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Management of retinoblastoma: are we there yet?
Can J Ophthalmol. 2024 Feb 28:S0008-4182(24)00028-0. doi: 10.1016/j.jcjo.2024.01.013. Online ahead of print.NO ABSTRACTPMID:38431272 | DOI:10.1016/j.jcjo.2024.01.013 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - March 2, 2024 Category: Opthalmology Authors: Vishal Raval Arun Singh Source Type: research

Circulating Tumor DNA Posttreatment Measurements in Retinoblastoma
This cohort study investigates the association between the disappearance of plasma RB1 circulating tumor DNA and metastasis-free survival in retinoblastoma. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - March 1, 2024 Category: Opthalmology Source Type: research

MicroRNA-506 Regulates Apoptosis in Retinoblastoma Cells by Targeting Sirtuin 1 [Retraction]
(Source: Cancer Management and Research)
Source: Cancer Management and Research - February 24, 2024 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

Overall survival comparison between pediatric and adult retinoblastoma and adult nomogram construction: A SEER population-based analysis
CONCLUSION: In this study, adult RB patients have worse OS than pediatric RB patients. Consequently, we constructed a Nomogram to predict the risk for adult RB patients. The Nomogram demonstrated good accuracy and reliability, making it suitable for widespread application in clinical practice to assist healthcare professionals in assessing patients' prognoses.PMID:38395709 | DOI:10.1016/j.asjsur.2024.02.046 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - February 23, 2024 Category: Surgery Authors: Fangxu Yin Zheng Guo Wei Sun Chong Hou Song Wang Fulong Ji Yong Liu Siqi Fu Chunxiang Liu Rui Li Yuchao Wang Daqing Sun Source Type: research

The CDK4/6 Inhibitor Palbociclib Induces Cell Senescence of High-grade Serous Ovarian Cancer Through Acetylation of p53
In conclusion, Palbociclib induced cell senescence of HGSOC through P300-mediated p53 acetylation, suggesting that Palbociclib may have the effect of treating HGSOC.PMID:38388849 | DOI:10.1007/s10528-024-10704-w (Source: Biochemical Genetics)
Source: Biochemical Genetics - February 22, 2024 Category: Genetics & Stem Cells Authors: Cong Ye Yan Cheng Xiaohong Qian Bo Zhong Jinchun Ma Hongling Guo Source Type: research

Correlating somatic copy number alteration in aqueous humour cfDNA with chemotherapy history, eye salvage and pathological features in retinoblastoma
This study determined to probe the potential association between somatic copy number alteration (SCNA) in retinoblastoma (RB) aqueous humour (AH) and pathological high-risk factors, clinical features and previous chemotherapy history. Methods Single-centre retrospective cohort study from including 58 AH samples collected from 58 patients diagnosed. Among them, 41 samples were collected after enucleation and 17 samples were collected before intravitreal chemotherapy. SCNAs were accessed by conducting shallow whole-genome sequencing in cell-free (cf) DNA of AH. HRs and ORs were applied to measure risk factors. Results Canon...
Source: British Journal of Ophthalmology - February 21, 2024 Category: Opthalmology Authors: Luo, Y., Xu, M., Yang, L., Yao, Y., Berry, J. L., Xu, L., Wen, X., He, X., Han, M., Fan, X., Fan, J., Jia, R. Tags: Ocular oncology Source Type: research

Primary Subretinal Seeding in Retinoblastoma: Clinical Presentation and Treatment Outcomes
CONCLUSION: Primary SRS pose a therapeutic challenge during RB treatment. The SRS responds moderately to systemic IVC, with one-third cases showing SRS recurrence and one-fifth ultimately requiring enucleation.PMID:38376084 | PMC:PMC10821785 | DOI:10.1159/000530497 (Source: Cancer Control)
Source: Cancer Control - February 20, 2024 Category: Cancer & Oncology Authors: Komal Bakal Vishal Raval Sai Krishna Gattu Vijay Anand Reddy Palkonda Swathi Kaliki Source Type: research

Audiology evaluation following intra-arterial carboplatin for retinoblastoma
Can J Ophthalmol. 2024 Feb 16:S0008-4182(24)00030-9. doi: 10.1016/j.jcjo.2024.01.014. Online ahead of print.NO ABSTRACTPMID:38373698 | DOI:10.1016/j.jcjo.2024.01.014 (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - February 19, 2024 Category: Opthalmology Authors: Aurora Rodriguez Todd Abruzzo James A Williams Aparna Ramasubramanian Source Type: research