Risk factors for cataract in retinoblastoma management
Conclusions
Repeated IAC and/or IvitC with melphalan were the most common eye-preserving therapies that induced cataract formation. The toxic effect of melphalan was an essential factor in cataract development, as indicated by the association of cataract occurrence with the melphalan dose. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - March 20, 2024 Category: Opthalmology Authors: Jia, S., Wen, X., Yu, J., Zhou, M., Yang, L., Feng, Y., He, X., Jia, R., Fan, J., Fan, X. Tags: Open access Ocular oncology Source Type: research
Advanced Interventional Treatments in Retinoblastoma Management: A Comprehensive Review
AbstractRetinoblastoma is the most common eye malignancy in children that if left untreated can invade intraocular structures, metastasize, and rarely lead to death. Traditionally treated with systemic chemotherapy, Intra-arterial chemotherapy is gaining popularity as it allows for the direct administration of chemotherapy through the ophthalmic artery, thus reducing systemic side effects. Intra-arterial chemotherapy procedures have evolved, with refinements to reduce risks and radiation exposure. Intra-arterial chemotherapy boasts an impressive technical success rate and one year ocular survival even amongst advanced case...
Source: CardioVascular and Interventional Radiology - March 20, 2024 Category: Radiology Source Type: research
Subscaling of a cytosolic RNA binding protein governs cell size homeostasis in the multiple fission alga Chlamydomonas
by Dianyi Liu, Cristina Lopez-Paz, Yubing Li, Xiaohong Zhuang, James Umen
Coordination of growth and division in eukaryotic cells is essential for populations of proliferating cells to maintain size homeostasis, but the underlying mechanisms that govern cell size have only been investigated in a few taxa. The green algaChlamydomonas reinhardtii (Chlamydomonas) proliferates using a multiple fission cell cycle that involves a long G1 phase followed by a rapid series of successive S and M phases (S/M) that produces 2n daughter cells. Two control points show cell-size dependence: the Commitment control point in mid-G1 phase r...
Source: PLoS Genetics - March 18, 2024 Category: Genetics & Stem Cells Authors: Dianyi Liu Source Type: research
Small extracellular vesicles loaded with carboplatin effectively enhance the cytotoxicity of drug-resistant cells from Y79 cells-in vitro
This study demonstrates that sequential exposure to CPT generates DR clones of Y79 cells, which could serve as an appropriate model to evaluate the efficacy of drugs. The sEVs-CPT were highly effective in enhancing cytotoxicity in DR-Y79 cells, and appear to hold promise as a novel complimentary drug delivery system.PMID:38490156 | DOI:10.1016/j.biopha.2024.116403 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Jyothi Attem Revu V L Narayana Radhika Manukonda Swathi Kaliki Geeta K Vemuganti Source Type: research
Small extracellular vesicles loaded with carboplatin effectively enhance the cytotoxicity of drug-resistant cells from Y79 cells-in vitro
This study demonstrates that sequential exposure to CPT generates DR clones of Y79 cells, which could serve as an appropriate model to evaluate the efficacy of drugs. The sEVs-CPT were highly effective in enhancing cytotoxicity in DR-Y79 cells, and appear to hold promise as a novel complimentary drug delivery system.PMID:38490156 | DOI:10.1016/j.biopha.2024.116403 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Jyothi Attem Revu V L Narayana Radhika Manukonda Swathi Kaliki Geeta K Vemuganti Source Type: research
ZNF862 induces cytostasis and apoptosis via the p21-RB1 and Bcl-xL-Caspase 3 signaling pathways in human gingival fibroblasts
CONCLUSION: Our results for the first time reveal that ZNF862 is localized in the cytoplasm of HGFs. ZNF862 can inhibit the proliferation of HGFs by inhibiting the p21-RB1 signaling pathway, and it also promotes the apoptosis of HGFs by enhancing the Bcl-xL-Caspase 3 signaling pathway.PMID:38482719 | DOI:10.1111/jre.13250 (Source: Cell Research)
Source: Cell Research - March 14, 2024 Category: Cytology Authors: Yaoyao Zhu Tian Zhao Yongkang Wu Sijing Xie Weibin Sun Juan Wu Source Type: research
Advancements in super-selective catheterization and drug selection for intra-arterial chemotherapy for retinoblastoma: a 15-year evolution
Conclusions
The overall rate of successful catheterization and IAC started high and has improved over 15 years, and catheterization-related complications are rare. There has been a significant trend towards triple chemotherapy over time. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - March 14, 2024 Category: Neurosurgery Authors: Kocharian, G., Gobin, Y. P., Kharas, N., Knopman, J., Francis, J. H., Abramson, D. H. Tags: New devices New devices and techniques Source Type: research
Low expression of NR1D1 and NR2E3 is associated with advanced features of retinoblastoma
ConclusionThe expression levels of NR1D1 and NR2E3 were decreased in RB and closely associated with the clinical stage and high invasion of the disease. These findings provide new insights into the mechanism of RB progression and suggest that NR1D1 and NR2E3 could be potential targets for treatment strategies. (Source: International Ophthalmology)
Source: International Ophthalmology - March 14, 2024 Category: Opthalmology Source Type: research
Strabismus management in retinoblastoma survivors
To report the result of strabismus surgery in eye-salvaged retinoblastoma (Rb) patients. (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - March 13, 2024 Category: Opthalmology Authors: Babak Masoomian, Carol L. Shields, Hamid Riazi Esfahani, Atefeh Khalili, Fariba Ghassemi, Pukhraj Rishi, Mohammad Reza Akbari and Masoud Khorrami-Nejad Tags: Research Source Type: research
Retinoblastoma and polydactyly in a child with 46, XY, 15pstk+ karyotype —A case report and literature review
ConclusionWe report the case of a baby boy with Rb and polydactyly exhibiting a 46, XY, 15pstk+ Karyotype. We discuss potential genetic factors related to both Rb and polydactyly. Furthermore, there is a need for further exploration into the impact of chromosomal polymorphisms in Rb with polydactyly. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - March 12, 2024 Category: Genetics & Stem Cells Authors: Xiaohuan Pi,
Qiming Zhang,
Xinghua Wang,
Fagang Jiang Tags: REVIEW ARTICLE Source Type: research
Retinoblastoma and polydactyly in a child with 46, XY, 15pstk+ karyotype-A case report and literature review
CONCLUSION: We report the case of a baby boy with Rb and polydactyly exhibiting a 46, XY, 15pstk+ Karyotype. We discuss potential genetic factors related to both Rb and polydactyly. Furthermore, there is a need for further exploration into the impact of chromosomal polymorphisms in Rb with polydactyly.PMID:38465842 | DOI:10.1002/mgg3.2414 (Source: Molecular Medicine)
Source: Molecular Medicine - March 11, 2024 Category: Molecular Biology Authors: Xiaohuan Pi Qiming Zhang Xinghua Wang Fagang Jiang Source Type: research
Retinoblastoma and polydactyly in a child with 46, XY, 15pstk+ karyotype-A case report and literature review
CONCLUSION: We report the case of a baby boy with Rb and polydactyly exhibiting a 46, XY, 15pstk+ Karyotype. We discuss potential genetic factors related to both Rb and polydactyly. Furthermore, there is a need for further exploration into the impact of chromosomal polymorphisms in Rb with polydactyly.PMID:38465842 | PMC:PMC10926652 | DOI:10.1002/mgg3.2414 (Source: Molecular Medicine)
Source: Molecular Medicine - March 11, 2024 Category: Molecular Biology Authors: Xiaohuan Pi Qiming Zhang Xinghua Wang Fagang Jiang Source Type: research
GSE226458 Bulk RNA-sequencing of MYCN-overexpressing chicken retinal cell lines
Contributors : Finn Hallb öök ; Hanzhao Zhang ; Dardan Konjusha ; Nima RafatiSeries Type : Expression profiling by high throughput sequencingOrganism : Gallus gallusBackground: MYCN gene is a transcription factor whose amplification and overexpression can lead to tumorigenesis. In retina, MYCN overexpression is related to tumorigenesis of retinoblastoma, a childhood cancer. Purpose: To find out differentially expressed genes in MYCN-overexpressing cells, which will give information of MYCN-related gene expression and possibly find out new pathways in mechanism of retinoblastoma tumorigenesis with MYCN overexpression....
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Gallus gallus Source Type: research
Di-n-butyl phthalate promotes the neural differentiation of mouse embryonic stem cells through neurogenic differentiation 1
Environ Pollut. 2024 Mar 7:123722. doi: 10.1016/j.envpol.2024.123722. Online ahead of print.ABSTRACTAn understanding of the risk of gene deletion and mutation posed by endocrine-disrupting chemicals (EDCs) is necessary for the identification of etiological reagents for many human diseases. Therefore, the characterization of the genetic traits caused by developmental exposure to EDCs is an important research subject. A new regenerative approach using embryonic stem cells (ESCs) holds promise for the development of stem-cell-based therapies and the identification of novel therapeutic agents against human diseases. Here, we f...
Source: Environmental Pollution - March 9, 2024 Category: Environmental Health Authors: Ying-Chu Lin Kenly Wuputra Kohsuke Kato Chia-Chen Ku Shigeo Saito Michiya Noguchi Yukio Nakamura Michael Hsiao Chang-Shen Lin Deng-Chyang Wu Atsushi Kawaguchi Hsin-Su Yu Kazunari K Yokoyama Source Type: research
Retinoblastoma Incidence in Taiwan Over a Recent 20-Year Period: A Comprehensive Nationwide Study
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - March 8, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
