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Increased Incidence of Retinoblastoma in Wisconsin: Coincidence or Public Health Concern?
WMJ. 2024 May;123(2):76-77.NO ABSTRACTPMID:38718232 (Source: WMJ)
Source: WMJ - May 8, 2024 Category: General Medicine Authors: Sudarshawn Damodharan Eric Monroe Source Type: research

Comment on “The association between race and age of diagnosis of retinoblastoma in United States children”
(Source: Journal of AAPOS)
Source: Journal of AAPOS - May 6, 2024 Category: Opthalmology Authors: Francisco Altamirano-Lamarque, Efren Gonzalez, Isdin Oke Tags: Letter to the Editor Source Type: research

The association between race and age of diagnosis of retinoblastoma in United States children
We read with interest the recent study by Black and colleagues1 using data from the Surveillance, Epidemiology, and End Results (SEER) Program to investigate the relationship between race, ethnicity, and the age of presentation of children with retinoblastoma. The authors concluded that a child ’s race or ethnicity does not increase their risk for delayed diagnosis (defined as presenting at age ≥2 years). While we appreciate efforts to understand how diagnostic delay may contribute to disparities in the outcomes of children with retinoblastoma,2-4 there are several limitations of the s tudy design and data source that ...
Source: Journal of AAPOS - May 6, 2024 Category: Opthalmology Authors: Francisco Altamirano-Lamarque, Efren Gonzalez, Isdin Oke Tags: Letter to the Editor Source Type: research

Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids
CONCLUSION: The study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.PMID:38704498 | DOI:10.1007/s11033-024-09564-9 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 4, 2024 Category: Molecular Biology Authors: Ambily Vincent Subramanian Krishnakumar Sowmya Parameswaran Source Type: research

Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids
CONCLUSION: The study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.PMID:38704498 | DOI:10.1007/s11033-024-09564-9 (Source: Molecular Medicine)
Source: Molecular Medicine - May 4, 2024 Category: Molecular Biology Authors: Ambily Vincent Subramanian Krishnakumar Sowmya Parameswaran Source Type: research

Heterozygous RB1 mutation enhanced ATP production in human iPSC-derived retinal organoids
CONCLUSION: The study provides novel insights into the metabolic phenotype of heterozygous RB1 mutant suggesting dysregulation of energy metabolism and glycolytic pathways to be first step even before the changes in cellular proliferation or other phenotypic consequences ensue.PMID:38704498 | DOI:10.1007/s11033-024-09564-9 (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 4, 2024 Category: Molecular Biology Authors: Ambily Vincent Subramanian Krishnakumar Sowmya Parameswaran Source Type: research

Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
CONCLUSION: This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.PMID:38687926 | DOI:10.4103/jcrt.jcrt_1504_23 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Yulu Chen Xi Xiao Guanghui Hu Rengyun Liu Junyu Xue Source Type: research

Advanced intraocular retinoblastoma: evolving criteria for group E disease (1)
Can J Ophthalmol. 2024 Apr 27:S0008-4182(24)00068-1. doi: 10.1016/j.jcjo.2024.03.005. Online ahead of print.ABSTRACTWith evolving criteria for classifying intraocular retinoblastoma (RB) from International Intraocular Retinoblastoma Classification (IIRC, 2005) to International Classification of Retinoblastoma (ICRB, 2006), there have been changes in the inclusion criteria for groups E eyes that have not been widely recognized. This brief review highlights issues with the current classification systems (ICRB and IIRC) and layouts a theoretical framework arguing for merging of 2 existing classifications into 1 and subdividin...
Source: Canadian Journal of Ophthalmology - April 30, 2024 Category: Opthalmology Authors: Ahad Sedaghat Vishal Raval Renbing Jia Xianqun Fan Arun D Singh Source Type: research