Ten-year experience with intracameral chemotherapy for aqueous seeding in retinoblastoma: long-term efficacy, safety and toxicity
Conclusion
ICC appears to be safe and efficient for AS without irreversible vision-threatening adverse effects. More data are needed to determine any superiority in efficiency/toxicity of topotecan versus melphalan. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - December 18, 2023 Category: Opthalmology Authors: Stathopoulos, C., Beck-Popovic, M., Moulin, A. P., Munier, F. L. Tags: Open access Oncology Source Type: research
Anophthalmic socket in retinoblastoma: Exploring complications and risk factors in a tertiary centre in Malaysia
CONCLUSIONS: Long-term post-enucleation complications were not uncommon. Luckily, most had good outcomes, with a few needing surgical intervention. Meticulous suturing technique on the Tenon and conjunctival layer is essential to prevent implant exposure.PMID:38105429 | DOI:10.1177/11206721231219530 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - December 17, 2023 Category: Opthalmology Authors: Lay Hui Ng Li Yen Chan Nor Fadhilah Mohamad Jamalia Bt Rahmat Source Type: research
LILRB3 Modulates Acute Myeloid Leukemia Progression and Acts as an Effective Target for CAR T-cell Therapy
In this study, we found that LILRB receptors can be induced under inflammatory stimuli and chemotherapy treatment conditions. Blockade of LILRB3 inhibited leukemia cell proliferation and leukemia progression. In addition, treatment with LILRB3 blocking antibodies upregulated myeloid lineage differentiation transcription factors, including PU.1, C/EBP family, and IRF, whereas phosphorylation of proliferation regulators, for example, AKT, cyclin D1, and retinoblastoma protein, was decreased. Conversely, transcriptomic analysis showed LILRB3 activation by agonist antibodies may enhance leukemia survival through upregulation o...
Source: Cell Research - December 15, 2023 Category: Cytology Authors: Sunny Mai Alan Hodges Hui-Ming Chen Jilu Zhang Yi-Ling Wang Yongbin Liu Fumiko Nakatsu Xiaoxuan Wang Jing Fang Yitian Xu Vitaliy Davidov Kyeongah Kang Sai Ravi Pingali Siddhartha Ganguly Masataka Suzuki Marina Konopleva Brooke Prinzing Youli Zu Stephen Go Source Type: research
MRPL48 is a novel prognostic and predictive biomarker of hepatocellular carcinoma
CONCLUSIONS: We demonstrated that MRPL48 expression may be associated with HCC development and prognosis. These findings may open up new research directions and opportunities for the development of HCC treatments.PMID:38093387 | DOI:10.1186/s40001-023-01571-z (Source: Cell Research)
Source: Cell Research - December 14, 2023 Category: Cytology Authors: Yu-Xiang Lin Jun-Yong Pan Wen-Du Feng Tian-Cong Huang Cheng-Zong Li Source Type: research
MRPL48 is a novel prognostic and predictive biomarker of hepatocellular carcinoma
ConclusionsWe demonstrated that MRPL48 expression may be associated with HCC development and prognosis. These findings may open up new research directions and opportunities for the development of HCC treatments. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - December 14, 2023 Category: Research Source Type: research
Optic nerve thickening on high-spatial-resolution MRI predicts early-stage postlaminar optic nerve invasion in retinoblastoma
ConclusionPostlaminar optic nerve thickening can predict early-stage postlaminar optic nerve invasion in retinoblastoma.Clinical relevance statementThis study provides an additional tool for clinicians to help determine postlaminar optic nerve invasion, which is a risk factor for developing metastatic disease in retinoblastoma patients.Key Points• The diagnostic accuracy of contrast-enhanced MRI for detecting postlaminar optic nerve invasion is limited in retinoblastoma patients.• Optic nerve thickening can predict postlaminar optic nerve invasion.• A prediction model combining MRI features has a high sensitivity and...
Source: European Radiology - December 13, 2023 Category: Radiology Source Type: research
Optic nerve thickening on high-spatial-resolution MRI predicts early-stage postlaminar optic nerve invasion in retinoblastoma
CONCLUSION: Postlaminar optic nerve thickening can predict early-stage postlaminar optic nerve invasion in retinoblastoma.CLINICAL RELEVANCE STATEMENT: This study provides an additional tool for clinicians to help determine postlaminar optic nerve invasion, which is a risk factor for developing metastatic disease in retinoblastoma patients.KEY POINTS: • The diagnostic accuracy of contrast-enhanced MRI for detecting postlaminar optic nerve invasion is limited in retinoblastoma patients. • Optic nerve thickening can predict postlaminar optic nerve invasion. • A prediction model combining MRI features has a high sensiti...
Source: Cancer Control - December 12, 2023 Category: Cancer & Oncology Authors: Christiaan M de Bloeme Robin W Jansen Sophia G öricke Steven T L Grauwels Sabien van Elst Petra Ketteler Herv é J Brisse Paolo Galluzzi Liesbeth Cardoen Selma Sirin M ériam Koob Philippe Maeder Paul van der Valk Annette C Moll Pim de Graaf Marcus C de Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
