Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cellsfv
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
Stigmasterol Depresses the Proliferation and Facilitates the Apoptosis of Fibroblast-Like Synoviocytes via the PI3K/AKT Signaling Pathway in Collagen-Induced Arthritis Rats
This study aims to investigate the effects of stigmasterol on FLS cell proliferation and apoptosis, as well as its impact on FLS cell cycle proteins and key genes in the Phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT) pathway, providing insights into the development of stigmasterol as an alternative therapeutic drug for RA. We administered 20 g/kg stigmasterol to rats continuously for 5 d to obtain stigmasterol-containing serum, and established rat models of osteoarthritis induced by ossein to obtain FLS. To explore the effects of stigmasterol on the viability, migration, proliferation and apoptosis of collagen-i...
Source: Alternative Therapies in Health and Medicine - December 8, 2023 Category: Complementary Medicine Authors: Daomin Lu Yuzheng Yang Wukai Ma Xueming Yao Yi Ling Ying Huang Qiuyi Wang Chengyu Xia Lei Hou Source Type: research
Aloe-Emodin Isolated from < em > Rheum Undulatum < /em > L. Regulates Cell Cycle Distribution and Cellular Senescence in Human Prostate Cancer LNCaP Cells
This study aimed to investigate the bioactivity of aloe-emodin in LNCaP cells via the activation of p21-mediated cellular senescence. Aloe-emodin treatment increased the percentage of cells in the G1 phase while decreasing the percentage in the S phase. This effect was reflected in the expression levels of proteins associated with cell cycle progression, such as p21CIP, retinoblastoma protein, and cyclin-dependent kinase2/4 in LNCaP cells. However, aloe-emodin-treated LNCaP cells did not induce cell cycle arrest at G2/M checkpoint. Moreover, increased senescence-associated-galactosidase activity was observed in a dose-depe...
Source: Journal of Dietary Supplements - December 8, 2023 Category: Nutrition Authors: Mei Tong He Quynh Nhu Nguyen Eun Ju Cho Seung Hyun Kim SeonJu Park Jun Yeon Park Sullim Lee Ki Sung Kang Source Type: research
