Assessment of a Large Language Model ’s Responses to Questions and Cases About Glaucoma and Retina Management
This cross-sectional study compares the diagnostic accuracy and comprehensiveness of responses from a large language model chatbot with those of fellowship-trained glaucoma and retina specialists on ophthalmological questions and real patient case management. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Accuracy of an AI Chatbot ’s Interpretation of Clinical Ophthalmic Images
This study evaluates the performance of the novel release of an artificial intelligence chatbot that is capable of processing imaging data. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
ATXN7 -Related Cone-Rod Dystrophy
This study describes baseline ophthalmological biomarkers in spinocerebellar ataxia type 7 carriers included in the Integrated Functional Evaluation of the Cerebellum (CERMOI) cross-sectional study. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Retinal End Points for ATXN7- Related Spinocerebellar Ataxia
Inherited neurological degenerations often involve the retina, including the spinocerebellar ataxias, a group of diseases that cause progressive neurological degeneration including ataxia. Even before neurological symptoms develop, patients often experience oculomotor and retinal abnormalities, including degeneration of cone and rod photoreceptors and degeneration of the optic nerve. Because SCA7 is autosomal dominant, asymptomatic family members could be identified genetically at presymptomatic stages, and treatments could be administered before degeneration caused irreversible loss of function. As potential treatments to...
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
A Suspicious Pigmented Lesion of the Conjunctiva
A 74-year-old woman with a history of breast cancer, now in remission, presented for evaluation of a conjunctival lesion of the right eye. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Severe Intraocular Inflammation Following Intravitreal Faricimab
This case series describes 3 initially culture-negative cases of acute, severe, posterior-segment intraocular inflammation events occurring within the same month following faricimab intravitreal injections at a single institution. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Water-Free Cyclosporine Ophthalmic Solution vs Vehicle for Dry Eye Disease
This randomized clinical trial investigates the safety and effectiveness of a water-free cyclosporine ophthalmic solution, 0.1%, for dry eye disease. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Multinational External Validation of Autonomous Retinopathy of Prematurity Screening
This diagnostic study evaluates how well autonomous artificial intelligence –based retinopathy of prematurity screening can detect more-than-mild and type 1 retinopathy of prematurity. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
PS-OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula
This case series examines the orientation and density of scleral collagen fibers found on polarization-sensitive optical coherence tomography (PS-OCT) of highly myopic eyes with and without dome-shaped macula. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Sudden Death in a Child With Ocular Lesions
This case report describes a patient treated for ocular lesions who died suddenly at age 8 years and was diagnosed postmortem with Carney complex. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Unraveling the Potential of Water-Free Cyclosporine in Dry Eye Disease
In this issue of JAMA Ophthalmology, Peng and associates scrutinize the efficacy of SHR8028 (CyclASol 0.1% [Novaliq GmbH]), a water-free cyclosporine ophthalmic solution, 0.1%, used in the treatment of aqueous-deficient dry eye disease. SHR8028 uses a novel water-free vehicle perfluorobutylpentane (F4H5). Peng and associates conducted a rigorous randomized, double-masked, and vehicle-controlled phase 3 clinical trial in China that meticulously evaluates this innovative solution. A study of comparable but larger scale, namely the ESSENCE-2 randomized clinical trial, was piloted in the United States and published in JAMA Oph...
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Artificial Intelligence for Retinopathy of Prematurity Screening
DeepMind scientists began with old-school Atari games. Using deep and reinforcement learning, they developed an artificial intelligence (AI) program that learned to play Breakout, Pong, and other games at super-human levels after being provided only display-pixels data and scores; see how remarkably quickly it learned at https://www.youtube.com/watch?v=EfGD2qveGdQ. They caught the eyes of Google executives, who promptly bought the company and convinced them to tackle the 3000-year-old game of Go. Go was an elusive goal for AI researchers, who had primarily used game-tree-search approaches that could not handle Go ’s comp...
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Decoding Scleral Structures With Polarized Light
In their article on dome-shaped macula in eyes with high myopia, Ohno-Matsui et al used polarized-sensitive optical tomographic (PS-OCT) imaging to assess the scleral abnormalities of these eyes. The use of polarized light to investigate scleral structures breaks new ground in clinical research in ophthalmology. Polarized microscopy has long been an important research tool in the fields of medicine and material science, and PS-OCT has been used in the study of biological tissues including various parts of the eye. However, it has not been used extensively to investigate the sclera. The unique properties of polarized light ...
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
A Case of a Bumpy Retina
A 77-year-old male had 3 months of progressive vision decline in the left eye. Dilated fundus examination revealed diffuse hyperpigmented lesions involving the macula and superior fundus that corresponded to areas of nodular retinal pigment epithelium thickening on optical coherence tomography. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
Safely Viewing a Solar Eclipse
The Patient Page published online today in JAMA provides safety recommendations for viewing the next total solar eclipse, which will cross major US cities on Monday afternoon, April 8. A solar eclipse can be one of nature ’s most extraordinary astronomical displays, but as many ophthalmologists know, improper viewing can cause serious eye damage, even blindness, if certain steps are not taken to protect the eyes. It may not be safe to view a total eclipse without added eye protection, even during the 90 seconds whe n an eclipse is total, unless one is certain that one is viewing during totality. The totality of an eclips...
Source: JAMA Ophthalmology - April 1, 2024 Category: Opthalmology Source Type: research
