A Rare Case of Pulseless Retinopathy
This case report describes a patient who complained of gradual, progressive visual acuity loss in both eyes for 3 months and was found to have Takayasu arteritis. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 12, 2020 Category: Opthalmology Source Type: research

Depigmented Chorioretinal Lesions Following Varicella-Zoster Virus Infection
This case report presents a rare case of choroidal depigmentation with iris atrophy in a patient with a history of varicella-zoster virus. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 12, 2020 Category: Opthalmology Source Type: research

Tangled Vasculature in the Eye of a Young Girl
This case report describes a 12-year-old girl with combined hamartoma of retina and retinal pigment epithelium diagnosed via notable imaging results. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 12, 2020 Category: Opthalmology Source Type: research

Gas Bubbles in the Anterior Chamber
This case report describes a man with rhegmatogenous retinal detachment whose treatment was complicated by a tic disorder involving continuous motion of the head. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 12, 2020 Category: Opthalmology Source Type: research

Presumed Sickle Cell Retinopathy in an Elderly Woman
An African American woman presents with a 1-day history of new floaters in her right eye and no history of sickle cell disease. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Progressive Vision Loss in a 62-Year-Old Woman
A woman in her 60s presents with a history of chronic angle-closure glaucoma and bilateral peripheral iridotomies. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Is Binocular Interference a Distinct Clinical Entity?
Clinicians who treat strabismus are cognizant of the tendency to close 1 eye that some patients display when performing complex or detailed visual tasks. Although the eye closure is frequently attributed to an attempt to alleviate binocular diplopia, it may occur even in the absence of double vision. A plausible explanation for this tendency in patients without diplopia is subnormal binocular summation or binocular inhibition. Scarce information is available regarding eye closure in ophthalmic conditions other than strabismus. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Presumed Chloroquine Retinopathy With Short-Term Therapy for Glioblastoma Multiforme
This article presents the case of a woman who developed gradual visual field loss after taking chloroquine as part of treatment for glioblastoma multiforme. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Binocular Interference vs Diplopia in Patients With Epiretinal Membrane
This study evaluates associations with monocular eye closure in patients with epiretinal membrane and reports on binocular interference (closing 1 eye to improve visual quality). (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

α-MSH and Corneal Endothelial Cell Survival During Oxidative and Inflammation-Induced Stress in Donor Tissue
This comparative research study evaluates the cytoprotective role of neuropeptide α-melanocyte–stimulating hormone treatment in preventing corneal endothelial cell loss in eye bank cold-stored corneas under oxidative and inflammatory cytokine-induced stress. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Scleritis and Retinal Detachment After Strabismus Surgery in a Patient With Thyroid Eye Disease
An elderly man presents with a nonhealing conjunctival epithelial defect and scleral thinning after strabismus surgery. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Association of Age at Myopia Onset With Risk of High Myopia in Adulthood
This national cohort study estimates the risk of developing high myopia in adulthood in association with a specific age at myopia onset based on a data set of Chinese patients with 12-year annual follow-up. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Association of Adrenal Insufficiency With Pediatric Pseudotumor Cerebri Syndrome
This case series describes 5 pediatric patients in whom pediatric pseudotumor cerebri syndrome was associated with adrenal insufficiency. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Association of Daily Wear of Eyeglasses With Susceptibility to COVID-19 Infection
This cohort study assesses the association between daily wear of eyeglasses and susceptibility to coronavirus disease 2019 among patients admitted to a single hospital with infection. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Eye Protection and the Risk of Coronavirus Disease 19
Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes coronavirus disease 2019 (COVID-19), continues in many countries and communities around the world. Until 1 or more effective vaccines or therapeutic agents are available, basic infection prevention measures, such as universal masking, physical distancing, and hand hygiene, offer the best known protection against the disease. In health care settings, eye protection is an important part of the personal protective equipment (PPE) ensemble recommended for frontline health care personnel who come into close and prolonged c...
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

A Pediatric Patient With an Asymptomatic, Unilateral Retinal Mass
A 4-year-old girl presents with an asymptomatic, unilateral retinal mass with no visible calcification or subretinal fluid in the right eye and no further remarkable history. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Interpreting Multiple Outcomes of Pupillary Light Reflex in Sport-Related Concussion in Adolescents
Sport-related concussions (SRCs), a form of traumatic brain injury, are a concern for athletes of all levels and parents of young athletes. Subjective measures of visual function, such as convergence, have shown promise in detecting subconcussive injury. However, there is currently no widely accepted, objective biomarker for SRC available to physicians to aid in diagnosis. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Using Data to Rethink the Ban on Cornea Donation From MSM
Puente et al have raised an important question for eye banking and corneal transplant. Should we reassess the current US Food and Drug Administration (FDA) guidance and Eye Bank Association of America medical standards that place restrictions on transplant of corneas from men who have sex with men (MSM)? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

When the Disease Does Not Follow the Textbook
Emerging therapies for inherited retinal degenerations are changing the way we talk to patients about these diseases. No longer are we regulated to confessing that there are no treatments and maybe something will come along in 5 years. Rather, we can now instill a sense of hope by highlighting the recent US Food and Drug Administration approval of the first gene augmentation therapy for retinal pigment epithelium –specific 65 kDa (RPE65)–associated retinopathy and the dozens of ongoing clinic trials for other genes. Our priorities have shifted to identifying causative genetic variants and determining which pati...
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

The Utility of Pupillary Light Reflex Metrics as a Physiologic Biomarker for Adolescent Sport-Related Concussion
This study evaluates the potential utility of pupillary light reflex metrics as physiologic biomarkers for concussion. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Federal Regulations in the US and Canada and Potential Corneal Donation by Men Who Have Sex With Men
This survey study estimates the number of potential corneal donations associated with deferral policies in the United States and Canada for men who have had sex with another man. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Association of a Novel Intronic Variant in RPGR With Hypomorphic Phenotype of X-Linked Retinitis Pigmentosa
This study investigates an X-linked retinal degeneration family with atypical preservation of visual acuity in the presence of a novel deep intronic splice site RPGR c.779-5T>G variant. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Myopia Control With Low-Dose Atropine Eyedrops
Myopia control in recent years has gone from a niche clinical care activity to the conduct of mainstream randomized treatment trials in children in many countries. This is because of concern about the remarkable increase in the prevalence of myopia internationally, reaching more than 80% among some East Asian university students. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Oxymetazoline for Ptosis
Oxymetazoline (Afrin) nasal spray was approved by the US Food and Drug Administration (FDA) more than 50 years ago for the treatment of nasal congestion. In July 2020, the FDA approved a new formulation in which a higher concentration of oxymetazoline has been incorporated into eyedrops. These eyedrops allow oxymetazoline to elevate the eyelid by activating α-adrenergic receptors in the Muller muscle. In this issue of JAMA Ophthalmology, Slonim et al report the results of 2 industry-sponsored randomized placebo-controlled masked trials that assess the efficacy of oxymetazoline, 0.1%, eyedrops for ptosis. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Put a Drop of Timolol Into Each Eye and Call Me in the Morning
Migraine is the most common, chronic, serious neurologic condition worldwide, affecting more than 11% of the world ’s population. In the United States, it affects approximately 16% of women and 6% of men. Although migraine is a neurologic illness, it is associated with a number of ocular and visual symptoms, including visual aura, photophobia, eye pain, and visual snow. As a result, it is not uncommon for pati ents with migraine to consult an ophthalmologist because they perceive their problem to be an eye problem and not a brain problem. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Outcomes of Adversarial Attacks on Deep Learning Models for Ophthalmology Imaging Domains
This study investigates whether adversarial attacks can confuse deep learning systems based on imaging domains. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Short-term Efficacy and Safety of Topical β-Blockers in Acute Migraine
This randomized crossover clinical trial compares the short-term efficacy of topical timolol ophthalmic solution with placebo for reducing pain scores after an acute migraine attack. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Association of Oxymetazoline Hydrochloride, 0.1%, Solution Administration With Visual Field in Acquired Ptosis
This pooled analysis of 2 randomized clinical trials examines the efficacy and safety of oxymetazoline hydrochloride, 0.1%, ophthalmic solution in participants with acquired ptosis. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Low-Dose Atropine Eyedrops for the Control of Myopia Progression in Chinese Children
This randomized clinical trial evaluates the efficacy and safety of atropine, 0.01%, eyedrops on slowing myopia progression and axial elongation in Chinese children (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

SARS-CoV-2 Nucleocapsid Protein in the Ocular Tissues of a Patient With Previous COVID-19
This case study compares a patient previously infected with coronavirus disease 2019 with a control participant in assessment of nucleocapsid protein antigens on the cells of the conjunctiva, iris, and trabecular meshwork. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Strategies to Address Racial and Ethnic Disparities in Vision Care Research
This Viewpoint discusses barriers to racial and ethnic minority representation in clinical research and provides recommendations to promote inclusion of these marginalized groups. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

JAMA Ophthalmology
Mission Statement: To be the indispensable source of ophthalmic knowledge by promptly publishing innovative, clinically relevant research through consistent and authoritative peer review and, thereby, to be the first choice of authors for their important manuscripts. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - November 1, 2020 Category: Opthalmology Source Type: research

Hemorrhagic Papilledema Secondary to Craniopharyngioma
This case report describes a case of hemorrhagic papilledema in a man diagnosed with a craniopharyngioma. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 8, 2020 Category: Opthalmology Source Type: research

Cornea Iris Lens Contact With Air-Puff Tonometry
This case report describes the use of a tonometry (corneal visualization Scheimpflug technology) device capable of videographically recording corneal deformation with an air puff. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 8, 2020 Category: Opthalmology Source Type: research

Migration of a Fluocinolone Acetonide Intravitreal Implant Into the Anterior Chamber
This case report describes the migration of an 0.18-mg intravitreal fluocinolone acetonide implant in the eye of a patient who lacked an intact posterior capsule. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 8, 2020 Category: Opthalmology Source Type: research

Exuberant Epipapillary Fibrosis in Williams Syndrome
This case report describes pseudopapilledema with exuberant epipapillary fibrosis in both eyes of a man with Williams syndrome. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 8, 2020 Category: Opthalmology Source Type: research

Optic Nerve Edema, Venous Stasis Retinopathy, and Peripheral Retinal Whitening in a Teenage Girl
A teenage girl presents with hemorrhagic optic disc edema, peripapillary and subfoveal subretinal fluid, many intraretinal hemorrhages in all 4 quadrants, and additional abnormal findings on fundus examination. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Deep Learning Algorithms and the Protection of Data Privacy
The application of artificial intelligence to pattern recognition in medicine has been described in recent studies in machine learning. In particular, the use of machine learning in the form of the convolutional neural network has underpinned the current popularity of so-called deep learning algorithms, which are essentially convolutional neural network models distinguished by having a large number of hidden layers with many adjustable parameters requiring a large quantity of data for training. A deep learning algorithm can be applied to raw data without the need for data normalization and can be used to extract the inhere...
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Retinal Vasculitis After Administration of Brolucizumab Resulting in Severe Loss of Visual Acuity
This case report describes retinal vasculitis and loss of visual acuity in an elderly woman who received brolucizumab for neovascular age-related macular degeneration. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Acute Macular Neuroretinopathy Associated With an Oral FLT3 Inhibitor
This case report describes acute macular neuroretinopathy in a young woman with acute myeloid leukemia who was treated with the FLT3 inhibitor gilteritinib. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Model-to-Data Approach for Deep Learning in OCT Intraretinal Fluid Segmentation
This cross-sectional study assesses whether a model-to-data deep learning approach (ie, validation of the algorithm without any data transfer) can be applied in ophthalmology. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Transient Vision Loss in a Healthy Older Woman
A 72-year-old woman presented with nontraumatic transient vision loss. Slitlamp biomicroscopy demonstrated abnormal blood vessels at the superotemporal pupillary margin of the iris. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Fibroblast Growth Factor Receptor Inhibitor –Associated Retinopathy
This case report details off-label treatment of a patient ’s gastric adenocarcinoma with erdafitinab. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Progression of Photoreceptor Degeneration in Geographic Atrophy Secondary to Age-related Macular Degeneration
This study attempts to quantify photoreceptor degeneration outside regions of geographic atrophy in eyes with nonexudative age-related macular degeneration, to evaluate its association with future geographic atrophy progression, and to characterize its spatio-temporal progression. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

An African American Man With Progressive Loss of Iris Pigmentation in Both Eyes
A 37-year-old African American man presents with 4 years of progressive decreased patchy pigmentation of both eyes and transillumination defects bilaterally on slitlamp examination. What would do you next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Treating Neovascular Age-Related Macular Degeneration —So Much More to Learn
Anti –vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (nAMD) has been a resounding success and a breakthrough in the treatment for a disease complication that can devastate lives. As a group, patients do very well, at least for the first few years, i f treated sufficiently often to control neovascular activity. However, even when treatments are delivered with appropriate, protocol-directed treatment frequencies, with time, atrophy and fibrosis affect the outcomes and can be associated with loss of visual acuity. Understanding the drivers and ris k factors for the d...
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Association of Sex With ABCA4 Alleles in Stargardt Disease
This cross-sectional study examines whether sex-related factors could alter the clinical presentation of Stargardt disease among individuals with a low-penetrant ABCA4 allele. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Variation in Retinal Thickness and Outcomes in Eyes With Neovascular AMD Lesions Treated With Anti-VEGF
This study investigates whether visual and anatomic outcomes in eyes with neovascular age-related macular degeneration (AMD) initiating anti –vascular endothelial growth factor (VEGF) treatment are associated with fluctuations in retinal thickness. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Observations on Ophthalmic Care and Surgery for Very Important People
This Viewpoint describes key considerations in the treatment of very important people, such as celebrities, politicians, and philanthropists. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research

Assessment of Simulated Respiratory Droplet Spread During an Ophthalmologic Slitlamp Examination
This study simulated respiratory droplet spread during an ophthalmologic slitlamp examination to help establish risk of infectious disease contagion in this setting. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - October 1, 2020 Category: Opthalmology Source Type: research