Presumed Posteriorly Luxated Schwalbe Line
A 22-year-old man presented with progressive diminution of vision in the left eye since early childhood. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 11, 2020 Category: Opthalmology Source Type: research

Evolution of a Peripapillary Combined Hamartoma of the Retina and Retinal Pigment Epithelium in a Child
This case report describes the evolution of a peripapillary combined hamartoma of the retina and retinal pigment epithelium in a child. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 11, 2020 Category: Opthalmology Source Type: research

Microrip of Retinal Pigment Epithelium in Central Serous Chorioretinopathy
This case report describes subretinal fluid at the macula with a discontinuation of the retinal pigment epithelium presumed to be a microrip or tear of the retinal pigment epithelium. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 11, 2020 Category: Opthalmology Source Type: research

Genetic, Anatomical, and Functional Correlation of Sector Retinitis Pigmentosa
This case report describes a 40-year-old woman with sector retinitis pigmentosa with well-defined genetic, anatomical, and functional attributes. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 11, 2020 Category: Opthalmology Source Type: research

Controlling Conjunctival Melanoma —To Infinity and Beyond
“To infinity and beyond” is the famous catchphrase credited to Pixar’s Buzz Lightyear in the movie Toy Story. This phrase has been echoed many times in subsequent Toy Story movies, in advertisements, on a Super Bowl commercial, and even by Woody when he appeared with Buzz at the 2016 Oscars ce remony. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Incidence and Survival of Patients With Conjunctival Melanoma in Europe
This cohort study uses data from 41 European cancer registries to estimate the incidence and survival of patients with conjunctival melanoma in Europe. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Two-Year Progression Along the AREDS AMD Scale and Development of Late AMD or Loss of Visual Acuity
This cohort study assesses whether 2-year progression along the Age-Related Eye Disease Study age-related macular degeneration (AREDS AMD) scale is associated with long-term clinically meaningful outcomes. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Assessment of Firework-Related Ocular Injury in the US
This cross-sectional study characterizes firework-related ocular injuries treated in emergency departments in the US from 1999 to 2017. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Homonymous Hemianopia With Normal Magnetic Resonance Imaging
A man in his 80s presented with 3 months of painless progressive vision loss, followed by gait changes, memory loss, and 10-pound unintentional weight loss. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Bilateral Enlargement of the Foveal Avascular Zone on Optical Coherence Tomography Angiography Associated With Cocaine Use
This case report describes bilateral enlargement of the foveal avascular zone in a man reporting long-term cocaine use. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Association of Visual Impairment With Risk of Incident Dementia
This cohort study examines the visual levels of participants in the Women ’s Health Initiative with vs without cognitive impairment. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Effect of Face-Down Positioning vs Support-the-Break Positioning After Macula-Involving Retinal Detachment Repair
This randomized clinical trial assesses whether face-down positioning in the 24-hour period after macula-involving retinal detachment repair influenced retinal displacement, distortion, and visual outcome at 6 months postoperatively. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Short-term Outcomes After Very Low-Dose Intravitreous Bevacizumab for Retinopathy of Prematurity
This study assesses the lowest effective dose of intravitreous bevacizumab for severe retinopathy of prematurity. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Slowly Progressive Unilateral Blepharoptosis in a 37-Year-Old Woman
A healthy 37-year-old woman presented for evaluation of left upper eyelid blepharoptosis. The results of her physical examination were notable for left-sided blepharoptosis with a palpable mass of the upper eyelid laterally. The patient was otherwise asymptomatic. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Inquiries on the Validation of a Model to Reduce Retinopathy of Prematurity Testing
To the Editor We congratulate Binenbaum et al on their work on validation of postnatal growth and retinopathy of prematurity screening criteria. Safely reducing the number of infants requiring a retinopathy of prematurity (ROP) examination is challenging. We respectfully share some concerns about the statistical aspects of the article. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Inquiries on the Validation of a Model to Reduce Retinopathy of Prematurity Testing —Reply
In Reply We thank the authors for their interest in the Postnatal Growth and Retinopathy of Prematurity (G-ROP) studies. We previously reported development of the G-ROP criteria and more recently successful validation in a new cohort. The authors ’ questions pertain to prediction model development. They question parameters for assessing discriminatory performance, which are associated with potential overfitting, and choice of predictive factors, which are associated with potential underfitting. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Retinal Displacement Following Pneumatic Retinopexy vs Pars Plana Vitrectomy
This case series compares the occurrence of retinal displacement following rhegmatogenous retinal detachment repair between pars plana vitrectomy vs pneumatic retinopexy. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Outcomes of Limbal Stem Cell Transplant
This meta-analysis evaluates the outcomes of different limbal stem cell transplant procedures. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Rapidly Progressive Bilateral Visual Acuity Loss in a Middle-Aged Woman
A 46-year-old woman presents with 2 days of photophobia in her right eye and declining best-corrected visual acuity on follow-up. What is your diagnosis? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Rhegmatogenous Retinal Detachment in the Age of Genomic Medicine
Rhegmatogenous retinal detachment (RRD) happens when a vitreous humor –filled gap forms between the neurosensory and the retinal pigment epithelium layers. Although the condition is relatively infrequent and has surgical repair success rates greater than 80%, the visual acuity outcomes are poor in half of cases, especially patients who present with a detached macula . Male sex, myopia, and cataract surgery are all risk factors disproportionally overrepresented among patients with RRD. Because of the difficulty assembling sufficiently well-powered prospective studies, which is particularly intense for low-frequency di...
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Safety and Vision Outcomes of Subretinal Gene Therapy in Achromatopsia
This nonrandomized controlled trial assesses safety and vision outcomes of gene therapy for patients with achromatopsia. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Association of Myopia and Intraocular Pressure With Retinal Detachment in the UK Biobank Cohort
This mendelian randomization study uses genetic data to assess the association of myopia and intraocular pressure with retinal detachment risk. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Retinal Nonperfusion and Neovascularization With Ultrawidefield Fluorescein Angiography in Patients With Diabetes
This study identifies demographic risk factors and markers of advanced diabetic retinopathy that are associated with increased areas of nonperfusion and neovascularization in eyes with disease ranging from no diabetic retinopathy but diagnosed as having diabetes to proliferative diabetic retinopathy. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Frequency of Abstracts Presented at Eye and Vision Conferences Being Developed Into Full-Length Publications
This systematic review and meta-analysis examines reports evaluating the proportion of abstracts presented at eye and vision conferences that are subsequently published in full and investigates factors associated with publication. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Ophthalmology After Coronavirus Disease 2019 (COVID-19)
This Viewpoint theorizes changes in ophthalmology practices after the coronavirus disease 2019 (COVID-19) pandemic. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

Update to Open Access Status
This article has been corrected onli ne. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

JAMA Ophthalmology
Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of authors for their important manuscripts. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - June 1, 2020 Category: Opthalmology Source Type: research

JAMA Ophthalmology Peer Reviewers in 2019
(Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 14, 2020 Category: Opthalmology Source Type: research

Wyburn-Mason Syndrome in an 11-Year-Old Girl
This case report describes retinal arteriovenous malformations with markedly convoluted, dilated, and tortuous retinal vessels extending from the disc. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 14, 2020 Category: Opthalmology Source Type: research

Posterior Staphyloma of Extreme Pathologic Myopia
This case report describes posterior staphyloma in an extremely myopic eye presenting as progressive eye protrusion. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 14, 2020 Category: Opthalmology Source Type: research

Diffuse Retinal Cavernous Hemangioma in a 2-Year-Old Girl
This case report describes a diffuse retinal cavernous hemangioma. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 14, 2020 Category: Opthalmology Source Type: research

Serous Macular Detachment in Probable Vogt-Koyanagi-Harada Syndrome
This case report describes serous retinal detachments involving the macula of the right and left eyes. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 14, 2020 Category: Opthalmology Source Type: research

A Man With Bilateral Corneal Verticillata and Corneal Crystals
A 77-year-old man presented with bilateral corneal verticillata, a history of taking amiodarone, and numerous fine anterior stromal crystals. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Implications of Multimodal Imaging –Defined Reticular Pseudodrusen for Ophthalmic Epidemiology
Ophthalmic epidemiology plays an important role in developing our understanding of the complex interactions between genetics, demographic characteristics, and lifestyle that are associated with ocular disease. In this issue of JAMA Ophthalmology, Dutheil et al present their findings on the incidence of multimodal imaging –defined reticular pseudodrusen (RPD) among an older French population. Given the unknown cause of RPD and the relatively recent understanding of its prognostic value for the progression of age-related macular degeneration, the epidemiologic profile of RPD is of great interest. In the ALIENOR (Ant io...
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Frequentist Analysis of Death Associated With Intravitreal Anti –Vascular Endothelial Growth Factor Therapy
We present some complementary frequentist meta-analysis to an article published. The authors only used articles published in the English language. Although with the Peters and Egger test, they did not find a publication bias (P  = .44; P = .19), when analyzing the funnel plot graph, an asymmetry is evidenced. This may reflect a selection bias by language; there is a lack of small articles that should have a result in the direction of a higher risk of mortality, so the presence of this bias may favor statistical non significance and must be taken into account when interpreting the results. (Sourc...
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Frequentist Analysis of Death Associated With Intravitreal Anti –Vascular Endothelial Growth Factor Therapy—Reply
In Reply We are grateful to Fau et al for conducting and providing further analyses on our data set, which reinforced our interpretation and the need for further investigation regarding long-term, intensive intravitreal anti –vascular endothelial growth factor (anti-VEGF) treatment. Specifically, the authors remarked on our finding of a potential increase in overall mortality in the subgroup with monthly injections for up to 24 months (odds ratio, 1.89 [95% CI, 1.06-3.36]), which is a key finding of our study. However , we have been conservative in drawing conclusions, because despite a relatively large sample size (...
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Current Applicant Perceptions of the Ophthalmology Residency Match
This cross-sectional, nonvalidated survey evaluates the experiences and preferences of ophthalmology residency applicants who applied to the Bascom Palmer Eye Institute in the 2018-2019 application cycle. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Incidence and Risk Factors of Reticular Pseudodrusen
This cohort study describes the incidence of reticular pseudodrusen using retinal color photographs, spectral-domain optical coherence tomography scans, fundus autofluorescence, and near-infrared reflectance images among individuals 77 years of age or older and analyzes the associated risk factors. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Eye Care Among US Adults at High Risk for Vision Loss in the United States in 2002 and 2017
This survey study estimates the number of US adults 18 years or older at high risk for vision loss in 2017 and evaluates use of eye care services compared with 2002. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Notice of Retraction and Replacement
. Kang et al. Association of statin use and high serum cholesterol levels with risk of primary open-angle glaucoma. JAMA Ophthalmol. 2019;137(7):756-765 (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Genomic and Transcriptomic Tumor Heterogeneity in Bilateral Retinoblastoma
This case reports documents 2 patients with bilateral retinoblastoma to compare the genomic features between each eye and a specimen from an orbital relapse. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Severe Progressive Bilateral Vision Loss With Headaches
An African American woman in her 20s presented to an outside hospital with progressive vision loss in both eyes, photophobia, and nausea, which had developed over weeks. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Virtual Reality Simulation to Identify Vision –Associated Disability in Patients With Glaucoma
In this study, they designed 5 interactive VR environments that included supermarket shopping and stair and city navigations in daytime and nighttime to simulate the daily act ivities in a local community and tested them on patients with glaucoma and healthy individuals. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Use of Virtual Reality Simulation to Identify Vision-Related Disability in Patients With Glaucoma
This cross-sectional study describes virtual reality simulation for shopping as well as stair and city navigation to assess vision-related disability in patients with glaucoma. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Parental Myopia and Higher Risk of Myopia Among Multiethnic Children Before School Age
This cohort study investigates the association of parental myopia with refractive error and ocular biometry in multiethnic children aged 6 to 72 months. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials Clinical Trial
This post hoc analysis of a cohort study within the Comparison of Age-Related Treatments Trials (CATT) clinical trial seeks to determine incidence and progression of and risk factors for nongeographic atrophy in eyes treated with anti –vascular endothelial growth factor for neovascular age-related macular degeneration. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

A Mass in the Greater Wing of the Sphenoid in a Pediatric Patient
A 4-year-old girl presents with painless periorbital swelling and erythema. The patient was previously treated with an oral combination of amoxicillin and clavulanic acid and topical gentamicin therapy without improvement. The child ’s visual acuity, color vision, and pupillary examination results are within normal limits, and intraocular pressures are 28 mm Hg OD and 20 mm Hg OS. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

JAMA Ophthalmology —The Year in Review, 2019
Each year, in the early spring, JAMA Ophthalmology leadership pauses momentarily to review substantial changes over the past year and to thank our editorial board, the Advisory Committee, other journal staff, peer reviewers, and authors for contributing to the journal ’s mission, “To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of authors for their important manuscripts.” We also look back over the year and reflect on how we are doing. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Sex Diversity in Ophthalmology Leadership in 2020 —A Call for Action
It is 2020 —a special year for ophthalmologists and an appropriate time to reflect on the state of our field. In this issue of JAMA Ophthalmology, Camacci and colleagues highlight yet another area where women lag behind men in ophthalmology. Evaluating the sex composition of 15 ophthalmology societies and 20 ophthalmic journals, the authors found that approximately one-quarter of the members of society and editorial boards were women, which seems reasonable when one considers that women make up approximately one-quarter of practicing ophthalmologists in the US. However, a completely different picture e merged for the...
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research

Artificial Intelligence for Refractive Surgery Screening
Research involving applications of artificial intelligence (AI) in health care has expanded rapidly in recent years. In particular, deep learning methods using convolutional neural networks has demonstrated the ability to achieve expert-level performance in image-based diagnosis. Although the highest-profile AI work in ophthalmology has applied this technology to retinal disease, there are several potential applications to corneal pathologic conditions. Most work to date has focused on keratoconus owing to its high prevalence and primarily image-based diagnosis. Convolutional neural networks have been trained to detect ker...
Source: JAMA Ophthalmology - May 1, 2020 Category: Opthalmology Source Type: research