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Phacoemulsification cataract surgery in patients receiving novel oral anticoagulant medications
ConclusionThe present study found no difference in haemorrhagic complications between cases continuing and withholding NOAC during phacoemulsification. Nevertheless, the potential risks and benefits to continue or withhold NOAC perioperatively should be carefully considered via a multidisciplinary approach. (Source: International Ophthalmology)
Source: International Ophthalmology - February 13, 2018 Category: Opthalmology Source Type: research

Retinal single-layer analysis with optical coherence tomography shows inner retinal layer thinning in Huntington ’s disease as a potential biomarker
AbstractPurposeThere have been ongoing clinical trials of therapeutic agents in Huntington ’s disease (HD) which requires development of reliable biomarkers of disease progression. There have been studies in the literature with conflicting results on the involvement of retina in HD, and up to date there is not a study evaluating the single retinal layers in HD. We aimed to evaluate the specific retinal changes in HD and their usability as potential disease progression markers.MethodsThis cross-sectional study used spectral-domain optical coherence tomography with automatic segmentation to measure peripapillary retina...
Source: International Ophthalmology - February 12, 2018 Category: Opthalmology Source Type: research

Results of ethanol-assisted epithelium-on corneal cross-linking with and without intrastromal corneal ring implantation
This study retrospectively evaluated the long-term topographic, refractive, and pachymetric changes in patients diagnosed with KC who underwent corneal cross-linking and/or intrastromal corneal ring segment (ICRS) implantation. The subjects were divided into three groups, corresponding to eyes treated with CXL alone (group  1), CXL and ICRS at the same time (group 2), and CXL after ICRS implantation (group 3). Corrected visual acuity and refraction, steep keratometry (SteepK) values, steepest keratometry reading on sagittal curvature map, and corneal thickness were recorded preoperatively and at each visit. ...
Source: International Ophthalmology - February 10, 2018 Category: Opthalmology Source Type: research

Bleb-related infections and long-term follow-up after trabeculectomy
AbstractPurposeBleb-related infections are serious complications after trabeculectomy. They can be limited to the bleb or disseminate and lead to endophthalmitis. We herein report on all bleb-related infections that have been diagnosed at the Eye Center of the University of Freiburg, Germany, since 1999.MethodsWe reviewed a total of 1816 consecutive trabeculectomies that were performed at our hospital between the years 1999 and 2014 (353 without and 1463 with intraoperative application of mitomycin C). All bleb-related infections that were diagnosed at our clinic during the same period were included in the analysis. We fit...
Source: International Ophthalmology - February 9, 2018 Category: Opthalmology Source Type: research

Clinical experience with urgent tube shunt implantation through the ciliary sulcus in phakic eyes
ConclusionsBased on our small and limited retrospective study, and under unusual circumstances, urgent tube shunt implantation through the ciliary sulcus may be considered in phakic eyes with severely uncontrolled IOP, shallow anterior chambers and poor view to the posterior segment, and when concomitant lensectomy is not recommended. We advise the use of appropriate surgical modifications by experienced glaucoma surgeons to prevent intraoperative complications. Further and larger studies are needed to evaluate the safety of this surgical option. (Source: International Ophthalmology)
Source: International Ophthalmology - February 9, 2018 Category: Opthalmology Source Type: research

Multi-viral canaliculitis: case report and review of literature
ConclusionAn encounter with an atypical canaliculitis with negative bacteriology work up, suboptimal response to routine therapies, and mid-canalicular obstructions should alert the physician to investigate for viral etiology. (Source: International Ophthalmology)
Source: International Ophthalmology - February 9, 2018 Category: Opthalmology Source Type: research

Damage to the inferior oblique muscle branch of the oculomotor nerve: a complication during orbital fat decompression
ConclusionsThis report indicates that injury to the inferior oblique muscle nerve branch can occur at a point posterior to the inferior oblique muscle during orbital fat decompression; however, the resulting ocular deviation improves considerably within 6  months of injury. (Source: International Ophthalmology)
Source: International Ophthalmology - February 8, 2018 Category: Opthalmology Source Type: research

Comparison of ARMS2/LOC387715 A69S and CFH Y402H risk effect in wet-type age-related macular degeneration: a meta-analysis
ConclusionOur inclusion criteria to select those studies which have analyzed the effect of these two loci in the same case-control samples showed much stronger effect of ARMS2 A69S in neovascular AMD compared to the CFH Y402H. (Source: International Ophthalmology)
Source: International Ophthalmology - February 8, 2018 Category: Opthalmology Source Type: research

Deep blue dot corneal degeneration: confocal characteristics
ConclusionsDeep blue dot corneal degeneration is a rare entity where blue deposits of amyloid are seen in the deep corneal stroma. It should be considered as a differential diagnosis when an old-aged person presents with good vision and the above mentioned findings. (Source: International Ophthalmology)
Source: International Ophthalmology - February 8, 2018 Category: Opthalmology Source Type: research

Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence
ConclusionCo-occurrence of OSSN and chronic fungal keratitis is rare. We recommend that patients with chronic ocular infections should be examined and followed closely for abnormally thickened limbal areas. (Source: International Ophthalmology)
Source: International Ophthalmology - February 8, 2018 Category: Opthalmology Source Type: research

Peyronie ’s disease and Dupuytren’s contracture secondary to topical timolol
ConclusionsWhilst uncommon, beta-blockers are known to be associated with such fibrotic conditions and have been reported with the use of topical timolol. This case serves to increase the current understanding of this association. (Source: International Ophthalmology)
Source: International Ophthalmology - February 8, 2018 Category: Opthalmology Source Type: research

Corneal perforation after noncontact tonometry in patients with active recurrent herpes simplex keratitis: case report
ConclusionNCT may not be sufficiently safe in patients with active infectious keratitis, particularly in cases where the cornea is relatively thin and necrotic. (Source: International Ophthalmology)
Source: International Ophthalmology - February 7, 2018 Category: Opthalmology Source Type: research

A rating scale is a proper method to evaluate changes in quality of life due to dry eye symptoms
AbstractPurposeTo determine which utility value assessment method is more suitable to evaluate changes in the quality of life due to dry eye symptoms.MethodsDry eye outpatients with a presenting visual acuity of 20/25 or better in the worse-seeing eye were recruited. Presenting distance visual acuity, tear film break-up time, Schirmer I test and fluorescein were assessed. The severity of dry eye symptoms was assessed using the Ocular Surface Disease Index (OSDI), and utility values were measured using the time trade-off (TTO), standard gamble (SG1 and SG2) and rating scale (RS) methods. Different utility values were compar...
Source: International Ophthalmology - February 7, 2018 Category: Opthalmology Source Type: research

The outcomes of subtotal vitrectomy in macular surgeries: a single surgeon case series
ConclusionSubtotal vitrectomy seems as an effective and safe surgical technique in the treatment of macular diseases. (Source: International Ophthalmology)
Source: International Ophthalmology - February 7, 2018 Category: Opthalmology Source Type: research

A case of conjunctival MALT lymphoma: successfully treated with solely extended rituximab therapy
ConclusionExtended rituximab therapy may be an effective and well-tolerated first-line treatment option for bilateral conjunctival MALT lymphoma. (Source: International Ophthalmology)
Source: International Ophthalmology - February 6, 2018 Category: Opthalmology Source Type: research

Intravitreal aflibercept for the treatment of choroidal neovascularization associated with rubella retinopathy
ConclusionIntravitreal aflibercept may be a treatment alternative, which provides satisfactory anatomical and functional results and leads to a better visual acuity in cases with RR complicated by CNV. (Source: International Ophthalmology)
Source: International Ophthalmology - February 6, 2018 Category: Opthalmology Source Type: research

Therapeutic potential of curcumin in major retinal pathologies
ConclusionsHowever, studies on curcumin ’s efficacy have been limited mostly to animal studies. Moreover, the biomedical potential of curcumin is not easy to use, given its low solubility and oral bioavailability—more attention therefore has been given to nanoparticles and liposomes. (Source: International Ophthalmology)
Source: International Ophthalmology - February 5, 2018 Category: Opthalmology Source Type: research

Ranibizumab versus aflibercept for the treatment of vascularized pigment epithelium detachment due to age-related macular degeneration
ConclusionsAlthough aflibercept was found to be superior to ranibizumab regarding BCVA improvement, both agents showed anatomical effectiveness with significant reduction in PED height and SRF absorption in patients with vPED due to AMD. (Source: International Ophthalmology)
Source: International Ophthalmology - February 5, 2018 Category: Opthalmology Source Type: research

Acquired myopia in Vogt –Koyanagi–Harada disease
ConclusionsMyopia progression as well as increase in axial length occurs in VKH disease. The link between choroidal thinning and axial length elongation in VKH patients gives some insights into axial length increase of pathologic myopia. (Source: International Ophthalmology)
Source: International Ophthalmology - February 3, 2018 Category: Opthalmology Source Type: research

Validation of the structure –function correlation report from the heidelberg edge perimeter and spectral-domain optical coherence tomography
ConclusionsThis study suggests that the automated structure –function report combining results from the SD-OCT and the HEP may assist in the evaluation and management of glaucoma. (Source: International Ophthalmology)
Source: International Ophthalmology - February 2, 2018 Category: Opthalmology Source Type: research

Efficacy and safety of pop-titrated versus fixed-energy trans-scleral diode laser cyclophotocoagulation for refractory glaucoma
ConclusionsPop-titrated DLTSC represents an effective and safe option for the management of refractory glaucoma. We found no statistically significant difference in success rates among both groups. However, there was a significantly higher risk of hypotony in eyes treated with the fixed-energy protocol. (Source: International Ophthalmology)
Source: International Ophthalmology - February 2, 2018 Category: Opthalmology Source Type: research

Long-term impact of dry eye symptoms on vision-related quality of life after phacoemulsification surgery
AbstractPurposeTo observe the long-term changes in dry eye symptoms and vision-related quality of life in age-related cataract patients after phacoemulsification.MethodsA total of 101 cataract patients after phacoemulsification combined with IOL implantation (Ph-IOL) in one eye were enrolled. Visual acuity, tear film breakup time (BUT), and Schirmer test 1 (ST1) were measured before and 1, 3, and 6  months after surgery. Ocular Surface Disease Index (OSDI) scores were used to evaluate the severity of dry eye symptoms. Utility values were assessed by the time trade-off (TTO), standard gamble for death (SGD), standard g...
Source: International Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy
ConclusionThe Meibomian gland morphology of the PBK eyes demonstrates significant differences when compared with normal fellow eyes and might be related to evaporative dry eye. For this reason, patients with PBK should be monitored for Meibomian gland dysfunction and when needed start prompt treatment in order to prevent further disturbance of the ocular surface. (Source: International Ophthalmology)
Source: International Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

Impairment of acquired color vision in multiple sclerosis: an early diagnostic sign linked to the greatness of disease
ConclusionWe think that the majority of the patients with the red –green deficiency will develop the coupled red–green and blue–yellow deficiency in the latter years of multiple sclerosis. (Source: International Ophthalmology)
Source: International Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

Optical coherence tomography angiography findings of an optic disc melanocytoma in a glaucoma eye
ConclusionsIn the presented case of a stable ODM and newly detected normal tension glaucoma, OCTA provided more information on perfusion than FA and ICGA which are limited by the heavy pigmentation of the ODM. OCTA also showed a similarly decreased capillary perfusion in both RNFL bundle defects suggesting that the structural damage was related to glaucoma and not compression by ODM. These results suggest that OCTA may be a method preferred over conventional angiography in ODM cases. (Source: International Ophthalmology)
Source: International Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

Modified technique of internal limiting membrane staining in idiopathic macular hole surgery
ConclusionThe modified technique of ILM staining using TB under PFCL is safe and effective in cases of idiopathic macular hole combined with the inverted ILM flap technique. (Source: International Ophthalmology)
Source: International Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

Association of polymorphisms of complement factor I rs141853578 (G119R) with age-related macular degeneration in Iranian population
ConclusionCurrent study showed that CFI rs141853578 (G119R) is a risk factor for developing advanced type AMD. This study also suggests that the frequency of G119R polymorphism in our population is not as rare as reported from other populations. (Source: International Ophthalmology)
Source: International Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

Corneal incision architecture after IOL implantation with three different injectors: an environmental scanning electron microscopy study
ConclusionsThe automated and preloaded delivery systems provided a good corneal incision architecture; after high-power IOL implantation the incisions were more regular and less damaged with the preloaded system than with the other devices. (Source: International Ophthalmology)
Source: International Ophthalmology - February 1, 2018 Category: Opthalmology Source Type: research

Primary desmoplastic small round cell tumor in the left orbit: a case report and literature review
ConclusionsIn the present study, for the first time, we report a case of desmoplastic small round cell tumor which is located in the orbital region. (Source: International Ophthalmology)
Source: International Ophthalmology - January 30, 2018 Category: Opthalmology Source Type: research

Ocular Demodex folliculorum : prevalence and associated symptoms in an Irish population
ConclusionThere is a strong association between the prevalence of DF and symptoms, in particular itchy eyes. However, not all patients with DF will be symptomatic. The newly developed questionnaire is a reliable instrument for measuring change in symptoms over a period of time and suitable for observing patient reported outcomes in interventional treatment studies. (Source: International Ophthalmology)
Source: International Ophthalmology - January 29, 2018 Category: Opthalmology Source Type: research

Intravitreal dexamethasone implant with retinal photocoagulation for adult-onset Coats ’ disease
ConclusionIntravitreal dexamethasone implant Ozurdex(®) (Allergan, Inc., Irvine, Calif., USA) may be an effective initial therapeutic approach for Coats ’ disease with massive exudation. (Source: International Ophthalmology)
Source: International Ophthalmology - January 29, 2018 Category: Opthalmology Source Type: research

Intravitreal dexamethasone implant as an option for anti-inflammatory therapy of tuberculosis uveitis
ConclusionIntravitreal dexamethasone implant injection seems to be a safe and potent option for the treatment of macular edema secondary to tuberculosis uveitis. (Source: International Ophthalmology)
Source: International Ophthalmology - January 29, 2018 Category: Opthalmology Source Type: research

Role of topical interferon alpha-2b in ‘mitomycin-C-resistant’ ocular surface squamous neoplasia: our preliminary findings
ConclusionThe OSSN lesions showing ‘less or no response’ to topical MMC may be shifted to topical recombinant IFNα-2b before proceeding for a surgical excision. (Source: International Ophthalmology)
Source: International Ophthalmology - January 23, 2018 Category: Opthalmology Source Type: research

Everything is ok on YouTube! Quality assessment of YouTube videos on the topic of phacoemulsification in eyes with small pupil
ConclusionsYouTube videos on small pupil phacoemulsification have low complication rates when compared to the literature, although no reliable mechanical dilatation methods are used in almost half of these videos. Until YouTube ’s place in e-learning becomes clearer, we suggest that viewers be cautious regarding small pupil phacoemulsification videos on YouTube. (Source: International Ophthalmology)
Source: International Ophthalmology - January 22, 2018 Category: Opthalmology Source Type: research

Prognostic factors of pediatric glaucoma: a retrospective study
ConclusionsWe concluded that glaucoma was earlier detected in children with primary congenital glaucoma, who exhibited increased corneal diameter and high percentage of Haab striae comparing to the other groups. However, these children responded successfully to any therapeutic intervention, exhibiting better BCVA and IOP values than the rest groups at the second visit. (Source: International Ophthalmology)
Source: International Ophthalmology - January 18, 2018 Category: Opthalmology Source Type: research

Sub-inner limiting membrane hemorrhage in a patient with Terson syndrome
ConclusionsIn patients with billateral Terson syndrome we recommend early surgery, especially if the neurological status allows it, a good visual acuity being helpful for the neurophysical rehabilitation of the patient. (Source: International Ophthalmology)
Source: International Ophthalmology - January 17, 2018 Category: Opthalmology Source Type: research

Mitomycin C 0.02 and 0.002% efficacy in preventing haze after photorefractive keratectomy
AbstractPurposeTo compare MMC 0.002% efficacy in preventing haze after PRK in relation to MMC 0.02%.Patients and methods We conducted a prospective study with patients with myopia or myopic astigmatism undergoing PRK in the same conditions. After PRK, MMC was applied for 30  s in a concentration of 0.02% on the right eye (group 1) and 0.002% on the left eye (group 2). Age, gender, spherical equivalent and haze intensity (1, 3, 6 and 12 months postoperatively) were assessed. Haze was quantified at biomicroscopy (0–4 +).P 
Source: International Ophthalmology - January 16, 2018 Category: Opthalmology Source Type: research

Assessment of ocular toxoplasmosis patients reported at a tertiary center in the northeast of Iran
ConclusionToxoplasma gondii was responsible for 20% of the patients of uveitis that presented to the largest ophthalmology center in the northeast of Iran. There is a high incidence of patients of ocular toxoplasmosis in the northeast of Iran, and it is a significant cause of uveitis and visual impairment in this area. (Source: International Ophthalmology)
Source: International Ophthalmology - January 15, 2018 Category: Opthalmology Source Type: research

Comparative evaluation of the aqueous humor proteome of primary angle closure and primary open angle glaucomas and age-related cataract eyes
ConclusionsA qualitative as well as a quantitative comparison of proteomes of AH from PACG, POAG and age-related cataract eyes showed significant differences, thus providing clues to the disease pathophysiology. (Source: International Ophthalmology)
Source: International Ophthalmology - January 13, 2018 Category: Opthalmology Source Type: research

Accommodative esotropia: the state of the art
AbstractPurposeTo review the state of the art of Accommodative Esotropia (AE) through careful study of what has been reported up to the point in literature.MethodsA literature search was done on PubMed using key words including “Accommodative esotropia”, “Infantile esotropia”, “Strabismus” and “Accommodation”. We systematically reviewed and critically appraised what has been written about AE and we tried to analyze that according to the current management of AE.ResultsAccommodative Esotropia (AE) is a form of strabismus characterized by convergent misalignment of the visual a...
Source: International Ophthalmology - January 13, 2018 Category: Opthalmology Source Type: research

A nationwide survey of factors influencing adherence to ocular hypotensive eyedrops in Japan
AbstractIntroductionFew reports have investigated the status of adherence in Japan on a large scale. We aimed to investigate the status of adherence to topical glaucoma treatment and its associated factors.MethodsA nationwide survey was conducted as a prospective fashion. Participants in this survey were subjects with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension or pseudoexfoliation glaucoma who had been prescribed anti-glaucoma ophthalmic eyedrops and whose ophthalmologist considered prescribing any fixed combination of ocular hypotensive eyedrops for the first time between 2011 and 2012. S...
Source: International Ophthalmology - January 12, 2018 Category: Opthalmology Source Type: research

Pars plana vitrectomy with transscleral fixation of posterior chamber lens in the treatment of post-traumatic lens dislocation
ConclusionBasing on the abovementioned facts, we believe that this surgical approach facilitates the fixation of the dislocated lens and allows a successful treatment of secondary implantation or repositioning of a dislocated intraocular lens. (Source: International Ophthalmology)
Source: International Ophthalmology - January 11, 2018 Category: Opthalmology Source Type: research

Presumed tuberculous uveitis in a university-based tertiary referral center in Saudi Arabia
ConclusionsThere is delay in presentation of patients with PTU. The most common anatomic diagnosis was panuveitis. Treatment with anti-tuberculous therapy combined with systemic corticosteroids resulted in resolution of inflammation and macular edema with significant improvement in visual acuity. (Source: International Ophthalmology)
Source: International Ophthalmology - January 9, 2018 Category: Opthalmology Source Type: research

Successful recovery from misdirection syndrome in nanophthalmic eyes by performing an anterior vitrectomy through the anterior chamber
ConclusionIn this study, we investigated an alternative option for the treatment of misdirection syndrome in nanophthalmic eyes. We undertook a lens capsulotomy and anterior vitrectomy through a peripheral iridectomy from the anterior chamber using a 25-gauge vitreous cutter, which was able to create a communication hole between the anterior and posterior chambers. (Source: International Ophthalmology)
Source: International Ophthalmology - January 3, 2018 Category: Opthalmology Source Type: research

Mutations in MERTK are not associated with age-related macular degeneration
ConclusionsThe present study provides a meaningfully negative result demonstrating that rare variants inMERTK are not associated with AMD. The study also demonstrates the role of large sample size genetic studies utilizing whole-genome sequencing as a powerful tool that can resolve clinically relevant questions regarding the genetic basis of ophthalmic disease. (Source: International Ophthalmology)
Source: International Ophthalmology - January 3, 2018 Category: Opthalmology Source Type: research

Intracameral povidone-iodine for endophthalmitis treatment
(Source: International Ophthalmology)
Source: International Ophthalmology - January 3, 2018 Category: Opthalmology Source Type: research

Pathophysiology of primary open-angle glaucoma from a neuroinflammatory and neurotoxicity perspective: a review of the literature
ConclusionsThe damage to ganglion cells and eventually glaucomatous injury can occur via various mechanisms including baric trauma, ischemia and impact of metabolic toxins, which triggers an inflammatory process and secondary degeneration in the ONH. (Source: International Ophthalmology)
Source: International Ophthalmology - December 30, 2017 Category: Opthalmology Source Type: research

Comparison of anterior segment parameters and axial lengths of myopic, emmetropic, and hyperopic children
AbstractPurposeTo compare the anterior segment parameters of myopic, hyperopic, and emmetropic children by using optical biometry.MethodsThis prospective cross-sectional study included 150 eyes of 150 children between 6 and 16  years old. The eyes were divided into three groups according to their spherical equivalent (SE) refractive error values as myopic [between − 1.0 and − 6.0 diopter (D)], emmetropic (between + 0.50 and − 0.50 D), and hyperopic (between + 1. 0 and + 3.0 D). Axial length (AL), central co rneal thickness, anterior chamber depth (ACD), lens th...
Source: International Ophthalmology - December 29, 2017 Category: Opthalmology Source Type: research

Bilateral Scheie ’s procedure with Ophthalmic Viscoelastic Device and 5-Fluorouracil
This report describes the first ever case, to our knowledge, of bilateral Scheie ’s procedures performed with retention of an ophthalmic viscoelastic device and intraoperative and post-operative 5-fluorouracil injections.DiscussionThese procedures have now successfully controlled the intraocular pressure in both of the patient ’s eyes for more than 17 years. (Source: International Ophthalmology)
Source: International Ophthalmology - December 28, 2017 Category: Opthalmology Source Type: research

Role of trabeculectomy in advanced glaucoma: Whether we stand to consider it a bane or a boon today?
ConclusionBesides being a cost-effective alternative to medical management, trabeculectomy not only provides a better IOP control but also has a high safety profile when performed by an experienced surgeon. (Source: International Ophthalmology)
Source: International Ophthalmology - December 26, 2017 Category: Opthalmology Source Type: research