors: Zhao Zhang Fengming Liang Jun Chang Xiaoqian Shan Zhixian Yin Li Wang Shujiao Li Source Type: research
Autophagy in dry AMD: a promising therapeutic strategy for retinal pigment epithelial cell damage
Exp Eye Res. 2024 Apr 7:109889. doi: 10.1016/j.exer.2024.109889. Online ahead of print.ABSTRACTDry age-related macular degeneration (AMD) is a prevalent clinical condition that leads to permanent damage to central vision and poses a significant threat to patients' visual health. Although the pathogenesis of dry AMD remains unclear, there is consensus on the role of retinal pigment epithelium (RPE) damage. Oxidative stress and chronic inflammation are major contributors to RPE cell damage, and the NOD-like receptor thermoprotein structural domain-associated protein 3 (NLRP3) inflammasome mediates the inflammatory response l...
Source: Experimental Eye Research - April 9, 2024 Category: Opthalmology Authors: Zhao Zhang Fengming Liang Jun Chang Xiaoqian Shan Zhixian Yin Li Wang Shujiao Li Source Type: research
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Exp Eye Res. 2024 Apr 5:109888. doi: 10.1016/j.exer.2024.109888. Online ahead of print.ABSTRACTCataracts and Alzheimer's disease (AD) are closely linked and are associated with aging and with systemic diseases that increase the molar ratio of free fatty acids to albumin (mFAR) in the blood. From the results of our earlier studies on the development of senile cataracts and from results recently published in the literature on the pathogenesis of Alzheimer's disease, we suggest that there is a common lipotoxic cascade for both diseases, explaining the strong connection between aging, an elevated mFAR in the blood, cataract fo...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Dietmar Glaesser Martin Iwig Source Type: research
INOS ablation promotes corneal wound healing via activation of Akt signaling
Exp Eye Res. 2024 Apr 5:109886. doi: 10.1016/j.exer.2024.109886. Online ahead of print.ABSTRACTCorneal injury leads to impaired normal structure of the cornea. Improving the wound healing process in epithelial cells significantly contributes to ocular damage treatments. Here, we aimed to investigate the potential mechanisms of nitric oxide (NO) and its mediator, inducible nitric oxide synthase (iNOS), in the process of corneal wound healing. We established a corneal injury model of iNOS-/- mice, and treated human corneal epithelial cell lines (HCE-2) with the iNOS inhibitor L-INL, with or without NO replenishment by supply...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Ziwen Sun Kunpeng Lu Qing He Yang Tang Haoru Li Emmanuel Eric Pazo Lizhi Hu Ruihua Wei Source Type: research
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Exp Eye Res. 2024 Apr 5:109888. doi: 10.1016/j.exer.2024.109888. Online ahead of print.ABSTRACTCataracts and Alzheimer's disease (AD) are closely linked and are associated with aging and with systemic diseases that increase the molar ratio of free fatty acids to albumin (mFAR) in the blood. From the results of our earlier studies on the development of senile cataracts and from results recently published in the literature on the pathogenesis of Alzheimer's disease, we suggest that there is a common lipotoxic cascade for both diseases, explaining the strong connection between aging, an elevated mFAR in the blood, cataract fo...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Dietmar Glaesser Martin Iwig Source Type: research
INOS ablation promotes corneal wound healing via activation of Akt signaling
Exp Eye Res. 2024 Apr 5:109886. doi: 10.1016/j.exer.2024.109886. Online ahead of print.ABSTRACTCorneal injury leads to impaired normal structure of the cornea. Improving the wound healing process in epithelial cells significantly contributes to ocular damage treatments. Here, we aimed to investigate the potential mechanisms of nitric oxide (NO) and its mediator, inducible nitric oxide synthase (iNOS), in the process of corneal wound healing. We established a corneal injury model of iNOS-/- mice, and treated human corneal epithelial cell lines (HCE-2) with the iNOS inhibitor L-INL, with or without NO replenishment by supply...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Ziwen Sun Kunpeng Lu Qing He Yang Tang Haoru Li Emmanuel Eric Pazo Lizhi Hu Ruihua Wei Source Type: research
Increased molar ratio of free fatty acids to albumin in blood as cause and early biomarker for the development of cataracts and Alzheimer's disease
Exp Eye Res. 2024 Apr 5:109888. doi: 10.1016/j.exer.2024.109888. Online ahead of print.ABSTRACTCataracts and Alzheimer's disease (AD) are closely linked and are associated with aging and with systemic diseases that increase the molar ratio of free fatty acids to albumin (mFAR) in the blood. From the results of our earlier studies on the development of senile cataracts and from results recently published in the literature on the pathogenesis of Alzheimer's disease, we suggest that there is a common lipotoxic cascade for both diseases, explaining the strong connection between aging, an elevated mFAR in the blood, cataract fo...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Dietmar Glaesser Martin Iwig Source Type: research
INOS ablation promotes corneal wound healing via activation of Akt signaling
Exp Eye Res. 2024 Apr 5:109886. doi: 10.1016/j.exer.2024.109886. Online ahead of print.ABSTRACTCorneal injury leads to impaired normal structure of the cornea. Improving the wound healing process in epithelial cells significantly contributes to ocular damage treatments. Here, we aimed to investigate the potential mechanisms of nitric oxide (NO) and its mediator, inducible nitric oxide synthase (iNOS), in the process of corneal wound healing. We established a corneal injury model of iNOS-/- mice, and treated human corneal epithelial cell lines (HCE-2) with the iNOS inhibitor L-INL, with or without NO replenishment by supply...
Source: Experimental Eye Research - April 7, 2024 Category: Opthalmology Authors: Ziwen Sun Kunpeng Lu Qing He Yang Tang Haoru Li Emmanuel Eric Pazo Lizhi Hu Ruihua Wei Source Type: research
Validation of retinal oximetry vessel selection using fluorescein angiography in patients with optic disc drusen
In conclusion, identifying vessel segments for retinal oximetry analysis based on vessel morphology and supported by a color-coded saturation overlay appears to be a valid method without the need for invasive angiography. A numerically small inter-grader variation may influence oximetry results. Further studies of retinal oximetry in ODD are warranted.PMID:38582182 | DOI:10.1016/j.exer.2024.109882 (Source: Experimental Eye Research)
Source: Experimental Eye Research - April 6, 2024 Category: Opthalmology Authors: Mia Uhre Guldfeldt Freja Pind Pilegaard Lasse Malmqvist Oliver Niels Klefter Steffen Hamann Source Type: research
