JAMA Ophthalmology Peer Reviewers in 2020
(Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 19, 2021 Category: Opthalmology Source Type: research

An Unusual, Idiopathic Scrolled Epiretinal Membrane
This case report describes a woman with an unusual, idiopathic epiretinal membrane visible on multiple types of imaging. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 19, 2021 Category: Opthalmology Source Type: research

A Global Assessment of Eye Health and Quality of Life
This cross-sectional study examines the association between vision impairment or eye disease and quality of life and the outcome of ophthalmic interventions on quality of life globally and across the life span. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Unilateral Hypopyon in an Elderly Man With Dementia
An elderly man with a history of Philadelphia chromosome –positive acute lymphocytic leukemia, diabetes, and dementia presented with decreased visual acuity and hypopyon in his right eye. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Retinal Detachment in a 40-Year-Old Man With Sturge-Weber Syndrome
A 40-year-old man presents with decreased vision 3 weeks after undergoing a 2-stage Baerveldt implantation. Ocular history shows Sturge-Weber syndrome, secondary glaucoma, and chronic retinal detachment. Examination showed a red glow of the fundus with shifting subretinal fluid and retinal detachment in the left eye, and retinal detachment and demonstrated homogeneous diffuse choroidal thickening in the right eye. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Bilateral Asymmetrical Corneal Deposits in an Asymptomatic Patient
A 70-year-old woman presented with a history of hypertension, hyperlipidemia, and bilateral asymmetric corneal lesions. What is your diagnosis? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

The Importance of Patients ’ Perspectives in Providing Ophthalmic Care
For patients with chronic eye disease, keeping scheduled appointments for monitoring and treatment is essential to minimize avoidable vision loss. Patients with retinal diseases depend on intravitreal injections as the standard of care, whereas for patients with glaucoma, monitoring and access to emergent care is essential. Other eye conditions also are dependent on maintaining time-sensitive treatments. The onset of the coronavirus disease 2019 (COVID-19) virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exacerbated the challenges of addressing eye care, because risk factors for developing COVID-19 are ...
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Response of Retinal Neovascularization to Aflibercept or Panretinal Photocoagulation in Proliferative DR
This post hoc analysis of the CLARITY randomized clinical trial investigates the distribution of neovascularization in patients with proliferative diabetic retinopathy and the topographical response of neovascularization to treatment with aflibercept or panretinal photocoagulation. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Patient Perceptions of SARS-CoV-2 Exposure Risk and Association With Continuity of Ophthalmic Care
This survey study uses data from a random sample of patients from 2 tertiary eye care centers to investigate the association of missed ophthalmic appointments with patient fear of contracting the coronavirus disease 2019 virus, SARS-CoV-2. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Painless Visual Loss in a Septuagenarian
A septuagenarian with a history of Crohn disease, coronary artery disease, hypercholesterolemia, and transient ischemic attack presents with sudden, painless visual loss. Examination of a temporal artery biopsy specimen shows chronic, nongranulomatous inflammation. Reexamination of the biopsy specimen 2 weeks later shows abundant transmural deposits of amorphous eosinophilic acellular material that exhibit apple-green birefringence consistent with amyloid deposits; IgM and lambda light chain restriction are also observed. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Association of Conjunctival Plaques With BRAF Inhibitor Treatment in Patients With Pediatric Brain Tumor
These case reports investigate the potential association between BRAF inhibitors and conjunctival plaques in patients with pediatric brain tumor. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Aflibercept Injection as Prophylaxis Against Conversion to Exudative AMD in High-risk Eyes
This randomized clinical trial evaluates the use of intravitreal aflibercept as prophylaxis against conversion to exudative age-related macular degeneration (AMD) in patients with dry AMD and high risk for conversion. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

JAMA Ophthalmology —The Year in Review, 2020
2020 —that number has always been important in ophthalmology, representing normal visual acuity when denoted as 20/20 and being the value ophthalmologists strive to attain when treating eye diseases or preserving vision. Now, though, with the pandemic of coronavirus disease 2019 (COVID-19) brought on b y the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 2020 is a number that has much more relevance in medicine beyond normal visual acuity. Despite the many challenges in medicine in 2020, the year was associated with many important milestones for JAMA Ophthalmology. These miles tones again are due...
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Structural and Functional Retinal Changes in Preclinical Alzheimer Disease
It has been more than 100 years since Alois Alzheimer identified Alzheimer disease (AD), and almost 40 years since the role of amyloid- β (Aβ) and tau proteins, 2 key molecular factors in the AD pathophysiologic patterns, were identified. Alzheimer disease is now recognized as a multifaceted process that progresses along a continuum with a commonly defined starting point being the accumulation of the Aβ biomarker demonstrated on positron emission tomography (PET) or cerebrospinal fluid analysis. The epidemic of AD has already decreased the life expectancy in the US, adding to the urgency to identify a noninv...
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

MOG-IgG Among Participants in the Pediatric Optic Neuritis Prospective Outcomes Study
This study examines the association of myelin oligodendrocyte glycoprotein immunoglobulin G –associated disorder with pediatric optic neuritis to guide prognosis and treatment. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Retinal Changes With Alzheimer Disease Neuroimaging Biomarkers in Cognitively Normal Individuals
This cross-sectional study examines the use of structural changes in the retina as biomarkers to identify amyloid- β deposition in assessment of individuals for preclinical Alzheimer disease. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Handheld Optical Coherence Tomography vs Binocular Indirect Ophthalmoscopy Examination for Retinopathy of Prematurity
This cross-sectional study compares stress during investigational optical coherence tomography imaging to that during binocular indirect ophthalmoscopy for retinopathy of prematurity. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Savings From Diagnosing and Preventing Conjunctivitis in Academic Medical Center Employees
This quality improvement study examines the institutional cost savings of a policy to diagnose adenoviral conjunctivitis and triage and furlough medical center employees with suspected adenoviral conjunctivitis to prevent outbreaks. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Keeping Red Eyes From Putting Workplaces in the Red
Adenoviral conjunctivitis disrupts workplaces, schools, and communities, costing hundreds of millions of dollars annually. With no proven treatment and the potential for rapid spread, vision-threatening complications, and prolonged recovery, employers must take its identification and containment seriously. Meanwhile, this condition frequently presents a diagnostic dilemma, with a wide range of less contagious or treatable conditions masquerading as viral conjunctivitis. This leads to several undesirable scenarios, including the unnecessary furlough of employees who come to work with red eyes and inappropriate prescription ...
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Survival Analysis vs Longitudinal Modeling With Multiple Imputation —a False Dichotomy—Reply
In Reply We thank VanderBeek et al and the journal for giving us the opportunity to respond to this letter and hope that our reply offers some reassurance. VanderBeek et al point out that missing data may present issues to the unwary researcher, and we are pleased that our article has drawn attention to this matter. We completely agree that there is great value in the use of multiple imputation in observational studies with missing data and are somewhat perplexed by the suggestion that our article indicated otherwise. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

An Emphasis on the Gap Between the Surveyed Myopia Rate and Eyeglass-Wearing Rate in the Study of Ocular Susceptibility to SARS-CoV-2 Infection —Reply
In Reply Many thanks to the researchers who expressed interest in the results of our article. The issues they raised were mainly the low number of tear samples that tested positive for SARS-CoV-2 infection and the accuracy of the eyeglass-wearing rate among the population. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Survival Analysis vs Longitudinal Modeling With Multiple Imputation —A False Dichotomy
To the Editor We read with interest the article by Fu et al and were struck by their strong statements regarding the validity of survival analysis and their dismissal of multiple imputation as a statistical tool in observational studies with missing data. We were most concerned by their assertion that survival analysis is not impacted by missing data while multiple imputation leads to biased results. Both multiple imputation and survival analysis (eg, Kaplan-Meier estimates or a proportional hazards model) rely on the missing at random assumption, according to which the probability that an observation is missing can be pre...
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

An Emphasis on the Gap Between the Surveyed Myopia Rate and Eyeglass-Wearing Rate in the Study of Ocular Susceptibility to SARS-CoV-2 Infection
This study supports the ocular surface as a point of entry for SARS-CoV-2 transmission. However, according to a recent systematic review, ocular manifestations were found in 0% to 31.6% of patients infected with SARS-CoV-2, and only 0% to 11.1% had positive test results in tear samples. This suggests that the ocular surface is not a major transmission route for SARS-CoV-2. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

Findings From the Ocular Hypertension Treatment Study After 20 Years of Follow-Up
This cohort study comprises phase 3 of the Ocular Hypertension Treatment Study and assesses the 20-year cumulative incidence and severity of primary open-angle glaucoma among the original cohort of participants with ocular hypertension. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

JAMA Ophthalmology
Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of authors for their important manuscripts. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2021 Category: Opthalmology Source Type: research

A Spiderweb-Like Fibrinous Reaction
This case report describes a man who experienced a postsurgical, spiderweb-like formation in the anterior chamber of an eye treated for cataract. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 21, 2021 Category: Opthalmology Source Type: research

Ocular Relapse of B-Cell Acute Lymphoblastic Leukemia
This case report describes a relapse of B-cell acute lymphoblastic leukemia/lymphoma that initially presented as uveitis. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 21, 2021 Category: Opthalmology Source Type: research

Perforation of Presumed Papillary Gliosis Resulting in an Optic Pit in a Child
This case report describes change over time in a translucent, gliotic-appearing membrane overlying the left optic nerve that first appeared in a 16-month-old boy. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 21, 2021 Category: Opthalmology Source Type: research

Cutaneous Malignant Melanoma Metastatic to the Intraocular Lens
This case report describes a rare case of cutaneous malignant melanoma metastatic to the intraocular lens. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 21, 2021 Category: Opthalmology Source Type: research

Presence of SARS-CoV-2 RNA in Cornea of Viremic Patients With COVID-19
This case series investigates the presence of viral severe acute respiratory syndrome coronavirus 2 RNA in corneal discs of deceased patients with confirmed coronavirus disease 2019 and assesses viral genomic and subgenomic RNA load, possible infectivity, and histologic abnormalities. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

A 47-Year-Old Woman Urgently Referred for Proliferative Diabetic Retinopathy Management
A woman with type 2 diabetes and acute onset of blurry vision was referred for possible proliferative diabetic management. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

White Macula After Pars Plana Vitrectomy in a 71-Year-Old Woman
Three weeks after uneventful pars plana vitrectomy of the right eye for vitreomacular traction, a 71-year-old woman presents with a painless central scotoma and worsening floaters. Optical coherence tomography shows atrophy, full-thickness hyperreflectivity, and a residual epiretinal membrane. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Calculating Utility Gain by Different Methods
Cataract surgery and drug treatment for neovascular age-related macular degeneration (NVAMD) are among the most common evidence-based ophthalmic procedures and yield substantial benefit to patients. For vulnerable populations who are elderly or disabled and minority populations who have struggled to obtain access to appropriate care most of their lives, loss of sight is devastating, so providing timely treatment ought to be straightforward. However, cataracts and NVAMD mostly occur late in life, which means that these conditions compete with other concurrent serious comorbidities, and benefits are spread across far fewer y...
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Opportunities to Reduce Potential Bias in Ophthalmic Cost-Utility Analysis
This economic evaluation assesses whether use of nonpatient vision utilities and a maximum limit model constraining vision utility gain to the systemic comorbidity utility level biases against ophthalmic cost-utility outcomes among patients with neovascular age-related macular degeneration and cataract. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Nonclearing Corneal Edema After Phacoemulsification and Intraocular Lens Implantation
An 82-year-old man presents with a history of bilateral nuclear sclerotic cataracts and blurred vision in the right eye after cataract extraction 8 weeks earlier. On examination, his best-corrected visual acuity is 20/80 OD and 20/20 OS with a few guttate in the left eye, and central corneal thickness is 957 and 547 μm in the right and left eyes, respectively. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Do Racial/Ethnic Disparities in Enucleation for UM Indicate Poor Quality of Care or Financial Obstacles?
To the Editor Rajeshuni et al examined the association of race/ethnicity and socioeconomic status with uveal melanoma treatment by performing a retrospective analysis of Surveillance, Epidemiology, and End Results (SEER) registries in the US. They reported that treatment consisted of primary enucleation in 27% of non-White individuals compared with 20% of non-Hispanic White individuals and in 27% of individuals in a lower socioeconomic group compared with 14% of those in a higher socioeconomic group. They concluded, “Given the consequences of enucleation, including postoperative vision loss, decreased quality of life...
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Do Racial/Ethnic Disparities in Enucleation for UM Indicate Poor Quality of Care or Financial Obstacles? —Reply
In Reply We appreciate Damato ’s interest in our work. We concur that there are a multitude of factors that impact treatment decisions in cancer care from all sides, including the patient, the medical team, and the structure of the health care system. It is our opinion that enucleation in uveal melanoma may, in many cases, be the most appropriate treatment for a particular tumor and may not represent a last-resort treatment even during a pandemic. The underlying premise behind our work is that there are no guidelines indicating that patients of different racial/ethnic or socioeconomic status (SES) groups should have ...
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Assessment of Trends in Incidence Rates of Central Artery Occlusion in Korea
This cohort study uses data from the Korean National Health Insurance Service database from 2002 to 2015 to estimate temporal trends in the incidence rates of central retinal artery occlusion among residents of Korea. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Unilateral Frosted Branch Angiitis in a Patient With Immunosuppression
A 49-year-old man presents with acute unilateral painless vision loss, antisynthetase syndrome, fever, and interstitial lung disease. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Is It Always Better to Get Faster Results in Temporal Artery Biopsies?
Diagnosis and treatment of giant cell arteritis (GCA) have evolved throughout the years. Before the 1990s, the diagnosis relied entirely on temporal artery biopsy (TAB) –proven disease to start the eyesight-saving steroid treatment. Pathologists used to do frozen sections to rapidly render a diagnosis that would inform the decision of whether or not to have the patient start corticosteroid treatment. This sounds like an ideal practice for patient care, so why hav e we stopped favoring this approach? Primarily, it is because we have reached a better understanding of GCA physiopathology, which has balanced the accuracy...
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Toward a Paradigm Shift in the Therapeutic Approach to Fuchs Endothelial Corneal Dystrophy
Over the past decade, Descemet membrane endothelial keratoplasty (DMEK) has become the standard for the treatment of endothelial diseases, with Fuchs endothelial corneal dystrophy (FECD) being the most common indication. Descemet membrane endothelial keratoplasty in eyes with FECD usually results in successful clinical outcomes with low postoperative complication rates. Because of the fast and reliable visual rehabilitation after DMEK, the visual threshold for undergoing corneal transplantation has decreased and DMEK is performed in a wide range of FECD stages. Currently, surgical indications are based mainly on best-corre...
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Discordance Rate Among Bilateral Simultaneous and Sequential Temporal Artery Biopsies in Giant Cell Arteritis
This cohort study evaluates the sensitivity and specificity of temporal artery biopsy frozen vs permanent section pathology results for giant cell arteritis and determines the discordance rate of bilateral temporal artery biopsies. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Tuberculosis Exposure With Risk of Beh çet Disease Among Patients With Uveitis
This mendelian randomization and cohort study evaluates associations of tuberculosis with several noninfectious uveitis conditions, particularly Beh çet disease, in cohorts in China and Japan, including a subgroup given T-SPOT.TB assays. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Predicting Edema Resolution After Descemet Membrane Endothelial Keratoplasty for Fuchs Dystrophy
This prognostic study develops a predictive model in which Scheimpflug tomographic imaging is used to evaluate edema resolution after Descemet membrane endothelial keratoplasty in patients with advanced Fuchs dystrophy. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Prevalence and Factors Associated With Eyeglass Wear Compliance Among Preschoolers From Low-Income Families
This cross-sectional study assesses the prevalence and factors associated with eyeglass wear compliance for a school year among preschool children who have a failed vision screening, are from low-income families, and receive eyeglasses through the See Well to Learn program. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Replacement of Nonauthor Collaborator Names
In the Original Investigation titled “Association of Sex With Frequent and Mild ABCA4 Alleles in Stargardt Disease,” that published in the October 1, 2020, issue, the nonauthor collaborator names were omitted from the PubMed listing. The article has been corrected by adding Supplement 2 containing all names. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Early Experience With Brolucizumab for Neovascular Age-Related Macular Degeneration
This case series reports clinical outcomes after intravitreous injection of brolucizumab, 6 mg, for neovascular age-related macular degeneration. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

What Is Just the Right Amount of Anti –Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema?
This Viewpoint asks what is the maximum that can be done to prevent vision loss in patients with diabetic macular edema. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Overminus Lens Therapy for Children With Intermittent Exotropia
Conservative management of intermittent exotropia in children includes fusion or convergence exercises, antisuppression eye patch therapy, overminus lens therapy, or observation alone. Overminus lenses improve strabismus control in children with intermittent exotropia by stimulating accommodative convergence, thereby reducing exotropia and facilitating sensory fusion. They have been recommended as nonsurgical treatment for children with intermittent exotropia associated with a high accommodative convergence/accommodation (AC/A) ratio, because standard strabismus surgery is associated with risk of consecutive esotropia for ...
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research

Association of No-Cost Genetic Testing and Characteristics of Patients With Inherited Retinal Degenerations
This cross-sectional study examines the use of no-cost genetic testing in patients with inherited retinal degeneration. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2021 Category: Opthalmology Source Type: research