Predictive Value of Parafoveal Diabetic Macular Ischemia for Diabetic Retinal Disease Progression and VA Deterioration
This cohort study investigates the association of the deep learning –based diabetic macular ischemia with the subsequent risk of diabetic retinopathy progression, diabetic macular edema development, and visual acuity deterioration. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Effect of Metformin on the Development of Age-related Macular Degeneration in the Diabetes Prevention Program Outcomes Study —Reply
In Reply We thank Asensio-S ánchez for sharing his thoughts and appreciate the opportunity to respond to the comments. Asensio-Sánchez has accurately interpreted that this is the first time in the Diabetes Prevention Program Outcomes Study that age-related macular degeneration (AMD) assessment was performed; therefore, one c annot hypothesize on the prevalence or stage of AMD before the images were acquired. The prevalence reported is for the current visit and does not account for previous time points. At the current visit, AMD was identified in 479 participants (30.0%) with early-stage AMD in 229 (14.4%), intermediate A...
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Improving Estimates of The Geographic Distribution of Pediatric Ophthalmologists to Identify Underserved Regions —Reply
In Reply We want to thank Oke et al for their responses to our recently published article that examined the geographic distribution of pediatric ophthalmologists in association with US population demographic characteristics. We agree that it is imperative to interpret our data within the context of the limitations we presented. Professional society memberships are free and accessible ways to estimate the geographic distribution of health care professionals of large areas, such as the US. We modeled our methods on several previously published reports that estimated physician distribution solely using professional society me...
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Retinal Damage After Repeated Low-level Red-Light Laser Exposure
This case report discusses retinal damage incurred after repeated low-level red-light laser exposure in a 12-year-old female patient with a history of myopia. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Effect of Metformin on the Development of Age-Related Macular Degeneration in the Diabetes Prevention Program Outcomes Study
To the Editor We read with interest the article “Association of Metformin With the Development of Age-Related Macular Degeneration” by Domalpally et al. The association between metformin use and the development of age-related macular degeneration (AMD) was evaluated in the Diabetes Prevention Program trial participants approximately 16 years after the trial completion. More than half of all participants had diabetes at the time of the AMD evaluation based on fundus photographs and spectral-domain ocular coherence tomography images. The authors conclude that the risk for AMD was not less among patients who were taking m...
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Improving Estimates of The Geographic Distribution of Pediatric Ophthalmologists to Identify Underserved Regions
To the Editor Understanding the geographic distribution of pediatric ophthalmologists is a fundamental step toward improving access to eye care for children. Walsh et al reported on the contemporary distribution of pediatric specialists in the US; however, several limitations of the data used in this analysis must be considered when interpreting the results. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Optical Coherence Tomography Angiography, Artificial Intelligence, and the Missing Capillaries
The earliest stages of diabetic retinopathy (DR) are clinically characterized by the presence of microaneurysms. However, it is well established that diabetes is histopathologically characterized by capillary loss long before microaneurysms appear and long after microaneurysms disappear. The juxtaposition of these facts may lead one to wonder why the clinical staging of an ischemic disease has been limited to semiquantitative assessments of perfused vascular features, such as number of microaneurysms, dot-blot hemorrhages, intraretinal microvascular anomalies, and neovascularization. The short answer is that the tools nece...
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Errors in Abstract and Key Points
The Original Investigation titled “Pulsed Oral Azithromycin vs 6-Week Oral Doxycycline for Moderate to Severe Meibomian Gland Dysfunction: A Randomized Clinical Trial,” published on March 23, 2023, was corrected to fix errors in the Abstract and Key Points. The Objective in the Abstract was changed from “To determine if the AE s of a 3-week course of oral azithromycin were equivalent to the AEs of a 6-week course of oral doxycycline.” to “To determine if the effects of a 3-week course of oral azithromycin were equivalent to a 6-week course of oral doxycycline.” The Question in the Key Points was changed from ...
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
An Unusual Spontaneous Acute Deepening of the Anterior Chamber
A 53-year-old woman presented with 20/32 visual acuity and a reverse pupillary block in her left eye. The left anterior chamber was substantially deepened with a backbowing of the iris, and an inferior retinal detachment without any associated visible tear was present in the left eye. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Systemic Adverse Events Among Patients With Diabetes Treated With Intravitreal Anti-VEGF Injections
This cohort study evaluates the risks of adverse events associated with intravitreal anti –vascular endothelial growth factor injections in individuals with diabetes. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Bibliometric Analysis of Ophthalmic Journals
This qualitative study identifies all ophthalmic journals and evaluates citation metrics relating to articles, journals, authors, institutions, and countries published therein. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Difficulty in Assessing the Systemic Adverse Effects of Intravitreal Anti –Vascular Endothelial Growth Factor Therapy
While the visual benefits of intravitreal anti –vascular endothelial growth factor (anti-VEGF) therapy are clear, the debate around financial costs and clinical efficacy between agents continues today. The potential treatment-associated systemic adverse effects are less discussed but of equal importance. Zafar and colleagues use the Veterans H ealth Administration database to assess the occurrence of systemic adverse events in 1.7 million patients with type 2 diabetes, over 14 000 of whom received intravitreal anti-VEGF agents. Acute myocardial infarction, cerebrovascular disease, and kidney disease were each evaluated...
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Error in Author Affiliations
This article was corrected online. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
A Man With Kaleidoscope Vision
A 63-year-old man with a history of stage 3 cutaneous melanoma of the scalp and chronic lymphocytic leukemia presents with kaleidoscope vision. What would you do next? (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
Accuracy of Artificial Intelligence in Estimating BCVA From Fundus Photographs in Eyes With Diabetic Macular Edema
This diagnostic/prognostic study uses data and color fundus photographs from a randomized clinical trial involving patients undergoing treatment of diabetic macular edema to enable artificial intelligence systems to estimate best-corrected visual acuity and to evaluate the accuracy of those estimates. (Source: JAMA Ophthalmology)
Source: JAMA Ophthalmology - July 1, 2023 Category: Opthalmology Source Type: research
