A novel missense < em > TGFBI < /em > variant p.(Ser591Phe) in a Finnish family with variant lattice corneal dystrophy
CONCLUSIONS: We classify the novel variant in TGFBI as possibly pathogenic, potentially causing the late-onset, asymmetric variant LCD. Our findings add to the growing number of TGFBI variants associated with a spectrum of phenotypes of variant LCD.PMID:33645289 | DOI:10.1177/1120672121997305 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - March 1, 2021 Category: Opthalmology Authors: Aino Maaria Jaakkola Petri J J ärventausta Reetta-Stiina J ärvinen Pauliina Repo Tero T Kivel ä Joni A Turunen Source Type: research

Fingolimod-associated macular edema: A case report of late onset
CONCLUSIONS: The authors report a case of late onset FAME. FAME may occur several years after starting fingolimod treatment and it should be part of differential diagnosis of blurred vision in patients receiving fingolimod. Both Microcystic Macular Edema secondary to MS and Macular Edema Associated with MS-induced Uveitis should always be excluded. Those two conditions, secondary to MS, might show the lack of drug effectiveness and the possible need for changing the existing therapy in order to prevent further disease progress.PMID:33645300 | DOI:10.1177/1120672121999632 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - March 1, 2021 Category: Opthalmology Authors: Christina Karakosta Christina Kourentis Source Type: research

The addition of a conjunctival flap to a posterior lamella auricular cartilage graft: A technique to avoid corneal complications
CONCLUSIONS: The confection of a conjunctival flap that lines the superior portion of an auricular cartilage graft in the lower eyelid provides protection against corneal postoperative complications until the graft is epithelized.PMID:33631967 | DOI:10.1177/1120672121998914 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Constanza Barrancos Ignacio Garc ía-Cruz Beatriz Ventas-Ayala Marco Sales-Sanz Source Type: research

Tear fluid collection methods: Review of current techniques
Eur J Ophthalmol. 2021 Feb 25:1120672121998922. doi: 10.1177/1120672121998922. Online ahead of print.ABSTRACTTear fluid, composed of lipid, aqueous, and mucin layers, contains electrolytes, water, proteins, peptides, and glycoproteins. Its components may serve as diagnostic indicators of local and systemic diseases. The aim of the study was to conduct literature review in order to identify the current methods of tear collection. The most commonly used method which was relatively easy to perform and allowed to obtain sufficient tear volume for further chemical and physical analysis was selected through PubMed database searc...
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Janusz Pieczy ński Urszula Szulc Joanna Harazna Aleksandra Szulc Jolanta Kiewisz Source Type: research

Impact of Covid-19 pandemic on Ophthalmic Emergency Department in an Italian tertiary eye centre
CONCLUSION: The COVID-19 pandemic drove a significant reduction of the overall OED activity. People with less urgent and milder conditions preferred to wait and endure their ocular discomfort for a few days rather than leaving home and risking to contract the infection. Our analysis highlights how several times the OED is used improperly by patients diagnosed with non-urgent disorders. A more accurate use of the OED would allow a reduction of management costs and the avoidance of overcrowding, which can lead to delays in the care of patients that really need assistance.PMID:33631983 | DOI:10.1177/1120672121998223 (Source: ...
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Franzolin Elia Casati Stefano Albertini Ottavia Antonelli Giulio Marchetti Pierpaolo Bonora Antonio Marchini Giorgio Source Type: research

Corneal cross-linking for treatment of progressive keratoconus in a patient with Alport syndrome: A case report
CONCLUSIONS: When diagnosing ocular clinical findings of Alport syndrome, keratoconus should be considered. Standard corneal cross-linking protocol can halt its progression.PMID:33631984 | DOI:10.1177/1120672121997672 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Iva Krolo Aida Kasumovi ć Ivana Radman Pavao Pavi ć Source Type: research

The addition of a conjunctival flap to a posterior lamella auricular cartilage graft: A technique to avoid corneal complications
CONCLUSIONS: The confection of a conjunctival flap that lines the superior portion of an auricular cartilage graft in the lower eyelid provides protection against corneal postoperative complications until the graft is epithelized.PMID:33631967 | DOI:10.1177/1120672121998914 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Constanza Barrancos Ignacio Garc ía-Cruz Beatriz Ventas-Ayala Marco Sales-Sanz Source Type: research

Tear fluid collection methods: Review of current techniques
Eur J Ophthalmol. 2021 Feb 25:1120672121998922. doi: 10.1177/1120672121998922. Online ahead of print.ABSTRACTTear fluid, composed of lipid, aqueous, and mucin layers, contains electrolytes, water, proteins, peptides, and glycoproteins. Its components may serve as diagnostic indicators of local and systemic diseases. The aim of the study was to conduct literature review in order to identify the current methods of tear collection. The most commonly used method which was relatively easy to perform and allowed to obtain sufficient tear volume for further chemical and physical analysis was selected through PubMed database searc...
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Janusz Pieczy ński Urszula Szulc Joanna Harazna Aleksandra Szulc Jolanta Kiewisz Source Type: research

Impact of Covid-19 pandemic on Ophthalmic Emergency Department in an Italian tertiary eye centre
CONCLUSION: The COVID-19 pandemic drove a significant reduction of the overall OED activity. People with less urgent and milder conditions preferred to wait and endure their ocular discomfort for a few days rather than leaving home and risking to contract the infection. Our analysis highlights how several times the OED is used improperly by patients diagnosed with non-urgent disorders. A more accurate use of the OED would allow a reduction of management costs and the avoidance of overcrowding, which can lead to delays in the care of patients that really need assistance.PMID:33631983 | DOI:10.1177/1120672121998223 (Source: ...
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Franzolin Elia Casati Stefano Albertini Ottavia Antonelli Giulio Marchetti Pierpaolo Bonora Antonio Marchini Giorgio Source Type: research

Corneal cross-linking for treatment of progressive keratoconus in a patient with Alport syndrome: A case report
CONCLUSIONS: When diagnosing ocular clinical findings of Alport syndrome, keratoconus should be considered. Standard corneal cross-linking protocol can halt its progression.PMID:33631984 | DOI:10.1177/1120672121997672 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Iva Krolo Aida Kasumovi ć Ivana Radman Pavao Pavi ć Source Type: research

The addition of a conjunctival flap to a posterior lamella auricular cartilage graft: A technique to avoid corneal complications
CONCLUSIONS: The confection of a conjunctival flap that lines the superior portion of an auricular cartilage graft in the lower eyelid provides protection against corneal postoperative complications until the graft is epithelized.PMID:33631967 | DOI:10.1177/1120672121998914 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Constanza Barrancos Ignacio Garc ía-Cruz Beatriz Ventas-Ayala Marco Sales-Sanz Source Type: research

Tear fluid collection methods: Review of current techniques
Eur J Ophthalmol. 2021 Feb 25:1120672121998922. doi: 10.1177/1120672121998922. Online ahead of print.ABSTRACTTear fluid, composed of lipid, aqueous, and mucin layers, contains electrolytes, water, proteins, peptides, and glycoproteins. Its components may serve as diagnostic indicators of local and systemic diseases. The aim of the study was to conduct literature review in order to identify the current methods of tear collection. The most commonly used method which was relatively easy to perform and allowed to obtain sufficient tear volume for further chemical and physical analysis was selected through PubMed database searc...
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Janusz Pieczy ński Urszula Szulc Joanna Harazna Aleksandra Szulc Jolanta Kiewisz Source Type: research

Impact of Covid-19 pandemic on Ophthalmic Emergency Department in an Italian tertiary eye centre
CONCLUSION: The COVID-19 pandemic drove a significant reduction of the overall OED activity. People with less urgent and milder conditions preferred to wait and endure their ocular discomfort for a few days rather than leaving home and risking to contract the infection. Our analysis highlights how several times the OED is used improperly by patients diagnosed with non-urgent disorders. A more accurate use of the OED would allow a reduction of management costs and the avoidance of overcrowding, which can lead to delays in the care of patients that really need assistance.PMID:33631983 | DOI:10.1177/1120672121998223 (Source: ...
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Franzolin Elia Casati Stefano Albertini Ottavia Antonelli Giulio Marchetti Pierpaolo Bonora Antonio Marchini Giorgio Source Type: research

Corneal cross-linking for treatment of progressive keratoconus in a patient with Alport syndrome: A case report
CONCLUSIONS: When diagnosing ocular clinical findings of Alport syndrome, keratoconus should be considered. Standard corneal cross-linking protocol can halt its progression.PMID:33631984 | DOI:10.1177/1120672121997672 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 26, 2021 Category: Opthalmology Authors: Iva Krolo Aida Kasumovi ć Ivana Radman Pavao Pavi ć Source Type: research

Effects of hydrogen peroxide solution on the biomechanics of porcine cornea
CONCLUSIONS: Treatment with 3.91 mmol/L H2O2 solution can safely and effectively increase the biomechanical strength of the cornea.PMID:33626917 | DOI:10.1177/1120672121996641 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Zuoxiang Pang Lijun Wang Chunxiao Zhang Jia Wang Zhipeng Gao Zhiwei Li Jiangdong Hao Guoying Mu Source Type: research

12-month interim results of a prospective study of patients with mild to moderate open-angle glaucoma undergoing combined viscodilation of Schlemm's canal and collector channels and 360 ° trabeculotomy as a standalone procedure or combined with cataract surgery
Eur J Ophthalmol. 2021 Feb 24:1120672121998234. doi: 10.1177/1120672121998234. Online ahead of print.ABSTRACTPURPOSE: To characterize clinical outcomes of combined viscodilation of Schlemm's canal and collector channels and 360° trabeculotomy as a standalone procedure or combined with cataract surgery in eyes with mild to moderate open-angle glaucoma (OAG).METHODS: In this prospective case series, the OMNI glaucoma surgical platform (Sight Sciences, Menlo Park, CA) was utilized to perform the procedure either combined with phacoemulsification or as a standalone procedure. Changes from baseline in intraocular pressure (...
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Iwona Grabska-Liberek Patrycja Duda Monika Rogowska Julita Majszyk-Ionescu Agnieszka Skowyra Anna Koziorowska Ingrid Kane Jaroslaw Chmielewski Source Type: research

Long-term follow-up of retinal sensitivity assessed by microperimetry in patients with internal limiting membrane peeling
CONCLUSION: After surgery, the retinal sensitivity assessed by microperimetry gradually improved until the 18th month and was not different from the values of the fellow eye. These results seemed to confirm that ILM peeling can be an effective and safe technique to treat patients with vitreomacular interface disease.PMID:33626933 | DOI:10.1177/1120672121997300 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Benjamin Blautain Agn ès Glacet-Bernard Rocio Blanco-Garavito Ad élaïde Toutée Camille Jung Manon Ortoli Eric H Souied Source Type: research

Venous-air embolism during vitrectomy for endoresection of choroidal melanoma: Case report
CONCLUSIONS: Although rare, vitreoretinal surgeons should be aware of this potentially fatal complication and take steps to prevent it.PMID:33626942 | DOI:10.1177/1120672121995101 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Miroslava Paolah Meraz Guti érrez Efrain Jose Camara Rodriguez Alejandra Pando Cifuentes Grecia Yael Ortiz-Ramirez Vidal Sober ón Ventura Source Type: research

Effects of hydrogen peroxide solution on the biomechanics of porcine cornea
CONCLUSIONS: Treatment with 3.91 mmol/L H2O2 solution can safely and effectively increase the biomechanical strength of the cornea.PMID:33626917 | DOI:10.1177/1120672121996641 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Zuoxiang Pang Lijun Wang Chunxiao Zhang Jia Wang Zhipeng Gao Zhiwei Li Jiangdong Hao Guoying Mu Source Type: research

12-month interim results of a prospective study of patients with mild to moderate open-angle glaucoma undergoing combined viscodilation of Schlemm's canal and collector channels and 360 ° trabeculotomy as a standalone procedure or combined with cataract surgery
Eur J Ophthalmol. 2021 Feb 24:1120672121998234. doi: 10.1177/1120672121998234. Online ahead of print.ABSTRACTPURPOSE: To characterize clinical outcomes of combined viscodilation of Schlemm's canal and collector channels and 360° trabeculotomy as a standalone procedure or combined with cataract surgery in eyes with mild to moderate open-angle glaucoma (OAG).METHODS: In this prospective case series, the OMNI glaucoma surgical platform (Sight Sciences, Menlo Park, CA) was utilized to perform the procedure either combined with phacoemulsification or as a standalone procedure. Changes from baseline in intraocular pressure (...
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Iwona Grabska-Liberek Patrycja Duda Monika Rogowska Julita Majszyk-Ionescu Agnieszka Skowyra Anna Koziorowska Ingrid Kane Jaroslaw Chmielewski Source Type: research

Long-term follow-up of retinal sensitivity assessed by microperimetry in patients with internal limiting membrane peeling
CONCLUSION: After surgery, the retinal sensitivity assessed by microperimetry gradually improved until the 18th month and was not different from the values of the fellow eye. These results seemed to confirm that ILM peeling can be an effective and safe technique to treat patients with vitreomacular interface disease.PMID:33626933 | DOI:10.1177/1120672121997300 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Benjamin Blautain Agn ès Glacet-Bernard Rocio Blanco-Garavito Ad élaïde Toutée Camille Jung Manon Ortoli Eric H Souied Source Type: research

Venous-air embolism during vitrectomy for endoresection of choroidal melanoma: Case report
CONCLUSIONS: Although rare, vitreoretinal surgeons should be aware of this potentially fatal complication and take steps to prevent it.PMID:33626942 | DOI:10.1177/1120672121995101 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 25, 2021 Category: Opthalmology Authors: Miroslava Paolah Meraz Guti érrez Efrain Jose Camara Rodriguez Alejandra Pando Cifuentes Grecia Yael Ortiz-Ramirez Vidal Sober ón Ventura Source Type: research

Surgical correction of severe congenital ptosis using a modified frontalis muscle advancement technique: A single-arm trial
CONCLUSION: A modified frontal muscle advancement flap produced a high success rate with a clear field of vision, mild trauma, and few complications. This technique is relatively simple and should be considered for correcting severe congenital ptosis.Date of registration: 29-03-2020Trial registration number: ChiCTR2000031364Registration site: http://www.chictr.org/.PMID:33624537 | DOI:10.1177/1120672121995754 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 24, 2021 Category: Opthalmology Authors: Lei Zhang Mingyu Ren Yuqing Yan Wenjuan Zhai Lihong Yang Chunhua Sun Ye Pan Hong Zhao Source Type: research

Inferior oblique recession associated to partial temporal inferior rectus recession in unilateral congenital superior oblique palsy
CONCLUSION: When performing recession of inferior oblique muscles in SOP associated to a full recession of the contralateral inferior rectus, there is a risk of overcorrection in those with moderate angles. Performing a partial recession in the contralateral inferior rectus eye corrected up to 20PD in primary position in our series, reducing this risk.PMID:33624544 | DOI:10.1177/1120672121997664 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 24, 2021 Category: Opthalmology Authors: Barbara Burgos-Blasco Elena Hernandez-Garcia Carlos Llorente-La-Orden Rosario Gomez-de-Lia ño Source Type: research

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis
We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0 × 1.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patient's medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20 years prior), followed by a diagnosis of MG with suspect thymic association (15 years prior). Three years prior, the patient had been diagnosed with polymyo...
Source: European Journal of Ophthalmology - February 23, 2021 Category: Opthalmology Authors: He Yu Xinyu Ma Nianting Tong Zhanyu Zhou Yu Zhang Source Type: research

Acute exudative paraneoplastic polymorphous vitelliform maculopathy in a patient with thymoma, myasthenia gravis, and polymyositis
We describe a 63-year-old woman who presented to our tertiary medical center with a 3-month history of reduced visual acuity in both eyes. Concurrent fundoscopy revealed a 2.0 × 1.7-mm, unifocal, yellow, round vitelliform lesion in the macular region, surrounded by multifocal, shallow, yellow-white pockets of subretinal fluid. The patient's medical history included thymoma with thymectomy treatment, combined with pericardiectomy and postoperative radiotherapy (20 years prior), followed by a diagnosis of MG with suspect thymic association (15 years prior). Three years prior, the patient had been diagnosed with polymyo...
Source: European Journal of Ophthalmology - February 23, 2021 Category: Opthalmology Authors: He Yu Xinyu Ma Nianting Tong Zhanyu Zhou Yu Zhang Source Type: research

Augmented fascia temporalis sling for paralytic ectropion of the lower lid
CONCLUSION: Combination of lower lid fascia temporalis sling, lateral canthoplasty and tarsorrhaphy as a single-session procedure can effectively improve the functional and aesthetic complications of paralytic ectropion.PMID:33607927 | DOI:10.1177/1120672121995744 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 20, 2021 Category: Opthalmology Authors: Abbas Bagheri Mohadeseh Feizi Ramin Sahebghalam Mehdi Tavakoli Source Type: research

Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database
Eur J Ophthalmol. 2021 Feb 19:1120672121997288. doi: 10.1177/1120672121997288. Online ahead of print.ABSTRACTPURPOSE: To assess whether metformin is associated with dry age-related macular degeneration (dAMD) development.METHODS: In this retrospective cohort study, patients enrolled in a nationwide U.S. medical insurance claims database from 2002 to 2016 were included if they had diabetes mellitus, were ⩾55 years old, and were enrolled for ⩾2 years without a prior AMD diagnosis. The primary exposure was metformin use analyzed as either active or prior use or cumulative metformin dosage over the study period. A time upd...
Source: European Journal of Ophthalmology - February 20, 2021 Category: Opthalmology Authors: Emily A Eton Thomas J Wubben Cagri G Besirli Peiying Hua Brendan McGeehan Brian L VanderBeek Source Type: research

Pupillometry: An objective test to assess endocular hereditary transthyretin amyloidosis
Eur J Ophthalmol. 2021 Feb 18:1120672121997294. doi: 10.1177/1120672121997294. Online ahead of print.ABSTRACTOBJECTIVE: To automatically study the pupillary light reflex in patients with hereditary transthyretin-associated amyloidosis (hATTR).METHODS: Prospective cross-sectional observational study in patients with hATTR with unilateral scalloped iris. Pupillary light reflex of scalloped iris eyes (21 eyes) were compared with non-scalloped iris eyes (21 eyes, paired eyes of the same patients) and also with a control group of 20 healthy eyes, using static and dynamic pupillometry with the Metrovision® MonPack One.RESULT...
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Jo ão Heitor Marques Lu ísa Malheiro Jorge Malheiro Lu ís Oliveira Maria Jo ão Menéres Jo ão Melo Beirão Source Type: research

Switching to intravitreal fluocinolone acetonide implant for refractory diabetic macular edema: 12- and 24-month results
DISCUSSION: Our results show that the visual and the anatomical improvements achieved by a single injection of a fluocinolone acetonide implant were maintained up to 24 months with minimal additional therapy even in eyes with a long and heavy history; however, IOP monitoring remains essential.PMID:33601897 | DOI:10.1177/1120672121992982 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Argyrios Chronopoulos Panagiotis Chronopoulos Agharza Ashurov Christina Korb Norbert Pfeiffer Lars-Olof Hattenbach Source Type: research

Bruch's membrane opening-minimum rim width: An alternative OCT biomarker study for multiple sclerosis
CONCLUSION: The novel APS-RNFL technique appears to be a bit more reliable alternative to S-RNFL technique to support therapeutic decision-making in MS. BMO-MRW has not been found as a successful alternative to S-RNFL.PMID:33601900 | DOI:10.1177/1120672121996638 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Kemal Turgay Özbilen Tuncay G ündüz Selva Nur Çukurova Kartal Ali Ceyhun Gedik Mefk üre Eraksoy Murat K ürtüncü Source Type: research

Efficacy of plasmapheresis as treatment for bilateral hyperviscosity syndrome related retinopathy in multiple myeloma
CONCLUSIONS: Fundoscopy lead to diagnosis of HVS, it is therefore advisable in all patients with MM in order to perform plasmapheresis as soon as possible if necessary. In case of atypical CRVO, haematological and inflammatory causes, should be always ruled out.PMID:33601903 | DOI:10.1177/1120672121997069 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Tommaso Merz Ivan Marchesoni Giulia Caminiti Federica Romanelli Source Type: research

Ocular Cicatricial Pemphigoid, Sj ögren's Syndrome, and Hashimoto's Thyroiditis as a Multiple Autoimmune Syndrome: A case report
CONCLUSION: A novel association of Multiple Autoimmune Syndrome is presented in this case. Ophthalmologists and other specialists involved in the evaluation and treatment of patients with autoimmune diseases, should be aware of this clinical presentation. A multidisciplinary approach in this condition is important for optimum treatment instauration and follow-up, in order to prevent complications.PMID:33601905 | DOI:10.1177/1120672121996637 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Carlos Cifuentes-Gonz ález Stefania Amaris-Mart ínez Juliana Reyes-Guanes Pilar Uribe-Reina Alejandra de-la-Torre Source Type: research

Rubeosis iridis and macular hemorrhages from multiple Corkscrew retinal vessels in a patient with NF1
CONCLUSIONS: We present a unique patient with NF1, rubeosis iridis, high IOP, and macular hemorrhages from multiple corkscrew retinal vessels in a well perfused retina, who underwent treatment with a single dose of intravitreal Bevacizumab and had an excellent response.PMID:33601906 | DOI:10.1177/1120672121996636 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Marilyn A M árquez Claudio P Ju árez Maria C S ánchez Jose D Luna Source Type: research

Augmented fascia temporalis sling for paralytic ectropion of the lower lid.
CONCLUSION: Combination of lower lid fascia temporalis sling, lateral canthoplasty and tarsorrhaphy as a single-session procedure can effectively improve the functional and aesthetic complications of paralytic ectropion. PMID: 33607927 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Bagheri A, Feizi M, Sahebghalam R, Tavakoli M Tags: Eur J Ophthalmol Source Type: research

Association of metformin and development of dry age-related macular degeneration in a U.S. insurance claims database.
Abstract PURPOSE: To assess whether metformin is associated with dry age-related macular degeneration (dAMD) development. METHODS: In this retrospective cohort study, patients enrolled in a nationwide U.S. medical insurance claims database from 2002 to 2016 were included if they had diabetes mellitus, were ⩾55 years old, and were enrolled for ⩾2 years without a prior AMD diagnosis. The primary exposure was metformin use analyzed as either active or prior use or cumulative metformin dosage over the study period. A time updating Cox proportional hazard regression was used to estimate the hazar...
Source: European Journal of Ophthalmology - February 19, 2021 Category: Opthalmology Authors: Eton EA, Wubben TJ, Besirli CG, Hua P, McGeehan B, VanderBeek BL Tags: Eur J Ophthalmol Source Type: research

Pupillometry: An objective test to assess endocular hereditary transthyretin amyloidosis.
atilde;o JM Abstract OBJECTIVE: To automatically study the pupillary light reflex in patients with hereditary transthyretin-associated amyloidosis (hATTR). METHODS: Prospective cross-sectional observational study in patients with hATTR with unilateral scalloped iris. Pupillary light reflex of scalloped iris eyes (21 eyes) were compared with non-scalloped iris eyes (21 eyes, paired eyes of the same patients) and also with a control group of 20 healthy eyes, using static and dynamic pupillometry with the Metrovision® MonPack One. RESULTS: No patient presented evident neurological involvment of the cran...
Source: European Journal of Ophthalmology - February 18, 2021 Category: Opthalmology Authors: Marques JH, Malheiro L, Malheiro J, Oliveira L, Menéres MJ, Beirão JM Tags: Eur J Ophthalmol Source Type: research

Switching to intravitreal fluocinolone acetonide implant for refractory diabetic macular edema: 12- and 24-month results.
DISCUSSION: Our results show that the visual and the anatomical improvements achieved by a single injection of a fluocinolone acetonide implant were maintained up to 24 months with minimal additional therapy even in eyes with a long and heavy history; however, IOP monitoring remains essential. PMID: 33601897 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 18, 2021 Category: Opthalmology Authors: Chronopoulos A, Chronopoulos P, Ashurov A, Korb C, Pfeiffer N, Hattenbach LO Tags: Eur J Ophthalmol Source Type: research

Bruch's membrane opening-minimum rim width: An alternative OCT biomarker study for multiple sclerosis.
CONCLUSION: The novel APS-RNFL technique appears to be a bit more reliable alternative to S-RNFL technique to support therapeutic decision-making in MS. BMO-MRW has not been found as a successful alternative to S-RNFL. PMID: 33601900 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 18, 2021 Category: Opthalmology Authors: Özbilen KT, Gündüz T, Çukurova Kartal SN, Gedik AC, Eraksoy M, Kürtüncü M Tags: Eur J Ophthalmol Source Type: research

Efficacy of plasmapheresis as treatment for bilateral hyperviscosity syndrome related retinopathy in multiple myeloma.
CONCLUSIONS: Fundoscopy lead to diagnosis of HVS, it is therefore advisable in all patients with MM in order to perform plasmapheresis as soon as possible if necessary. In case of atypical CRVO, haematological and inflammatory causes, should be always ruled out. PMID: 33601903 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 18, 2021 Category: Opthalmology Authors: Merz T, Marchesoni I, Caminiti G, Romanelli F Tags: Eur J Ophthalmol Source Type: research

Ocular Cicatricial Pemphigoid, Sj ögren's Syndrome, and Hashimoto's Thyroiditis as a Multiple Autoimmune Syndrome: A case report.
CONCLUSION: A novel association of Multiple Autoimmune Syndrome is presented in this case. Ophthalmologists and other specialists involved in the evaluation and treatment of patients with autoimmune diseases, should be aware of this clinical presentation. A multidisciplinary approach in this condition is important for optimum treatment instauration and follow-up, in order to prevent complications. PMID: 33601905 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 18, 2021 Category: Opthalmology Authors: Cifuentes-González C, Amaris-Martínez S, Reyes-Guanes J, Uribe-Reina P, de-la-Torre A Tags: Eur J Ophthalmol Source Type: research

Rubeosis iridis and macular hemorrhages from multiple Corkscrew retinal vessels in a patient with NF1.
CONCLUSIONS: We present a unique patient with NF1, rubeosis iridis, high IOP, and macular hemorrhages from multiple corkscrew retinal vessels in a well perfused retina, who underwent treatment with a single dose of intravitreal Bevacizumab and had an excellent response. PMID: 33601906 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 18, 2021 Category: Opthalmology Authors: Márquez MA, Juárez CP, Sánchez MC, Luna JD Tags: Eur J Ophthalmol Source Type: research

Optical coherence tomography analyses based segmentation and relative intensity evaluation of outer retinal layers in patients affected with X-linked juvenile retinoschisis.
CONCLUSION: Data suggested that both anatomic and functional characteristic of outer macula hyperreflective bands were notably associated with the pathogenesis cascade in the photoreceptor cells. External limiting membrane line disruption is initiated by the volume of macular edema and followed by disorganization of the three lines in a stepwise pattern, first at the ellipsoid zone, followed by the cone outer segment tips zone and finally at the External limiting membrane. PMID: 33594896 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 17, 2021 Category: Opthalmology Authors: Christodoulou PD Tags: Eur J Ophthalmol Source Type: research

Comparison of accuracy of different intraocular lens power calculation methods using artificial intelligence.
CONCLUSION: Better accuracy of PE might be obtained by the Hill-RBF 2.0 method compared with BUII. The Kane and Pearl-DGS methods showed similar accuracy when compared with BUII. PMID: 33594897 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 17, 2021 Category: Opthalmology Authors: Nemeth G, Kemeny-Beke A, Modis L Tags: Eur J Ophthalmol Source Type: research

Ophthalmia neonatorum in a tertiary referral children's hospital: A retrospective study.
CONCLUSIONS: C. trachomatis was the most common cause of ON in this study and may be responsible for an even higher proportion of cases due to incomplete testing. In keeping with studies in different populations, S. aureus, H. influenzae and S. pneumoniae were also common. As a result, an improved management algorithm for cases of ON has been introduced in this centre. PMID: 33583215 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 14, 2021 Category: Opthalmology Authors: Gildea D, Goetz R, Drew R, Chamney S Tags: Eur J Ophthalmol Source Type: research

Simultaneous bilateral or sequential DCR? What to choose?
CONCLUSION: The lack of intergroup differences in clinical, surgical, and outcome parameters suggests that in cases of bilateral nasolacrimal duct obstruction in adults and children, simultaneous bilateral endoscopic-endonasal dacryocystorhinostomy may yield excellent therapeutic results. PMID: 33583229 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 14, 2021 Category: Opthalmology Authors: Weinberger Y, Soudry E, Avisar I Tags: Eur J Ophthalmol Source Type: research

Paracentral acute middle maculopathy in the setting of central retinal artery occlusion following COVID-19 diagnosis.
CONCLUSION: This is the first case that reports PAMM in the setting of CRAO following COVID-19 diagnosis. Viral induced microangiopathy may involve in the development of CRAO in our patient without a hypercoagulable state and additional risk factors. Physicians should be vigilant to seek for retinal evaluation in patients with significant visual loss even after a mild COVID-19 history. PMID: 33583231 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 14, 2021 Category: Opthalmology Authors: Turedi N, Onal Gunay B Tags: Eur J Ophthalmol Source Type: research

Visual outcomes in advanced keratoconus using different strategies: Scleral lens, intracorneal ring segment and lamellar keratoplasty.
CONCLUSION: We showed that the CDVA of eyes fitted with SCL without any surgical treatment was statistically better than CDVA of eyes after ICRS insertion. After DALK and ICRS insertion, many patients needed a complimentary treatment to improve CDVA. The most chosen treatment was fitting a SCL. After this, all eyes showed statistically significant improvement in f-VA, with statistically better results for DALK + SCL when compared to SCL fitted in advanced keratoconus without any surgical treatment. PMID: 33583232 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 14, 2021 Category: Opthalmology Authors: Rocha G, Vieira BV, Mendes BMS, Iguma CI, Silva TCS, de Sousa LB, Tzelikis PF Tags: Eur J Ophthalmol Source Type: research

Structural and vascular features in cavitary congenital optic disc anomaly associated with metaphyseal acroscyphodysplasia.
CONCLUSION: The presence of coloboma disc congenital defect linked to embryological abnormalities during the development process could pave the way for a wider understanding of the pathogenesis of metaphyseal acroscyphodysplasia by increasingly framing it as a systemic disease. PMID: 33583233 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 14, 2021 Category: Opthalmology Authors: Fossataro F, D'Andrea L, Cennamo G Tags: Eur J Ophthalmol Source Type: research

The impact of COVID-19 on primary retinopexy in preventing retinal detachment in a tertiary eye hospital emergency department.
CONCLUSION: This study demonstrates a reduction of primary retinopexy, an increased risk for RRD following primary retinopexy and a significant shift in type of primary retinopexy performed, demographics, operator and change in characteristics of type of retinal break observed during this pandemic. This study contributes to the growing literature of the secondary effects of the COVID-19 pandemic on other aspects of healthcare that is not just limited to the virus itself. PMID: 33573420 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 11, 2021 Category: Opthalmology Authors: Moussa G, Samia-Aly E, Andreatta W, Lett KS, Mitra A, Sharma A, Tyagi AK, Ch'ng SW Tags: Eur J Ophthalmol Source Type: research